AU2005230818B2
(en)
|
2004-04-02 |
2010-11-25 |
Osi Pharmaceuticals, Inc. |
6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors
|
EP1906950A4
(en)
*
|
2005-06-21 |
2008-09-24 |
Infinity Discovery Inc |
ANSAMYCIN FORMULATIONS AND METHODS OF USE
|
EP2027087A2
(en)
*
|
2006-05-18 |
2009-02-25 |
MannKind Corporation |
Intracellular kinase inhibitors
|
BRPI0714963A2
(pt)
*
|
2006-08-16 |
2013-07-30 |
Novartis Ag |
processo de fabricaÇço de dispersÕes sàlidas de compostos terapÊuticos altamente cristalinos
|
SI2530083T1
(sl)
|
2006-09-22 |
2016-09-30 |
Pharmacyclics Llc |
Inhibitorji Bruton tirozin kinaze
|
ES2403546T3
(es)
*
|
2006-11-03 |
2013-05-20 |
Pharmacyclics, Inc. |
Sonda de actividad de la tirosina-cinasa de Bruton y procedimiento de utilización
|
US8809273B2
(en)
*
|
2007-03-28 |
2014-08-19 |
Pharmacyclics, Inc. |
Inhibitors of Bruton's tyrosine kinase
|
ES2562215T3
(es)
|
2007-03-28 |
2016-03-03 |
Pharmacyclics Llc |
Inhibidores de la tirosina quinasa de Bruton
|
US20080255080A1
(en)
*
|
2007-04-12 |
2008-10-16 |
Wright James L |
Hydroquinone Ansamycin Formulations
|
US7989465B2
(en)
*
|
2007-10-19 |
2011-08-02 |
Avila Therapeutics, Inc. |
4,6-disubstituted pyrimidines useful as kinase inhibitors
|
TWI552752B
(zh)
*
|
2007-10-19 |
2016-10-11 |
賽基艾維洛米斯研究股份有限公司 |
雜芳基化合物及其用途
|
US20110046144A1
(en)
*
|
2008-01-18 |
2011-02-24 |
Mulvihill Mark J |
Imidazopyrazinol derivatives for the treatment of cancers
|
WO2009143051A1
(en)
*
|
2008-05-19 |
2009-11-26 |
Osi Pharmaceuticals, Inc. |
Substituted imidazopyr-and imidazotri-azines
|
US20090301928A1
(en)
*
|
2008-06-05 |
2009-12-10 |
United Comb & Novelty Corporation |
Packaging For Lipped Containers
|
US8338439B2
(en)
|
2008-06-27 |
2012-12-25 |
Celgene Avilomics Research, Inc. |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
JP2011526299A
(ja)
|
2008-06-27 |
2011-10-06 |
アビラ セラピューティクス, インコーポレイテッド |
ヘテロアリール化合物およびそれらの使用
|
US11351168B1
(en)
|
2008-06-27 |
2022-06-07 |
Celgene Car Llc |
2,4-disubstituted pyrimidines useful as kinase inhibitors
|
ES2552681T3
(es)
*
|
2008-07-15 |
2015-12-01 |
F. Hoffmann-La Roche Ag |
Nuevas fenil-imidazopiridinas y piridazinas
|
AU2009270856B2
(en)
*
|
2008-07-16 |
2013-07-25 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
AU2013245503B2
(en)
*
|
2008-07-16 |
2015-09-24 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
|
CN102405284B
(zh)
*
|
2008-09-05 |
2016-01-20 |
新基阿维罗米克斯研究公司 |
设计不可逆抑制剂的算法
|
JP5583680B2
(ja)
*
|
2008-10-15 |
2014-09-03 |
インフィニティー ファーマスーティカルズ インコーポレイテッド |
アンサマイシンヒドロキノン組成物
|
WO2010043633A1
(en)
*
|
2008-10-15 |
2010-04-22 |
Palau Pharma, S. A. |
2h-pyrazolo [4,3-d]pyrimidin-5-amine derivatives as h4 histamine receptor antagonists for the treatment of allergic, immunological and inflammatory diseases
|
US9095592B2
(en)
*
|
2008-11-07 |
2015-08-04 |
The Research Foundation For The State University Of New York |
Bruton's tyrosine kinase as anti-cancer drug target
|
US8426428B2
(en)
*
|
2008-12-05 |
2013-04-23 |
Principia Biopharma, Inc. |
EGFR kinase knockdown via electrophilically enhanced inhibitors
|
CA2752826A1
(en)
|
2009-04-20 |
2010-10-28 |
OSI Pharmaceuticals, LLC |
Preparation of c-pyrazine-methylamines
|
WO2010126960A1
(en)
*
|
2009-04-29 |
2010-11-04 |
Locus Pharmaceuticals, Inc. |
Pyrrolotriazine compounds
|
US9908884B2
(en)
|
2009-05-05 |
2018-03-06 |
Dana-Farber Cancer Institute, Inc. |
EGFR inhibitors and methods of treating disorders
|
JP2012526138A
(ja)
*
|
2009-05-07 |
2012-10-25 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
副腎皮質癌を治療するためのosi−906の使用
|
JP5699149B2
(ja)
*
|
2009-09-04 |
2015-04-08 |
バイオジェン・アイデック・エムエイ・インコーポレイテッド |
Bruton型チロシンキナーゼ阻害薬
|
AU2010292116A1
(en)
*
|
2009-09-11 |
2012-05-03 |
Cylene Pharmaceuticals Inc. |
Pharmaceutically useful heterocycle-substituted lactams
|
NZ620174A
(en)
|
2009-09-16 |
2016-08-26 |
Celgene Avilomics Res Inc |
Protein kinase conjugates and inhibitors
|
US7965498B2
(en)
|
2009-09-30 |
2011-06-21 |
Apple Inc. |
Cover glass to housing interface system
|
US7741330B1
(en)
*
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
EP2937345B1
(en)
|
2009-12-29 |
2018-03-21 |
Dana-Farber Cancer Institute, Inc. |
Type ii raf kinase inhibitors
|
AU2010339456A1
(en)
|
2009-12-30 |
2012-07-05 |
Celgene Avilomics Research, Inc. |
Ligand-directed covalent modification of protein
|
WO2011110478A1
(en)
*
|
2010-03-08 |
2011-09-15 |
Ratiopharm Gmbh |
Dabigatran etexilate-containing pharmaceutical composition
|
US9371567B2
(en)
*
|
2010-04-19 |
2016-06-21 |
The Translational Genomics Research Institute |
Methods and kits to predict therapeutic outcome of BTK inhibitors
|
NZ603643A
(en)
*
|
2010-05-31 |
2014-07-25 |
Ono Pharmaceutical Co |
Purinone derivative
|
EP2575818A4
(en)
*
|
2010-06-03 |
2013-11-06 |
Pharmacyclics Inc |
USE OF INHIBITORS OF BRUTON TYROSINE KINASE (BTK)
|
US20120053189A1
(en)
*
|
2010-06-28 |
2012-03-01 |
Pharmacyclics, Inc. |
Btk inhibitors for the treatment of immune mediated conditions
|
CA2804648C
(en)
|
2010-07-09 |
2019-01-22 |
The Walter And Eliza Hall Institute Of Medical Research |
Protein kinase inhibitors and methods of treatment
|
EP2603081B1
(en)
|
2010-08-10 |
2016-10-05 |
Celgene Avilomics Research, Inc. |
Besylate salt of a btk inhibitor
|
CA2808543C
(en)
*
|
2010-08-20 |
2016-01-26 |
Hutchison Medipharma Limited |
Pyrrolopyrimidine compounds and uses thereof
|
JP5956999B2
(ja)
|
2010-11-01 |
2016-07-27 |
セルジーン アヴィロミクス リサーチ, インコーポレイテッド |
ヘテロアリール化合物およびその使用
|
RU2644151C2
(ru)
|
2010-11-01 |
2018-02-08 |
Селджен Авиломикс Рисерч, Инк. |
Гетероциклические соединения и их применение
|
EP2637502B1
(en)
|
2010-11-10 |
2018-01-10 |
Celgene CAR LLC |
Mutant-selective egfr inhibitors and uses thereof
|
AU2012221828C1
(en)
|
2011-02-23 |
2015-10-01 |
Pfizer Inc. |
Imidazo[5,1-f][1,2,4]triazines for treatment of neurological disorders
|
EP2710005B1
(en)
|
2011-05-17 |
2016-10-05 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
US20140107151A1
(en)
*
|
2011-05-17 |
2014-04-17 |
Principia Biophama Inc. |
Tyrosine kinase inhibitors
|
US9376438B2
(en)
|
2011-05-17 |
2016-06-28 |
Principia Biopharma, Inc. |
Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
|
ES2770550T3
(es)
*
|
2011-05-17 |
2020-07-02 |
Univ California |
Inhibidores de quinasa
|
WO2013003629A2
(en)
*
|
2011-06-28 |
2013-01-03 |
Pharmacyclics, Inc. |
Methods and compositions for inhibition of bone resorption
|
CA2840687C
(en)
|
2011-07-01 |
2020-04-28 |
Dana-Farber Cancer Institute, Inc. |
Discovery of a somatic mutation in myd88 gene in lymphoplasmacytic lymphoma
|
CA2841111A1
(en)
|
2011-07-08 |
2013-01-17 |
Novartis Ag |
Novel pyrrolo pyrimidine derivatives
|
KR20140048968A
(ko)
*
|
2011-07-13 |
2014-04-24 |
파마시클릭스, 인코포레이티드 |
브루톤형 티로신 키나제의 억제제
|
EP2548877A1
(en)
*
|
2011-07-19 |
2013-01-23 |
MSD Oss B.V. |
4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors
|
DK3689878T3
(da)
*
|
2011-07-19 |
2021-11-08 |
Merck Sharp & Dohme |
4-imidazopyridazin-1-yl-benzamider og 4-imidazotriazin-1-yl-benzamider som btk-inhibitorer
|
PL3409278T3
(pl)
|
2011-07-21 |
2021-02-22 |
Sumitomo Pharma Oncology, Inc. |
Heterocykliczne inhibitory kinazy białkowej
|
EP2771010A4
(en)
*
|
2011-10-19 |
2015-04-01 |
Pharmacyclics Inc |
USE OF INHIBITORS OF BRUTON TYROSINE KINASE (BTK)
|
WO2013063401A1
(en)
|
2011-10-28 |
2013-05-02 |
Celgene Avilomics Research, Inc. |
Methods of treating a bruton's tyrosine kinase disease or disorder
|
GB2496135B
(en)
|
2011-11-01 |
2015-03-18 |
Valirx Plc |
Inhibitors of the interaction between a Src family kinase and an androgen receptor or estradiol receptor for treatment of endometriosis
|
UA111756C2
(uk)
*
|
2011-11-03 |
2016-06-10 |
Ф. Хоффманн-Ля Рош Аг |
Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
|
WO2013067260A1
(en)
*
|
2011-11-03 |
2013-05-10 |
Genentech, Inc. |
Bicyclic piperazine compounds
|
US9212381B2
(en)
*
|
2011-11-10 |
2015-12-15 |
President And Fellows Of Harvard College |
Methods and compositions for labeling polypeptides
|
WO2013074986A1
(en)
|
2011-11-17 |
2013-05-23 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-jun-n-terminal kinase (jnk)
|
RU2750538C2
(ru)
|
2011-11-29 |
2021-06-29 |
Оно Фармасьютикал Ко., Лтд. |
Гидрохлорид производного пуринона
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
ES2672367T3
(es)
|
2012-01-09 |
2018-06-14 |
X-Chem, Inc. |
Derivados de triptolina que tienen actividad inhibidora de quinasas y sus usos
|
US9458162B2
(en)
*
|
2012-01-31 |
2016-10-04 |
Nanjing Allgen Pharma Co. Ltd. |
Cyclic molecules as bruton's tyrosine kinase inhibitors
|
US8501724B1
(en)
|
2012-01-31 |
2013-08-06 |
Pharmacyclics, Inc. |
Purinone compounds as kinase inhibitors
|
TW201336847A
(zh)
*
|
2012-02-07 |
2013-09-16 |
Taiho Pharmaceutical Co Ltd |
喹啉基吡咯并嘧啶化合物或其鹽
|
CA2861980C
(en)
*
|
2012-02-23 |
2016-11-08 |
Taiho Pharmaceutical Co., Ltd. |
Quinolylpyrrolopyrimidyl fused-ring compound or salt thereof
|
CN103312670A
(zh)
|
2012-03-12 |
2013-09-18 |
西安西电捷通无线网络通信股份有限公司 |
一种认证方法及***
|
ES2698298T3
(es)
|
2012-03-15 |
2019-02-04 |
Celgene Car Llc |
Sales de un inhibidor de quinasa receptor de factor de crecimiento epidérmico
|
CN104302178B
(zh)
|
2012-03-15 |
2018-07-13 |
西建卡尔有限责任公司 |
表皮生长因子受体激酶抑制剂的固体形式
|
WO2013148603A1
(en)
|
2012-03-27 |
2013-10-03 |
Takeda Pharmaceutical Company Limited |
Cinnoline derivatives as as btk inhibitors
|
US9353062B2
(en)
|
2012-04-04 |
2016-05-31 |
Hangzhouderenyucheng Biotechnology Ltd |
Substituted quinolines as bruton's tyrosine kinases inhibitors
|
EP2836214B1
(en)
|
2012-04-11 |
2018-06-27 |
Acerta Pharma B.V. |
Bruton's tyrosine kinase inhibitors for hematopoietic mobilization
|
WO2013154778A1
(en)
|
2012-04-11 |
2013-10-17 |
Dana-Farber Cancer Institute, Inc. |
Host targeted inhibitors of dengue virus and other viruses
|
CN103374001B
(zh)
*
|
2012-04-19 |
2015-10-28 |
山东轩竹医药科技有限公司 |
咪唑并三嗪类mTOR抑制剂
|
BR112014029718A2
(pt)
*
|
2012-05-31 |
2017-06-27 |
Pharmascience Inc |
inibidores da proteína quinase
|
KR20220093389A
(ko)
*
|
2012-06-04 |
2022-07-05 |
파마싸이클릭스 엘엘씨 |
브루톤 타이로신 키나아제 저해제의 결정 형태
|
AR091273A1
(es)
*
|
2012-06-08 |
2015-01-21 |
Biogen Idec Inc |
Inhibidores de pirimidinil tirosina quinasa
|
EP2861599B1
(en)
*
|
2012-06-18 |
2019-12-18 |
Principia Biopharma Inc. |
Reversible covalent pyrrolo- or pyrazolopyrimidines useful for the treatment of cancer and autoimmune diseases
|
US20150140085A1
(en)
|
2012-06-29 |
2015-05-21 |
Principia Biopharma Inc. |
Formulations comprising ibrutinib
|
JP6575950B2
(ja)
|
2012-07-24 |
2019-09-18 |
ファーマサイクリックス エルエルシー |
Bruton型チロシンキナーゼ(Btk)阻害剤に対する耐性を伴う変異
|
ES2682043T3
(es)
*
|
2012-07-30 |
2018-09-18 |
Concert Pharmaceuticals Inc. |
Ibrutinib deuterado
|
WO2014022569A1
(en)
*
|
2012-08-03 |
2014-02-06 |
Principia Biopharma Inc. |
Treatment of dry eye
|
MX2015001802A
(es)
|
2012-08-10 |
2015-05-07 |
Boehringer Ingelheim Int |
Compuestos heteroaromaticos como inhibidores de btk.
|
CN103121999A
(zh)
*
|
2012-08-29 |
2013-05-29 |
苏州迪飞医药科技有限公司 |
一种酪氨酸激酶抑制剂pci-32765的合成方法
|
EP2890691B1
(en)
|
2012-08-31 |
2018-04-25 |
Principia Biopharma Inc. |
Benzimidazole derivatives as itk inhibitors
|
ME03455B
(me)
*
|
2012-09-10 |
2020-01-20 |
Principia Biopharma Inc |
Jedinjenja pirazolopirimidina kao inhibitori kinaze
|
CH706997A1
(en)
|
2012-09-20 |
2014-03-31 |
Ferag Ag |
Access control on operating modules of a control unit.
|
WO2014063068A1
(en)
|
2012-10-18 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
US9758522B2
(en)
|
2012-10-19 |
2017-09-12 |
Dana-Farber Cancer Institute, Inc. |
Hydrophobically tagged small molecules as inducers of protein degradation
|
US10000483B2
(en)
|
2012-10-19 |
2018-06-19 |
Dana-Farber Cancer Institute, Inc. |
Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
|
GEP201606597B
(en)
|
2012-11-02 |
2017-01-10 |
Pfizer |
Bruton's tyrosine kinase inhibitors
|
MX2015005633A
(es)
*
|
2012-11-02 |
2016-02-03 |
Pharmacyclics Inc |
Terapia adyuvante con inhibidores de quinasa de la familia tec.
|
PE20151495A1
(es)
*
|
2012-11-15 |
2015-10-23 |
Pharmacyclics Inc |
Compuestos de pirrolopirimidina como inhibidores de quinasas
|
CN104918935B
(zh)
|
2012-11-16 |
2017-07-28 |
百时美施贵宝公司 |
二氢吡唑gpr40调节剂
|
CN103848810A
(zh)
*
|
2012-11-30 |
2014-06-11 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
EP2935226A4
(en)
|
2012-12-21 |
2016-11-02 |
Celgene Avilomics Res Inc |
HETEROARYL COMPOUNDS AND USES THEREOF
|
CN104869983A
(zh)
*
|
2012-12-21 |
2015-08-26 |
泰华制药工业有限公司 |
醋酸格拉替雷的透粘膜给药
|
WO2014113942A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2014113932A1
(en)
*
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2014114185A1
(en)
|
2013-01-23 |
2014-07-31 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
KR20150119012A
(ko)
|
2013-02-08 |
2015-10-23 |
셀진 아빌로믹스 리서치, 인코포레이티드 |
Erk 억제제 및 이의 용도
|
US20140357636A1
(en)
*
|
2013-02-21 |
2014-12-04 |
Wayne Rothbaum |
Treatment of Skeletal-Related Disorders
|
EP2960241A4
(en)
|
2013-02-22 |
2016-07-13 |
Taiho Pharmaceutical Co Ltd |
PROCESS FOR PREPARING TRICYCLIC COMPOUNDS AND TRICYCLIC COMPOUNDS MADE ACCORDING TO THE SAID MANUFACTURING METHOD
|
JO3377B1
(ar)
|
2013-03-11 |
2019-03-13 |
Takeda Pharmaceuticals Co |
مشتقات بيريدينيل وبيريدينيل مندمج
|
WO2014165253A1
(en)
*
|
2013-03-12 |
2014-10-09 |
Nbip, Llc |
Compositions and methods for preventing infection of a wound and for advancing the healing process
|
CN103142601A
(zh)
*
|
2013-03-13 |
2013-06-12 |
杭州雷索药业有限公司 |
Pci-32765在制备抗血管生成类药物中的应用
|
KR20160006668A
(ko)
*
|
2013-03-14 |
2016-01-19 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제 억제제와 cyp3a4 억제제의 배합물
|
WO2014151620A1
(en)
|
2013-03-14 |
2014-09-25 |
Boehringer Ingelheim International Gmbh |
5-thiazolecarboxamide dervatives and their use as btk inhibitors
|
ES2738493T3
(es)
|
2013-03-14 |
2020-01-23 |
Tolero Pharmaceuticals Inc |
Inhibidores de JAK2 y ALK2 y métodos para su uso
|
WO2014152114A1
(en)
|
2013-03-15 |
2014-09-25 |
Boehringer Ingelheim International Gmbh |
Heteroaromatic compounds as btk inhibitors
|
HUE058914T2
(hu)
*
|
2013-03-15 |
2022-09-28 |
Janssen Pharmaceutica Nv |
Gyógyszer elõállítására szolgáló eljárások és köztitermékek
|
US9156847B2
(en)
*
|
2013-03-15 |
2015-10-13 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a medicament
|
US10138256B2
(en)
|
2013-03-15 |
2018-11-27 |
Celgene Car Llc |
MK2 inhibitors and uses thereof
|
UY35468A
(es)
|
2013-03-16 |
2014-10-31 |
Novartis Ag |
Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19
|
MX369503B
(es)
*
|
2013-04-08 |
2019-11-11 |
Pharmacyclics Llc |
Combinaciones que comprenden ibrutinib y abt-199 para tratar trastornos proliferativos de células b y métodos de uso de las mismas.
|
WO2014168986A1
(en)
|
2013-04-08 |
2014-10-16 |
Brown Dennis M |
Therapeutic benefit of suboptimally administered chemical compounds
|
US8957080B2
(en)
|
2013-04-09 |
2015-02-17 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
KR101793807B1
(ko)
|
2013-04-25 |
2017-11-03 |
베이진 엘티디 |
단백질 키나제 억제제로서의 융합된 헤테로시클릭 화합물
|
GB2513615A
(en)
|
2013-05-01 |
2014-11-05 |
Cancer Rec Tech Ltd |
Medical use
|
GB201309085D0
(en)
|
2013-05-20 |
2013-07-03 |
Redx Pharma Ltd |
Compounds
|
WO2014187319A1
(en)
|
2013-05-21 |
2014-11-27 |
Jiangsu Medolution Ltd |
Substituted pyrazolopyrimidines as kinases inhibitors
|
US9637487B2
(en)
|
2013-07-02 |
2017-05-02 |
Pharmacyclics Llc |
Purinone compounds as kinase inhibitors
|
BR112015029972A2
(pt)
|
2013-07-03 |
2017-07-25 |
Hoffmann La Roche |
composto, composição farmacêutica, processo para a preparação de uma composição farmacêutica, método para o tratamento de uma doença, conjunto e utilização de um composto
|
WO2015013579A1
(en)
|
2013-07-26 |
2015-01-29 |
Update Pharma Inc. |
Compositions to improve the therapeutic benefit of bisantrene
|
JP6800750B2
(ja)
|
2013-08-02 |
2020-12-16 |
ファーマサイクリックス エルエルシー |
固形腫瘍の処置方法
|
EP2832358A1
(en)
|
2013-08-02 |
2015-02-04 |
Bionsil S.r.l. |
Pharmaceutical kit for use in the treatment of colon and colorectal cancer
|
WO2015023703A1
(en)
|
2013-08-12 |
2015-02-19 |
Pharmacyclics, Inc. |
Methods for the treatment of her2 amplified cancer
|
US9492471B2
(en)
|
2013-08-27 |
2016-11-15 |
Celgene Avilomics Research, Inc. |
Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
|
EP4130044A1
(en)
|
2013-09-13 |
2023-02-08 |
BeiGene Switzerland GmbH |
Anti-pd1 antibodies and their use as therapeutics and diagnostics
|
AU2014324595B2
(en)
|
2013-09-30 |
2018-12-20 |
Beijing Innocare Pharma Tech Co., Ltd |
Substituted nicotinimide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease
|
BR112016006978A2
(pt)
*
|
2013-09-30 |
2017-08-01 |
Pharmacyclics Llc |
inibidores de tirosina quinase de bruton
|
WO2015054197A1
(en)
*
|
2013-10-10 |
2015-04-16 |
Acetylon Pharmaceuticals, Inc. |
Hdac inhibitors, alone or in combination with btk inhibitors, for treating non-hodgkin's lymphoma
|
WO2015057992A1
(en)
|
2013-10-16 |
2015-04-23 |
Izumi Raquel |
Btk inhibitors for hematopoietic mobilization
|
CA2927917C
(en)
|
2013-10-18 |
2022-08-09 |
Syros Pharmaceuticals, Inc. |
Heteroaromatic compounds useful for the treatment of proliferative diseases
|
AU2014337044A1
(en)
|
2013-10-18 |
2016-05-05 |
Dana-Farber Cancer Institute, Inc. |
Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
|
US20160272645A1
(en)
*
|
2013-10-18 |
2016-09-22 |
Medivation Technologies, Inc. |
Heterocyclic Compounds and Methods of Use
|
US20210317140A1
(en)
|
2013-10-18 |
2021-10-14 |
Medivation Technologies, Inc. |
Heterocyclic Compounds and Methods of Use
|
EP3060218A4
(en)
*
|
2013-10-25 |
2017-07-19 |
Pharmacyclics LLC |
Methods of treating and preventing graft versus host disease
|
TWI617309B
(zh)
*
|
2013-10-25 |
2018-03-11 |
製藥公司 |
使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法
|
US9636340B2
(en)
|
2013-11-12 |
2017-05-02 |
Ayyappan K. Rajasekaran |
Kinase inhibitors
|
WO2015071432A1
(en)
|
2013-11-14 |
2015-05-21 |
Sandoz Ag |
Pharmaceutical compositions of ibrutinib
|
US20150141438A1
(en)
*
|
2013-11-15 |
2015-05-21 |
Pharmacyclics, Inc. |
Methods for delaying or preventing the onset of type 1 diabetes
|
CN103626774B
(zh)
*
|
2013-11-20 |
2015-11-04 |
苏州明锐医药科技有限公司 |
伊鲁替尼的制备方法
|
CA2833867A1
(en)
|
2013-11-21 |
2015-05-21 |
Pharmascience Inc. |
Protein kinase inhibitors
|
CN103694241A
(zh)
*
|
2013-11-27 |
2014-04-02 |
苏州晶云药物科技有限公司 |
Pci-32765的新晶型a及其制备方法
|
US9512084B2
(en)
|
2013-11-29 |
2016-12-06 |
Novartis Ag |
Amino pyrimidine derivatives
|
WO2015084857A1
(en)
*
|
2013-12-02 |
2015-06-11 |
Pharmacyclics, Inc. |
Methods of treating and preventing alloantibody driven chronic graft versus host disease
|
SI3077395T1
(en)
|
2013-12-05 |
2018-03-30 |
Pfizer Inc. |
Pyrrolo (2,3-d) pyrimidinyl, pyrrolo (2,3-b) pyrazinyl and pyrrolo (2,3-d) pyridinyl acrylamides
|
WO2015083008A1
(en)
|
2013-12-05 |
2015-06-11 |
Acerta Pharma B.V. |
Therapeutic combination of a pi3k inhibitor and a btk inhibitor
|
WO2015082583A1
(en)
|
2013-12-05 |
2015-06-11 |
F. Hoffmann-La Roche Ag |
Heteroaryl pyridone and aza-pyridone compounds with electrophilic functionality
|
JP6878004B2
(ja)
*
|
2013-12-13 |
2021-05-26 |
ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド |
リンパ形質細胞性リンパ腫を処置する方法
|
CA2932351A1
(en)
|
2013-12-13 |
2015-06-18 |
Dana-Farber Cancer Institute, Inc. |
Methods to treat lymphoplasmacytic lymphoma
|
US9834554B2
(en)
|
2013-12-20 |
2017-12-05 |
Merck Sharp & Dohme Corp. |
BTK inhibitors
|
EP3082809B1
(en)
*
|
2013-12-20 |
2021-01-20 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
US9415049B2
(en)
|
2013-12-20 |
2016-08-16 |
Celgene Avilomics Research, Inc. |
Heteroaryl compounds and uses thereof
|
US10272083B2
(en)
|
2014-01-21 |
2019-04-30 |
Acerta Pharma B.V. |
Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor
|
CN106008515A
(zh)
*
|
2014-01-29 |
2016-10-12 |
苏州晶云药物科技有限公司 |
依鲁替尼的新晶型及其制备方法
|
JP6486954B2
(ja)
|
2014-01-29 |
2019-03-20 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Btk阻害剤としてのピラゾール化合物
|
JP6162904B2
(ja)
*
|
2014-02-03 |
2017-07-12 |
カディラ ヘルスケア リミティド |
新規複素環式化合物
|
ES2841248T3
(es)
|
2014-02-21 |
2021-07-07 |
Principia Biopharma Inc |
Sales y forma sólida de un inhibidor de BTK
|
JP6526065B2
(ja)
|
2014-02-28 |
2019-06-05 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
WO2015143400A1
(en)
|
2014-03-20 |
2015-09-24 |
Pharmacyclics, Inc. |
Phospholipase c gamma 2 and resistance associated mutations
|
GB201404987D0
(en)
*
|
2014-03-20 |
2014-05-07 |
Redx Pharma Ltd |
Compounds
|
WO2015146159A1
(en)
|
2014-03-25 |
2015-10-01 |
Ono Pharmaceutical Co., Ltd. |
Prophylactic agent and/or therapeutic agent for diffuse large b-cell lymphoma
|
WO2015151006A1
(en)
*
|
2014-03-29 |
2015-10-08 |
Lupin Limited |
Substituted purine compounds as btk inhibitors
|
WO2015185998A2
(en)
|
2014-04-11 |
2015-12-10 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase
|
WO2015181633A2
(en)
|
2014-04-11 |
2015-12-03 |
Acerta Pharma B.V. |
Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase
|
CN105017256A
(zh)
|
2014-04-29 |
2015-11-04 |
浙江导明医药科技有限公司 |
多氟化合物作为布鲁顿酪氨酸激酶抑制剂
|
CN105085474B
(zh)
|
2014-05-07 |
2018-05-18 |
北京赛林泰医药技术有限公司 |
鲁顿酪氨酸激酶抑制剂
|
CN105085529A
(zh)
*
|
2014-05-15 |
2015-11-25 |
广东东阳光药业有限公司 |
依鲁替尼新晶型及其制备方法
|
CN104086551B
(zh)
*
|
2014-06-06 |
2016-09-21 |
人福医药集团股份公司 |
化合物及其制备方法和用途
|
GB201410430D0
(en)
*
|
2014-06-11 |
2014-07-23 |
Redx Pharma Ltd |
Compounds
|
TW201613644A
(en)
|
2014-06-17 |
2016-04-16 |
Acerta Pharma Bv |
Therapeutic combinations of a BTK inhibitor, a PI3K inhibitor, and/or a JAK-2 inhibitor
|
CN104945404B
(zh)
*
|
2014-06-25 |
2018-09-14 |
广东东阳光药业有限公司 |
一种n-丙烯羰基哌啶衍生物的制备方法
|
TW201613919A
(en)
|
2014-07-02 |
2016-04-16 |
Pharmacyclics Llc |
Inhibitors of Bruton's tyrosine kinase
|
CN105294571B
(zh)
*
|
2014-07-03 |
2019-04-23 |
浙江九洲药业股份有限公司 |
一种依鲁替尼中间体及其制备方法和用途
|
KR102130600B1
(ko)
|
2014-07-03 |
2020-07-08 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
BR112017000470B1
(pt)
*
|
2014-07-07 |
2022-11-29 |
Jiangsu Hengrui Medicine Co., Ltd |
Compostos, composição farmacêutica e uso do composto ou da composição
|
WO2016008411A1
(en)
*
|
2014-07-18 |
2016-01-21 |
Beigene, Ltd. |
5-amino-4-carbamoyl-pyrazole compounds as selective and irreversible t790m over wt-egfr kinase inhibitors and use thereof
|
WO2016019237A2
(en)
*
|
2014-07-31 |
2016-02-04 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
AU2015296215A1
(en)
*
|
2014-08-01 |
2017-03-23 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
WO2016020901A1
(en)
|
2014-08-07 |
2016-02-11 |
Acerta Pharma B.V. |
Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
|
KR20170033358A
(ko)
|
2014-08-07 |
2017-03-24 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나아제 저해제의 신규한 제제
|
CN105461720B
(zh)
*
|
2014-08-08 |
2019-08-06 |
南京圣和药业股份有限公司 |
吗啉类酪氨酸激酶抑制剂
|
CN106714909A
(zh)
|
2014-08-08 |
2017-05-24 |
药品循环有限责任公司 |
布鲁顿氏酪氨酸激酶抑制剂组合及其用途
|
US20170231995A1
(en)
|
2014-08-11 |
2017-08-17 |
Acerta Pharma B.V. |
BTK Inhibitors to Treat Solid Tumors Through Modulation of the Tumor Microenvironment
|
PL3179991T3
(pl)
|
2014-08-11 |
2022-02-14 |
Acerta Pharma B.V. |
Kombinacje terapeutyczne inhibitora btk i inhibitora bcl-2
|
DK3179992T3
(da)
|
2014-08-11 |
2022-07-11 |
Acerta Pharma Bv |
Terapeutisk kombination af en btk-inhibitor, en pd-1-inhibitor og/eller en pd-l1-inhibitor
|
TW201618773A
(zh)
|
2014-08-11 |
2016-06-01 |
艾森塔製藥公司 |
Btk抑制劑、pi3k抑制劑、jak-2抑制劑、及/或cdk4/6抑制劑的治療組合物
|
AU2015303835B2
(en)
|
2014-08-12 |
2020-04-09 |
Monash University |
Lymph directing prodrugs
|
DK3179858T3
(da)
|
2014-08-13 |
2019-07-22 |
Celgene Car Llc |
Forme og sammensætninger af en ERK-inhibitor
|
WO2016025720A1
(en)
|
2014-08-14 |
2016-02-18 |
Assia Chemical Industries Ltd. |
Solid state forms of ibrutinib
|
CN106922146B
(zh)
|
2014-10-02 |
2020-05-26 |
豪夫迈·罗氏有限公司 |
用于治疗由布鲁顿酪氨酸激酶(btk)介导的疾病的吡唑甲酰胺化合物
|
EP3715346B1
(en)
|
2014-10-22 |
2024-01-03 |
Dana-Farber Cancer Institute, Inc. |
Thiazolyl-containing compounds for treating proliferative diseases
|
ME03807B
(me)
|
2014-10-24 |
2021-04-20 |
Bristol Myers Squibb Co |
Jedinjenja indol karboksamida korisna kao inhibitori kinaze
|
EP3212645B1
(en)
|
2014-10-27 |
2018-11-28 |
F.Hoffmann-La Roche Ag |
Process for making tricyclic lactam compounds
|
US20170327504A1
(en)
*
|
2014-10-30 |
2017-11-16 |
Sandoz Ag |
Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
|
WO2016079693A1
(en)
|
2014-11-19 |
2016-05-26 |
Sun Pharmaceutical Industries Limited |
A process for the preparation of ibrutinib
|
WO2016079216A1
(en)
|
2014-11-20 |
2016-05-26 |
Sandoz Ag |
Physical forms of ibrutinib, a bruton's kinase inhibitor
|
CN104447761A
(zh)
*
|
2014-11-27 |
2015-03-25 |
广东东阳光药业有限公司 |
一种吡唑衍生物的制备方法
|
AR102871A1
(es)
*
|
2014-12-03 |
2017-03-29 |
Pharmacyclics Llc |
Métodos de tratamiento de fibrosis
|
WO2016088074A1
(en)
*
|
2014-12-03 |
2016-06-09 |
Dr. Reddy’S Laboratories Limited |
Process for the preparation of amorphous ibrutinib
|
CN104478884A
(zh)
*
|
2014-12-05 |
2015-04-01 |
广东东阳光药业有限公司 |
一种中间体的制备方法
|
WO2016087994A1
(en)
|
2014-12-05 |
2016-06-09 |
Acerta Pharma B.V. |
Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment
|
TW201702218A
(zh)
|
2014-12-12 |
2017-01-16 |
美國杰克森實驗室 |
關於治療癌症、自體免疫疾病及神經退化性疾病之組合物及方法
|
BR112017013022A2
(pt)
|
2014-12-18 |
2018-02-27 |
Principia Biopharma Inc |
métodos para tratar uma doença inflamatória e/ou autoimune aguda num mamífero que a necessite onde a terapia de corticosteróides é utilizada como terapia de primeira ou segunda linha e/ou para tratar uma doença inflamatória e/ou autoimune num mamífero que a necessite, onde a terapia de corticosteróides é utilizada como terapia de manutenção de primeira ou segunda linha e/ou para eliminar ou reduzir dose terapêutica de corticosteróides utilizado no tratamento de uma doença inflamatória e/ou autoimune num mamífero que a necessite, onde a terapia de corticosteróides é utilizada como terapia de manutenção crônica de primeira ou segunda linha e/ou de tratamento de uma doença autoimune e/ou inflamatória num mamífero que a necessite
|
KR102559719B1
(ko)
|
2014-12-18 |
2023-07-26 |
에프. 호프만-라 로슈 아게 |
테트라하이드로-피리도[3,4-b]인돌 에스트로겐 수용체 조절제 및 이의 용도
|
WO2016105528A2
(en)
|
2014-12-23 |
2016-06-30 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinase 7 (cdk7)
|
WO2016106628A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106652A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Biarylether imidazopyrazine btk inhibitors
|
WO2016106629A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Btk inhibitors
|
WO2016106624A1
(en)
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
CN105820168B
(zh)
*
|
2015-01-09 |
2018-12-04 |
上海医药工业研究院 |
一种依鲁替尼中间体的制备方法
|
MA41350A
(fr)
*
|
2015-01-14 |
2017-11-21 |
Janssen Pharmaceutica Nv |
Synthèse d'un inhibiteur de la tyrosine kinase de bruton
|
WO2016115869A1
(zh)
|
2015-01-21 |
2016-07-28 |
中国科学院合肥物质科学研究院 |
Flt3激酶的新型抑制剂及其用途
|
WO2016123504A1
(en)
*
|
2015-01-30 |
2016-08-04 |
Pharmacyclics Llc |
Btk inhibitor combinations and multidrug-resistance
|
CZ201584A3
(cs)
|
2015-02-09 |
2016-08-17 |
Zentiva, K.S. |
Sůl Ibrutinib sulfátu
|
RU2712440C2
(ru)
*
|
2015-02-12 |
2020-01-29 |
Шанхай Дьюд Медикал Сайенс Энд Текнолоджи Ко., Лтд |
Способ получения ибрутиниба
|
WO2016132383A1
(en)
|
2015-02-18 |
2016-08-25 |
Mylan Laboratories Limited |
Process for the preparation of ibrutinib
|
ES2930585T3
(es)
|
2015-02-27 |
2022-12-19 |
Nimbus Lakshmi Inc |
Inhibidores de TYK2 y usos de los mismos
|
DK3265084T3
(da)
|
2015-03-03 |
2024-02-12 |
Pharmacyclics Llc |
Farmaceutiske formuleringer af Bruton's tyrosinkinase-hæmmer
|
US10045990B2
(en)
|
2015-03-04 |
2018-08-14 |
Arizona Board Of Regents On Behalf Of Arizona State University |
ERBB4 inhibitors and methods of use thereof
|
CN106146508A
(zh)
*
|
2015-03-19 |
2016-11-23 |
浙江导明医药科技有限公司 |
优化的联合用药及其治疗癌症和自身免疫疾病的用途
|
US9717745B2
(en)
|
2015-03-19 |
2017-08-01 |
Zhejiang DTRM Biopharma Co. Ltd. |
Pharmaceutical compositions and their use for treatment of cancer and autoimmune diseases
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
AU2016243529B2
(en)
|
2015-03-27 |
2021-03-25 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
ES2733460T3
(es)
*
|
2015-04-02 |
2019-11-29 |
Ratiopharm Gmbh |
Co-cristales de Ibrutinib
|
WO2016161248A1
(en)
*
|
2015-04-02 |
2016-10-06 |
Tolero Pharmaceuticals, Inc. |
Targeting pim kinases in combination with btk inhibition
|
CN106146511A
(zh)
*
|
2015-04-03 |
2016-11-23 |
安润医药科技(苏州)有限公司 |
吡唑并嘧啶衍生物、制备方法、药物组合物及用途
|
UA125681C2
(uk)
|
2015-04-06 |
2022-05-18 |
Янссен Фармацевтика Нв |
Композиції, які містять ібрутиніб
|
CN105906621A
(zh)
*
|
2015-04-06 |
2016-08-31 |
四川百利药业有限责任公司 |
用作fgfr抑制剂的乙醇类化合物
|
US10253086B2
(en)
|
2015-04-08 |
2019-04-09 |
Novartis Ag |
CD20 therapies, CD22 therapies, and combination therapies with a CD19 chimeric antigen receptor (CAR)-expressing cell
|
CN106146512B
(zh)
*
|
2015-04-09 |
2018-07-17 |
北京睿创康泰医药研究院有限公司 |
依鲁替尼的制备方法
|
ES2955554T3
(es)
|
2015-04-09 |
2023-12-04 |
Ono Pharmaceutical Co |
Proceso para producir un derivado de purinona
|
KR20170134462A
(ko)
*
|
2015-04-13 |
2017-12-06 |
다이이찌 산쿄 가부시키가이샤 |
Mdm2 저해제와 btk 저해제의 병용 치료법
|
CN106146482B
(zh)
*
|
2015-04-14 |
2020-06-23 |
宁波文达医药科技有限公司 |
布鲁顿酪氨酸激酶抑制剂
|
WO2016170545A1
(en)
*
|
2015-04-22 |
2016-10-27 |
Msn Laboratories Private Limited |
Process for the preparation of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenvl)-1h- pvrazolo[3,4-d]pyriniidin-1-y1]-1-piperidinvl]-2-propen-1-one and its polymorphs thereof
|
US20180289685A1
(en)
|
2015-04-30 |
2018-10-11 |
Bayer Pharma Aktiengesellschaft |
Combinations of inhibitors of irak4 with inhibitors of btk
|
EP3195865A1
(de)
|
2016-01-25 |
2017-07-26 |
Bayer Pharma Aktiengesellschaft |
Kombinationen von irak4 inhibitoren und btk inhibitoren
|
RS59605B1
(sr)
|
2015-05-26 |
2020-01-31 |
Morphosys Ag |
Kombinacija anti-cd19 antitela i inhibitora brutonove tirozin kinaze i njene upotrebe
|
RS62290B1
(sr)
|
2015-06-03 |
2021-09-30 |
Principia Biopharma Inc |
Inhibitori tirozinske kinaze
|
US10702527B2
(en)
|
2015-06-12 |
2020-07-07 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
US9394312B1
(en)
*
|
2015-06-14 |
2016-07-19 |
Mark Quang Nguyen |
Ibrutinib prodrugs, pharmaceutical compositions thereof, and methods of use
|
RU2719477C2
(ru)
|
2015-06-22 |
2020-04-17 |
Оно Фармасьютикал Ко., Лтд. |
Соединение, ингибирующее brk
|
US20180305350A1
(en)
|
2015-06-24 |
2018-10-25 |
Principia Biopharma Inc. |
Tyrosine kinase inhibitors
|
CZ2015442A3
(cs)
*
|
2015-06-26 |
2017-01-04 |
Zentiva, K.S. |
Ibrutinib hemisulfát
|
WO2016207172A1
(en)
*
|
2015-06-26 |
2016-12-29 |
Sandoz Gmbh |
Preparation of pure amorphous ibrutinib
|
WO2017004134A1
(en)
|
2015-06-29 |
2017-01-05 |
Nimbus Iris, Inc. |
Irak inhibitors and uses thereof
|
WO2017001658A1
(en)
|
2015-07-02 |
2017-01-05 |
F. Hoffmann-La Roche Ag |
Benzoxazepin oxazolidinone compounds and methods of use
|
TWI649326B
(zh)
|
2015-07-02 |
2019-02-01 |
瑞士商赫孚孟拉羅股份公司 |
苯并氧氮呯噁唑啶酮化合物及其製備方法
|
PT3954690T
(pt)
|
2015-07-02 |
2023-06-06 |
Acerta Pharma Bv |
Formas sólidas e formulações de (s)-4-(8-amino-3-(1-(but- 2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-n- (piridin-2-il)benzamida
|
ITUB20152576A1
(it)
*
|
2015-07-29 |
2017-01-29 |
Laboratorio Chimico Int S P A |
Procedimento per la preparazione di ibrutinib e nuovo intermedio di sintesi.
|
WO2017029586A1
(en)
*
|
2015-08-19 |
2017-02-23 |
Sun Pharmaceutical Industries Limited |
Crystalline forms of ibrutinib
|
US20190008859A1
(en)
|
2015-08-21 |
2019-01-10 |
Acerta Pharma B.V. |
Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor
|
EP3344254A1
(en)
|
2015-08-31 |
2018-07-11 |
Pharmacyclics LLC |
Btk inhibitor combinations for treating multiple myeloma
|
JP6802263B2
(ja)
|
2015-09-02 |
2020-12-16 |
ニンバス ラクシュミ, インコーポレイテッド |
Tyk2阻害剤およびその使用
|
US11738087B2
(en)
|
2015-09-08 |
2023-08-29 |
Monash University |
Lymph directing prodrugs
|
AU2016319125B2
(en)
|
2015-09-09 |
2021-04-08 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of cyclin-dependent kinases
|
CN105753863B
(zh)
*
|
2015-09-11 |
2018-07-31 |
东莞市真兴贝特医药技术有限公司 |
氧代二氢咪唑并吡啶类化合物及其应用
|
US10683308B2
(en)
|
2015-09-11 |
2020-06-16 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
CA2904270A1
(en)
*
|
2015-09-11 |
2017-03-11 |
Pharmascience Inc. |
Protein kinase inhibitors
|
MA44909A
(fr)
|
2015-09-15 |
2018-07-25 |
Acerta Pharma Bv |
Association thérapeutique d'un inhibiteur du cd19 et d'un inhibiteur de la btk
|
US20190022092A1
(en)
|
2015-09-15 |
2019-01-24 |
Acerta Pharma B.V. |
Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist
|
EA201890730A1
(ru)
|
2015-09-16 |
2018-10-31 |
Локсо Онколоджи, Инк. |
Производные пиразолопиримидина в качестве ингибиторов btk для лечения злокачественного новообразования
|
ES2900482T3
(es)
|
2015-10-01 |
2022-03-17 |
Gilead Sciences Inc |
Combinación de un inhibidor de Btk y un inhibidor de punto de control para el tratamiento del cáncer
|
CN106608877B
(zh)
*
|
2015-10-21 |
2018-11-13 |
新发药业有限公司 |
一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
|
PT3364958T
(pt)
|
2015-10-23 |
2023-04-10 |
Navitor Pharm Inc |
Moduladores de interação sestrina-gator2 e utilizações dos mesmos
|
US9834561B2
(en)
|
2015-10-28 |
2017-12-05 |
Scinopharm Taiwan, Ltd. |
Process for preparing ibrutinib and its intermediates
|
DK3377484T3
(da)
*
|
2015-11-17 |
2023-11-27 |
Merck Patent Gmbh |
Fremgangsmåder til behandling af multipel sklerose under anvendelse af pyrimidin- og pyridinforbindelser med btk- inhiberende aktivitet
|
CN105294696A
(zh)
*
|
2015-11-19 |
2016-02-03 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
CA2950640A1
(en)
|
2015-12-04 |
2017-06-04 |
Portola Pharmaceuticals, Inc. |
Cerdulatinib for treating hematological cancers
|
EP4012415A3
(en)
|
2015-12-04 |
2022-12-07 |
Juno Therapeutics, Inc. |
Methods and compositions related to toxicity associated with cell therapy
|
JO3794B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
المركبات متعددة الحلقات كمثبطات لتيروزين كيناز بروتون
|
JO3793B1
(ar)
|
2015-12-10 |
2021-01-31 |
Janssen Pharmaceutica Nv |
مثبطات تيروزين كاينيز بروتون وأساليب استخدامها
|
WO2017106352A1
(en)
|
2015-12-14 |
2017-06-22 |
Raze Therapeutics, Inc. |
Caffeine inhibitors of mthfd2 and uses thereof
|
CN108368086B
(zh)
|
2015-12-16 |
2021-01-08 |
勃林格殷格翰国际有限公司 |
可用于治疗自身免疫疾病的二吡唑基衍生物
|
PE20220502A1
(es)
|
2015-12-16 |
2022-04-07 |
Loxo Oncology Inc |
Compuestos utiles como inhibidores de cinasa
|
JP6916185B2
(ja)
|
2016-01-13 |
2021-08-11 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Btk阻害剤としてのイソキノロン類
|
HUE052893T2
(hu)
|
2016-01-13 |
2021-05-28 |
Acerta Pharma Bv |
Antifolát és BTK-gátló terápiás kombinációi
|
WO2017125423A1
(en)
|
2016-01-19 |
2017-07-27 |
Janssen Pharmaceutica Nv |
Formulations/compositions comprising a btk inhibitor
|
EP3405178A1
(en)
|
2016-01-19 |
2018-11-28 |
Janssen Pharmaceutica NV |
Formulations/compositions comprising a btk inhibitor
|
US10793566B2
(en)
|
2016-01-21 |
2020-10-06 |
Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. |
Bruton's tyrosine kinase inhibitors
|
MX2018008815A
(es)
*
|
2016-01-21 |
2019-03-28 |
Zibo Biopolar Changsheng Pharmaceutical Co Ltd |
Inhibidores de tirosina quinasa de bruton.
|
CN105732638B
(zh)
*
|
2016-01-22 |
2018-01-30 |
成都倍特药业有限公司 |
一种具有螺环或桥环结构的布鲁顿酪氨酸激酶抑制剂及其制备方法
|
CN106995446B
(zh)
*
|
2016-01-22 |
2021-07-02 |
山东新时代药业有限公司 |
布鲁顿酪氨酸激酶抑制剂制备方法
|
WO2017134684A2
(en)
|
2016-02-01 |
2017-08-10 |
Natco Pharma Limited |
An improved process for the preparation of ibrutinib
|
WO2017134685A2
(en)
*
|
2016-02-02 |
2017-08-10 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazino compounds as btk inhibitors
|
WO2017134588A1
(en)
|
2016-02-04 |
2017-08-10 |
Shilpa Medicare Limited |
Process for the preparation of ibrutinib
|
CN108602834B
(zh)
*
|
2016-02-05 |
2021-01-08 |
北京盛诺基医药科技股份有限公司 |
一种布鲁顿酪氨酸激酶抑制剂
|
GB2558514A
(en)
*
|
2016-02-09 |
2018-07-18 |
Azad Pharmaceutical Ingredients Ag |
Process for the synthesis of stable amorphous ibrutinib
|
CA3015172A1
(en)
|
2016-02-18 |
2017-08-24 |
Privo Technologies, Inc. |
Two-stage microparticle-based therapeutic delivery system and method
|
CN105646499A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型g及制备方法
|
CN105646498A
(zh)
*
|
2016-03-01 |
2016-06-08 |
孙霖 |
依鲁替尼晶型f及制备方法
|
RS62271B1
(sr)
|
2016-03-09 |
2021-09-30 |
Raze Therapeutics Inc |
Inhibitori 3-fosfoglicerat dehidrogenaze i njihova upotreba
|
EP3426244B1
(en)
|
2016-03-09 |
2023-06-07 |
Raze Therapeutics, Inc. |
3-phosphoglycerate dehydrogenase inhibitors and uses thereof
|
KR102416971B1
(ko)
|
2016-03-11 |
2022-07-04 |
엔젤 파마슈티칼 컴퍼니, 리미티드 |
브루톤형 티로신 키나제를 조절하기 위한 화합물 및 방법
|
WO2017163257A1
(en)
*
|
2016-03-21 |
2017-09-28 |
Ind-Swift Laboratories Limited |
Process for preparing pure lh-pyrazolo[3,4-d] pyrimidine derivative
|
AU2017240609B2
(en)
|
2016-03-31 |
2021-07-15 |
Takeda Pharmaceutical Company Limited |
Isoquinolinyl triazolone complexes
|
CZ2016196A3
(cs)
|
2016-04-06 |
2017-10-18 |
Zentiva, K.S. |
Pevné formy Ibrutinibu
|
CA3019394A1
(en)
|
2016-04-08 |
2017-10-12 |
X4 Pharmaceuticals, Inc. |
Methods for treating cancer
|
RS63609B1
(sr)
|
2016-04-15 |
2022-10-31 |
Cancer Research Tech Ltd |
Heterociklična jedinjenja kao inhibitori ret kinaze
|
JP6943876B2
(ja)
|
2016-04-15 |
2021-10-06 |
キャンサー・リサーチ・テクノロジー・リミテッドCancer Research Technology Limited |
Retキナーゼ阻害剤としての複素環化合物
|
US11813261B2
(en)
|
2016-04-19 |
2023-11-14 |
Acetylon Pharmaceuticals, Inc. |
HDAC inhibitors, alone or in combination with BTK inhibitors, for treating chronic lymphocytic leukemia
|
AU2017258510A1
(en)
*
|
2016-04-29 |
2018-10-11 |
Dana-Farber Cancer Institute, Inc. |
HCK as a therapeutic target in MYD88 mutated diseases
|
CZ2016276A3
(cs)
|
2016-05-11 |
2017-11-22 |
Zentiva, K.S. |
Pevné formy volné báze ibrutinibu
|
DK3458053T3
(da)
|
2016-05-20 |
2022-02-21 |
Biohaven Therapeutics Ltd |
Anvendelse af riluzol, riluzolprodrugs eller riluzolanaloger med immunterapier til cancerbehandling
|
CN105859728B
(zh)
*
|
2016-05-26 |
2018-06-08 |
江苏中邦制药有限公司 |
一种依鲁替尼的制备方法
|
WO2017205843A1
(en)
|
2016-05-27 |
2017-11-30 |
Tg Therapeutics, Inc. |
Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders
|
CN109311876B
(zh)
|
2016-06-16 |
2022-05-03 |
豪夫迈·罗氏有限公司 |
杂芳基***受体调节剂及其用途
|
JP2019521983A
(ja)
|
2016-06-16 |
2019-08-08 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
テトラヒドロ−ピリド[3,4−b]インドールエストロゲン受容体モジュレーター及びその使用
|
US11091489B2
(en)
*
|
2016-06-20 |
2021-08-17 |
Novartis Ag |
Crystalline forms of a triazolopyrimidine compound
|
WO2017223229A1
(en)
|
2016-06-21 |
2017-12-28 |
X4 Pharmaceuticals, Inc. |
Cxcr4 inhibitors and uses thereof
|
EP3808748A1
(en)
|
2016-06-21 |
2021-04-21 |
X4 Pharmaceuticals, Inc. |
Substituted piperidines as cxcr4-inhibitors
|
CN109641838A
(zh)
|
2016-06-21 |
2019-04-16 |
X4 制药有限公司 |
Cxcr4抑制剂及其用途
|
CN106117214A
(zh)
*
|
2016-06-29 |
2016-11-16 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
JP7129704B2
(ja)
|
2016-06-29 |
2022-09-02 |
プリンシピア バイオファーマ インコーポレイテッド |
2-[3-[4-アミノ-3-(2-フルオロ-4-フェノキシ-フェニル)ピラゾロ[3,4-d]ピリミジン-1-イル]ピペリジン-1-カルボニル]-4-メチル-4-[4-(オキセタン-3-イル)ピペラジン-1-イル]ペント-2-エネニトリルの放出調節製剤
|
WO2018000250A1
(zh)
*
|
2016-06-29 |
2018-01-04 |
上海创诺医药集团有限公司 |
依鲁替尼新晶型及其制备方法
|
RU2714206C1
(ru)
|
2016-06-30 |
2020-02-13 |
Даевунг Фармасьютикал Ко., Лтд. |
Пиразолопиримидиновые производные в качестве ингибитора киназы
|
WO2018002958A1
(en)
|
2016-06-30 |
2018-01-04 |
Sun Pharma Advanced Research Company Limited |
Novel hydrazide containing compounds as btk inhibitors
|
AU2017293423B2
(en)
|
2016-07-05 |
2023-05-25 |
Beigene, Ltd. |
Combination of a PD-1 antagonist and a RAF inhibitor for treating cancer
|
ES2965081T3
(es)
*
|
2016-07-07 |
2024-04-11 |
Daewoong Pharmaceutical Co Ltd |
Derivados 4-aminopirazolo[3,4-d]pirimidinil-azabiciclo y composición farmacéutica que comprende dichos derivados
|
CN107641123A
(zh)
*
|
2016-07-20 |
2018-01-30 |
南京亿华药业有限公司 |
一种依鲁替尼及其关键中间体的制备新方法
|
RU2019104758A
(ru)
|
2016-07-21 |
2020-08-21 |
Байоджен Ма Инк. |
Сукцинатные формы и композиции ингибиторов тирозинкиназы брутона
|
WO2018033853A2
(en)
|
2016-08-16 |
2018-02-22 |
Beigene, Ltd. |
Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof
|
CN108368119B
(zh)
*
|
2016-08-17 |
2019-04-23 |
深圳市塔吉瑞生物医药有限公司 |
用于抑制酪氨酸激酶活性的稠合双环类化合物
|
WO2018033135A1
(en)
|
2016-08-19 |
2018-02-22 |
Beigene, Ltd. |
Use of a combination comprising a btk inhibitor for treating cancers
|
IL292938A
(en)
|
2016-09-19 |
2022-07-01 |
Mei Pharma Inc |
Combined treatment
|
CN109790121B
(zh)
*
|
2016-10-06 |
2024-01-05 |
詹森药业有限公司 |
用于制备btk抑制剂的方法和中间体
|
CA3039202A1
(en)
|
2016-10-14 |
2018-04-19 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
CA3040840A1
(en)
|
2016-10-17 |
2018-04-26 |
Daiichi Sankyo Company, Limited |
Combined use of mdm2 inhibitor and dna methyltransferase inhibitor for cancer treatment
|
WO2018075937A1
(en)
|
2016-10-21 |
2018-04-26 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
MX2019005029A
(es)
|
2016-11-03 |
2019-10-24 |
Juno Therapeutics Inc |
Terapia de combinación de una terapia de células t y un inhibidor de tirosina cinasa de bruton (btk).
|
EP3538091A4
(en)
|
2016-11-08 |
2020-06-10 |
Navitor Pharmaceuticals, Inc. |
PHENYL AMINO PIPERIDINE MTORC INHIBITORS AND USES THEREOF
|
WO2018090792A1
(zh)
*
|
2016-11-15 |
2018-05-24 |
杭州和正医药有限公司 |
一种选择性布鲁顿酪氨酸激酶抑制剂及其应用
|
CN108101905A
(zh)
*
|
2016-11-24 |
2018-06-01 |
中国科学院上海药物研究所 |
嘧啶并[5,4-b]吲嗪或嘧啶并[5,4-b]吡呤化合物、其制备方法及用途
|
AU2017368050A1
(en)
|
2016-11-29 |
2019-06-20 |
Puretech Lyt, Inc. |
Exosomes for delivery of therapeutic agents
|
US10183024B2
(en)
|
2016-12-02 |
2019-01-22 |
Apotex Inc. |
Crystalline forms of ibrutinib
|
US11590167B2
(en)
|
2016-12-03 |
2023-02-28 |
Juno Therapeutic, Inc. |
Methods and compositions for use of therapeutic T cells in combination with kinase inhibitors
|
WO2018106636A1
(en)
|
2016-12-05 |
2018-06-14 |
Raze Therapeutics, Inc. |
Shmt inhibitors and uses thereof
|
BR112019012604A2
(pt)
*
|
2016-12-21 |
2019-11-26 |
Acerta Pharma Bv |
composto da fórmula (i) ou fórmula (ii), uso de um composto, métodos para tratar um distúrbio hiperproliferativo, um distúrbio inflamatório, um distúrbio imune, ou um distúrbio autoimune e para tratar um câncer de tumor sólido, e, composição farmacêutica.
|
US11730819B2
(en)
|
2016-12-23 |
2023-08-22 |
Bicycletx Limited |
Peptide derivatives having novel linkage structures
|
WO2018127699A1
(en)
|
2017-01-06 |
2018-07-12 |
Bicyclerd Limited |
Compounds for treating cancer
|
WO2018137681A1
(en)
|
2017-01-25 |
2018-08-02 |
Beigene, Ltd. |
Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof
|
WO2018151849A1
(en)
|
2017-02-17 |
2018-08-23 |
Privo Technologies, Inc. |
Particle-based multi-layer therapeutic delivery device and method
|
EP3585789A1
(en)
|
2017-02-24 |
2020-01-01 |
Gilead Sciences, Inc. |
Inhibitors of bruton's tyrosine kinase
|
WO2018156895A1
(en)
|
2017-02-24 |
2018-08-30 |
Gilead Sciences, Inc. |
Inhibitors of bruton's tyrosine kinase
|
EP4338802A2
(en)
|
2017-03-08 |
2024-03-20 |
Takeda Pharmaceutical Company Limited |
Tyk2 inhibitors, uses, and methods for production thereof
|
CN108570036A
(zh)
*
|
2017-03-09 |
2018-09-25 |
北京赛林泰医药技术有限公司 |
一种btk抑制剂的多晶型物及其制备方法
|
GB201703876D0
(en)
|
2017-03-10 |
2017-04-26 |
Berlin-Chemie Ag |
Pharmaceutical combinations
|
EP3595777A4
(en)
*
|
2017-03-14 |
2021-01-20 |
Dana-Farber Cancer Institute, Inc. |
SENSITIZATION OF SMALL MOLECULES TO BAX ACTIVATION FOR INDUCTION OF CELLULAR DEATH
|
EP3375778A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aryl-piperidine derivatives
|
EP3375784A1
(en)
|
2017-03-14 |
2018-09-19 |
Artax Biopharma Inc. |
Aza-dihydro-acridone derivatives
|
AU2018237123B2
(en)
*
|
2017-03-22 |
2022-08-04 |
Xibin Liao |
Bruton's tyrosine kinase inhibitors
|
WO2018191146A1
(en)
|
2017-04-10 |
2018-10-18 |
Navitor Pharmaceuticals, Inc. |
Heteroaryl rheb inhibitors and uses thereof
|
GB201705971D0
(en)
|
2017-04-13 |
2017-05-31 |
Cancer Res Tech Ltd |
Inhibitor compounds
|
CA3058682A1
(en)
|
2017-04-20 |
2018-10-25 |
Apotex Inc. |
Processes for the preparation of acalabrutinib and intermediates thereof
|
CN107043366B
(zh)
*
|
2017-04-25 |
2020-05-26 |
中国药科大学 |
4-氨基嘧啶类化合物、其制备方法及医药用途
|
CN110809467B
(zh)
|
2017-04-26 |
2023-03-10 |
纳维托制药有限公司 |
Sestrin-gator2相互作用的调节剂及其用途
|
US10857196B2
(en)
|
2017-04-27 |
2020-12-08 |
Bicycletx Limited |
Bicyclic peptide ligands and uses thereof
|
US10478403B1
(en)
|
2017-05-03 |
2019-11-19 |
Privo Technologies, Inc. |
Intraoperative topically-applied non-implantable rapid release patch
|
MA48781A
(fr)
|
2017-06-02 |
2020-04-08 |
Juno Therapeutics Inc |
Articles de fabrication et procédés liés à la toxicité associée à la thérapie cellulaire
|
BR112019025403A2
(pt)
|
2017-06-02 |
2020-08-18 |
Juno Therapeutics Inc |
artigos de fabricação e métodos para tratamento usando terapia celular adotiva
|
CN109111446B
(zh)
|
2017-06-22 |
2021-11-30 |
上海度德医药科技有限公司 |
一种具有药物活性的杂芳基化合物
|
CA3066518A1
(en)
|
2017-06-26 |
2019-01-03 |
Beigene, Ltd. |
Immunotherapy for hepatocellular carcinoma
|
US10899798B2
(en)
|
2017-06-26 |
2021-01-26 |
Bicyclerd Limited |
Bicyclic peptide ligands with detectable moieties and uses thereof
|
JP2020526194A
(ja)
|
2017-06-29 |
2020-08-31 |
ジュノー セラピューティクス インコーポレイテッド |
免疫療法薬と関連する毒性を評価するためのマウスモデル
|
KR102384924B1
(ko)
*
|
2017-07-12 |
2022-04-08 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
WO2019013562A1
(ko)
|
2017-07-12 |
2019-01-17 |
주식회사 대웅제약 |
신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
|
CN111194317A
(zh)
|
2017-07-28 |
2020-05-22 |
林伯士拉克许米公司 |
Tyk2抑制剂与其用途
|
WO2019034009A1
(en)
|
2017-08-12 |
2019-02-21 |
Beigene, Ltd. |
BTK INHIBITOR WITH ENHANCED DOUBLE SELECTIVITY
|
WO2019034868A1
(en)
|
2017-08-14 |
2019-02-21 |
Bicyclerd Limited |
CONJUGATES PEPTIDE BICYCLIC-LIGAND PPR-A AND USES THEREOF
|
WO2019034866A1
(en)
|
2017-08-14 |
2019-02-21 |
Bicyclerd Limited |
BICYCLIC PEPTIDE LIGANDS CONJUGATES AND USES THEREOF
|
US11883497B2
(en)
|
2017-08-29 |
2024-01-30 |
Puretech Lyt, Inc. |
Lymphatic system-directing lipid prodrugs
|
AU2018324037A1
(en)
|
2017-08-29 |
2020-04-16 |
Monash University |
Lymphatic system-directing lipid prodrugs
|
US20210071258A1
(en)
|
2017-09-01 |
2021-03-11 |
Juno Therapeutics, Inc. |
Gene expression and assessment of risk of developing toxicity following cell therapy
|
JP7366031B2
(ja)
|
2017-09-22 |
2023-10-20 |
カイメラ セラピューティクス, インコーポレイテッド |
タンパク質分解剤およびそれらの使用
|
WO2019060693A1
(en)
|
2017-09-22 |
2019-03-28 |
Kymera Therapeutics, Inc. |
CRBN LIGANDS AND USES THEREOF
|
EA037031B1
(ru)
*
|
2017-10-06 |
2021-01-28 |
Асерта Фарма Б.В. |
Имидазопиразиновые ингибиторы тирозинкиназы брутона
|
KR102613433B1
(ko)
*
|
2017-10-11 |
2023-12-13 |
주식회사 대웅제약 |
신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
|
TW201922256A
(zh)
|
2017-10-27 |
2019-06-16 |
中國大陸商浙江導明醫藥科技有限公司 |
治療淋巴樣惡性疾病之方法
|
US11564946B2
(en)
|
2017-11-01 |
2023-01-31 |
Juno Therapeutics, Inc. |
Methods associated with tumor burden for assessing response to a cell therapy
|
US11786529B2
(en)
|
2017-11-29 |
2023-10-17 |
Beigene Switzerland Gmbh |
Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors
|
CZ2017787A3
(cs)
|
2017-12-08 |
2019-06-19 |
Zentiva, K.S. |
Farmaceutické kompozice obsahující ibrutinib
|
US11304954B2
(en)
|
2017-12-19 |
2022-04-19 |
Puretech Lyt, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
US11608345B1
(en)
|
2017-12-19 |
2023-03-21 |
Puretech Lyt, Inc. |
Lipid prodrugs of rapamycin and its analogs and uses thereof
|
GB201721265D0
(en)
|
2017-12-19 |
2018-01-31 |
Bicyclerd Ltd |
Bicyclic peptide ligands specific for EphA2
|
TWI825046B
(zh)
|
2017-12-19 |
2023-12-11 |
英商拜西可泰克斯有限公司 |
Epha2特用之雙環胜肽配位基
|
WO2019126378A1
(en)
|
2017-12-19 |
2019-06-27 |
Ariya Therapeutics, Inc. |
Lipid prodrugs of mycophenolic acid and uses thereof
|
BR112020012997A2
(pt)
|
2017-12-26 |
2020-12-01 |
Kymera Therapeutics, Inc. |
degradadores de irak e usos dos mesmos
|
WO2019127008A1
(zh)
*
|
2017-12-26 |
2019-07-04 |
清华大学 |
一种靶向降解btk的化合物及其应用
|
CN108220261B
(zh)
*
|
2017-12-29 |
2021-05-14 |
安徽联创生物医药股份有限公司 |
酮还原酶、核酸、重组表达载体、重组表达菌株及应用
|
WO2019140387A1
(en)
|
2018-01-12 |
2019-07-18 |
Kymera Therapeutics, Inc. |
Crbn ligands and uses thereof
|
US11485743B2
(en)
|
2018-01-12 |
2022-11-01 |
Kymera Therapeutics, Inc. |
Protein degraders and uses thereof
|
WO2019142207A1
(en)
|
2018-01-20 |
2019-07-25 |
Natco Pharma Limited |
Pharmaceutical compositions comprising ibrutinib
|
CA3089769A1
(en)
|
2018-01-29 |
2019-08-01 |
Merck Patent Gmbh |
Gcn2 inhibitors and uses thereof
|
SG11202006701TA
(en)
|
2018-01-29 |
2020-08-28 |
Merck Patent Gmbh |
Gcn2 inhibitors and uses thereof
|
CN112189009B
(zh)
|
2018-02-27 |
2023-09-29 |
阿塔克斯生物制药有限公司 |
作为tcr-nck相互作用的抑制剂的色烯衍生物
|
US11013741B1
(en)
|
2018-04-05 |
2021-05-25 |
Sumitomo Dainippon Pharma Oncology, Inc. |
AXL kinase inhibitors and use of the same
|
CA3095580A1
(en)
|
2018-04-13 |
2019-10-17 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer
|
HUE058746T2
(hu)
|
2018-04-24 |
2022-09-28 |
Merck Patent Gmbh |
Antiproliferációs vegyületek és felhasználásuk
|
WO2019209757A1
(en)
|
2018-04-24 |
2019-10-31 |
Vertex Pharmaceuticals Incorporated |
Pteridinone compounds and uses thereof
|
KR102106821B1
(ko)
|
2018-04-27 |
2020-05-06 |
재단법인대구경북과학기술원 |
이브루티닙을 유효성분으로 포함하는 퇴행성 뇌질환의 예방 또는 치료용 약학적 조성물
|
WO2019208805A1
(ja)
|
2018-04-27 |
2019-10-31 |
小野薬品工業株式会社 |
Btk阻害活性を有する化合物を有効成分として含む自己免疫疾患の予防および/または治療剤
|
AU2019261986A1
(en)
|
2018-05-03 |
2020-11-26 |
Juno Therapeutics, Inc. |
Combination therapy of a chimeric antigen receptor (CAR) T cell therapy and a kinase inhibitor
|
TW202014412A
(zh)
|
2018-05-04 |
2020-04-16 |
美商普托拉製藥有限公司 |
賽度替尼(cerdulatinib)之固體型式
|
EP3575300A1
(en)
|
2018-05-31 |
2019-12-04 |
Apotex Inc. |
Novel crystalline forms of ibrutinib
|
IL259810A
(en)
|
2018-06-04 |
2018-07-31 |
Yeda Res & Dev |
Mitogen-activated protein kinase kinase 7 inhibitors
|
RU2711106C2
(ru)
*
|
2018-06-06 |
2020-01-15 |
Общество с ограниченной ответственностью "АКСЕЛЬФАРМ" |
Кристаллическая μ-модификация 1-[(3R)-3-[4-амино-3-(4-фенокси-фенил)-1Н-пиразоло[3,4-d]пиримидин-1-ил]-1-пиперидил]-2-пропенил-1-она, способ её получения и фармацевтическая композиция на её основе
|
MA52874A
(fr)
|
2018-06-15 |
2021-04-21 |
Janssen Pharmaceutica Nv |
Formulations/compositions comprenant de l'ibrutinib
|
US10980784B2
(en)
|
2018-06-15 |
2021-04-20 |
Navitor Pharmaceuticals, Inc. |
Rapamycin analogs and uses thereof
|
GB201810316D0
(en)
|
2018-06-22 |
2018-08-08 |
Bicyclerd Ltd |
Peptide ligands for binding to EphA2
|
US11180531B2
(en)
|
2018-06-22 |
2021-11-23 |
Bicycletx Limited |
Bicyclic peptide ligands specific for Nectin-4
|
WO2020010177A1
(en)
|
2018-07-06 |
2020-01-09 |
Kymera Therapeutics, Inc. |
Tricyclic crbn ligands and uses thereof
|
CA3103995A1
(en)
|
2018-07-26 |
2020-01-30 |
Sumitomo Dainippon Pharma Oncology, Inc. |
Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same
|
KR102545594B1
(ko)
|
2018-07-31 |
2023-06-21 |
록쏘 온콜로지, 인코포레이티드 |
(s)-5-아미노-3-(4-((5-플루오로-2-메톡시벤즈아미도)메틸)페닐)-1-(1,1,1-트리플루오로프로판-2-일)-1h-피라졸-4-카르복스아미드의 분무-건조된 분산물 및 제제
|
WO2020045941A1
(ko)
|
2018-08-27 |
2020-03-05 |
주식회사 대웅제약 |
신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
|
US10548889B1
(en)
|
2018-08-31 |
2020-02-04 |
X4 Pharmaceuticals, Inc. |
Compositions of CXCR4 inhibitors and methods of preparation and use
|
WO2020043321A1
(en)
*
|
2018-08-31 |
2020-03-05 |
Stichting Katholieke Universiteit |
Synergistic combinations of amino acid depletion agent sensitizers (aadas) and amino acid depletion agents (aada), and therapeutic methods of use thereof
|
EP3846793B1
(en)
|
2018-09-07 |
2024-01-24 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
CN110964016B
(zh)
*
|
2018-09-29 |
2021-05-28 |
南京药捷安康生物科技有限公司 |
氨基降茨烷衍生物及其制备方法与应用
|
CA3115088A1
(en)
|
2018-10-15 |
2020-04-23 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
JP2022512779A
(ja)
|
2018-10-23 |
2022-02-07 |
バイスクルテクス・リミテッド |
二環式ペプチドリガンドおよびその使用
|
US11345654B2
(en)
|
2018-10-24 |
2022-05-31 |
Navitor Pharmaceuticals, Inc. |
Polymorphic compounds and uses thereof
|
CN111170986A
(zh)
|
2018-11-13 |
2020-05-19 |
北京睿熙生物科技有限公司 |
布鲁顿酪氨酸激酶的抑制剂
|
CN109293630A
(zh)
*
|
2018-11-15 |
2019-02-01 |
山东大学 |
含取代吡唑类化合物及其制备方法与应用
|
CN109369654A
(zh)
*
|
2018-11-20 |
2019-02-22 |
山东大学 |
1,3-二取代-4-氨基吡唑并嘧啶类化合物及其制备方法和应用
|
US11053241B2
(en)
|
2018-11-30 |
2021-07-06 |
Nimbus Lakshmi, Inc. |
TYK2 inhibitors and uses thereof
|
KR20210117260A
(ko)
|
2018-11-30 |
2021-09-28 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 요법을 사용한 치료방법
|
US20220031746A1
(en)
|
2018-11-30 |
2022-02-03 |
Juno Therapeutics, Inc. |
Methods for dosing and treatment of b cell malignancies in adoptive cell therapy
|
WO2020113233A1
(en)
|
2018-11-30 |
2020-06-04 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
WO2020132561A1
(en)
|
2018-12-20 |
2020-06-25 |
C4 Therapeutics, Inc. |
Targeted protein degradation
|
EP3670659A1
(en)
|
2018-12-20 |
2020-06-24 |
Abivax |
Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
|
EP3669867A1
(en)
|
2018-12-21 |
2020-06-24 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
US10688050B1
(en)
|
2018-12-21 |
2020-06-23 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
JPWO2020130125A1
(ja)
|
2018-12-21 |
2021-11-04 |
第一三共株式会社 |
抗体−薬物コンジュゲートとキナーゼ阻害剤の組み合わせ
|
AU2020206884A1
(en)
|
2019-01-09 |
2021-08-05 |
Beth Israel Deaconess Medical Center, Inc. |
Modulators of Pin1 activity and uses thereof
|
CN111454268B
(zh)
*
|
2019-01-18 |
2023-09-08 |
明慧医药(上海)有限公司 |
作为布鲁顿酪氨酸激酶抑制剂的环状分子
|
CA3126034A1
(en)
|
2019-01-23 |
2020-07-30 |
Nimbus Lakshmi, Inc. |
Tyk2 inhibitors and uses thereof
|
WO2020167990A1
(en)
|
2019-02-12 |
2020-08-20 |
Tolero Pharmaceuticals, Inc. |
Formulations comprising heterocyclic protein kinase inhibitors
|
WO2020165600A1
(en)
|
2019-02-14 |
2020-08-20 |
Bicycletx Limited |
Bicyclic peptide ligand sting conjugates and uses thereof
|
WO2020170270A1
(en)
*
|
2019-02-19 |
2020-08-27 |
Msn Laboratories Private Limited, R&D Center |
Novel crystalline polymorphs of 1-[(3r)-3-[4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one and process for preparation thereof
|
CN114364798A
(zh)
|
2019-03-21 |
2022-04-15 |
欧恩科斯欧公司 |
用于治疗癌症的Dbait分子与激酶抑制剂的组合
|
EP3946462A1
(en)
|
2019-04-02 |
2022-02-09 |
BicycleTX Limited |
Bicycle toxin conjugates and uses thereof
|
SG11202110829YA
(en)
|
2019-04-05 |
2021-10-28 |
Kymera Therapeutics Inc |
Stat degraders and uses thereof
|
MX2021014246A
(es)
|
2019-05-21 |
2022-01-06 |
Janssen Pharmaceutica Nv |
Procedimientos y productos intermedios para preparar un inhibidor de btk.
|
WO2020234379A1
(en)
|
2019-05-21 |
2020-11-26 |
Janssen Pharmaceutica Nv |
Processes and intermediates for preparing a btk inhibitor
|
US10937541B2
(en)
|
2019-05-28 |
2021-03-02 |
PAIGE.AI, Inc. |
Systems and methods for processing images to prepare slides for processed images for digital pathology
|
CA3141826A1
(en)
|
2019-05-31 |
2020-12-03 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
WO2021038540A1
(en)
|
2019-08-31 |
2021-03-04 |
Sun Pharma Advanced Research Company Limited |
Cycloalkylidene carboxylic acids and derivatives as btk inhibitors
|
WO2021050992A1
(en)
|
2019-09-11 |
2021-03-18 |
Vincere Biosciences, Inc. |
Usp30 inhibitors and uses thereof
|
WO2021050964A1
(en)
|
2019-09-13 |
2021-03-18 |
Nimbus Saturn, Inc. |
Hpk1 antagonists and uses thereof
|
BR112022008287A2
(pt)
|
2019-11-01 |
2022-07-26 |
Navitor Pharm Inc |
Métodos de tratamento usando um modulador de mtorc1
|
AU2020378630A1
(en)
|
2019-11-08 |
2022-05-26 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
|
CA3163680A1
(en)
|
2019-12-05 |
2021-06-10 |
David John O'neill |
Rapamycin analogs and uses thereof
|
CN115398231A
(zh)
|
2019-12-06 |
2022-11-25 |
朱诺治疗学股份有限公司 |
与治疗b细胞恶性肿瘤的细胞疗法相关的毒性和反应的相关方法
|
WO2021127283A2
(en)
|
2019-12-17 |
2021-06-24 |
Kymera Therapeutics, Inc. |
Irak degraders and uses thereof
|
JP2023509366A
(ja)
|
2019-12-17 |
2023-03-08 |
カイメラ セラピューティクス, インコーポレイテッド |
Irak分解剤およびそれらの使用
|
JP2023509394A
(ja)
|
2019-12-23 |
2023-03-08 |
カイメラ セラピューティクス, インコーポレイテッド |
Smarca分解剤およびそれらの使用
|
WO2021148581A1
(en)
|
2020-01-22 |
2021-07-29 |
Onxeo |
Novel dbait molecule and its use
|
WO2021164697A1
(zh)
*
|
2020-02-18 |
2021-08-26 |
深圳市塔吉瑞生物医药有限公司 |
取代的酰胺衍生物及其组合物及用途
|
CN115151537A
(zh)
|
2020-02-26 |
2022-10-04 |
株式会社大熊制药 |
制备杂环胺衍生物的方法
|
AR121506A1
(es)
|
2020-03-03 |
2022-06-08 |
Pic Therapeutics Inc |
Inhibidores del eif4e y sus usos
|
IL296451A
(en)
|
2020-03-19 |
2022-11-01 |
Kymera Therapeutics Inc |
mdm2 joints and their uses
|
TW202210483A
(zh)
|
2020-06-03 |
2022-03-16 |
美商凱麥拉醫療公司 |
Irak降解劑之結晶型
|
CN114057724A
(zh)
*
|
2020-07-29 |
2022-02-18 |
鲁南制药集团股份有限公司 |
一种btk抑制剂
|
AU2021327130A1
(en)
|
2020-08-17 |
2023-03-02 |
Bicycletx Limited |
Bicycle conjugates specific for Nectin-4 and uses thereof
|
WO2022043251A1
(en)
|
2020-08-28 |
2022-03-03 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
US20240024325A1
(en)
*
|
2020-08-28 |
2024-01-25 |
Emory University |
Methods of Managing Cocaine or Other Drug Addictions
|
WO2022120353A1
(en)
|
2020-12-02 |
2022-06-09 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
AU2021392040A1
(en)
|
2020-12-02 |
2023-06-29 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
CN112574216B
(zh)
*
|
2020-12-16 |
2022-03-08 |
天津济坤医药科技有限公司 |
一种化合物及其制备方法以及其在制备治疗抗癌药物中的应用
|
US20240092785A1
(en)
|
2021-01-21 |
2024-03-21 |
Synthon B.V. |
Process for making ibrutinib
|
EP4288427A1
(en)
|
2021-02-02 |
2023-12-13 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
WO2022167445A1
(en)
|
2021-02-02 |
2022-08-11 |
Liminal Biosciences Limited |
Gpr84 antagonists and uses thereof
|
TW202245789A
(zh)
|
2021-02-15 |
2022-12-01 |
美商凱麥拉醫療公司 |
Irak4降解劑及其用途
|
JP2024509192A
(ja)
|
2021-03-05 |
2024-02-29 |
ニンバス サターン, インコーポレイテッド |
Hpk1アンタゴニスト及びその使用
|
KR20230172548A
(ko)
|
2021-04-16 |
2023-12-22 |
이케나 온콜로지, 인코포레이티드 |
Mek 억제제 및 이의 용도
|
US20220387340A1
(en)
*
|
2021-06-01 |
2022-12-08 |
Privo Technologies, Inc. |
Enhanced Two-Stage Microparticle-Based Localized Therapeutic Delivery System
|
US11433072B1
(en)
|
2021-06-10 |
2022-09-06 |
Hikma Pharmaceuticals USA, Inc. |
Oral dosage forms of ibrutinib
|
WO2022260667A1
(en)
|
2021-06-10 |
2022-12-15 |
Hikma Pharmaceuticals Usa Inc. |
Oral dosage forms of ibrutinib
|
CN113583001A
(zh)
*
|
2021-07-13 |
2021-11-02 |
江苏君若药业有限公司 |
依鲁替尼的制备
|
WO2023014817A1
(en)
|
2021-08-03 |
2023-02-09 |
Syros Pharmaceuticals, Inc. |
Compositions and methods for treating lymphomas with a cdk7 inhibitor in combination with a btk inhibitor
|
CN115702898B
(zh)
*
|
2021-08-04 |
2024-02-09 |
成都倍特药业股份有限公司 |
一种btk抑制剂固体制剂及其制备方法
|
IL310924A
(en)
|
2021-08-25 |
2024-04-01 |
Pic Therapeutics Inc |
EIF4E inhibitors and their uses
|
WO2023028238A1
(en)
|
2021-08-25 |
2023-03-02 |
PIC Therapeutics, Inc. |
Eif4e inhibitors and uses thereof
|
WO2023071973A1
(en)
*
|
2021-10-26 |
2023-05-04 |
Shenzhen Targetrx, Inc. |
Fused bicyclic compound for inhibiting activity of tyrosine kinase
|
WO2023104808A1
(en)
|
2021-12-10 |
2023-06-15 |
Synthon B.V. |
Pharmaceutical composition comprising ibrutinib
|
WO2023114984A1
(en)
|
2021-12-17 |
2023-06-22 |
Ikena Oncology, Inc. |
Tead inhibitors and uses thereof
|
WO2023173053A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
WO2023173057A1
(en)
|
2022-03-10 |
2023-09-14 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
CN114605418B
(zh)
*
|
2022-03-15 |
2023-09-05 |
广东医科大学附属医院 |
一类具有抗肿瘤活性的依鲁替尼丙烯酰胺类衍生物及其合成方法与应用
|
WO2023211889A1
(en)
|
2022-04-25 |
2023-11-02 |
Ikena Oncology, Inc. |
Polymorphic compounds and uses thereof
|
WO2023220655A1
(en)
|
2022-05-11 |
2023-11-16 |
Celgene Corporation |
Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
|
WO2023230205A1
(en)
|
2022-05-25 |
2023-11-30 |
Ikena Oncology, Inc. |
Mek inhibitors and uses thereof
|
US11814439B1
(en)
|
2022-06-01 |
2023-11-14 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11884740B1
(en)
|
2022-06-01 |
2024-01-30 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11807689B1
(en)
|
2022-06-01 |
2023-11-07 |
Tg Therapeutics, Inc. |
Anti-CD20 antibody compositions
|
US11786531B1
(en)
|
2022-06-08 |
2023-10-17 |
Beigene Switzerland Gmbh |
Methods of treating B-cell proliferative disorder
|
WO2023242384A1
(en)
|
2022-06-17 |
2023-12-21 |
Krka, D.D., Novo Mesto |
Crystalline form of ibrutinib
|
WO2023249980A1
(en)
*
|
2022-06-22 |
2023-12-28 |
Genzyme Corporation |
Methods of making modified btk inhibitors
|
WO2024028365A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Substituted pyridone gpr84 antagonists and uses thereof
|
WO2024028363A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
|
WO2024028364A1
(en)
|
2022-08-02 |
2024-02-08 |
Liminal Biosciences Limited |
Aryl-triazolyl and related gpr84 antagonists and uses thereof
|
CN115417827B
(zh)
*
|
2022-09-30 |
2023-05-26 |
中国药科大学 |
6-氨基-1,3,5-三嗪类化合物及其合成方法和应用
|