ATE433979T1
(de)
*
|
2004-04-02 |
2009-07-15 |
Osi Pharm Inc |
Mit einem 6,6-bicyclischen ring substituierte heterobicyclische proteinkinaseinhibitoren
|
US20100279994A1
(en)
*
|
2005-06-21 |
2010-11-04 |
Inifinity Discovery, Inc. |
Ansamycin Formulations and Methods of Use Thereof
|
MX2008014450A
(es)
*
|
2006-05-18 |
2009-03-09 |
Mannkind Corp |
Inhibidores de cinasa intracelular.
|
WO2008021347A2
(en)
*
|
2006-08-16 |
2008-02-21 |
Novartis Ag |
Method for making solid dispersions of highly crystalline therapeutic compounds
|
US7514444B2
(en)
|
2006-09-22 |
2009-04-07 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
EP2089391B1
(en)
*
|
2006-11-03 |
2013-01-16 |
Pharmacyclics, Inc. |
Bruton's tyrosine kinase activity probe and method of using
|
US20120101113A1
(en)
|
2007-03-28 |
2012-04-26 |
Pharmacyclics, Inc. |
Inhibitors of bruton's tyrosine kinase
|
IL295053A
(en)
*
|
2007-03-28 |
2022-09-01 |
Pharmacyclics Llc |
Broton tyrosine kinase inhibitors
|
EP2134338A1
(en)
*
|
2007-04-12 |
2009-12-23 |
Infinity Discovery, Inc. |
Hydroquinone ansamycin formulations
|
US7989465B2
(en)
*
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
TWI475996B
(zh)
*
|
2007-10-19 |
2015-03-11 |
Celgene Avilomics Res Inc |
雜芳基化合物及其用途
|
EP2250173A1
(en)
*
|
2008-01-18 |
2010-11-17 |
OSI Pharmaceuticals, Inc. |
Imidazopyrazinol derivatives for the treatment of cancers
|
ES2396613T3
(es)
*
|
2008-05-19 |
2013-02-22 |
OSI Pharmaceuticals, LLC |
Imidazopirazinas e imidazotriazinas sustituidas
|
US20100101977A1
(en)
*
|
2008-06-05 |
2010-04-29 |
United Comb & Novelty Corporation |
Stackable Packaging For Lipped Containers
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
CA2986640C
(en)
*
|
2008-06-27 |
2019-03-26 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
CN102066370B
(zh)
*
|
2008-07-15 |
2014-05-14 |
霍夫曼-拉罗奇有限公司 |
苯基-咪唑并吡啶类和哒嗪类
|
AU2013245503B2
(en)
*
|
2008-07-16 |
2015-09-24 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
CN102159214A
(zh)
*
|
2008-07-16 |
2011-08-17 |
药品循环公司 |
用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂
|
CA2735937A1
(en)
*
|
2008-09-05 |
2010-03-11 |
Avila Therapeutics, Inc. |
Algorithm for designing irreversible inhibitors
|
WO2010043633A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Palau Pharma, S. A. |
2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
|
JP5583680B2
(ja)
|
2008-10-15 |
2014-09-03 |
インフィニティー ファーマスーティカルズ インコーポレイテッド |
アンサマイシンヒドロキノン組成物
|
US9095592B2
(en)
*
|
2008-11-07 |
2015-08-04 |
The Research Foundation For The State University Of New York |
Bruton's tyrosine kinase as anti-cancer drug target
|
US8426428B2
(en)
*
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
US8513415B2
(en)
|
2009-04-20 |
2013-08-20 |
OSI Pharmaceuticals, LLC |
Preparation of C-pyrazine-methylamines
|
JP5656976B2
(ja)
*
|
2009-04-29 |
2015-01-21 |
ローカス ファーマシューティカルズ インコーポレイテッド |
ピロロトリアジン化合物
|
WO2010129053A2
(en)
|
2009-05-05 |
2010-11-11 |
Dana Farber Cancer Institute |
Egfr inhibitors and methods of treating disorders
|
WO2010129740A1
(en)
*
|
2009-05-07 |
2010-11-11 |
Osi Pharmaceuticals, Inc. |
Use of osi-906 for treating adrenocortical carcinoma
|
EP2473049B1
(en)
|
2009-09-04 |
2018-11-28 |
Biogen MA Inc. |
Bruton's tyrosine kinase inhibitors
|
JP2013504594A
(ja)
*
|
2009-09-11 |
2013-02-07 |
サイリーン ファーマシューティカルズ インコーポレーティッド |
薬学的に有用な複素環置換ラクタム
|
SG179172A1
(en)
*
|
2009-09-16 |
2012-04-27 |
Avila Therapeutics Inc |
Protein kinase conjugates and inhibitors
|
US7965498B2
(en)
|
2009-09-30 |
2011-06-21 |
Apple Inc. |
Cover glass to housing interface system
|
US7718662B1
(en)
*
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
CA2784807C
(en)
|
2009-12-29 |
2021-12-14 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
AU2010339456A1
(en)
|
2009-12-30 |
2012-07-05 |
Celgene Avilomics Research, Inc. |
Ligand-directed covalent modification of protein
|
WO2011110478A1
(en)
*
|
2010-03-08 |
2011-09-15 |
Ratiopharm Gmbh |
Dabigatran etexilate-containing pharmaceutical composition
|
WO2011133609A2
(en)
*
|
2010-04-19 |
2011-10-27 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of btk inhibitors
|
CN102918040B
(zh)
|
2010-05-31 |
2015-03-18 |
小野药品工业株式会社 |
6-羟基嘌呤衍生物
|
MY191929A
(en)
*
|
2010-06-03 |
2022-07-18 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
US20120053189A1
(en)
*
|
2010-06-28 |
2012-03-01 |
Pharmacyclics, Inc. |
Btk inhibitors for the treatment of immune mediated conditions
|
JP5810157B2
(ja)
*
|
2010-07-09 |
2015-11-11 |
ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ |
プロテインキナーゼ阻害剤および処置の方法
|
US8563568B2
(en)
|
2010-08-10 |
2013-10-22 |
Celgene Avilomics Research, Inc. |
Besylate salt of a BTK inhibitor
|
SG187742A1
(en)
*
|
2010-08-20 |
2013-03-28 |
Hutchison Medipharma Ltd |
Pyrrolopyrimidine compounds and uses thereof
|
MY181898A
(en)
|
2010-11-01 |
2021-01-12 |
Celgene Car Llc |
Heterocyclic compounds and uses thereof
|
JP5956999B2
(ja)
|
2010-11-01 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
PE20140236A1
(es)
|
2011-02-23 |
2014-03-14 |
Pfizer |
IMIDAZO[5,1-f][1,2,4]TRIAZINAS PARA EL TRATAMIENTO DE TRASTORNOS NEUROLOGICOS
|
WO2012158810A1
(en)
*
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
WO2012158795A1
(en)
|
2011-05-17 |
2012-11-22 |
Principia Biopharma Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
MX347040B
(es)
*
|
2011-05-17 |
2017-04-10 |
Principia Biopharma Inc |
Inhibidores de tirosina-cinasas.
|
WO2012158843A2
(en)
*
|
2011-05-17 |
2012-11-22 |
The Regents Of The University Of California |
Kinase inhibitors
|
BR112013033534A2
(pt)
*
|
2011-06-28 |
2017-02-07 |
Pharmacyclics Inc |
métodos e composições para inibição de reabsorção de osso
|
WO2013006443A2
(en)
|
2011-07-01 |
2013-01-10 |
Dana-Farber Cancer Institute, Inc. |
Discovery of a somatic mutation in myd88 gene in lymphoplasmacytic lymphoma
|
EA201490229A1
(ru)
|
2011-07-08 |
2014-05-30 |
Новартис Аг |
Новые пирролопиримидиновые производные
|
US9138436B2
(en)
|
2011-07-13 |
2015-09-22 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
WO2013010868A1
(en)
|
2011-07-19 |
2013-01-24 |
Msd Oss B.V. |
4 - imidazopyridazin- 1 -yl-benzamides and 4 - imidazotriazin- 1 - yl - benzamides as btk- inhibitors
|
EP2548877A1
(en)
*
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
EP3812387A1
(en)
|
2011-07-21 |
2021-04-28 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Heterocyclic protein kinase inhibitors
|
KR20210065203A
(ko)
*
|
2011-10-19 |
2021-06-03 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 인산화효소(btk)의 억제제의 용도
|
AR088570A1
(es)
|
2011-10-28 |
2014-06-18 |
Celgene Avilomics Res Inc |
Metodos para tratar una enfermedad o trastorno relacionado con la tirosina quinasa de bruton
|
GB2496135B
(en)
|
2011-11-01 |
2015-03-18 |
Valirx Plc |
Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
|
EP2773640B1
(en)
*
|
2011-11-03 |
2015-08-19 |
Hoffmann-La Roche AG |
Bicyclic piperazine compounds
|
UA111756C2
(uk)
*
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
US9212381B2
(en)
*
|
2011-11-10 |
2015-12-15 |
President And Fellows Of Harvard College |
Methods and compositions for labeling polypeptides
|
US9382239B2
(en)
|
2011-11-17 |
2016-07-05 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-terminal kinase (JNK)
|
WO2013081016A1
(ja)
|
2011-11-29 |
2013-06-06 |
小野薬品工業株式会社 |
プリノン誘導体塩酸塩
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
JP6248048B2
(ja)
|
2012-01-09 |
2017-12-13 |
エックス−アールエックス,インコーポレーテッド |
キナーゼ阻害活性を有するトリプトリン誘導体及びその使用
|
US9458162B2
(en)
*
|
2012-01-31 |
2016-10-04 |
Nanjing Allgen Pharma Co. Ltd. |
Cyclic molecules as bruton's tyrosine kinase inhibitors
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
TW201336847A
(zh)
*
|
2012-02-07 |
2013-09-16 |
Taiho Pharmaceutical Co Ltd |
喹啉基吡咯并嘧啶化合物或其鹽
|
JP5557963B2
(ja)
*
|
2012-02-23 |
2014-07-23 |
大鵬薬品工業株式会社 |
キノリルピロロピリミジル縮合環化合物又はその塩
|
CN103312670A
(zh)
|
2012-03-12 |
2013-09-18 |
西安西电捷通无线网络通信股份有限公司 |
一种认证方法及***
|
ES2880109T3
(es)
|
2012-03-15 |
2021-11-23 |
Celgene Car Llc |
Formas sólidas de un inhibidor de la cinasa del receptor del factor de crecimiento epidérmico
|
PL2825042T3
(pl)
|
2012-03-15 |
2019-02-28 |
Celgene Car Llc |
Sole inhibitora kinazy receptora czynnika wzrostu naskórka
|
WO2013148603A1
(en)
|
2012-03-27 |
2013-10-03 |
Takeda Pharmaceutical Company Limited |
Cinnoline derivatives as as btk inhibitors
|
CN104203242B
(zh)
|
2012-04-04 |
2017-03-15 |
杭州德润玉成生物科技有限公司 |
取代的喹啉类作为布鲁顿酪氨酸激酶抑制剂
|
US9522917B2
(en)
|
2012-04-11 |
2016-12-20 |
Acerta Pharma B.V. |
Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
|
WO2013154778A1
(en)
|
2012-04-11 |
2013-10-17 |
Dana-Farber Cancer Institute, Inc. |
Host targeted inhibitors of dengue virus and other viruses
|
CN103374001B
(zh)
*
|
2012-04-19 |
2015-10-28 |
山东轩竹医药科技有限公司 |
咪唑并三嗪类mTOR抑制剂
|
CA2874211A1
(en)
*
|
2012-05-31 |
2013-12-05 |
Pharmascience Inc. |
Protein kinase inhibitors
|
BR112014030424A8
(pt)
|
2012-06-04 |
2017-07-11 |
Pharmacyclics Inc |
Formas cristalinas de um inibidor de quinase de tirosina de bruton
|
AR091273A1
(es)
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
JP6189945B2
(ja)
*
|
2012-06-18 |
2017-08-30 |
プリンシピア バイオファーマ インコーポレイテッド |
癌および自己免疫疾患の治療に有用な可逆性共有結合ピロロ−またはピラゾロピリミジン
|
WO2014004707A1
(en)
|
2012-06-29 |
2014-01-03 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
CN104704129A
(zh)
|
2012-07-24 |
2015-06-10 |
药品循环公司 |
与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
|
JP6261580B2
(ja)
*
|
2012-07-30 |
2018-01-17 |
コンサート ファーマシューティカルズ インコーポレイテッド |
重水素化イブルチニブ
|
WO2014022569A1
(en)
*
|
2012-08-03 |
2014-02-06 |
Principia Biopharma Inc. |
Treatment of dry eye
|
AU2013299557B2
(en)
|
2012-08-10 |
2017-06-22 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as Bruton's tyrosine kinase (BTK) inhibitors
|
CN103121999A
(zh)
*
|
2012-08-29 |
2013-05-29 |
苏州迪飞医药科技有限公司 |
一种酪氨酸激酶抑制剂pci-32765的合成方法
|
US9573958B2
(en)
|
2012-08-31 |
2017-02-21 |
Principia Biopharma, Inc. |
Benzimidazole derivatives as ITK inhibitors
|
US9266895B2
(en)
*
|
2012-09-10 |
2016-02-23 |
Principia Biopharma Inc. |
Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
|
CH706997A1
(en)
|
2012-09-20 |
2014-03-31 |
Ferag Ag |
Access control on operating modules of a control unit.
|
EP2909194A1
(en)
|
2012-10-18 |
2015-08-26 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
WO2014063061A1
(en)
*
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
SG11201502893WA
(en)
*
|
2012-11-02 |
2015-05-28 |
Pfizer |
Bruton's tyrosine kinase inhibitors
|
MX2015005633A
(es)
|
2012-11-02 |
2016-02-03 |
Pharmacyclics Inc |
Terapia adyuvante con inhibidores de quinasa de la familia tec.
|
AU2013344656A1
(en)
*
|
2012-11-15 |
2015-06-04 |
Pharmacyclics Llc |
Pyrrolopyrimidine compounds as kinase inhibitors
|
ES2605856T3
(es)
|
2012-11-16 |
2017-03-16 |
Bristol-Myers Squibb Company |
Moduladores GPR40 de dihidropirazol
|
CN103848810A
(zh)
*
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
WO2014100748A1
(en)
|
2012-12-21 |
2014-06-26 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
BR112015014095A2
(pt)
*
|
2012-12-21 |
2017-07-11 |
Teva Pharma |
entrega transmucosal de acetato de glatirâmero
|
WO2014113942A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2014113932A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
US9481682B2
(en)
|
2013-01-23 |
2016-11-01 |
Merck Sharp & Dohme Corp. |
Substituted benzamides and substituted pyridinecarboxamides as Btk inhibitors
|
US9561228B2
(en)
|
2013-02-08 |
2017-02-07 |
Celgene Avilomics Research, Inc. |
ERK inhibitors and uses thereof
|
US20140357636A1
(en)
*
|
2013-02-21 |
2014-12-04 |
Wayne Rothbaum |
Treatment of Skeletal-Related Disorders
|
WO2014129596A1
(ja)
|
2013-02-22 |
2014-08-28 |
大鵬薬品工業株式会社 |
三環性化合物の製造方法及び当該製造方法により得ることができる三環性化合物
|
JO3377B1
(ar)
|
2013-03-11 |
2019-03-13 |
Takeda Pharmaceuticals Co |
مشتقات بيريدينيل وبيريدينيل مندمج
|
US9610282B2
(en)
*
|
2013-03-12 |
2017-04-04 |
Nbip, Llc |
Compositions and methods for preventing infection of a wound and for advancing the healing process
|
CN103142601A
(zh)
*
|
2013-03-13 |
2013-06-12 |
杭州雷索药业有限公司 |
Pci-32765在制备抗血管生成类药物中的应用
|
US20160022683A1
(en)
*
|
2013-03-14 |
2016-01-28 |
Pharmacyclics Llc |
Combinations of bruton's tyrosine kinase inhibitors and cyp3a4 inhibitors
|
EP2970163B1
(en)
|
2013-03-14 |
2018-02-28 |
Boehringer Ingelheim International GmbH |
5-thiazolecarboxamide dervatives and their use as btk inhibitors
|
CA2905993C
(en)
|
2013-03-14 |
2022-12-06 |
Tolero Pharmaceuticals, Inc. |
Substituted 4-amino-pyrimidinyl-2-amino-phenyl derivatives and pharmaceutical compositions thereof for use as jak2 and alk2 inhibitors
|
CA2908098A1
(en)
|
2013-03-15 |
2014-09-25 |
Celgene Avilomics Research, Inc. |
Mk2 inhibitors and uses thereof
|
US8940893B2
(en)
|
2013-03-15 |
2015-01-27 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as BTK inhibitors
|
US9156847B2
(en)
|
2013-03-15 |
2015-10-13 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a medicament
|
DK2970291T3
(da)
*
|
2013-03-15 |
2022-08-01 |
Janssen Pharmaceutica Nv |
Fremgangsmåder og mellemprodukter til fremstilling af et medikament
|
TWI654206B
(zh)
|
2013-03-16 |
2019-03-21 |
諾華公司 |
使用人類化抗-cd19嵌合抗原受體治療癌症
|
WO2014168986A1
(en)
|
2013-04-08 |
2014-10-16 |
Brown Dennis M |
Therapeutic benefit of suboptimally administered chemical compounds
|
KR20150141971A
(ko)
*
|
2013-04-08 |
2015-12-21 |
파마싸이클릭스 엘엘씨 |
이브루티닙 병용 요법
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
AU2014256633B2
(en)
|
2013-04-25 |
2017-02-02 |
Beigene Switzerland Gmbh |
Fused heterocyclic compounds as protein kinase inhibitors
|
GB2513615A
(en)
|
2013-05-01 |
2014-11-05 |
Cancer Rec Tech Ltd |
Medical use
|
GB201309085D0
(en)
|
2013-05-20 |
2013-07-03 |
Redx Pharma Ltd |
Compounds
|
CN105408334B
(zh)
*
|
2013-05-21 |
2017-10-10 |
江苏迈度药物研发有限公司 |
作为激酶抑制剂的取代的吡唑并嘧啶类化合物
|
EP3016953A4
(en)
*
|
2013-07-02 |
2017-03-01 |
Pharmacyclics, LLC |
Purinone compounds as kinase inhibitors
|
EP3016943B1
(en)
|
2013-07-03 |
2019-08-21 |
F. Hoffmann-La Roche AG |
Heteroaryl pyridone and aza-pyridone amide compounds
|
CN112472699A
(zh)
|
2013-07-26 |
2021-03-12 |
种族肿瘤学公司 |
改善比生群及衍生物的治疗益处的组合方法
|
CA2919996A1
(en)
|
2013-08-02 |
2015-02-05 |
Pharmacyclics Llc |
Methods for the treatment of solid tumors
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
CA2920534A1
(en)
|
2013-08-12 |
2015-02-19 |
Pharmacyclics Llc |
Methods for the treatment of her2 amplified cancer
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
PL3702373T3
(pl)
|
2013-09-13 |
2022-12-05 |
Beigene Switzerland Gmbh |
Przeciwciała anty-PD1 i ich zastosowanie jako środki terapeutyczne i diagnostyczne
|
US9624224B2
(en)
*
|
2013-09-30 |
2017-04-18 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
RS60934B1
(sr)
|
2013-09-30 |
2020-11-30 |
Guangzhou Innocare Pharma Tech Co Ltd |
Supstituisani nikotinimidni inhibitori btk i njihova priprema i upotreba u lečenju karcinoma, inflamatorne i autoimune bolesti
|
JP2016536354A
(ja)
*
|
2013-10-10 |
2016-11-24 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
非ホジキンリンパ腫を治療するための、hdac阻害剤単独またはbtk阻害剤との組み合わせ
|
WO2015057992A1
(en)
|
2013-10-16 |
2015-04-23 |
Izumi Raquel |
Btk inhibitors for hematopoietic mobilization
|
US20210317140A1
(en)
|
2013-10-18 |
2021-10-14 |
Medivation Technologies, Inc. |
Heterocyclic Compounds and Methods of Use
|
US20160272645A1
(en)
*
|
2013-10-18 |
2016-09-22 |
Medivation Technologies, Inc. |
Heterocyclic Compounds and Methods of Use
|
WO2015058126A1
(en)
|
2013-10-18 |
2015-04-23 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of prolferative diseases
|
US10047070B2
(en)
|
2013-10-18 |
2018-08-14 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
KR20230170797A
(ko)
*
|
2013-10-25 |
2023-12-19 |
파마싸이클릭스 엘엘씨 |
이식편 대 숙주 질환의 치료 및 예방 방법
|
JP6508785B2
(ja)
*
|
2013-10-25 |
2019-05-08 |
ファーマサイクリックス エルエルシー |
ブルトンチロシンキナーゼ阻害剤および免疫療法を使用する処置
|
US9636340B2
(en)
|
2013-11-12 |
2017-05-02 |
Ayyappan K. Rajasekaran |
Kinase inhibitors
|
WO2015071432A1
(en)
|
2013-11-14 |
2015-05-21 |
Sandoz Ag |
Pharmaceutical compositions of ibrutinib
|
WO2015073833A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Pharmacyclics, Inc. |
Methods for delaying or preventing the onset of type 1 diabetes
|
CN103626774B
(zh)
*
|
2013-11-20 |
2015-11-04 |
苏州明锐医药科技有限公司 |
伊鲁替尼的制备方法
|
CA2833867A1
(en)
*
|
2013-11-21 |
2015-05-21 |
Pharmascience Inc. |
Protein kinase inhibitors
|
CN103694241A
(zh)
*
|
2013-11-27 |
2014-04-02 |
苏州晶云药物科技有限公司 |
Pci-32765的新晶型a及其制备方法
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
CA3210338A1
(en)
*
|
2013-12-02 |
2015-06-11 |
Pharmacyclics Llc |
Methods of treating and preventing alloantibody driven chronic graft versus host disease
|
US9260415B2
(en)
|
2013-12-05 |
2016-02-16 |
Genentech, Inc. |
Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
|
PL3318565T3
(pl)
|
2013-12-05 |
2021-10-04 |
Pfizer Inc. |
Pirolo[2,3-d]pirymidynylowe, pirolo[2,3-b]pirazynylowe i pirolo[2,3-d]pirydynylowe akryloamidy
|
EA201691169A1
(ru)
|
2013-12-05 |
2016-09-30 |
Асерта Фарма Б.В. |
Терапевтическая комбинация ингибитора pi3k и ингибитора btk
|
WO2015089481A2
(en)
*
|
2013-12-13 |
2015-06-18 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
EP3079683A4
(en)
|
2013-12-13 |
2017-12-20 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
US9834554B2
(en)
|
2013-12-20 |
2017-12-05 |
Merck Sharp & Dohme Corp. |
BTK inhibitors
|
US9637486B2
(en)
|
2013-12-20 |
2017-05-02 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
US10272083B2
(en)
|
2014-01-21 |
2019-04-30 |
Acerta Pharma B.V. |
Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
|
CN106008514A
(zh)
*
|
2014-01-29 |
2016-10-12 |
苏州晶云药物科技有限公司 |
依鲁替尼的新晶型及其制备方法
|
EP3099674B1
(en)
|
2014-01-29 |
2018-10-24 |
Boehringer Ingelheim International Gmbh |
Pyrazole compounds as btk inhibitors
|
BR112016016844A2
(pt)
*
|
2014-02-03 |
2017-08-08 |
Cadila Healthcare Ltd |
Compostos heterocíclicos
|
SG11201606858RA
(en)
|
2014-02-21 |
2016-09-29 |
Principia Biopharma Inc |
Salts and solid form of a btk inhibitor
|
JP6526065B2
(ja)
|
2014-02-28 |
2019-06-05 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
GB201404987D0
(en)
*
|
2014-03-20 |
2014-05-07 |
Redx Pharma Ltd |
Compounds
|
US9885086B2
(en)
|
2014-03-20 |
2018-02-06 |
Pharmacyclics Llc |
Phospholipase C gamma 2 and resistance associated mutations
|
JP6528779B2
(ja)
|
2014-03-25 |
2019-06-12 |
小野薬品工業株式会社 |
びまん性大細胞型b細胞リンパ腫の予防および/または治療剤
|
WO2015151006A1
(en)
*
|
2014-03-29 |
2015-10-08 |
Lupin Limited |
Substituted purine compounds as btk inhibitors
|
WO2015185998A2
(en)
|
2014-04-11 |
2015-12-10 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase
|
US9937171B2
(en)
|
2014-04-11 |
2018-04-10 |
Acerta Pharma B.V. |
Methods of blocking the CXCR-4/SDF-1 signaling pathway with inhibitors of bruton's tyrosine kinase
|
CN105017256A
(zh)
*
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
CN105085474B
(zh)
*
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
CN105085529A
(zh)
*
|
2014-05-15 |
2015-11-25 |
广东东阳光药业有限公司 |
依鲁替尼新晶型及其制备方法
|
CN104086551B
(zh)
*
|
2014-06-06 |
2016-09-21 |
人福医药集团股份公司 |
化合物及其制备方法和用途
|
GB201410430D0
(en)
|
2014-06-11 |
2014-07-23 |
Redx Pharma Ltd |
Compounds
|
TW201613644A
(en)
|
2014-06-17 |
2016-04-16 |
Acerta Pharma Bv |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, and/or a JAK-2 inhibitor
|
CN104945404B
(zh)
*
|
2014-06-25 |
2018-09-14 |
广东东阳光药业有限公司 |
一种n-丙烯羰基哌啶衍生物的制备方法
|
US9580416B2
(en)
|
2014-07-02 |
2017-02-28 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
TWI726608B
(zh)
|
2014-07-03 |
2021-05-01 |
英屬開曼群島商百濟神州有限公司 |
抗pd-l1抗體及其作為治療及診斷之用途
|
CN105294571B
(zh)
*
|
2014-07-03 |
2019-04-23 |
浙江九洲药业股份有限公司 |
一种依鲁替尼中间体及其制备方法和用途
|
PL3166608T3
(pl)
*
|
2014-07-07 |
2019-07-31 |
Jiangsu Hengrui Medicine Co., Ltd. |
Związki aminopirydazynonowe jako inhibitory kinaz białkowych
|
WO2016008411A1
(en)
*
|
2014-07-18 |
2016-01-21 |
Beigene, Ltd. |
5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof
|
WO2016019237A2
(en)
*
|
2014-07-31 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
EP3174539A4
(en)
*
|
2014-08-01 |
2017-12-13 |
Pharmacyclics, LLC |
Inhibitors of bruton's tyrosine kinase
|
TW201618783A
(zh)
|
2014-08-07 |
2016-06-01 |
艾森塔製藥公司 |
以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
|
SG11201700849XA
(en)
|
2014-08-07 |
2017-03-30 |
Pharmacyclics Llc |
Novel formulations of a bruton's tyrosine kinase inhibitor
|
CN106714909A
(zh)
|
2014-08-08 |
2017-05-24 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶抑制剂组合及其用途
|
CN105461720B
(zh)
*
|
2014-08-08 |
2019-08-06 |
南京圣和药业股份有限公司 |
吗啉类酪氨酸激酶抑制剂
|
AR101504A1
(es)
|
2014-08-11 |
2016-12-21 |
Acerta Pharma Bv |
Combinaciones terapéuticas de un inhibidor de la btk, un inhibidor de la pi3k, un inhibidor de la jak-2, y/o un inhibidor de la cdk4/6
|
LT3179992T
(lt)
|
2014-08-11 |
2022-06-27 |
Acerta Pharma B.V. |
Btk inhibitoriaus, pd-1 inhibitoriaus ir (arba) pd-l1 inhibitoriaus terapiniai deriniai
|
SI3179991T1
(sl)
|
2014-08-11 |
2022-04-29 |
Acerta Pharma B.V. |
Terapevtske kombinacije zaviralca BTK in zaviralca BCL-2
|
WO2016024227A1
(en)
|
2014-08-11 |
2016-02-18 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
JP6749890B2
(ja)
|
2014-08-12 |
2020-09-02 |
モナッシュ ユニバーシティ |
リンパ指向プロドラッグ
|
DK3179858T3
(da)
|
2014-08-13 |
2019-07-22 |
Celgene Car Llc |
Forme og sammensætninger af en ERK-inhibitor
|
WO2016025720A1
(en)
|
2014-08-14 |
2016-02-18 |
Assia Chemical Industries Ltd. |
Solid state forms of ibrutinib
|
WO2016050921A1
(en)
|
2014-10-02 |
2016-04-07 |
F. Hoffmann-La Roche Ag |
Pyrazole carboxamide compounds for use in the treament of disorders mediated by bruton's tyrosine kinase (btk)
|
EP3209648B1
(en)
|
2014-10-22 |
2020-03-11 |
Dana-Farber Cancer Institute, Inc. |
Thiazolyl-containing compounds for treating proliferative diseases
|
UY36371A
(es)
|
2014-10-24 |
2016-04-29 |
Bristol Myers Squibb Company Una Corporación Del Estado De Delaware |
Compuestos de indolcarboxamida inhibidores de quinasas tipo btk y tipo tec
|
CN107108604B
(zh)
|
2014-10-27 |
2020-07-24 |
豪夫迈·罗氏有限公司 |
制备三环内酰胺化合物的方法
|
EP3212624A1
(en)
*
|
2014-10-30 |
2017-09-06 |
Sandoz AG |
Synthesis of substituted 1h-pyrazolo[3,4-d]pyrimidines
|
WO2016079693A1
(en)
*
|
2014-11-19 |
2016-05-26 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of ibrutinib
|
WO2016079216A1
(en)
|
2014-11-20 |
2016-05-26 |
Sandoz Ag |
Physical forms of ibrutinib, a bruton's kinase inhibitor
|
CN104447761A
(zh)
*
|
2014-11-27 |
2015-03-25 |
广东东阳光药业有限公司 |
一种吡唑衍生物的制备方法
|
AR102871A1
(es)
|
2014-12-03 |
2017-03-29 |
Pharmacyclics Llc |
Métodos de tratamiento de fibrosis
|
WO2016088074A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Dr. Reddy’S Laboratories Limited |
Process for the preparation of amorphous ibrutinib
|
CN104478884A
(zh)
*
|
2014-12-05 |
2015-04-01 |
广东东阳光药业有限公司 |
一种中间体的制备方法
|
WO2016087994A1
(en)
|
2014-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
EA036269B1
(ru)
|
2014-12-18 |
2020-10-21 |
Принсипиа Биофарма Инк. |
Лечение пузырчатки
|
NZ769496A
(en)
|
2014-12-18 |
2023-09-29 |
Hoffmann La Roche |
Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof
|
AU2015371251B2
(en)
|
2014-12-23 |
2020-06-11 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (CDK7)
|
WO2016106628A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106652A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Biarylether imidazopyrazine btk inhibitors
|
WO2016106629A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106624A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
CN105820168B
(zh)
*
|
2015-01-09 |
2018-12-04 |
上海医药工业研究院 |
一种依鲁替尼中间体的制备方法
|
MA41350A
(fr)
*
|
2015-01-14 |
2017-11-21 |
Janssen Pharmaceutica Nv |
Synthèse d'un inhibiteur de la tyrosine kinase de bruton
|
US10266535B2
(en)
|
2015-01-21 |
2019-04-23 |
Hefei Institutes Of Physical Science, Chinese Academy Of Sciences |
Inhibitor of FLT3 kinase and use thereof
|
WO2016123504A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
CZ201584A3
(cs)
|
2015-02-09 |
2016-08-17 |
Zentiva, K.S. |
Sůl Ibrutinib sulfátu
|
CN107207519B
(zh)
*
|
2015-02-12 |
2019-11-08 |
正大天晴药业集团股份有限公司 |
伊布替尼的制备方法
|
WO2016132383A1
(en)
*
|
2015-02-18 |
2016-08-25 |
Mylan Laboratories Limited |
Process for the preparation of ibrutinib
|
EP3262049B1
(en)
|
2015-02-27 |
2022-07-20 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
KR20170122220A
(ko)
|
2015-03-03 |
2017-11-03 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나제 저해제의 약제학적 제제
|
WO2016141044A1
(en)
|
2015-03-04 |
2016-09-09 |
Arizona Board Of Regents On Behalf Of Arizona State University |
Erbb4 inhibitors and methods of use thereof
|
US9717745B2
(en)
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
CN106146508A
(zh)
*
|
2015-03-19 |
2016-11-23 |
浙江导明医药科技有限公司 |
优化的联合用药及其治疗癌症和自身免疫疾病的用途
|
WO2016160617A2
(en)
|
2015-03-27 |
2016-10-06 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
WO2016161248A1
(en)
*
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
ES2733460T3
(es)
*
|
2015-04-02 |
2019-11-29 |
Ratiopharm Gmbh |
Co-cristales de Ibrutinib
|
CN106146511A
(zh)
*
|
2015-04-03 |
2016-11-23 |
安润医药科技(苏州)有限公司 |
吡唑并嘧啶衍生物、制备方法、药物组合物及用途
|
CN105906621A
(zh)
*
|
2015-04-06 |
2016-08-31 |
四川百利药业有限责任公司 |
用作fgfr抑制剂的乙醇类化合物
|
AU2016246669B2
(en)
|
2015-04-06 |
2021-07-15 |
Janssen Pharmaceutica Nv |
Compositions containing Ibrutinib
|
SI3280729T1
(sl)
|
2015-04-08 |
2022-09-30 |
Novartis Ag |
Terapije CD20, terapije CD22 in kombinacija terapij s celico, ki izraža himerni antigenski receptor CD19 (CAR)
|
CN106146512B
(zh)
*
|
2015-04-09 |
2018-07-17 |
北京睿创康泰医药研究院有限公司 |
依鲁替尼的制备方法
|
WO2016163531A1
(ja)
|
2015-04-09 |
2016-10-13 |
小野薬品工業株式会社 |
プリノン誘導体の製造方法
|
KR20170134462A
(ko)
|
2015-04-13 |
2017-12-06 |
다이이찌 산쿄 가부시키가이샤 |
Mdm2 저해제와 btk 저해제의 병용 치료법
|
CN106146482B
(zh)
*
|
2015-04-14 |
2020-06-23 |
宁波文达医药科技有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
WO2016170545A1
(en)
*
|
2015-04-22 |
2016-10-27 |
Msn Laboratories Private Limited |
Process for the preparation of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenvl)-1h- pvrazolo[3,4-d]pyriniidin-1-y1]-1-piperidinvl]-2-propen-1-one and its polymorphs thereof
|
TW201701879A
(zh)
|
2015-04-30 |
2017-01-16 |
拜耳製藥公司 |
Irak4抑制劑組合
|
EP3195865A1
(de)
|
2016-01-25 |
2017-07-26 |
Bayer Pharma Aktiengesellschaft |
Kombinationen von irak4 inhibitoren und btk inhibitoren
|
PT3302550T
(pt)
|
2015-05-26 |
2019-11-26 |
Morphosys Ag |
Combinação de um anticorpo anti-cd19 e de um inibidor de tirosina cinase de bruton e utilizações da mesma
|
WO2016196840A1
(en)
*
|
2015-06-03 |
2016-12-08 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
EP3307728A4
(en)
|
2015-06-12 |
2019-07-17 |
Dana Farber Cancer Institute, Inc. |
ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
|
US9394312B1
(en)
*
|
2015-06-14 |
2016-07-19 |
Mark Quang Nguyen |
Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use
|
RU2719477C2
(ru)
|
2015-06-22 |
2020-04-17 |
Оно Фармасьютикал Ко., Лтд. |
Соединение, ингибирующее brk
|
TW201718572A
(zh)
|
2015-06-24 |
2017-06-01 |
普林斯匹亞生物製藥公司 |
酪胺酸激酶抑制劑
|
WO2016207172A1
(en)
*
|
2015-06-26 |
2016-12-29 |
Sandoz Gmbh |
Preparation of pure amorphous ibrutinib
|
CZ2015442A3
(cs)
*
|
2015-06-26 |
2017-01-04 |
Zentiva, K.S. |
Ibrutinib hemisulfát
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
ES2797987T3
(es)
|
2015-07-02 |
2020-12-04 |
Acerta Pharma Bv |
Formas sólidas y formulaciones de (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamida
|
US9650393B2
(en)
|
2015-07-02 |
2017-05-16 |
Genentech, Inc. |
Benzoxazepin oxazolidinone compounds and methods of use
|
WO2017001658A1
(en)
|
2015-07-02 |
2017-01-05 |
F. Hoffmann-La Roche Ag |
Benzoxazepin oxazolidinone compounds and methods of use
|
ITUB20152576A1
(it)
*
|
2015-07-29 |
2017-01-29 |
Laboratorio Chimico Int S P A |
Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.
|
US11001585B2
(en)
|
2015-08-19 |
2021-05-11 |
Sun Pharmaceutical Industries Limited |
Crystalline forms of ibrutinib
|
US20190008859A1
(en)
|
2015-08-21 |
2019-01-10 |
Acerta Pharma B.V. |
Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
|
JP2018525411A
(ja)
|
2015-08-31 |
2018-09-06 |
ファーマサイクリックス エルエルシー |
多発性骨髄腫を治療するためのbtk阻害剤の組み合わせ
|
EP3344624B8
(en)
|
2015-09-02 |
2023-11-29 |
Takeda Pharmaceutical Company Limited |
Tyk2 inhibitors and uses thereof
|
EP3347340A4
(en)
|
2015-09-08 |
2019-01-23 |
Monash University |
PROMOTERS TARGETING THE LYMPH
|
US11142507B2
(en)
|
2015-09-09 |
2021-10-12 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
CN105753863B
(zh)
*
|
2015-09-11 |
2018-07-31 |
东莞市真兴贝特医药技术有限公司 |
氧代二氢咪唑并吡啶类化合物及其应用
|
CA2904270A1
(en)
*
|
2015-09-11 |
2017-03-11 |
Pharmascience Inc. |
Protein kinase inhibitors
|
WO2017044720A1
(en)
|
2015-09-11 |
2017-03-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
WO2017046746A1
(en)
|
2015-09-15 |
2017-03-23 |
Acerta Pharma B.V. |
Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist
|
MA44909A
(fr)
|
2015-09-15 |
2018-07-25 |
Acerta Pharma Bv |
Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk
|
US10611766B2
(en)
|
2015-09-16 |
2020-04-07 |
Loxo Oncology Inc. |
Pyrazolopyrimidine derivatives as BTK inhibitors for the treatment of cancer
|
ES2900482T3
(es)
|
2015-10-01 |
2022-03-17 |
Gilead Sciences Inc |
Combinación de un inhibidor de Btk y un inhibidor de punto de control para el tratamiento del cáncer
|
CN106608877B
(zh)
*
|
2015-10-21 |
2018-11-13 |
新发药业有限公司 |
一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
|
KR20180072704A
(ko)
|
2015-10-23 |
2018-06-29 |
나비토르 파마슈티칼스 인코포레이티드 |
세스트린-gator2 상호작용의 조절제 및 이의 용도
|
TWI642671B
(zh)
*
|
2015-10-28 |
2018-12-01 |
台灣神隆股份有限公司 |
依魯替尼之製備方法及其中間體
|
HRP20231547T1
(hr)
*
|
2015-11-17 |
2024-03-15 |
Merck Patent Gmbh |
Postupci liječenja multiple skleroze primjenom spojeva pirimidina i piridina s aktivnošću inhibicije btk
|
CN105294696A
(zh)
*
|
2015-11-19 |
2016-02-03 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
EP3384294B1
(en)
|
2015-12-04 |
2021-10-13 |
Juno Therapeutics, Inc. |
Methods and compositions related to toxicity associated with cell therapy
|
US10736895B2
(en)
|
2015-12-04 |
2020-08-11 |
Portola Pharmaceuticals, Inc. |
Cerdulatinib for treating hematological cancers
|
JO3793B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
مثبطات تيروزين كاينيز بروتون وأساليب استخدامها
|
JO3794B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون
|
EP3389664A4
(en)
|
2015-12-14 |
2020-01-08 |
Raze Therapeutics Inc. |
MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF
|
TWI726017B
(zh)
|
2015-12-16 |
2021-05-01 |
德商百靈佳殷格翰國際股份有限公司 |
做為布魯頓式酪胺酸激酶(btk)抑制劑之雜芳族化合物
|
SI3390395T1
(sl)
|
2015-12-16 |
2020-11-30 |
Loxo Oncology, Inc. |
Spojine uporabne kot inhibitorji kinaz
|
EP3402503B1
(en)
|
2016-01-13 |
2020-10-21 |
Acerta Pharma B.V. |
Therapeutic combinations of an antifolate and a btk inhibitor
|
WO2017123695A1
(en)
|
2016-01-13 |
2017-07-20 |
Boehringer Ingelheim International Gmbh |
Isoquinolones as btk inhibitors
|
KR20180101521A
(ko)
|
2016-01-19 |
2018-09-12 |
얀센 파마슈티카 엔.브이. |
Btk 저해제를 포함하는 제형/조성물
|
MA43650A
(fr)
|
2016-01-19 |
2018-11-28 |
Janssen Pharmaceutica Nv |
Formulations/compositions comprenant un inhibiteur de btk
|
JP6950897B2
(ja)
*
|
2016-01-21 |
2021-10-13 |
ジーボ・バイオポーラー・チャンシェン・ファーマシューティカル・カンパニー・リミテッドZibo Biopolar Changsheng Pharmaceutical Co. Ltd. |
ブルトン型チロシンキナーゼ阻害剤
|
US10793566B2
(en)
|
2016-01-21 |
2020-10-06 |
Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. |
Bruton's tyrosine kinase inhibitors
|
CN105732638B
(zh)
*
|
2016-01-22 |
2018-01-30 |
成都倍特药业有限公司 |
一种具有螺环或桥环结构的布鲁顿酪氨酸激酶抑制剂及其制备方法
|
CN106995446B
(zh)
*
|
2016-01-22 |
2021-07-02 |
山东新时代药业有限公司 |
布鲁顿酪氨酸激酶抑制剂制备方法
|
WO2017134684A2
(en)
|
2016-02-01 |
2017-08-10 |
Natco Pharma Limited |
An improved process for the preparation of ibrutinib
|
WO2017134685A2
(en)
*
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
WO2017134588A1
(en)
|
2016-02-04 |
2017-08-10 |
Shilpa Medicare Limited |
Process for the preparation of ibrutinib
|
CN108602834B
(zh)
*
|
2016-02-05 |
2021-01-08 |
北京盛诺基医药科技股份有限公司 |
一种布鲁顿酪氨酸激酶抑制剂
|
GB2558514A
(en)
*
|
2016-02-09 |
2018-07-18 |
Azad Pharmaceutical Ingredients Ag |
Process for the synthesis of stable amorphous ibrutinib
|
CA3015172A1
(en)
|
2016-02-18 |
2017-08-24 |
Privo Technologies, Inc. |
Two-stage microparticle-based therapeutic delivery system and method
|
CN105646498A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型f及制备方法
|
CN105646499A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型g及制备方法
|
EP4234552A3
(en)
|
2016-03-09 |
2023-10-18 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
DK3426243T3
(da)
|
2016-03-09 |
2021-07-19 |
Raze Therapeutics Inc |
3-phosphoglyceratdehydrogenase-inhibitorer og anvendelser deraf
|
JP6972002B2
(ja)
|
2016-03-11 |
2021-11-24 |
エンジェル・ファーマシューティカル・カンパニー・リミテッド |
ブルトン型チロシンキナーゼを調節する化合物及び方法
|
WO2017163257A1
(en)
*
|
2016-03-21 |
2017-09-28 |
Ind-Swift Laboratories Limited |
Process for preparing pure lh-pyrazolo[3,4-d] pyrimidine derivative
|
PL3436447T3
(pl)
|
2016-03-31 |
2021-12-27 |
Takeda Pharmaceutical Company Limited |
Kompleksy triazolonu izochinolinylowego
|
CZ2016196A3
(cs)
|
2016-04-06 |
2017-10-18 |
Zentiva, K.S. |
Pevné formy Ibrutinibu
|
JP2019510785A
(ja)
|
2016-04-08 |
2019-04-18 |
エックス4 ファーマシューティカルズ, インコーポレイテッド |
癌を処置する方法
|
WO2017178844A1
(en)
|
2016-04-15 |
2017-10-19 |
Cancer Research Technology Limited |
Heterocyclic compounds as ret kinase inhibitors
|
RS63609B1
(sr)
|
2016-04-15 |
2022-10-31 |
Cancer Research Tech Ltd |
Heterociklična jedinjenja kao inhibitori ret kinaze
|
EP3445364A4
(en)
|
2016-04-19 |
2019-11-27 |
Acetylon Pharmaceuticals, Inc. |
HDAC INHIBITORS, ONLY OR IN ASSOCIATION WITH BTK INHIBITORS, TO TREAT CHRONIC LYMPHOCYTIC LEUKEMIA
|
CN109152781A
(zh)
*
|
2016-04-29 |
2019-01-04 |
达纳-法伯癌症研究所有限公司 |
作为myd88突变疾病中的治疗靶标的hck
|
CZ2016276A3
(cs)
|
2016-05-11 |
2017-11-22 |
Zentiva, K.S. |
Pevné formy volné báze ibrutinibu
|
DK3458053T3
(da)
|
2016-05-20 |
2022-02-21 |
Biohaven Therapeutics Ltd |
Anvendelse af riluzol, riluzolprodrugs eller riluzolanaloger med immunterapier til cancerbehandling
|
CN105859728B
(zh)
*
|
2016-05-26 |
2018-06-08 |
江苏中邦制药有限公司 |
一种依鲁替尼的制备方法
|
EA201892284A1
(ru)
|
2016-05-27 |
2019-08-30 |
Тг Терапьютикс, Инк. |
Комбинация антитела против cd20, селективного ингибитора pi3-киназы-дельта и ингибитора btk для лечения b-клеточных пролиферативных расстройств
|
EP3472159A1
(en)
|
2016-06-16 |
2019-04-24 |
F. Hoffmann-La Roche AG |
TETRAHYDRO-PYRIDO[3,4-b]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF
|
JP7018026B2
(ja)
|
2016-06-16 |
2022-02-09 |
エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト |
ヘテロアリールエストロゲン受容体モジュレーター及びその使用
|
AU2017282871B2
(en)
*
|
2016-06-20 |
2020-03-05 |
Novartis Ag |
Crystalline forms of triazolopyrimidine compound
|
US11332470B2
(en)
|
2016-06-21 |
2022-05-17 |
X4 Pharmaceuticals, Inc. |
CXCR4 inhibitors and uses thereof
|
CN109562106B
(zh)
|
2016-06-21 |
2023-03-21 |
X4 制药有限公司 |
Cxcr4抑制剂及其用途
|
US10988465B2
(en)
|
2016-06-21 |
2021-04-27 |
X4 Pharmaceuticals, Inc. |
CXCR4 inhibitors and uses thereof
|
MX2018016056A
(es)
|
2016-06-29 |
2019-07-04 |
Principia Biopharma Inc |
Formulaciones de liberacion modificada de 2-[3-[4-amino-3-(2-fluor o-4-fenoxi-fenil)pirazolo[3,4-d]pirimidin-1-il]piperidina-1-carbo nil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrilo.
|
WO2018000250A1
(zh)
*
|
2016-06-29 |
2018-01-04 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
CN106117214A
(zh)
*
|
2016-06-29 |
2016-11-16 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
EP3478687B1
(en)
|
2016-06-30 |
2024-03-20 |
Daewoong Pharmaceutical Co., Ltd. |
Pyrazolopyrimidine derivatives as kinase inhibitor
|
WO2018007885A1
(en)
|
2016-07-05 |
2018-01-11 |
Beigene, Ltd. |
COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER
|
US10399988B2
(en)
|
2016-07-07 |
2019-09-03 |
Daewoong Pharmaceutical Co., Ltd. |
4-aminopyrazolo[3,4-d]pyrimidinylazabicyclo derivatives and pharmaceutical composition comprising the same
|
CN107641123A
(zh)
*
|
2016-07-20 |
2018-01-30 |
南京亿华药业有限公司 |
一种依鲁替尼及其关键中间体的制备新方法
|
AU2017298035B2
(en)
|
2016-07-21 |
2021-10-28 |
Biogen Ma Inc. |
Succinate forms and compositions of Bruton's tyrosine kinase inhibitors
|
CN116478165A
(zh)
|
2016-08-16 |
2023-07-25 |
百济神州(苏州)生物科技有限公司 |
一种化合物的晶型、其制备和用途
|
CN109851620B
(zh)
*
|
2016-08-17 |
2020-08-07 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制酪氨酸激酶活性的稠合双环类化合物
|
CN110087680B
(zh)
|
2016-08-19 |
2024-03-19 |
百济神州有限公司 |
使用包含btk抑制剂的组合产品治疗癌症
|
IL292938A
(en)
|
2016-09-19 |
2022-07-01 |
Mei Pharma Inc |
Combined treatment
|
EP3523280A1
(en)
*
|
2016-10-06 |
2019-08-14 |
Janssen Pharmaceutica NV |
Processes and intermediates for preparing a btk inhibitor
|
US10323036B2
(en)
|
2016-10-14 |
2019-06-18 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
CA3040840A1
(en)
|
2016-10-17 |
2018-04-26 |
Daiichi Sankyo Company, Limited |
Combined use of mdm2 inhibitor and dna methyltransferase inhibitor for cancer treatment
|
EP3528816A4
(en)
|
2016-10-21 |
2020-04-08 |
Nimbus Lakshmi, Inc. |
TYK2 INHIBITORS AND USES THEREOF
|
JP2019532997A
(ja)
|
2016-11-03 |
2019-11-14 |
ジュノー セラピューティクス インコーポレイテッド |
T細胞療法とbtk阻害剤との併用療法
|
EP3538091A4
(en)
|
2016-11-08 |
2020-06-10 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE MTORC INHIBITORS AND USES THEREOF
|
CA3043376A1
(en)
*
|
2016-11-15 |
2018-05-24 |
Hangzhou Hertz Pharmaceutical Co., Ltd. |
L-h-pyrazolo[3,4-d]pyrimidinyl derivatives and pharmaceutical compositions thereof useful as selective bruton's tyrosine kinase inhibitor
|
CN108101905A
(zh)
*
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
CN110177544A
(zh)
|
2016-11-29 |
2019-08-27 |
普尔泰克健康有限公司 |
用于递送治疗剂的外泌体
|
US10183024B2
(en)
|
2016-12-02 |
2019-01-22 |
Apotex Inc. |
Crystalline forms of ibrutinib
|
CA3045339A1
(en)
|
2016-12-03 |
2018-06-07 |
Juno Therapeutics, Inc. |
Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors
|
WO2018106636A1
(en)
|
2016-12-05 |
2018-06-14 |
Raze Therapeutics, Inc. |
Shmt inhibitors and uses thereof
|
MX2019007156A
(es)
*
|
2016-12-21 |
2019-09-05 |
Acerta Pharma Bv |
Inhibidores de imidazopirazina de la tirosina cinasa de bruton.
|
US11730819B2
(en)
|
2016-12-23 |
2023-08-22 |
Bicycletx Limited |
Peptide derivatives having novel linkage structures
|
WO2018127699A1
(en)
|
2017-01-06 |
2018-07-12 |
Bicyclerd Limited |
Compounds for treating cancer
|
EP3573989A4
(en)
|
2017-01-25 |
2020-11-18 |
Beigene, Ltd. |
CRYSTALLINE FORMS OF (S) -7- (1- (BUT-2-YNOYL) -PIPERIDINE-4-YL) -2- (4-PHENOXYPHENYL) -4,5,6,7-TETRAHYDROPYRAZOLO [1,5-A ] PYRIMIDINE-3-CARBOXAMIDE, MANUFACTURING AND USES THEREOF
|
WO2018151849A1
(en)
|
2017-02-17 |
2018-08-23 |
Privo Technologies, Inc. |
Particle-based multi-layer therapeutic delivery device and method
|
CN110312720A
(zh)
|
2017-02-24 |
2019-10-08 |
吉利德科学公司 |
布鲁顿氏酪氨酸激酶的抑制剂
|
WO2018156901A1
(en)
|
2017-02-24 |
2018-08-30 |
Gilead Sciences, Inc. |
Inhibitors of bruton's tyrosine kinase
|
US10336752B2
(en)
|
2017-03-08 |
2019-07-02 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors, uses, and methods for production thereof
|
CN108570036A
(zh)
*
|
2017-03-09 |
2018-09-25 |
北京赛林泰医药技术有限公司 |
一种btk抑制剂的多晶型物及其制备方法
|
GB201703876D0
(en)
|
2017-03-10 |
2017-04-26 |
Berlin-Chemie Ag |
Pharmaceutical combinations
|
JP2020514367A
(ja)
*
|
2017-03-14 |
2020-05-21 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
細胞死の誘導のためのbax活性化の小分子敏感化
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
US11554118B2
(en)
*
|
2017-03-22 |
2023-01-17 |
Xibin Liao |
Bruton's tyrosine kinase inhibitors
|
US11339144B2
(en)
|
2017-04-10 |
2022-05-24 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl Rheb inhibitors and uses thereof
|
GB201705971D0
(en)
|
2017-04-13 |
2017-05-31 |
Cancer Res Tech Ltd |
Inhibitor compounds
|
US10800787B2
(en)
|
2017-04-20 |
2020-10-13 |
Apotex Inc. |
Process for the preparation of acalabrutinib
|
CN107043366B
(zh)
*
|
2017-04-25 |
2020-05-26 |
中国药科大学 |
4-氨基嘧啶类化合物、其制备方法及医药用途
|
US10912750B2
(en)
|
2017-04-26 |
2021-02-09 |
Navitor Pharmaceuticals, Inc. |
Modulators of Sestrin-GATOR2 interaction and uses thereof
|
US10857196B2
(en)
|
2017-04-27 |
2020-12-08 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
US10478403B1
(en)
|
2017-05-03 |
2019-11-19 |
Privo Technologies, Inc. |
Intraoperative topically-applied non-implantable rapid release patch
|
KR20200054160A
(ko)
|
2017-06-02 |
2020-05-19 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 요법을 사용한 치료를 위한 물품 제조 및 방법
|
EP3631468A1
(en)
|
2017-06-02 |
2020-04-08 |
Juno Therapeutics, Inc. |
Articles of manufacture and methods related to toxicity associated with cell therapy
|
CN109111446B
(zh)
|
2017-06-22 |
2021-11-30 |
上海度德医药科技有限公司 |
一种具有药物活性的杂芳基化合物
|
WO2019002842A1
(en)
|
2017-06-26 |
2019-01-03 |
Bicyclerd Limited |
BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE FRACTIONS AND USES THEREOF
|
CN110799543A
(zh)
|
2017-06-26 |
2020-02-14 |
百济神州有限公司 |
肝细胞癌的免疫治疗
|
CA3067602A1
(en)
|
2017-06-29 |
2019-01-03 |
Juno Therapeutics, Inc. |
Mouse model for assessing toxicities associated with immunotherapies
|
WO2019013562A1
(ko)
|
2017-07-12 |
2019-01-17 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
KR102384924B1
(ko)
*
|
2017-07-12 |
2022-04-08 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
JP7216705B2
(ja)
|
2017-07-28 |
2023-02-02 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用方法
|
WO2019034009A1
(en)
|
2017-08-12 |
2019-02-21 |
Beigene, Ltd. |
BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
|
US20200283482A1
(en)
|
2017-08-14 |
2020-09-10 |
Bicyclerd Limited |
Bicyclic peptide ligand prr-a conjugates and uses thereof
|
EP3668887A1
(en)
|
2017-08-14 |
2020-06-24 |
Bicyclerd Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
EP3675838A4
(en)
|
2017-08-29 |
2021-04-21 |
PureTech LYT, Inc. |
LIPID PRODUCTS DIRECTED TO THE LYMPHATIC SYSTEM
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
MA50057A
(fr)
|
2017-09-01 |
2020-07-08 |
Juno Therapeutics Inc |
Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire
|
US11623932B2
(en)
|
2017-09-22 |
2023-04-11 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
US11358948B2
(en)
|
2017-09-22 |
2022-06-14 |
Kymera Therapeutics, Inc. |
CRBN ligands and uses thereof
|
EA037031B1
(ru)
*
|
2017-10-06 |
2021-01-28 |
Асерта Фарма Б.В. |
Имидазопиразиновые ингибиторы тирозинкиназы брутона
|
KR102613433B1
(ko)
*
|
2017-10-11 |
2023-12-13 |
주식회사 대웅제약 |
신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
|
TW201922256A
(zh)
|
2017-10-27 |
2019-06-16 |
中國大陸商浙江導明醫藥科技有限公司 |
治療淋巴樣惡性疾病之方法
|
WO2019089848A1
(en)
|
2017-11-01 |
2019-05-09 |
Juno Therapeutics, Inc. |
Methods associated with tumor burden for assessing response to a cell therapy
|
US11786529B2
(en)
|
2017-11-29 |
2023-10-17 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
|
CZ2017787A3
(cs)
|
2017-12-08 |
2019-06-19 |
Zentiva, K.S. |
Farmaceutické kompozice obsahující ibrutinib
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
WO2019126378A1
(en)
|
2017-12-19 |
2019-06-27 |
Ariya Therapeutics, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
WO2019127008A1
(zh)
*
|
2017-12-26 |
2019-07-04 |
清华大学 |
一种靶向降解btk的化合物及其应用
|
JP2021508703A
(ja)
|
2017-12-26 |
2021-03-11 |
カイメラ セラピューティクス, インコーポレイテッド |
Irak分解剤およびそれらの使用
|
CN108220261B
(zh)
*
|
2017-12-29 |
2021-05-14 |
安徽联创生物医药股份有限公司 |
酮还原酶、核酸、重组表达载体、重组表达菌株及应用
|
EP3737666A4
(en)
|
2018-01-12 |
2022-01-05 |
Kymera Therapeutics, Inc. |
PROTEIN DEGRADANTS AND USES THEREOF
|
US11512080B2
(en)
|
2018-01-12 |
2022-11-29 |
Kymera Therapeutics, Inc. |
CRBN ligands and uses thereof
|
CA3089537A1
(en)
|
2018-01-20 |
2019-07-25 |
Natco Pharma Limited |
Pharmaceutical compositions comprising ibrutinib
|
AU2019211485A1
(en)
|
2018-01-29 |
2020-08-06 |
Merck Patent Gmbh |
GCN2 inhibitors and uses thereof
|
EP3746071A4
(en)
|
2018-01-29 |
2021-09-01 |
Merck Patent GmbH |
GCN2 INHIBITORS AND THEIR USES
|
CN112189009B
(zh)
|
2018-02-27 |
2023-09-29 |
阿塔克斯生物制药有限公司 |
作为tcr-nck相互作用的抑制剂的色烯衍生物
|
MX2020010437A
(es)
|
2018-04-05 |
2021-01-29 |
Sumitomo Pharma Oncology Inc |
Inhibidores de axl cinasa y uso de los mismos.
|
CN117959303A
(zh)
|
2018-04-13 |
2024-05-03 |
住友制药肿瘤公司 |
用于治疗骨髓增殖性肿瘤和与癌症相关的纤维化的pim激酶抑制剂
|
BR112020020940A2
(pt)
|
2018-04-24 |
2021-03-02 |
Merck Patent Gmbh |
compostos antiproliferação e uso dos mesmos
|
CA3097774A1
(en)
|
2018-04-24 |
2019-10-31 |
Vertex Pharmaceuticals Incorporated |
Pteridinone compounds and uses thereof
|
KR102106821B1
(ko)
|
2018-04-27 |
2020-05-06 |
재단법인대구경북과학기술원 |
이브루티닙을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
|
JP7331843B2
(ja)
|
2018-04-27 |
2023-08-23 |
小野薬品工業株式会社 |
Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤
|
US20210121466A1
(en)
|
2018-05-03 |
2021-04-29 |
Juno Therapeutics, Inc. |
Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
|
EP3788035A2
(en)
|
2018-05-04 |
2021-03-10 |
Portola Pharmaceuticals, Inc. |
Solid forms of cerdulatinib
|
EP3575300A1
(en)
|
2018-05-31 |
2019-12-04 |
Apotex Inc. |
Novel crystalline forms of ibrutinib
|
IL259810A
(en)
|
2018-06-04 |
2018-07-31 |
Yeda Res & Dev |
Mitogen-activated protein kinase kinase 7 inhibitors
|
RU2711106C2
(ru)
*
|
2018-06-06 |
2020-01-15 |
Общество с ограниченной ответственностью "АКСЕЛЬФАРМ" |
Кристаллическая μ-модификация 1-[(3R)-3-[4-амино-3-(4-фенокси-фенил)-1Н-пиразоло[3,4-d]пиримидин-1-ил]-1-пиперидил]-2-пропенил-1-она, способ её получения и фармацевтическая композиция на её основе
|
BR112020025283A2
(pt)
|
2018-06-15 |
2021-03-09 |
Navitor Pharmaceuticals, Inc. |
Análogos de rapamicina e usos dos mesmos
|
WO2019238904A1
(en)
|
2018-06-15 |
2019-12-19 |
Janssen Pharmaceutica Nv |
Formulations/compositions comprising ibrutinib
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
US11180531B2
(en)
|
2018-06-22 |
2021-11-23 |
Bicycletx Limited |
Bicyclic peptide ligands specific for Nectin-4
|
US11292792B2
(en)
|
2018-07-06 |
2022-04-05 |
Kymera Therapeutics, Inc. |
Tricyclic CRBN ligands and uses thereof
|
US11040038B2
(en)
|
2018-07-26 |
2021-06-22 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal ACVR1 expression and ACVR1 inhibitors for use in the same
|
EP3829543A1
(en)
|
2018-07-31 |
2021-06-09 |
Loxo Oncology, Inc. |
Spray-dried dispersions and formulations of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoro propan-2-yl)-1h-pyrazole-4-carboxamide
|
WO2020045941A1
(ko)
|
2018-08-27 |
2020-03-05 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
WO2020043321A1
(en)
|
2018-08-31 |
2020-03-05 |
Stichting Katholieke Universiteit |
Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
CN113164419A
(zh)
|
2018-09-07 |
2021-07-23 |
皮克医疗公司 |
Eif4e抑制剂和其用途
|
CN110964016B
(zh)
*
|
2018-09-29 |
2021-05-28 |
南京药捷安康生物科技有限公司 |
氨基降茨烷衍生物及其制备方法与应用
|
CN113271940A
(zh)
|
2018-10-15 |
2021-08-17 |
林伯士拉克许米公司 |
Tyk2抑制剂和其用途
|
WO2020084305A1
(en)
|
2018-10-23 |
2020-04-30 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
US11345654B2
(en)
|
2018-10-24 |
2022-05-31 |
Navitor Pharmaceuticals, Inc. |
Polymorphic compounds and uses thereof
|
CN111170986A
(zh)
|
2018-11-13 |
2020-05-19 |
北京睿熙生物科技有限公司 |
布鲁顿酪氨酸激酶的抑制剂
|
CN109293630A
(zh)
*
|
2018-11-15 |
2019-02-01 |
山东大学 |
含取代吡唑类化合物及其制备方法与应用
|
CN109369654A
(zh)
*
|
2018-11-20 |
2019-02-22 |
山东大学 |
1,3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用
|
MX2021006154A
(es)
|
2018-11-30 |
2021-08-24 |
Kymera Therapeutics Inc |
Degradadores de cinasas asociadas al receptor de interleucina 1 (irak) y usos de los mismos.
|
CA3120866A1
(en)
|
2018-11-30 |
2020-06-04 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
CA3120869A1
(en)
|
2018-11-30 |
2020-06-04 |
Juno Therapeutics, Inc. |
Methods for treatment using adoptive cell therapy
|
SG11202105380RA
(en)
|
2018-11-30 |
2021-06-29 |
Juno Therapeutics Inc |
Methods for dosing and treatment of b cell malignancies in adoptive cell therapy
|
EP3897631A4
(en)
|
2018-12-20 |
2022-11-23 |
C4 Therapeutics, Inc. |
TARGETED PROTEIN DEGRADATION
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
US10688050B1
(en)
|
2018-12-21 |
2020-06-23 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
EP3669867A1
(en)
|
2018-12-21 |
2020-06-24 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
JPWO2020130125A1
(ja)
|
2018-12-21 |
2021-11-04 |
第一三共株式会社 |
抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
|
WO2020144695A1
(en)
|
2019-01-09 |
2020-07-16 |
Yeda Research And Development Co. Ltd. |
Modulators of pin1 activity and uses thereof
|
CN111454268B
(zh)
*
|
2019-01-18 |
2023-09-08 |
明慧医药(上海)有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
CA3126034A1
(en)
|
2019-01-23 |
2020-07-30 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
AU2020221247A1
(en)
|
2019-02-12 |
2021-08-05 |
Sumitomo Pharma Oncology, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
WO2020170270A1
(en)
*
|
2019-02-19 |
2020-08-27 |
Msn Laboratories Private Limited, R&D Center |
Novel crystalline polymorphs of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one and process for preparation thereof
|
KR20210142154A
(ko)
|
2019-03-21 |
2021-11-24 |
옹쎄오 |
암 치료를 위한 키나제 억제제와 조합된 dbait 분자
|
JP2022528887A
(ja)
|
2019-04-02 |
2022-06-16 |
バイスクルテクス・リミテッド |
バイシクルトキシンコンジュゲートおよびその使用
|
SG11202110829YA
(en)
|
2019-04-05 |
2021-10-28 |
Kymera Therapeutics Inc |
Stat degraders and uses thereof
|
CA3135211A1
(en)
|
2019-05-21 |
2020-11-26 |
Philip James Pye |
Processes and intermediates for preparing a btk inhibitor
|
WO2020234381A1
(en)
|
2019-05-21 |
2020-11-26 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a btk inhibitor
|
AU2020284538B2
(en)
*
|
2019-05-28 |
2022-03-24 |
PAIGE.AI, Inc. |
Systems and methods for processing images to prepare slides for processed images for digital pathology
|
JP2022534425A
(ja)
|
2019-05-31 |
2022-07-29 |
イケナ オンコロジー, インコーポレイテッド |
Tead阻害剤およびその使用
|
TW202118770A
(zh)
|
2019-07-30 |
2021-05-16 |
英商拜西可泰克斯有限公司 |
異質雙環肽複合物
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
WO2021050992A1
(en)
|
2019-09-11 |
2021-03-18 |
Vincere Biosciences, Inc. |
Usp30 inhibitors and uses thereof
|
AU2020347274A1
(en)
|
2019-09-13 |
2022-03-31 |
Nimbus Saturn, Inc. |
HPK1 antagonists and uses thereof
|
MX2022005215A
(es)
|
2019-11-01 |
2022-06-08 |
Navitor Pharm Inc |
Metodos de tratamiento que usan un modulador de la diana mecanicista del complejo 1 de rapamicina (mtorc1).
|
US20220401436A1
(en)
|
2019-11-08 |
2022-12-22 |
INSERM (Institute National de la Santé et de la Recherche Médicale) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
CN115209897A
(zh)
|
2019-12-05 |
2022-10-18 |
安纳库利亚治疗公司 |
雷帕霉素类似物及其用途
|
WO2021113770A1
(en)
|
2019-12-06 |
2021-06-10 |
Juno Therapeutics, Inc. |
Methods related to toxicity and response associated with cell therapy for treating b cell malignancies
|
AU2020407200A1
(en)
|
2019-12-17 |
2022-07-21 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
EP4076524A4
(en)
|
2019-12-17 |
2023-11-29 |
Kymera Therapeutics, Inc. |
IRAQ DEGRADERS AND USES THEREOF
|
TW202136242A
(zh)
|
2019-12-23 |
2021-10-01 |
美商凱麥拉醫療公司 |
Smarca降解劑及其用途
|
CA3168146A1
(en)
|
2020-01-20 |
2021-07-29 |
Genzyme Corporation |
Therapeutic tyrosine kinase inhibitors for relapsing multiple sclerosis (rms)
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
CN115348864A
(zh)
|
2020-02-05 |
2022-11-15 |
纯技术Lyt股份有限公司 |
神经甾体的脂质前药
|
WO2021164697A1
(zh)
*
|
2020-02-18 |
2021-08-26 |
深圳市塔吉瑞生物医药有限公司 |
取代的酰胺衍生物及其组合物及用途
|
CN115151537A
(zh)
|
2020-02-26 |
2022-10-04 |
株式会社大熊制药 |
制备杂环胺衍生物的方法
|
JP2023515888A
(ja)
|
2020-03-03 |
2023-04-14 |
ピク セラピューティクス, インコーポレイテッド |
eIF4E阻害剤及びその使用
|
KR20230005160A
(ko)
|
2020-03-19 |
2023-01-09 |
카이메라 쎄라퓨틱스 인코포레이티드 |
Mdm2 분해제 및 이의 용도
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
CN114057724A
(zh)
*
|
2020-07-29 |
2022-02-18 |
鲁南制药集团股份有限公司 |
一种btk抑制剂
|
WO2022038158A1
(en)
|
2020-08-17 |
2022-02-24 |
Bicycletx Limited |
Bicycle conjugates specific for nectin-4 and uses thereof
|
US20230320990A1
(en)
|
2020-08-28 |
2023-10-12 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
EP4203942A1
(en)
*
|
2020-08-28 |
2023-07-05 |
Emory University |
Methods of managing ***e or other drug addictions
|
JP2023553866A
(ja)
|
2020-12-02 |
2023-12-26 |
イケナ オンコロジー, インコーポレイテッド |
Tead阻害剤、及びその使用
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
CN112574216B
(zh)
*
|
2020-12-16 |
2022-03-08 |
天津济坤医药科技有限公司 |
一种化合物及其制备方法以及其在制备治疗抗癌药物中的应用
|
WO2022157250A1
(en)
|
2021-01-21 |
2022-07-28 |
Synthon B.V. |
Process for making ibrutinib
|
CN117098757A
(zh)
|
2021-02-02 |
2023-11-21 |
里米诺生物科学有限公司 |
Gpr84拮抗剂和其用途
|
CN116888116A
(zh)
|
2021-02-02 |
2023-10-13 |
里米诺生物科学有限公司 |
Gpr84拮抗剂和其用途
|
TW202245789A
(zh)
|
2021-02-15 |
2022-12-01 |
美商凱麥拉醫療公司 |
Irak4降解劑及其用途
|
EP4301756A1
(en)
|
2021-03-05 |
2024-01-10 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
WO2022221866A1
(en)
|
2021-04-16 |
2022-10-20 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
KR20240041285A
(ko)
*
|
2021-06-01 |
2024-03-29 |
프리보 테크놀로지스, 인코포레이티드 |
향상된 2단계 미세입자 기반 국소 치료제 전달 시스템
|
US11433072B1
(en)
|
2021-06-10 |
2022-09-06 |
Hikma Pharmaceuticals USA, Inc. |
Oral dosage forms of ibrutinib
|
WO2022260667A1
(en)
|
2021-06-10 |
2022-12-15 |
Hikma Pharmaceuticals Usa Inc. |
Oral dosage forms of ibrutinib
|
CN113583001A
(zh)
*
|
2021-07-13 |
2021-11-02 |
江苏君若药业有限公司 |
依鲁替尼的制备
|
WO2023014817A1
(en)
|
2021-08-03 |
2023-02-09 |
Syros Pharmaceuticals, Inc. |
Compositions and methods for treating lymphomas with a cdk7 inhibitor in combination with a btk inhibitor
|
CN115702898B
(zh)
*
|
2021-08-04 |
2024-02-09 |
成都倍特药业股份有限公司 |
一种btk抑制剂固体制剂及其制备方法
|
WO2023028238A1
(en)
|
2021-08-25 |
2023-03-02 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
US20230150997A1
(en)
|
2021-08-25 |
2023-05-18 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
WO2023071973A1
(en)
*
|
2021-10-26 |
2023-05-04 |
Shenzhen Targetrx, Inc. |
Fused bicyclic compound for inhibiting activity of tyrosine kinase
|
WO2023104808A1
(en)
|
2021-12-10 |
2023-06-15 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
CN114605418B
(zh)
*
|
2022-03-15 |
2023-09-05 |
广东医科大学附属医院 |
一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
WO2023220655A1
(en)
|
2022-05-11 |
2023-11-16 |
Celgene Corporation |
Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
|
WO2023230205A1
(en)
|
2022-05-25 |
2023-11-30 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
US11807689B1
(en)
|
2022-06-01 |
2023-11-07 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11884740B1
(en)
|
2022-06-01 |
2024-01-30 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11814439B1
(en)
|
2022-06-01 |
2023-11-14 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11786531B1
(en)
|
2022-06-08 |
2023-10-17 |
Beigene Switzerland Gmbh |
Methods of treating B-cell proliferative disorder
|
WO2023242384A1
(en)
|
2022-06-17 |
2023-12-21 |
Krka, D.D., Novo Mesto |
Crystalline form of ibrutinib
|
WO2023249980A1
(en)
*
|
2022-06-22 |
2023-12-28 |
Genzyme Corporation |
Methods of making modified btk inhibitors
|
WO2024028363A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
|
WO2024028365A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Substituted pyridone gpr84 antagonists and uses thereof
|
WO2024028364A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Aryl-triazolyl and related gpr84 antagonists and uses thereof
|
CN115417827B
(zh)
*
|
2022-09-30 |
2023-05-26 |
中国药科大学 |
6-氨基-1,3,5-三嗪类化合物及其合成方法和应用
|