JOP20200222A1 - أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون - Google Patents

أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون

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Publication number
JOP20200222A1
JOP20200222A1 JOP/2020/0222A JOP20200222A JOP20200222A1 JO P20200222 A1 JOP20200222 A1 JO P20200222A1 JO P20200222 A JOP20200222 A JO P20200222A JO P20200222 A1 JOP20200222 A1 JO P20200222A1
Authority
JO
Jordan
Prior art keywords
bruton
tyrosine kinase
crystalline forms
conditions
kinase inhibitor
Prior art date
Application number
JOP/2020/0222A
Other languages
English (en)
Inventor
Goldman Erick
Smyth Mark
Purro Norbert
D Wirth David
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712527&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200222(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of JOP20200222A1 publication Critical patent/JOP20200222A1/ar

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

يتعلق الاختراع الحالي عن مثبط إنزيم تيروسين كيناز لبروتون (Btk) 1- ((R)- 3- (4-فينوكسي فينيل)-1H- بيرازولول [3، 4-d] بيريميدين-1-يل)بيريميدين-1-يل)بيبريدين-1-يل)بروب-2- ين-1- أون، بما في ذلك صورة البلورية، وذواباته، وأملاحه المقبولة صيدلانياً. كما يتم الكشف عن تركيبات صيدلانية تشتمل على مثط Btk، وكذلك طرق لاستخدام مثبط Btk، سواء بمفرده أو بالاشتراك مع عوامل علاجية أخلى، في علاج أمراض أو حالات مناعة ذاتية، أو أمراض أو حالات مناعة غير متجانسة، أو سرطان، مثل الأورام الليمفاوية، وأمراض أو حالات التهابية.
JOP/2020/0222A 2012-06-04 2020-09-09 أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون JOP20200222A1 (ar)

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US201261655381P 2012-06-04 2012-06-04

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JOP20200222A1 true JOP20200222A1 (ar) 2022-10-30

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JOP/2013/0168A JO3754B1 (ar) 2012-06-04 2013-06-03 أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون
JOP/2020/0222A JOP20200222A1 (ar) 2012-06-04 2020-09-09 أشكال كريستالين لمثبط أنزيم كيناز تيروسين بروتون

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US (25) US9296753B2 (ar)
EP (1) EP2854859A4 (ar)
JP (8) JP6236071B2 (ar)
KR (7) KR20220093389A (ar)
CN (2) CN104736178A (ar)
AR (2) AR092844A1 (ar)
AU (6) AU2013271918C1 (ar)
BR (1) BR112014030424A8 (ar)
CA (4) CA2991994C (ar)
CL (3) CL2014003306A1 (ar)
CO (1) CO7240408A2 (ar)
CR (1) CR20140558A (ar)
DO (3) DOP2014000274A (ar)
EA (1) EA201492082A1 (ar)
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MX (2) MX348290B (ar)
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PE (2) PE20150174A1 (ar)
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UA (2) UA114421C2 (ar)
UY (2) UY34848A (ar)
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WO2010009342A2 (en) 2008-07-16 2010-01-21 Pharmacyclics, Inc. Inhibitors of bruton's tyrosine kinase for the treatment of solid tumors
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