ES2396613T3 - Imidazopirazinas e imidazotriazinas sustituidas - Google Patents
Imidazopirazinas e imidazotriazinas sustituidas Download PDFInfo
- Publication number
- ES2396613T3 ES2396613T3 ES09751280T ES09751280T ES2396613T3 ES 2396613 T3 ES2396613 T3 ES 2396613T3 ES 09751280 T ES09751280 T ES 09751280T ES 09751280 T ES09751280 T ES 09751280T ES 2396613 T3 ES2396613 T3 ES 2396613T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- independently selected
- substituted
- cr8r9
- cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Un compuesto de acuerdo con la Fórmula I: en la que: A es CH o N; Q1 es -X1-Y1-Z1; o Q1 es: X1 es cíclico5-10, que puede estar sustituido con uno o más grupos G1 seleccionados independientemente; Y1 se selecciona entre >C(R2)R3, >C(OR2)R3, >C>=O, >C>=C(R2)R3, >C>=NR2, >C>=NOR2, >NR2, >O, >S(O)m; Z1 se selecciona entre cíclico5-10 o alcoxi C1-6, cualquiera de los cuales puede estar sustituido con uno o más gruposG1 seleccionados independientemente; y en la que cuando Y es >O y R1 es ciclobutilo, al menos uno de X o Z está sustituido; cada caso de G1 seselecciona independientemente entre halo, -CN, -CF3, -OCF3, -NO2, alquilo C1-6, cíclico3-6alquilo C0-6, -OR4, -NR4R5, -C(O)R4, -C(O)NR4R5, -C(O)OR4 o -NR4C(O)R5 , cualquiera de los cuales puede estar sustituido con uno o más grupos G2 seleccionados independientemente; cada caso de G2 se selecciona independientemente entre halo, -CN, -OH, -NH2, -NO2, oxo, -CF3, -OCF3 o alquilo C1-6, cualquiera de los cuales puede estar sustituido con uno o más grupos seleccionados independientemente entrehalo, -CN, -OH, -NH2, alquilo C1-6 (en el que cualquiera de los siguientes puede estar parcial o totalmentehalogenado), -Oalquilo C1-6 o -N(alquil C1-6) alquilo C1-6; cada caso de G3 se selecciona independientemente entre halo, oxo, -CN, -CF3, -OCF3, alquilo C1-6, cíclico3-6alquiloC0-6, -OR8, -NR8R9, -C(O)R8, -C(O)NR8R9, -C(O)OR8, -NR8C(O)R9, -(CR8R9)nNR6R7, -(CR8R9)nOR6, -NR8C(O)OR9, -O(CR8R9)nNR6R7, -N(CR8R9)nOR6 o - (CR8R9)nNR6C(O)OR7, cualquiera de los cuales puede estar sustituido con unoo más sustituyentes G2 seleccionados independientemente R1 se selecciona entre -SR2, alquilo C1-6, 5,6-bicíclicoarilo, o cíclico3-6, cualquiera de los cuales puede estar sustituidocon uno o más grupos G3 seleccionados independientemente; cada caso de R2 y R3 se selecciona independientemente entre H, halo o -alquilo C1-6; cada caso de R4, R5, R6, R7, R8, R9 se selecciona independientemente entre H, alquilo C1-6 o cíclico3-6alquilo C0-6; enlos que cualquier par R4/R5, R6/R7, R8/R9, junto con el átomo al que está unido, puede formar un cíclico3-6 quepueden incluir uno o más heteroátomos seleccionados entre O, N(alquilo C0-3) o S(O)m; cada m se selecciona independientemente entre 0-2; y cada n se selecciona independientemente entre 0-4; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5434508P | 2008-05-19 | 2008-05-19 | |
US54345P | 2008-05-19 | ||
PCT/US2009/044325 WO2009143051A1 (en) | 2008-05-19 | 2009-05-18 | Substituted imidazopyr-and imidazotri-azines |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2396613T3 true ES2396613T3 (es) | 2013-02-22 |
Family
ID=40983400
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09751280T Active ES2396613T3 (es) | 2008-05-19 | 2009-05-18 | Imidazopirazinas e imidazotriazinas sustituidas |
Country Status (5)
Country | Link |
---|---|
US (1) | US8481733B2 (es) |
EP (1) | EP2283020B8 (es) |
JP (1) | JP2011520970A (es) |
ES (1) | ES2396613T3 (es) |
WO (1) | WO2009143051A1 (es) |
Families Citing this family (40)
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AU2005230818B2 (en) | 2004-04-02 | 2010-11-25 | Osi Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
US20110046144A1 (en) * | 2008-01-18 | 2011-02-24 | Mulvihill Mark J | Imidazopyrazinol derivatives for the treatment of cancers |
CA2752826A1 (en) | 2009-04-20 | 2010-10-28 | OSI Pharmaceuticals, LLC | Preparation of c-pyrazine-methylamines |
JP2012526138A (ja) * | 2009-05-07 | 2012-10-25 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 副腎皮質癌を治療するためのosi−906の使用 |
AU2012221828C1 (en) | 2011-02-23 | 2015-10-01 | Pfizer Inc. | Imidazo[5,1-f][1,2,4]triazines for treatment of neurological disorders |
HUE027461T2 (en) | 2011-07-13 | 2016-09-28 | Basf Agro Bv | Fungicide substituted 2- [2-haloalkyl-4- (phenoxyphenyl) -1- [1,2,4] triazol-1-yl-ethanol compounds |
IN2014CN00832A (es) | 2011-07-15 | 2015-04-03 | Basf Se | |
CN103648281B (zh) | 2011-07-15 | 2016-05-25 | 巴斯夫欧洲公司 | 杀真菌的烷基取代的2-[2-氯-4-(4-氯苯氧基)苯基]-1-[1,2,4]***-1-基乙醇化合物 |
UY34258A (es) | 2011-08-15 | 2013-02-28 | Basf Se | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]-2-alcoxi-2-alquinil/alquenil-etil}-1h-[1,2,4]triazol sustituidos |
MX2014000824A (es) | 2011-08-15 | 2014-02-27 | Basf Se | Compuestos fungicidas de 1-{2-[2-halo-4-(4-halogen-fenoxi)-fenil]- 2-alcoxi-3-metil-butil}-1h-[1,2,4]triazol sustituidos. |
JP2014529594A (ja) | 2011-08-15 | 2014-11-13 | ビーエーエスエフ ソシエタス・ヨーロピアBasf Se | 殺菌性置換1−{2−シクリルオキシ−2−[2−ハロ−4−(4−ハロゲン−フェノキシ)−フェニル]−エチル}−1h−[1,2,4]トリアゾール化合物 |
CN103374001B (zh) * | 2012-04-19 | 2015-10-28 | 山东轩竹医药科技有限公司 | 咪唑并三嗪类mTOR抑制剂 |
KR20150061651A (ko) * | 2012-09-26 | 2015-06-04 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ire1의 조절 |
PL2934147T3 (pl) | 2012-12-20 | 2020-06-29 | BASF Agro B.V. | Kompozycje zawierające związki triazolowe |
PL3219707T3 (pl) | 2013-01-09 | 2020-01-31 | BASF Agro B.V. | Sposób wytwarzania podstawionych oksiranów i triazoli |
WO2014113942A1 (en) * | 2013-01-23 | 2014-07-31 | Merck Sharp & Dohme Corp. | Btk inhibitors |
RU2669997C2 (ru) | 2013-07-08 | 2018-10-17 | Басф Агро Б.В. | Композиции, содержащие триазольное соединение и биопестицид |
US20210317140A1 (en) * | 2013-10-18 | 2021-10-14 | Medivation Technologies, Inc. | Heterocyclic Compounds and Methods of Use |
CA2833867A1 (en) | 2013-11-21 | 2015-05-21 | Pharmascience Inc. | Protein kinase inhibitors |
EA032078B1 (ru) | 2014-06-25 | 2019-04-30 | Басф Агро Б.В. | Пестицидные композиции |
WO2016019237A2 (en) * | 2014-07-31 | 2016-02-04 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
BR112017009282A2 (pt) | 2014-11-07 | 2018-01-30 | Basf Se | misturas fungicidas, composição pesticida, métodos para controlar pragas fitopatogênicas, para melhorar a fitossanidade e para proteção de material de propagação de plantas contra pragas, e, material de propagação de plantas. |
WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
WO2016106624A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Tertiary alcohol imidazopyrazine btk inhibitors |
WO2016106628A1 (en) | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
WO2016161571A1 (en) | 2015-04-08 | 2016-10-13 | Merck Sharp & Dohme Corp. | Indazole and azaindazole btk inhibitors |
KR102416971B1 (ko) * | 2016-03-11 | 2022-07-04 | 엔젤 파마슈티칼 컴퍼니, 리미티드 | 브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법 |
BR112018068705B1 (pt) | 2016-03-16 | 2022-09-06 | Basf Se | Método para controlar fungos fitopatogênicos |
US10905122B2 (en) | 2016-03-16 | 2021-02-02 | Basf Se | Use of tetrazolinones for combating resistant phytopathogenic fungi on cereals |
BR112018068695B1 (pt) | 2016-03-16 | 2022-12-27 | Basf Se | Uso de um composto e método para controlar fungos fitopatogênicos |
CN106831787B (zh) * | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
AU2018237123B2 (en) | 2017-03-22 | 2022-08-04 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
MX2020002322A (es) * | 2017-09-01 | 2020-10-05 | Optikira Llc | Compuestos y composiciones para la inhibicion de ire1. |
CN108191871B (zh) * | 2018-01-02 | 2020-02-18 | 成都倍特药业有限公司 | 新型布鲁顿酪氨酸激酶抑制剂及其制备方法和应用 |
AU2020207953A1 (en) * | 2019-01-18 | 2021-08-26 | Hangzhou Bangshun Pharmaceutical Co., Ltd. | Bruton's tyrosine kinase inhibitors |
ES2961673T3 (es) * | 2019-03-15 | 2024-03-13 | Alterity Therapeutics Ltd | Compuestos para y métodos para tratar enfermedades |
US20230122807A1 (en) * | 2020-01-02 | 2023-04-20 | Dizal (Jiangsu) Pharmaceutical Co., Ltd. | Btk inhibitors |
US11155547B1 (en) | 2020-06-18 | 2021-10-26 | Alterity Therapeutics Limited | Compounds for and methods of treating diseases |
CN113943294A (zh) * | 2020-07-15 | 2022-01-18 | 成都海博为药业有限公司 | 一种作为btk抑制剂的化合物及其制备方法与用途 |
CN113861179A (zh) * | 2021-10-22 | 2021-12-31 | 上海应用技术大学 | 一种新型flt3激酶抑制剂及其合成与应用 |
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-
2009
- 2009-05-18 WO PCT/US2009/044325 patent/WO2009143051A1/en active Application Filing
- 2009-05-18 JP JP2011510616A patent/JP2011520970A/ja not_active Ceased
- 2009-05-18 ES ES09751280T patent/ES2396613T3/es active Active
- 2009-05-18 EP EP09751280A patent/EP2283020B8/en not_active Not-in-force
- 2009-05-19 US US12/468,188 patent/US8481733B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2009143051A1 (en) | 2009-11-26 |
US8481733B2 (en) | 2013-07-09 |
US20090286768A1 (en) | 2009-11-19 |
EP2283020A1 (en) | 2011-02-16 |
EP2283020B8 (en) | 2012-12-12 |
JP2011520970A (ja) | 2011-07-21 |
EP2283020B1 (en) | 2012-10-31 |
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