MX2017012939A - Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. - Google Patents

Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.

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Publication number
MX2017012939A
MX2017012939A MX2017012939A MX2017012939A MX2017012939A MX 2017012939 A MX2017012939 A MX 2017012939A MX 2017012939 A MX2017012939 A MX 2017012939A MX 2017012939 A MX2017012939 A MX 2017012939A MX 2017012939 A MX2017012939 A MX 2017012939A
Authority
MX
Mexico
Prior art keywords
therapies
car
combination
antigen receptor
chimeric antigen
Prior art date
Application number
MX2017012939A
Other languages
English (en)
Inventor
H June Carl
Lei Ming
Zhou Li
Brannetti Barbara
Brogdon Jennifer
Li Na
Gill Saar
Ruella Marco
Bitter Hans
Mary Bordeaux Jennifer
Kumar Dakappagari Naveen
Highfill Steven
Huang Lu
Young Kim Ju
Orlando Elena
Tran Thai
Zhang Jimin
Loew Andreas
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2017012939A publication Critical patent/MX2017012939A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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Abstract

La invención proporciona composiciones y métodos para tratar enfermedades asociadas con la expresión de CD19, por ejemplo, mediante la administración de una célula T recombinante que comprende el CAR de CD19 tal como se describe en el presente documento, en combinación con uno o más inhibidores de células B, por ejemplo, inhibidores de una o más de CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, o CD79a. La invención también proporciona dominios de unión a antígeno novedosos y moléculas de CAR que se dirigen a CD20 y CD22 y usos, por ejemplo como monoterapia o en terapia de combinación. La invención también proporciona kits y composiciones descritas en el presente documento.
MX2017012939A 2015-04-08 2016-04-08 Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. MX2017012939A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562144497P 2015-04-08 2015-04-08
US201562144615P 2015-04-08 2015-04-08
US201562144639P 2015-04-08 2015-04-08
US201562207255P 2015-08-19 2015-08-19
US201562263423P 2015-12-04 2015-12-04
PCT/US2016/026655 WO2016164731A2 (en) 2015-04-08 2016-04-08 Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell

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MX2017012939A true MX2017012939A (es) 2018-05-22

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MX2017012939A MX2017012939A (es) 2015-04-08 2016-04-08 Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19.
MX2022006568A MX2022006568A (es) 2015-04-08 2017-10-06 Agentes anti-cd20, agentes anti-cd22, y usos y combinaciones de los mismos con una celula que expresa un receptor de antigeno quimerico (car) de cd19.

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