MX347525B - Inhibidores de tirosina cinasa de bruton. - Google Patents

Inhibidores de tirosina cinasa de bruton.

Info

Publication number
MX347525B
MX347525B MX2012014021A MX2012014021A MX347525B MX 347525 B MX347525 B MX 347525B MX 2012014021 A MX2012014021 A MX 2012014021A MX 2012014021 A MX2012014021 A MX 2012014021A MX 347525 B MX347525 B MX 347525B
Authority
MX
Mexico
Prior art keywords
disclosed
inhibitors
bruton
tyrosine kinase
compounds
Prior art date
Application number
MX2012014021A
Other languages
English (en)
Inventor
Lee Honigberg
Erik Verner
Zhengying Pan
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39225888&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347525(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX347525B publication Critical patent/MX347525B/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Abstract

La presente invención se refiere a compuestos que forman enlaces covalentes con la tirosina cinasa de Bruton (Btk); también se describen inhibidores irreversibles de Btk; se describen métodos para la preparación de los compuestos; también se describen composiciones farmacéuticas que incluyen los compuestos; se describen métodos para usar los inhibidores de Btk, solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, que incluye linfoma y enfermedades o condiciones inflamatorias.
MX2012014021A 2006-09-22 2006-12-28 Inhibidores de tirosina cinasa de bruton. MX347525B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82672006P 2006-09-22 2006-09-22
US82859006P 2006-10-06 2006-10-06
PCT/US2006/049626 WO2008039218A2 (en) 2006-09-22 2006-12-28 Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
MX347525B true MX347525B (es) 2017-04-27

Family

ID=39225888

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2009003122A MX2009003122A (es) 2006-09-22 2006-12-28 Inhibidores de tirosina cinasa de bruton.
MX2012014021A MX347525B (es) 2006-09-22 2006-12-28 Inhibidores de tirosina cinasa de bruton.
MX2019012657A MX2019012657A (es) 2006-09-22 2009-03-20 Inhibidores de tirosina cinasa de bruton.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2009003122A MX2009003122A (es) 2006-09-22 2006-12-28 Inhibidores de tirosina cinasa de bruton.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2019012657A MX2019012657A (es) 2006-09-22 2009-03-20 Inhibidores de tirosina cinasa de bruton.

Country Status (28)

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US (48) US7514444B2 (es)
EP (11) EP2526934B1 (es)
JP (4) JP4934197B2 (es)
KR (4) KR101464424B1 (es)
CN (4) CN102887900B (es)
AT (1) ATE531263T1 (es)
AU (2) AU2006348662B8 (es)
BR (2) BRPI0622054B8 (es)
CA (3) CA2663116C (es)
CY (11) CY1112513T1 (es)
DK (7) DK2529621T3 (es)
EA (3) EA018573B1 (es)
ES (8) ES2564647T3 (es)
FR (1) FR15C0029I2 (es)
HK (3) HK1129274A1 (es)
HU (10) HUE031334T2 (es)
IL (1) IL197550A0 (es)
LT (7) LT2526771T (es)
LU (3) LU92692I2 (es)
MX (3) MX2009003122A (es)
NL (1) NL300728I2 (es)
NZ (3) NZ575650A (es)
PL (8) PL2526933T3 (es)
PT (7) PT2526771T (es)
SG (2) SG10201503235VA (es)
SI (8) SI2081435T1 (es)
WO (1) WO2008039218A2 (es)
ZA (4) ZA200901784B (es)

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CN102924458B (zh) 2004-04-02 2014-11-05 Osi制药有限责任公司 6,6-双环取代的杂双环蛋白激酶抑制剂
EP1906950A4 (en) * 2005-06-21 2008-09-24 Infinity Discovery Inc ANSAMYCIN FORMULATIONS AND METHODS OF USE
CA2858520A1 (en) * 2006-05-18 2007-11-29 Pharmacyclics Inc. Intracellular kinase inhibitors
DE602007013567D1 (de) * 2006-08-16 2011-05-12 Novartis Ag Verfahren zur herstellung fester dispersionen von midostaurin
HUE031334T2 (hu) 2006-09-22 2017-07-28 Pharmacyclics Llc Bruton-tirozinkináz inhibitorok
US8987233B2 (en) 2006-11-03 2015-03-24 Pharmacyclics, Inc. Bruton's tyrosine kinase activity probe and method of using
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