AU3176297A - Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof - Google Patents

Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof

Info

Publication number
AU3176297A
AU3176297A AU31762/97A AU3176297A AU3176297A AU 3176297 A AU3176297 A AU 3176297A AU 31762/97 A AU31762/97 A AU 31762/97A AU 3176297 A AU3176297 A AU 3176297A AU 3176297 A AU3176297 A AU 3176297A
Authority
AU
Australia
Prior art keywords
pyrimidines
pyrrolo
amino
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU31762/97A
Inventor
Eva Altmann
Jurgen Klaus Maibaum
Martin Missbach
Leo Widler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Publication of AU3176297A publication Critical patent/AU3176297A/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
AU31762/97A 1996-06-25 1997-06-16 Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof Abandoned AU3176297A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH159196 1996-06-25
CH1591/96 1996-06-25
PCT/EP1997/003115 WO1997049706A1 (en) 1996-06-25 1997-06-16 SUBSTITUTED 7-AMINO-PYRROLO[3,2-d]PYRIMIDINES AND THE USE THEREOF

Publications (1)

Publication Number Publication Date
AU3176297A true AU3176297A (en) 1998-01-14

Family

ID=4214005

Family Applications (1)

Application Number Title Priority Date Filing Date
AU31762/97A Abandoned AU3176297A (en) 1996-06-25 1997-06-16 Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof

Country Status (2)

Country Link
AU (1) AU3176297A (en)
WO (1) WO1997049706A1 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE267200T1 (en) 1997-10-20 2004-06-15 Hoffmann La Roche BICYCLIC KINASE INHIBITORS
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
PA8474101A1 (en) 1998-06-19 2000-09-29 Pfizer Prod Inc PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS
ID26698A (en) 1998-06-19 2001-02-01 Pfizer Prod Inc PIROLO COMPOUNDS [2,3-d] PYRIMIDINE
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US7071199B1 (en) * 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
EP1382339B1 (en) 1999-12-10 2007-12-05 Pfizer Products Inc. Compositions containing pyrrolo ¬2,3-d pyrimidine derivatives
WO2001072751A1 (en) * 2000-03-29 2001-10-04 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
NZ522364A (en) 2000-06-26 2004-09-24 Pfizer Prod Inc Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
US6515013B2 (en) 2000-07-13 2003-02-04 Abbott Laboratories 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic applications
DK1301480T3 (en) * 2000-07-13 2008-01-21 Abbott Lab 1,3-disubstituted and 1,3,3-trisubstituted pyrrolidines as histamine-3 receptor ligands and their therapeutic use
AR035885A1 (en) 2001-05-14 2004-07-21 Novartis Ag DERIVATIVES OF 4-AMINO-5-FENIL-7-CYCLLOBUTILPIRROLO (2,3-D) PYRIMIDINE, A PROCESS FOR ITS PREPARATION, A PHARMACEUTICAL COMPOSITION AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
CA2810339A1 (en) 2001-08-10 2003-02-20 Novartis Ag Use of c-src inhibitors alone or in combination with sti571 for the treatment of leukaemia
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
ES2201899B1 (en) * 2002-04-01 2005-06-01 Almirall Prodesfarma, S.A. DERIVATIVES OF AZAINDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
CA2494421A1 (en) 2002-08-06 2004-02-12 Astrazeneca Ab Condensed pyridines and pyrimidines with tie2 (tek) activity
BR0316487A (en) 2002-11-26 2005-10-11 Pfizer Prod Inc Whole method of treating transplant rejection
US8293751B2 (en) 2003-01-14 2012-10-23 Arena Pharmaceuticals, Inc. 1,2,3-trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia
NZ544200A (en) 2003-07-14 2009-07-31 Arena Pharm Inc Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
TW200509938A (en) * 2003-08-26 2005-03-16 Teijin Pharma Ltd Pyrrolopyrimidine thion derivatives
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
US8809273B2 (en) 2007-03-28 2014-08-19 Pharmacyclics, Inc. Inhibitors of Bruton's tyrosine kinase
CN101674834B (en) * 2007-03-28 2013-06-12 环状药物公司 Inhibitors of bruton's tyrosine kinase
UA103195C2 (en) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
JP4884570B2 (en) 2008-08-20 2012-02-29 ファイザー・インク Pyrrolo [2,3-d] pyrimidine compound
KR20120093867A (en) 2009-09-10 2012-08-23 아이알엠 엘엘씨 Ether derivatives of bicyclic heteroaryls
KR101483215B1 (en) 2010-01-29 2015-01-16 한미약품 주식회사 Bicyclic heteroaryl derivatives having inhibitory activity for protein kinases
WO2011146313A1 (en) 2010-05-19 2011-11-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
NZ772688A (en) 2010-06-03 2022-09-30 Pharmacyclics Llc The use of inhibitors of bruton’s tyrosine kinase (btk)
WO2011157793A1 (en) 2010-06-17 2011-12-22 Novartis Ag Piperidinyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
EP2582680A1 (en) 2010-06-17 2013-04-24 Novartis AG Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
CA2812061A1 (en) 2010-09-22 2012-03-29 Arena Pharmaceuticals, Inc. Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012093809A2 (en) * 2011-01-03 2012-07-12 Hanmi Pharm Co., Ltd. New bicyclic compound for modulating g protein-coupled receptors
CN103492390A (en) 2011-03-08 2014-01-01 诺瓦提斯公司 Fluorophenyl bicyclic heteroaryl compounds
BR112013023050A8 (en) 2011-03-09 2018-09-25 G Pestell Richard ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or at risk of metastasis, to identify a ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or under risk of developing metastasis, to identify a candidate compound, to produce in vitro primary epithelial cells, to diagnose prostate cancer, to select a treatment for an individual having a prostate cancer / tumor, cell line, and, animal model
CA2831843A1 (en) * 2011-04-04 2012-10-11 Pharmascience Inc. Protein kinase inhibitors
CA2760174A1 (en) * 2011-12-01 2013-06-01 Pharmascience Inc. Protein kinase inhibitors and uses thereof
AU2012283775A1 (en) 2011-07-13 2014-01-23 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
WO2013014052A1 (en) 2011-07-22 2013-01-31 Glaxosmithkline Llc Composition
AU2012318896B2 (en) * 2011-10-03 2017-03-02 The University Of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for the treatment of cancer
US8377946B1 (en) 2011-12-30 2013-02-19 Pharmacyclics, Inc. Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
WO2013173312A1 (en) 2012-05-14 2013-11-21 Pestell Richard G Using modulators of ccr5 for treating cancer
AU2013266438B2 (en) 2012-05-22 2017-09-07 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
NZ702548A (en) 2012-06-04 2015-11-27 Pharmacyclics Llc Crystalline forms of a bruton’s tyrosine kinase inhibitor
KR20180088926A (en) 2012-07-24 2018-08-07 파마싸이클릭스 엘엘씨 Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk)
UA114109C2 (en) 2012-08-24 2017-04-25 PYRAZOLOPYRIMIDINE COMPOUNDS
WO2014062774A1 (en) 2012-10-17 2014-04-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
JP2015537033A (en) 2012-11-15 2015-12-24 ファーマサイクリックス,インク. Pyrrolopyrimidine compounds as kinase inhibitors
PT2922549T (en) 2012-11-20 2017-09-01 Glaxosmithkline Llc Novel compounds
ES2625023T3 (en) * 2012-11-20 2017-07-18 Glaxosmithkline Llc Novel compounds
EP2922550B1 (en) * 2012-11-20 2017-04-19 Glaxosmithkline LLC Novel compounds
EP2925752A4 (en) 2012-11-27 2016-06-01 Univ North Carolina Pyrimidine compounds for the treatment of cancer
AU2014324532A1 (en) 2013-09-30 2016-04-21 Pharmacyclics Llc Inhibitors of Bruton's tyrosine kinase
CA2922058A1 (en) * 2013-10-18 2015-04-23 Medivation Technologies, Inc. Heterocyclic compounds and methods of use
CA2833701A1 (en) * 2013-11-19 2015-05-19 Pharmascience Inc. Protein kinase inhibitors
CA2942528A1 (en) 2014-03-20 2015-09-24 Pharmacyclics Inc. Phospholipase c gamma 2 and resistance associated mutations
EP3129379A4 (en) 2014-04-11 2017-09-13 The University of North Carolina at Chapel Hill Mertk-specific pyrrolopyrimidine compounds
US11920164B2 (en) 2014-07-30 2024-03-05 Yeda Research And Development Co. Ltd. Media for culturing naive human pluripotent stem cells
BR112017002231A2 (en) 2014-08-07 2018-07-17 Pharmacyclics Llc new formulations of a bruton tyrosine kinase inhibitor
MX2021011472A (en) 2015-01-06 2022-08-17 Arena Pharm Inc Methods of treating conditions related to the s1p1 receptor.
SG10202102078VA (en) 2015-03-03 2021-04-29 Pharmacyclics Llc Pharmaceutical formulations of a bruton’s tyrosine kinase inhibitor
MA42807A (en) 2015-06-22 2018-07-25 Arena Pharm Inc SALT L-ARGININE CRYSTALLINE ACID (R) -2- (7- (4-CYCLOPENTYL-3- (TRIFLUOROMETHYL) BENZYLOXY) -1,2,3,4-TETRAHYDROCYCLO-PENTA [B] INDOL-3-YL) ACETIC (COMPOUND 1) FOR USE IN CONDITIONS ASSOCIATED WITH THE S1P1 RECEIVER
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
CN112585147B (en) * 2017-10-13 2023-12-05 帝国理工学院创新有限公司 MAP4K4 inhibitors
EP3730483B1 (en) 2017-12-21 2023-08-30 Hefei Institutes of Physical Science, Chinese Academy of Sciences Class of pyrimidine derivative kinase inhibitors
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
GB201819839D0 (en) * 2018-12-05 2019-01-23 Imperial Innovations Ltd MAP4K4 inhibitors
EP3914698A1 (en) 2019-01-23 2021-12-01 Yeda Research and Development Co. Ltd Culture media for pluripotent stem cells
US20220395553A1 (en) 2019-11-14 2022-12-15 Cohbar, Inc. Cxcr4 antagonist peptides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1046731C (en) * 1994-09-29 1999-11-24 诺瓦蒂斯有限公司 Pyrrolo [2,3-d] pyrimidines and their use
JP3290666B2 (en) * 1995-06-07 2002-06-10 ファイザー・インコーポレーテッド Heterocyclic fused-ring pyrimidine derivatives

Also Published As

Publication number Publication date
WO1997049706A1 (en) 1997-12-31

Similar Documents

Publication Publication Date Title
AU3176297A (en) Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof
AU694696B2 (en) Sulfonamides and their use
AU1794697A (en) 7-alkyl-pyrrolo{2,3-d}pyrimidines
AU5752398A (en) Novel ketobenzamides and their use
AU4239896A (en) Dihydropyrimidines and uses thereof
AU3008297A (en) Dihydropyrimidines and uses thereof
EP1032377A4 (en) Substituted 2-aminoacetamides and the use thereof
AU1559897A (en) Bumper, and the fabrication thereof
AU2440997A (en) Calixpyrroles, calixpyridinopyrroles and calixpyridines
AU9284698A (en) Bumper, and the fabrication thereof
ZA964710B (en) Novel compounds, the preparation and use thereof.
AU1378500A (en) Novel pyrimidines, the production thereof and their use
AU6636598A (en) Novel 3,4-dialkoxyphenyl derivatives and the use thereof
AU1416195A (en) Substituted 1,2,3,4-tetrahydro-5-nitro pyrimidines
AU2894297A (en) 2,4-diaminopyrimidine derivatives
AU1441195A (en) Phenylmethyl hexanamides, and the use thereof
AU7495796A (en) Novel oligopeptides, the preparation and use thereof
HUP9600730A1 (en) 1,4-tetrazolinone-derivatives and use thereof as herbicides
AU6872896A (en) 4,4-difluoro-3-butenylester derivatives or 4,4-difluoro-3-halogen-3-butenylester derivatives and the use thereof as pesticides
AU5557698A (en) Novel calpaines, their preparation and use
AU8095598A (en) Hair-drier or the like
AU5646394A (en) Hinge arrangements, their construction and use
AU2766197A (en) Substituted phenyluracils and their use as herbicides
AU4619297A (en) Ptx sensitive g proteins, the production and use thereof
AU4506499A (en) Novel 2,4-diaminophenol derivatives and the use thereof