MA43377A - Méthodes et compositions liées à la toxicité associée à la thérapie cellulaire - Google Patents
Méthodes et compositions liées à la toxicité associée à la thérapie cellulaireInfo
- Publication number
- MA43377A MA43377A MA043377A MA43377A MA43377A MA 43377 A MA43377 A MA 43377A MA 043377 A MA043377 A MA 043377A MA 43377 A MA43377 A MA 43377A MA 43377 A MA43377 A MA 43377A
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- cell therapy
- toxicity associated
- compositions related
- compositions
- Prior art date
Links
- 238000002659 cell therapy Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001988 toxicity Effects 0.000 title 1
- 231100000419 toxicity Toxicity 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6866—Interferon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562263612P | 2015-12-04 | 2015-12-04 | |
US201662417284P | 2016-11-03 | 2016-11-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA43377A true MA43377A (fr) | 2021-05-19 |
Family
ID=57737968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA043377A MA43377A (fr) | 2015-12-04 | 2016-12-02 | Méthodes et compositions liées à la toxicité associée à la thérapie cellulaire |
Country Status (5)
Country | Link |
---|---|
US (2) | US11815514B2 (fr) |
EP (2) | EP4012415A3 (fr) |
ES (1) | ES2901795T3 (fr) |
MA (1) | MA43377A (fr) |
WO (1) | WO2017096331A1 (fr) |
Families Citing this family (23)
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KR20170068504A (ko) | 2014-10-08 | 2017-06-19 | 노파르티스 아게 | 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도 |
EP3932950A1 (fr) | 2014-10-20 | 2022-01-05 | Juno Therapeutics, Inc. | Procédés et compositions pour dosage en thérapie cellulaire adoptive |
EP3344996A2 (fr) | 2015-09-03 | 2018-07-11 | The Trustees Of The University Of Pennsylvania | Biomarqueurs prédictifs du syndrome de libération de cytokines |
AU2017295886C1 (en) * | 2016-07-15 | 2024-01-25 | Novartis Ag | Treatment and prevention of cytokine release syndrome using a chimeric antigen receptor in combination with a kinase inhibitor |
CA3052474A1 (fr) * | 2017-02-09 | 2018-08-16 | Fred Hutchinson Cancer Research Center | Biomarqueurs et leurs utilisations permettant la selection d'une intervention d'immunotherapie |
CA3065120A1 (fr) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles de fabrication et procedes de traitement utilisant une therapie cellulaire adoptive |
KR102557834B1 (ko) | 2017-06-07 | 2023-07-21 | 프레시전 인코포레이티드 | 신규의 세포 태그의 발현 |
JP2020533962A (ja) * | 2017-08-11 | 2020-11-26 | フレッド ハッチンソン キャンサー リサーチ センター | Braf特異的tcrおよびその使用 |
US10899831B2 (en) | 2017-10-02 | 2021-01-26 | Humanigen, Inc. | Method of reducing the level of non-GM-CSF cytokines/chemokines in immunotherapy-related toxicity |
US11130805B2 (en) | 2017-10-02 | 2021-09-28 | Humanigen, Inc. | Methods of treating CART-T cell therapy-induced neuroinflammation using a GM-CSF antagonist |
US10870703B2 (en) | 2017-10-02 | 2020-12-22 | Humanigen, Inc. | Methods of treating immunotherapy-related toxicity using a GM-CSF antagonist |
US10927168B2 (en) | 2017-10-02 | 2021-02-23 | Humanicen, Inc. | Method of reducing tumor relapse rate in immunotherapy by administration of lenzilumab |
KR20200075851A (ko) * | 2017-10-19 | 2020-06-26 | 셀렉티스 | 개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합 |
WO2019089848A1 (fr) * | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Procédés associés à une charge tumorale pour évaluer une réponse à une thérapie cellulaire |
WO2019109053A1 (fr) * | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Procédés de dosage et de modulation de cellules génétiquement modifiées |
KR20200128043A (ko) | 2018-02-16 | 2020-11-11 | 인사이트 코포레이션 | 사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제 |
CA3116412A1 (fr) * | 2018-10-31 | 2020-05-07 | Humanigen, Inc. | Substances et methodes pour le traitement du cancer |
WO2021168375A1 (fr) * | 2020-02-20 | 2021-08-26 | Kite Pharma, Inc. | Thérapie par lymphocytes t à récepteurs antigéniques chimériques |
JP2023518814A (ja) * | 2020-03-23 | 2023-05-08 | ジェネンテック, インコーポレイテッド | Covid-19肺炎における、il-6アンタゴニストに対する応答を予測するためのバイオマーカー |
WO2022109340A1 (fr) * | 2020-11-20 | 2022-05-27 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Profils de biomarqueurs cliniques immunomodulateurs et leurs utilisations |
CA3204374A1 (fr) | 2020-12-08 | 2022-06-16 | Incyte Corporation | Inhibiteurs de la voie jak1 destines au traitement du vitiligo |
AR125827A1 (es) * | 2021-05-11 | 2023-08-16 | Janssen Biotech Inc | Métodos para minimizar la neurotoxicidad asociada a la terapia con células t del receptor de antígeno quimérico (car) |
US20230268031A1 (en) * | 2021-07-30 | 2023-08-24 | Kite Pharma, Inc. | Monitoring and management of cell therapy-induced toxicities |
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CA3065120A1 (fr) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles de fabrication et procedes de traitement utilisant une therapie cellulaire adoptive |
-
2016
- 2016-12-02 EP EP21202223.0A patent/EP4012415A3/fr active Pending
- 2016-12-02 US US15/781,089 patent/US11815514B2/en active Active
- 2016-12-02 EP EP16822558.9A patent/EP3384294B1/fr active Active
- 2016-12-02 WO PCT/US2016/064865 patent/WO2017096331A1/fr active Application Filing
- 2016-12-02 ES ES16822558T patent/ES2901795T3/es active Active
- 2016-12-02 MA MA043377A patent/MA43377A/fr unknown
-
2023
- 2023-09-27 US US18/476,120 patent/US20240103012A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
ES2901795T3 (es) | 2022-03-23 |
EP4012415A3 (fr) | 2022-12-07 |
EP3384294A1 (fr) | 2018-10-10 |
EP4012415A2 (fr) | 2022-06-15 |
US11815514B2 (en) | 2023-11-14 |
WO2017096331A1 (fr) | 2017-06-08 |
EP3384294B1 (fr) | 2021-10-13 |
US20240103012A1 (en) | 2024-03-28 |
US20190277858A1 (en) | 2019-09-12 |
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