MX2017012411A - Co-cristales de un inhibidor de tirosina cinasa de bruton. - Google Patents
Co-cristales de un inhibidor de tirosina cinasa de bruton.Info
- Publication number
- MX2017012411A MX2017012411A MX2017012411A MX2017012411A MX2017012411A MX 2017012411 A MX2017012411 A MX 2017012411A MX 2017012411 A MX2017012411 A MX 2017012411A MX 2017012411 A MX2017012411 A MX 2017012411A MX 2017012411 A MX2017012411 A MX 2017012411A
- Authority
- MX
- Mexico
- Prior art keywords
- crystals
- bruton
- tyrosine kinase
- conditions
- kinase inhibitor
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
- G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
- G01N23/20075—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials by measuring interferences of X-rays, e.g. Borrmann effect
Abstract
La presente invención se refiere a co-cristales de inhibidor de la tirosina cinasa de Bruton (Btk) 1-((R)-3-(4-amino-3-(4-fenoxife nil)-1H-pirazol [3,4-d]pirimidin-1-il)piperidin-1-il)prop-2-en-1-o na, que incluye formas cristalinas, y sales farmacéuticamente aceptables de las mismas. También se describen composiciones farmacéuticas que incluyen los co-cristales, así como métodos de uso de co-cristales, solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o afecciones autoinmunes, enfermedades o afecciones heteroinmunes, incluyendo linfoma y enfermedades o afecciones inflamatorias.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562139599P | 2015-03-27 | 2015-03-27 | |
PCT/US2016/024321 WO2016160604A1 (en) | 2015-03-27 | 2016-03-25 | Co-crystals of a bruton's tyrosine kinase inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017012411A true MX2017012411A (es) | 2018-04-26 |
Family
ID=57006345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017012411A MX2017012411A (es) | 2015-03-27 | 2016-03-25 | Co-cristales de un inhibidor de tirosina cinasa de bruton. |
Country Status (11)
Country | Link |
---|---|
US (3) | US20180072739A1 (es) |
EP (1) | EP3273962A4 (es) |
JP (3) | JP2018509458A (es) |
CN (1) | CN107530347A (es) |
AU (1) | AU2016243122A1 (es) |
BR (1) | BR112017020743A2 (es) |
CA (1) | CA2981046A1 (es) |
HK (2) | HK1248148A1 (es) |
MA (1) | MA41828A (es) |
MX (1) | MX2017012411A (es) |
WO (1) | WO2016160604A1 (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ702548A (en) | 2012-06-04 | 2015-11-27 | Pharmacyclics Llc | Crystalline forms of a bruton’s tyrosine kinase inhibitor |
SG10202102078VA (en) | 2015-03-03 | 2021-04-29 | Pharmacyclics Llc | Pharmaceutical formulations of a bruton’s tyrosine kinase inhibitor |
JP6705833B2 (ja) * | 2015-04-02 | 2020-06-03 | ラティオファルム ゲー・エム・ベー・ハー | イブルチニブとカルボン酸との共結晶 |
US10183024B2 (en) | 2016-12-02 | 2019-01-22 | Apotex Inc. | Crystalline forms of ibrutinib |
WO2019070698A1 (en) | 2017-10-02 | 2019-04-11 | Johnson Matthey Public Limited Company | NEW FORMS OF IBRUTINIB |
CN109776543A (zh) * | 2017-11-14 | 2019-05-21 | 上海医药工业研究院 | 依鲁替尼盐、其晶体、制备方法、药物组合物及应用 |
CZ2017787A3 (cs) | 2017-12-08 | 2019-06-19 | Zentiva, K.S. | Farmaceutické kompozice obsahující ibrutinib |
WO2019195827A1 (en) | 2018-04-06 | 2019-10-10 | Johnson Matthey Public Limited Company | Novel form of ibrutinib |
EP3575300A1 (en) | 2018-05-31 | 2019-12-04 | Apotex Inc. | Novel crystalline forms of ibrutinib |
CN112292117A (zh) | 2018-06-15 | 2021-01-29 | 詹森药业有限公司 | 包含依鲁替尼的配制品/组合物 |
CN115397426B (zh) * | 2020-04-20 | 2024-02-09 | 天津睿创康泰生物技术有限公司 | 伊布替尼葡萄糖酸内酯共晶体及其制备方法 |
EP4196111A1 (en) * | 2020-08-14 | 2023-06-21 | Board of Regents, The University of Texas System | Method of producing pharmaceutical cocrystals for additive manufacturing |
CN114685512B (zh) * | 2020-12-31 | 2022-11-29 | 鲁南制药集团股份有限公司 | 一种伊布替尼-烟酸共晶及其制备方法 |
WO2023242384A1 (en) | 2022-06-17 | 2023-12-21 | Krka, D.D., Novo Mesto | Crystalline form of ibrutinib |
CN115417812B (zh) * | 2022-08-05 | 2024-04-05 | 天津大学 | 一种阿西替尼-烟酰胺共晶及其制备方法和应用 |
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EP1664762A4 (en) | 2003-09-03 | 2008-08-13 | Us Gov Health & Human Serv | METHODS OF IDENTIFICATION, DIAGNOSIS AND PREDICTION FOR LYMPHOMES SURVIVAL |
DK2526933T3 (en) | 2006-09-22 | 2015-05-18 | Pharmacyclics Inc | Inhibitors of Bruton's tyrosine kinase |
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EP2123626A1 (en) * | 2008-05-21 | 2009-11-25 | Laboratorios del Dr. Esteve S.A. | Co-crystals of duloxetine and co-crystal formers for the treatment of pain |
MX2011004759A (es) * | 2011-05-04 | 2012-11-21 | Senosiain S A De C V Lab | Nuevas formas solidas de antibioticos. |
NZ702548A (en) | 2012-06-04 | 2015-11-27 | Pharmacyclics Llc | Crystalline forms of a bruton’s tyrosine kinase inhibitor |
EA027213B9 (ru) * | 2012-09-10 | 2017-09-29 | Принсипиа Биофарма Инк. | Соединения пиразолопиримидина в качестве ингибиторов киназ |
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JP6705833B2 (ja) | 2015-04-02 | 2020-06-03 | ラティオファルム ゲー・エム・ベー・ハー | イブルチニブとカルボン酸との共結晶 |
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2016
- 2016-03-24 MA MA041828A patent/MA41828A/fr unknown
- 2016-03-25 CN CN201680028365.2A patent/CN107530347A/zh active Pending
- 2016-03-25 AU AU2016243122A patent/AU2016243122A1/en not_active Abandoned
- 2016-03-25 WO PCT/US2016/024321 patent/WO2016160604A1/en active Application Filing
- 2016-03-25 MX MX2017012411A patent/MX2017012411A/es unknown
- 2016-03-25 US US15/561,624 patent/US20180072739A1/en not_active Abandoned
- 2016-03-25 BR BR112017020743A patent/BR112017020743A2/pt not_active Application Discontinuation
- 2016-03-25 EP EP16773865.7A patent/EP3273962A4/en not_active Withdrawn
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- 2016-03-25 JP JP2017550542A patent/JP2018509458A/ja active Pending
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2018
- 2018-06-20 HK HK18107890.6A patent/HK1248148A1/zh unknown
- 2018-07-17 HK HK18109250.6A patent/HK1249736A1/zh unknown
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2019
- 2019-03-01 US US16/289,936 patent/US20200031829A1/en not_active Abandoned
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2021
- 2021-01-22 JP JP2021009155A patent/JP2021075540A/ja active Pending
- 2021-09-10 US US17/471,662 patent/US20220242868A1/en not_active Abandoned
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2022
- 2022-07-11 JP JP2022111272A patent/JP2022160433A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
MA41828A (fr) | 2018-01-30 |
US20180072739A1 (en) | 2018-03-15 |
EP3273962A4 (en) | 2018-11-21 |
US20200031829A1 (en) | 2020-01-30 |
CN107530347A (zh) | 2018-01-02 |
CA2981046A1 (en) | 2016-10-06 |
WO2016160604A1 (en) | 2016-10-06 |
AU2016243122A1 (en) | 2017-10-19 |
US20220242868A1 (en) | 2022-08-04 |
JP2021075540A (ja) | 2021-05-20 |
JP2022160433A (ja) | 2022-10-19 |
HK1248148A1 (zh) | 2018-10-12 |
JP2018509458A (ja) | 2018-04-05 |
EP3273962A1 (en) | 2018-01-31 |
HK1249736A1 (zh) | 2018-11-09 |
BR112017020743A2 (pt) | 2018-07-17 |
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