MA41654B2 - Formes cristallines d'un inhibiteur de tyrosine kinase de bruton - Google Patents
Formes cristallines d'un inhibiteur de tyrosine kinase de brutonInfo
- Publication number
- MA41654B2 MA41654B2 MA41654A MA41654A MA41654B2 MA 41654 B2 MA41654 B2 MA 41654B2 MA 41654 A MA41654 A MA 41654A MA 41654 A MA41654 A MA 41654A MA 41654 B2 MA41654 B2 MA 41654B2
- Authority
- MA
- Morocco
- Prior art keywords
- tyrosine kinase
- kinase inhibitor
- conditions
- crystal forms
- diseases
- Prior art date
Links
- 229940124291 BTK inhibitor Drugs 0.000 title abstract 3
- 229940125814 BTK kinase inhibitor Drugs 0.000 title 1
- 239000013078 crystal Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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Abstract
La présente invention concerne l'inhibiteur de tyrosine kinase de bruton (btk) 1-((r)-3-(4-amino-3-(4-phénoxyphényl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)pipéridin-1-yl)prop-2-èn-1-one, celui-ci comprenant des formes cristallines, des solvates et des sels de qualité pharmaceutique de celui-ci. L'invention concerne également des compositions pharmaceutiques qui comprennent l'inhibiteur de btk, ainsi que des procédés d'utilisation de l'inhibiteur de btk, seul ou en combinaison avec d'autres agents thérapeutiques, pour le traitement de maladies ou d'états auto-immuns, de maladies ou d'états hétéro-immuns, du cancer, y compris un lymphome, et de maladies ou d'états inflammatoires.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261655381P | 2012-06-04 | 2012-06-04 | |
PCT/US2013/043888 WO2013184572A1 (fr) | 2012-06-04 | 2013-06-03 | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
Publications (2)
Publication Number | Publication Date |
---|---|
MA41654A1 MA41654A1 (fr) | 2018-07-31 |
MA41654B2 true MA41654B2 (fr) | 2020-12-31 |
Family
ID=49712527
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37711A MA37711A1 (fr) | 2012-06-04 | 2013-06-03 | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
MA41654A MA41654B2 (fr) | 2012-06-04 | 2013-06-03 | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37711A MA37711A1 (fr) | 2012-06-04 | 2013-06-03 | Formes cristallines d'un inhibiteur de tyrosine kinase de bruton |
Country Status (32)
Country | Link |
---|---|
US (25) | US9540382B2 (fr) |
EP (1) | EP2854859A4 (fr) |
JP (8) | JP6236071B2 (fr) |
KR (7) | KR20220093389A (fr) |
CN (2) | CN104736178A (fr) |
AR (2) | AR092844A1 (fr) |
AU (6) | AU2013271918C1 (fr) |
BR (1) | BR112014030424A8 (fr) |
CA (4) | CA3015208C (fr) |
CL (3) | CL2014003306A1 (fr) |
CO (1) | CO7240408A2 (fr) |
CR (1) | CR20140558A (fr) |
DO (3) | DOP2014000274A (fr) |
EA (1) | EA201492082A1 (fr) |
EC (2) | ECSP14033163A (fr) |
GT (1) | GT201400281A (fr) |
HK (1) | HK1208803A1 (fr) |
IL (3) | IL235894B (fr) |
JO (2) | JO3754B1 (fr) |
MA (2) | MA37711A1 (fr) |
MX (2) | MX348290B (fr) |
MY (2) | MY194911A (fr) |
NZ (4) | NZ702548A (fr) |
PE (2) | PE20150174A1 (fr) |
PH (2) | PH12014502681A1 (fr) |
SG (2) | SG11201408067YA (fr) |
TN (1) | TN2014000492A1 (fr) |
TW (3) | TWI662964B (fr) |
UA (2) | UA126959C2 (fr) |
UY (2) | UY39740A (fr) |
WO (1) | WO2013184572A1 (fr) |
ZA (2) | ZA202105175B (fr) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
US8809273B2 (en) | 2007-03-28 | 2014-08-19 | Pharmacyclics, Inc. | Inhibitors of Bruton's tyrosine kinase |
US20110224235A1 (en) | 2008-07-16 | 2011-09-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
NZ772688A (en) | 2010-06-03 | 2022-09-30 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
US20130288984A1 (en) | 2011-01-11 | 2013-10-31 | Glaxosmithkline Llc | Combination |
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BR112017002231A2 (pt) | 2014-08-07 | 2018-07-17 | Pharmacyclics Llc | novas formulações de um inibidor de tirosina cinase de bruton |
EP3180343A1 (fr) | 2014-08-14 | 2017-06-21 | Assia Chemical Industries Ltd. | Formes à l'état solide d'ibrutinib |
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CN105640961A (zh) | 2014-11-18 | 2016-06-08 | 山东瑞禾医药科技有限公司 | 一种含依鲁替尼的药物组合物 |
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US20150224060A1 (en) | 2015-01-03 | 2015-08-13 | David Wong | Gastric retentive tablet compositions |
CZ201584A3 (cs) | 2015-02-09 | 2016-08-17 | Zentiva, K.S. | Sůl Ibrutinib sulfátu |
SG10202102078VA (en) | 2015-03-03 | 2021-04-29 | Pharmacyclics Llc | Pharmaceutical formulations of a bruton’s tyrosine kinase inhibitor |
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MA41827A (fr) | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton |
MA41828A (fr) | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton |
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