MX348290B - Formas cristalinas de un inhibidor de tirosina quinasa de bruton. - Google Patents
Formas cristalinas de un inhibidor de tirosina quinasa de bruton.Info
- Publication number
- MX348290B MX348290B MX2014014848A MX2014014848A MX348290B MX 348290 B MX348290 B MX 348290B MX 2014014848 A MX2014014848 A MX 2014014848A MX 2014014848 A MX2014014848 A MX 2014014848A MX 348290 B MX348290 B MX 348290B
- Authority
- MX
- Mexico
- Prior art keywords
- bruton
- tyrosine kinase
- crystalline forms
- conditions
- kinase inhibitor
- Prior art date
Links
- 229940125814 BTK kinase inhibitor Drugs 0.000 title abstract 2
- 229940124291 BTK inhibitor Drugs 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010025323 Lymphomas Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 crystalline forms Chemical compound 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XYFPWWZEPKGCCK-GOSISDBHSA-N ibrutinib Chemical compound C1=2C(N)=NC=NC=2N([C@H]2CN(CCC2)C(=O)C=C)N=C1C(C=C1)=CC=C1OC1=CC=CC=C1 XYFPWWZEPKGCCK-GOSISDBHSA-N 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract
La presente invención se refiere al inhibidor de tirosina quinasa (Btk) de Bruton 1-((R)-3-(4-amino-3-(4-fenoxifenil)-1H-pirazolo [3,4-d] pirimidin-1-il) piperidin-1-il) prop-2-en-1-ona, incluyendo las formas cristalinas, solvatos y sus sales aceptables en el campo farmacéutico. Se describe también composiciones farmacéuticas que incluyen al inhibidor Btk, así como métodos para usar a dicho inhibidor solo o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones autoinmunes, enfermedades o condiciones heteroinmunes, cáncer, incluyendo linfoma, así como enfermedades o condiciones inflamatorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261655381P | 2012-06-04 | 2012-06-04 | |
PCT/US2013/043888 WO2013184572A1 (en) | 2012-06-04 | 2013-06-03 | Crystalline forms of a bruton's tyrosine kinase inhibitor |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014014848A MX2014014848A (es) | 2015-07-06 |
MX348290B true MX348290B (es) | 2017-06-05 |
Family
ID=49712527
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014014848A MX348290B (es) | 2012-06-04 | 2013-06-03 | Formas cristalinas de un inhibidor de tirosina quinasa de bruton. |
MX2021012478A MX2021012478A (es) | 2012-06-04 | 2014-12-04 | Formas cristalinas de un inhibidor de tirosina quinasa de bruton. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021012478A MX2021012478A (es) | 2012-06-04 | 2014-12-04 | Formas cristalinas de un inhibidor de tirosina quinasa de bruton. |
Country Status (32)
Country | Link |
---|---|
US (25) | US9540382B2 (es) |
EP (1) | EP2854859A4 (es) |
JP (8) | JP6236071B2 (es) |
KR (7) | KR20220093389A (es) |
CN (2) | CN104736178A (es) |
AR (2) | AR092844A1 (es) |
AU (6) | AU2013271918C1 (es) |
BR (1) | BR112014030424A8 (es) |
CA (4) | CA3015208C (es) |
CL (3) | CL2014003306A1 (es) |
CO (1) | CO7240408A2 (es) |
CR (1) | CR20140558A (es) |
DO (3) | DOP2014000274A (es) |
EA (1) | EA201492082A1 (es) |
EC (2) | ECSP14033163A (es) |
GT (1) | GT201400281A (es) |
HK (1) | HK1208803A1 (es) |
IL (3) | IL235894B (es) |
JO (2) | JO3754B1 (es) |
MA (2) | MA37711A1 (es) |
MX (2) | MX348290B (es) |
MY (2) | MY194911A (es) |
NZ (4) | NZ702548A (es) |
PE (2) | PE20150174A1 (es) |
PH (2) | PH12014502681A1 (es) |
SG (2) | SG11201408067YA (es) |
TN (1) | TN2014000492A1 (es) |
TW (3) | TWI662964B (es) |
UA (2) | UA126959C2 (es) |
UY (2) | UY39740A (es) |
WO (1) | WO2013184572A1 (es) |
ZA (2) | ZA202105175B (es) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
US8809273B2 (en) | 2007-03-28 | 2014-08-19 | Pharmacyclics, Inc. | Inhibitors of Bruton's tyrosine kinase |
US20110224235A1 (en) | 2008-07-16 | 2011-09-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors |
US8491927B2 (en) * | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
NZ772688A (en) | 2010-06-03 | 2022-09-30 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
US20130288984A1 (en) | 2011-01-11 | 2013-10-31 | Glaxosmithkline Llc | Combination |
AU2012283775A1 (en) | 2011-07-13 | 2014-01-23 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
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MA41828A (fr) | 2015-03-27 | 2018-01-30 | Pharmacyclics Llc | Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton |
JP6705833B2 (ja) | 2015-04-02 | 2020-06-03 | ラティオファルム ゲー・エム・ベー・ハー | イブルチニブとカルボン酸との共結晶 |
MX2017012822A (es) | 2015-04-06 | 2018-06-13 | Janssen Pharmaceutica Nv | Composiciones que contienen ibrutinib. |
CN105294696A (zh) | 2015-11-19 | 2016-02-03 | 上海创诺医药集团有限公司 | 依鲁替尼新晶型及其制备方法 |
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CN108472259A (zh) | 2016-01-19 | 2018-08-31 | 詹森药业有限公司 | 包含btk抑制剂的配制品/组合物 |
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