BR112014001665A2 - compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz - Google Patents

compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz

Info

Publication number
BR112014001665A2
BR112014001665A2 BR112014001665A BR112014001665A BR112014001665A2 BR 112014001665 A2 BR112014001665 A2 BR 112014001665A2 BR 112014001665 A BR112014001665 A BR 112014001665A BR 112014001665 A BR112014001665 A BR 112014001665A BR 112014001665 A2 BR112014001665 A2 BR 112014001665A2
Authority
BR
Brazil
Prior art keywords
plaz
dihydroimidazo
pyrimidin
inhibitors
compounds used
Prior art date
Application number
BR112014001665A
Other languages
English (en)
Inventor
Long Kai
Su Xiaobo
Sang Yingxia
Wan Zehong
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR112014001665A2 publication Critical patent/BR112014001665A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

resumo “compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz” compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(ih)-ona que inibem lp-plaz, processos para a sua preparação, composições que os contêm e sua utiliza-ção no tratamento de doenças associadas com a atividade de lp-plaz, por exem-plo, aterosclerose, doença de alzheimer são divulgados.
BR112014001665A 2011-07-27 2012-07-25 compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz BR112014001665A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011077697 2011-07-27
PCT/CN2012/000999 WO2013013503A1 (en) 2011-07-27 2012-07-25 2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors

Publications (1)

Publication Number Publication Date
BR112014001665A2 true BR112014001665A2 (pt) 2017-02-14

Family

ID=47600511

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001665A BR112014001665A2 (pt) 2011-07-27 2012-07-25 compostos de 2,3-di-hidroimidazo[1,2-c]pirimidin-5(1h)-ona utilizados como inibidores de lp-plaz

Country Status (9)

Country Link
US (1) US8975400B2 (pt)
EP (1) EP2739627A4 (pt)
JP (1) JP2014521611A (pt)
KR (1) KR20140059203A (pt)
AU (1) AU2012289492B2 (pt)
BR (1) BR112014001665A2 (pt)
CA (1) CA2842965A1 (pt)
RU (1) RU2014107484A (pt)
WO (1) WO2013013503A1 (pt)

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UY35276A (es) * 2013-01-25 2014-08-29 Glaxosmithkline Ip Dev Ltd Nuevos compuestos que inhiben la actividad de Lp-PLA2
CN103789401A (zh) * 2014-02-14 2014-05-14 苏州莱泰生物科技有限公司 用于特异测定蛋白磷脂酶pla2g7活性的化合物
WO2016012916A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016011930A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited Compounds
WO2016012917A1 (en) * 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN105777653A (zh) * 2014-12-26 2016-07-20 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物
CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
AU2019395201A1 (en) 2018-12-06 2021-05-20 Daiichi Sankyo Company, Limited Cycloalkane-1,3-diamine derivative
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
CN114805389B (zh) 2019-11-09 2023-08-29 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
WO2024027116A1 (en) * 2022-08-04 2024-02-08 4B Technologies (Beijing) Co., Limited Dihydroimidazo-pyrimidinone compounds as lp-pla2 inhibitors and use thereof

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Also Published As

Publication number Publication date
AU2012289492A1 (en) 2014-02-13
WO2013013503A1 (en) 2013-01-31
CA2842965A1 (en) 2013-01-31
EP2739627A1 (en) 2014-06-11
RU2014107484A (ru) 2015-09-10
KR20140059203A (ko) 2014-05-15
EP2739627A4 (en) 2015-01-21
AU2012289492B2 (en) 2016-02-04
US8975400B2 (en) 2015-03-10
JP2014521611A (ja) 2014-08-28
US20140179715A1 (en) 2014-06-26

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)