AR091273A1 - Inhibidores de pirimidinil tirosina quinasa - Google Patents

Inhibidores de pirimidinil tirosina quinasa

Info

Publication number
AR091273A1
AR091273A1 ARP130101980A AR091273A1 AR 091273 A1 AR091273 A1 AR 091273A1 AR P130101980 A ARP130101980 A AR P130101980A AR 091273 A1 AR091273 A1 AR 091273A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
nitrogen
sulfur
oxygen
monocyclic heterocyclic
Prior art date
Application number
Other languages
English (en)
Original Assignee
Biogen Idec Inc
Sunesis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc, Sunesis Pharmaceuticals Inc filed Critical Biogen Idec Inc
Publication of AR091273A1 publication Critical patent/AR091273A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Abstract

Reivindicación 1: Un compuesto de fórmula (1) o una de sus sales aceptables desde el punto de vista farmacéutico, en donde: cada R¹ es en forma independiente hidrógeno, un grupo alifático C₁₋₆ sustituido en forma opcional, un grupo heterocíclico monocíclico de 3 - 7 miembros sustituido en forma opcional, o un grupo heterocicloalquilo sustituido en forma opcional que tiene 3 - 7 átomos de carbono y 1 - 3 heteroátomos seleccionados en forma independiente de nitrógeno, oxígeno, o azufre; o dos grupos R¹ se toman junto con sus átomos intervinientes para formar un anillo heterocíclico monocíclico parcialmente insaturado o saturado de 3 - 7 miembros sustituido en forma opcional que tiene 1 - 2 heteroátomos seleccionados en forma independiente de nitrógeno, oxígeno, o azufre; en donde los grupos opcionalmente sustituidos pueden sustituirse con halógeno, -NO₂, -CN, -OR, -SR, -N(R)₂, -C(O)R, -CO₂R, -N(R)C(O)OR, -C(O)N(R)₂, -OC(O)R, -N(R)C(O)R, -S(O)R, -S(O)₂R, o -S(O)₂N(R)₂; cada R es en forma independiente hidrógeno o alifático C₁₋₆; o dos grupos R unidos al mismo nitrógeno se toman junto con sus átomos intervinientes para formar un anillo heterocíclico monocíclico parcialmente insaturado o saturado de 3 - 7 miembros sustituido en forma opcional que tiene 1 - 2 heteroátomos, en los cuales un segundo heteroátomo se selecciona en forma independiente de nitrógeno, oxígeno, o azufre; el Anillo A es un compuesto de fórmula (2); R² es -Cl o -F; y R³ es -CF₃, -OCF₃, o -F.
ARP130101980 2012-06-08 2013-06-05 Inhibidores de pirimidinil tirosina quinasa AR091273A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261657360P 2012-06-08 2012-06-08

Publications (1)

Publication Number Publication Date
AR091273A1 true AR091273A1 (es) 2015-01-21

Family

ID=49712704

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP130101980 AR091273A1 (es) 2012-06-08 2013-06-05 Inhibidores de pirimidinil tirosina quinasa

Country Status (30)

Country Link
US (5) US9394277B2 (es)
EP (3) EP2858499B1 (es)
JP (6) JP6214643B2 (es)
KR (4) KR102468430B1 (es)
CN (3) CN104540385B (es)
AR (1) AR091273A1 (es)
AU (5) AU2013271407B2 (es)
BR (2) BR112014030655B1 (es)
CA (2) CA2875799C (es)
CY (1) CY1120638T1 (es)
DK (1) DK2858499T3 (es)
EA (2) EA027823B1 (es)
ES (2) ES2834333T3 (es)
HK (1) HK1209284A1 (es)
HR (1) HRP20181294T1 (es)
HU (1) HUE039897T2 (es)
IL (2) IL235938B (es)
IN (1) IN2014DN10576A (es)
LT (1) LT2858499T (es)
MX (2) MX363672B (es)
NZ (1) NZ702715A (es)
PH (2) PH12014502699A1 (es)
PL (1) PL2858499T3 (es)
PT (1) PT2858499T (es)
RS (1) RS57978B1 (es)
SG (2) SG11201408173WA (es)
SI (1) SI2858499T1 (es)
TW (3) TWI719209B (es)
WO (1) WO2013185084A1 (es)
ZA (1) ZA201409255B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5699149B2 (ja) 2009-09-04 2015-04-08 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｂｒｕｔｏｎ型チロシンキナーゼ阻害薬
EP2632898A4 (en) 2010-10-29 2014-04-02 Biogen Idec Inc HETEROCYCLIC TYROSINE KINASE HEMMER
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
LT3080103T (lt) * 2013-12-11 2018-08-10 Biogen Ma Inc. Biarilo junginiai, tinkami panaudoti žmogaus ligų gydymui onkologijoje, neurologijoje ir imunologijoje
WO2015151006A1 (en) 2014-03-29 2015-10-08 Lupin Limited Substituted purine compounds as btk inhibitors
WO2015170266A1 (en) 2014-05-07 2015-11-12 Lupin Limited Substituted pyrimidine compounds as btk inhibitors
ME03807B (me) 2014-10-24 2021-04-20 Bristol Myers Squibb Co Jedinjenja indol karboksamida korisna kao inhibitori kinaze
RU2019104758A (ru) * 2016-07-21 2020-08-21 Байоджен Ма Инк. Сукцинатные формы и композиции ингибиторов тирозинкиназы брутона
WO2019208805A1 (ja) 2018-04-27 2019-10-31 小野薬品工業株式会社 Ｂｔｋ阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および／または治療剤
KR102545594B1 (ko) 2018-07-31 2023-06-21 록쏘 온콜로지, 인코포레이티드 (s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
WO2022212893A1 (en) 2021-04-02 2022-10-06 Biogen Ma Inc. Combination treatment methods of multiple sclerosis
WO2023081709A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Vecabrutinib for the treatment of graft-versus-host disease
WO2023081715A1 (en) 2021-11-03 2023-05-11 Viracta Therapeutics, Inc. Combination of car t-cell therapy with btk inhibitors and methods of use thereof
WO2023110970A1 (en) 2021-12-14 2023-06-22 Netherlands Translational Research Center Holding B.V Macrocyclic btk inhibitors

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1624A (en) * 1840-06-10 Cooking-stove
US4528138A (en) 1984-06-20 1985-07-09 E. R. Squibb & Sons, Inc. 16-Keto-17-substituted thia-17-alkyl(or alkenyl or alkynyl) androstenes
US4911920A (en) 1986-07-30 1990-03-27 Alcon Laboratories, Inc. Sustained release, comfort formulation for glaucoma therapy
FR2588189B1 (fr) 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
JP2594486B2 (ja) 1991-01-15 1997-03-26 アルコン ラボラトリーズ インコーポレイテッド 局所的眼薬組成物
US5212162A (en) 1991-03-27 1993-05-18 Alcon Laboratories, Inc. Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6919178B2 (en) 2000-11-21 2005-07-19 Sunesis Pharmaceuticals, Inc. Extended tethering approach for rapid identification of ligands
NZ521248A (en) 2000-03-17 2004-04-30 Bristol Myers Squibb Pharma Co Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
MY137020A (en) 2000-04-27 2008-12-31 Abbott Lab Diazabicyclic central nervous system active agents
ATE423120T1 (de) 2000-06-26 2009-03-15 Pfizer Prod Inc Pyrroloä2,3-düpyrimidin verbindungen als immunosuppressive wirkstoffe
PE20020507A1 (es) * 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
AU2002363236A1 (en) * 2001-10-30 2003-05-12 Millennium Pharmaceuticals, Inc. Compounds, pharmaceutical compositions and methods of use therefor
EP1442039A1 (en) 2001-10-31 2004-08-04 Bayer HealthCare AG Pyrimido (4,5-b) indole derivatives
GEP20084540B (en) 2003-01-14 2008-11-25 Arena Pharm Inc 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prpphylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
US7326712B2 (en) 2003-10-14 2008-02-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Substituted tricyclic compounds as protein kinase inhibitors
US20080253960A1 (en) * 2004-04-01 2008-10-16 The Trustees Of The University Of Pennsylvania Center For Technology Transfer Lipoprotein-Based Nanoplatforms
AU2005249380C1 (en) 2004-04-23 2012-09-20 Exelixis, Inc. Kinase modulators and methods of use
FR2870541B1 (fr) 2004-05-18 2006-07-14 Proskelia Sas Derives de pyrimidines antigonistes du recepteur de la vitronectine
TW200621760A (en) 2004-09-09 2006-07-01 Mitsubishi Pharma Corp 2-morpholino-4-pyrimidone compound
ZA200704476B (en) * 2004-11-04 2008-09-25 Vertex Pharma Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
NZ555320A (en) 2004-12-03 2010-11-26 Schering Corp Substituted piperazines as CB1 antagonists
ATE543821T1 (de) 2004-12-28 2012-02-15 Exelixis Inc Ä1h-pyrazoloä3,4-düpyrimidin-4-ylü-piperidin- oder piperazinverbindungen als serin-threonin- kinasemodulatoren (p70s6k, atk1 und atk2) zur behandlung von immunologischen, entzündlichen und proliferativen erkrankungen
WO2006071875A1 (en) 2004-12-29 2006-07-06 Millennium Pharmaceuticals, Inc. Compounds useful as chemokine receptor antagonists
US7423043B2 (en) * 2005-02-18 2008-09-09 Lexicon Pharmaceuticals, Inc. 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds
US20060281700A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using aminopyrimidines kinase modulators
US20060281764A1 (en) 2005-06-10 2006-12-14 Gaul Michael D Aminopyrimidines as kinase modulators
TW200740779A (en) 2005-07-22 2007-11-01 Mitsubishi Pharma Corp Intermediate compound for synthesizing pharmaceutical agent and production method thereof
RU2597364C2 (ru) 2005-11-01 2016-09-10 Таргеджен, Инк. Би-арил-мета-пиримидиновые ингибиторы киназ
US20070142369A1 (en) * 2005-12-21 2007-06-21 Margaret Van Heek Combination of an H3 antagonist/inverse agonist and an appetite suppressant
US20080076924A1 (en) 2006-06-30 2008-03-27 Patrick Betschmann Piperazines as P2X7 antagonists
WO2008012635A2 (en) 2006-07-26 2008-01-31 Pfizer Products Inc. Amine derivatives useful as anticancer agents
WO2008014307A2 (en) 2006-07-26 2008-01-31 Novartis Ag Inhibitors of undecaprenyl pyrophosphate synthase
EP2068849A2 (en) * 2006-09-11 2009-06-17 CGI Pharmaceuticals, Inc. Kinase inhibitors, and methods of using and identifying kinase inhibitors
SI2530083T1 (sl) 2006-09-22 2016-09-30 Pharmacyclics Llc Inhibitorji Bruton tirozin kinaze
JP2010520199A (ja) * 2007-03-02 2010-06-10 シェーリング コーポレイション ピペリジン誘導体およびその使用方法
CN101730699A (zh) 2007-03-21 2010-06-09 百时美施贵宝公司 可用于治疗增殖性、变应性、自身免疫性和炎症性疾病的稠合杂环化合物
WO2008144253A1 (en) 2007-05-14 2008-11-27 Irm Llc Protein kinase inhibitors and methods for using thereof
US8093239B2 (en) 2007-06-01 2012-01-10 Glaxosmithkline Llc Imidazopyridine kinase inhibitors
AU2009211514B2 (en) * 2008-02-05 2014-02-20 F. Hoffmann-La Roche Ag Novel pyridinones and pyridazinones
CA2760044A1 (en) 2008-04-29 2009-11-05 Immunexcite, Inc. Immunomodulating compositions and methods of use thereof
AU2009270856B2 (en) 2008-07-16 2013-07-25 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
WO2010068788A1 (en) * 2008-12-10 2010-06-17 Cgi Pharmaceuticals, Inc. Heterocyclic amides as btk inhibitors
MX2011006171A (es) * 2008-12-19 2011-06-20 Squibb Bristol Myers Co Compuestos de carbazol carboxamida utiles como inhibidores de cinasa.
US9266890B2 (en) * 2009-01-06 2016-02-23 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
WO2010136422A1 (de) 2009-05-25 2010-12-02 Sandoz Ag Verfahren zur herstellung von ceftobiprol medocaril
JP5699149B2 (ja) 2009-09-04 2015-04-08 バイオジェン・アイデック・エムエイ・インコーポレイテッド Ｂｒｕｔｏｎ型チロシンキナーゼ阻害薬
WO2011029043A1 (en) 2009-09-04 2011-03-10 Biogen Idec Ma Inc. Heteroaryl btk inhibitors
US8685880B2 (en) 2010-06-30 2014-04-01 Chevron U.S.A. Inc. On-site drying of aqueous salt for ionic liquid make-up
EP2632898A4 (en) 2010-10-29 2014-04-02 Biogen Idec Inc HETEROCYCLIC TYROSINE KINASE HEMMER
US9353087B2 (en) 2012-06-08 2016-05-31 Biogen Ma Inc. Inhibitors of Bruton's tyrosine kinase
AR091273A1 (es) * 2012-06-08 2015-01-21 Biogen Idec Inc Inhibidores de pirimidinil tirosina quinasa
WO2015089327A1 (en) 2013-12-11 2015-06-18 Biogen Idec Ma Inc. Biaryl compounds useful for the treatment of human diseases in oncology, neurology and immunology
LT3080103T (lt) 2013-12-11 2018-08-10 Biogen Ma Inc. Biarilo junginiai, tinkami panaudoti žmogaus ligų gydymui onkologijoje, neurologijoje ir imunologijoje
WO2016054627A1 (en) 2014-10-03 2016-04-07 Ohio State Innovation Foundation Biomarkers of bruton tyrosine kinase inhibitor resistance

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DK2858499T3 (en) 2018-08-20
IN2014DN10576A (es) 2015-08-28
EP3385263A1 (en) 2018-10-10
JP6214643B2 (ja) 2017-10-18
CA3108186A1 (en) 2013-12-12
MX363672B (es) 2019-03-29
TWI592406B (zh) 2017-07-21
KR102102587B1 (ko) 2020-04-22
ES2684268T3 (es) 2018-10-02
US20150158843A1 (en) 2015-06-11
US20190047986A1 (en) 2019-02-14
JP2021073299A (ja) 2021-05-13
BR112014030655B1 (pt) 2021-04-20
SG10201708535UA (en) 2017-11-29
BR112014030655A8 (pt) 2018-01-02
AU2022275504A1 (en) 2023-01-05
ES2834333T3 (es) 2021-06-17
CN104540385A (zh) 2015-04-22
AU2013271407B2 (en) 2016-12-08
KR20200043497A (ko) 2020-04-27
SG11201408173WA (en) 2015-01-29
RS57978B1 (sr) 2019-01-31
US20160304494A1 (en) 2016-10-20
HUE039897T2 (hu) 2019-02-28
US10618887B2 (en) 2020-04-14
AU2021202412A1 (en) 2021-05-20
US20230174511A1 (en) 2023-06-08
US9394277B2 (en) 2016-07-19
CA2875799A1 (en) 2013-12-12
HRP20181294T1 (hr) 2018-10-05
NZ702715A (en) 2016-11-25
IL235938B (en) 2020-10-29
WO2013185084A1 (en) 2013-12-12
JP2023052415A (ja) 2023-04-11
BR122021002178B1 (pt) 2022-03-22
US9944622B2 (en) 2018-04-17
TW202142535A (zh) 2021-11-16
SI2858499T1 (sl) 2018-10-30
EP3753934A1 (en) 2020-12-23
PT2858499T (pt) 2018-10-24
KR20210072139A (ko) 2021-06-16
PH12014502699B1 (en) 2015-02-02
CN113549055A (zh) 2021-10-26
MX2019003618A (es) 2019-07-18
CA2875799C (en) 2021-03-23
AU2019203476B2 (en) 2021-01-28
EA201790418A1 (ru) 2017-11-30
MX2014015044A (es) 2015-09-22
ZA201409255B (en) 2015-12-23
AU2019203476A1 (en) 2019-06-06
CN109305959B (zh) 2022-02-08
CN104540385B (zh) 2018-06-05
TWI719209B (zh) 2021-02-21
JP2017193583A (ja) 2017-10-26
KR20150036020A (ko) 2015-04-07
EP2858499A1 (en) 2015-04-15
BR112014030655A2 (pt) 2017-06-27
EA201492056A1 (ru) 2015-05-29
CN109305959A (zh) 2019-02-05
PH12018501463A1 (en) 2019-03-04
PL2858499T3 (pl) 2019-03-29
EA027823B1 (ru) 2017-09-29
TW201805279A (zh) 2018-02-16
PH12014502699A1 (en) 2015-02-02
IL277951A (en) 2020-11-30
AU2017201536A1 (en) 2017-03-23
TW201410668A (zh) 2014-03-16
EP3385263B1 (en) 2020-07-22
JP2021073298A (ja) 2021-05-13
KR20220154850A (ko) 2022-11-22
US20210017155A1 (en) 2021-01-21
TWI792158B (zh) 2023-02-11
AU2017201536B2 (en) 2019-03-07
JP2019077728A (ja) 2019-05-23
HK1209284A1 (en) 2016-04-01
AU2013271407A1 (en) 2015-01-22
EP2858499A4 (en) 2016-01-20
IL235938A0 (en) 2015-02-01
CY1120638T1 (el) 2019-12-11
LT2858499T (lt) 2018-09-10
KR102468430B1 (ko) 2022-11-21
EP2858499B1 (en) 2018-05-16
JP2015518903A (ja) 2015-07-06

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