BR112016012794A2 - Combinação terapêutica de um inibidor de pi3k e um inibidor de btk - Google Patents
Combinação terapêutica de um inibidor de pi3k e um inibidor de btkInfo
- Publication number
- BR112016012794A2 BR112016012794A2 BR112016012794A BR112016012794A BR112016012794A2 BR 112016012794 A2 BR112016012794 A2 BR 112016012794A2 BR 112016012794 A BR112016012794 A BR 112016012794A BR 112016012794 A BR112016012794 A BR 112016012794A BR 112016012794 A2 BR112016012794 A2 BR 112016012794A2
- Authority
- BR
- Brazil
- Prior art keywords
- cells
- inhibitor
- pi3k
- btk
- therapeutic combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Abstract
Em algumas modalidades, a invenção inclui uma combinação terapêutica de um inibidor de fosfoinositídeo 3-quinase (PI3K), incluindo inibidores de PI3K seletivos para as isoformas ¿ e d e seletivos para ambas as isoformas ¿ e d-isoforms, e um inibidor da tirosina quinase de Bruton (BTK). Em algumas modalidades, a invenção inclui métodos terapêuticos de uso de um inibidor de BTK e um inibidor de PI3K-d para tratar cânceres tumorais sólidos pela modulação do microambiente do tumor, inclusive macrófagos, monócitos, mastócitos, células T auxiliares, células T citotóxicas, células T regulatórias, células "natural killer", células supressoras de origem mielóide, células B regulatórias, neutrófilos, células dendríticas e fibroblastos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361912515P | 2013-12-05 | 2013-12-05 | |
US201461974665P | 2014-04-03 | 2014-04-03 | |
US201462035777P | 2014-08-11 | 2014-08-11 | |
PCT/IB2014/003121 WO2015083008A1 (en) | 2013-12-05 | 2014-12-05 | Therapeutic combination of a pi3k inhibitor and a btk inhibitor |
Publications (1)
Publication Number | Publication Date |
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BR112016012794A2 true BR112016012794A2 (pt) | 2017-08-08 |
Family
ID=52697466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016012794A BR112016012794A2 (pt) | 2013-12-05 | 2014-12-05 | Combinação terapêutica de um inibidor de pi3k e um inibidor de btk |
Country Status (10)
Country | Link |
---|---|
US (2) | US10328080B2 (pt) |
EP (1) | EP3076974A1 (pt) |
JP (1) | JP2016540053A (pt) |
KR (1) | KR20160093062A (pt) |
CN (1) | CN105979948A (pt) |
AU (1) | AU2014358868A1 (pt) |
BR (1) | BR112016012794A2 (pt) |
CA (1) | CA2931431A1 (pt) |
EA (1) | EA201691169A1 (pt) |
WO (1) | WO2015083008A1 (pt) |
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CN105073115A (zh) | 2013-03-14 | 2015-11-18 | 药品循环有限责任公司 | 布鲁顿氏酪氨酸激酶抑制剂和cyp3a4抑制剂的组合 |
WO2014143807A2 (en) | 2013-03-15 | 2014-09-18 | Stromatt Scott | Anti-cd37 antibody and bcr pathway antagonist combination therapy for treatment of b-cell malignancies and disorders |
JP6575952B2 (ja) | 2013-04-08 | 2019-09-18 | ファーマサイクリックス エルエルシー | イブルチニブ併用療法 |
WO2015018522A1 (en) | 2013-08-06 | 2015-02-12 | Oncoethix Sa | Bet-bromodomain inhibitor shows synergism with several anti-cancer agents in pre-clinical models of diffuse large b-cell lymphoma (dlbcl) |
-
2014
- 2014-12-05 US US15/101,864 patent/US10328080B2/en active Active
- 2014-12-05 WO PCT/IB2014/003121 patent/WO2015083008A1/en active Application Filing
- 2014-12-05 EA EA201691169A patent/EA201691169A1/ru unknown
- 2014-12-05 BR BR112016012794A patent/BR112016012794A2/pt not_active IP Right Cessation
- 2014-12-05 JP JP2016557202A patent/JP2016540053A/ja active Pending
- 2014-12-05 CN CN201480074916.XA patent/CN105979948A/zh active Pending
- 2014-12-05 EP EP14846732.7A patent/EP3076974A1/en not_active Withdrawn
- 2014-12-05 AU AU2014358868A patent/AU2014358868A1/en not_active Abandoned
- 2014-12-05 KR KR1020167017741A patent/KR20160093062A/ko not_active Application Discontinuation
- 2014-12-05 CA CA2931431A patent/CA2931431A1/en not_active Abandoned
-
2019
- 2019-04-18 US US16/388,832 patent/US20190358235A1/en not_active Abandoned
Also Published As
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CA2931431A1 (en) | 2015-06-11 |
JP2016540053A (ja) | 2016-12-22 |
KR20160093062A (ko) | 2016-08-05 |
AU2014358868A1 (en) | 2016-06-09 |
US20170266191A1 (en) | 2017-09-21 |
EA201691169A1 (ru) | 2016-09-30 |
US10328080B2 (en) | 2019-06-25 |
US20190358235A1 (en) | 2019-11-28 |
CN105979948A (zh) | 2016-09-28 |
WO2015083008A1 (en) | 2015-06-11 |
EP3076974A1 (en) | 2016-10-12 |
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