DK2270150T3 - Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. - Google Patents
Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. Download PDFInfo
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- DK2270150T3 DK2270150T3 DK10180043.1T DK10180043T DK2270150T3 DK 2270150 T3 DK2270150 T3 DK 2270150T3 DK 10180043 T DK10180043 T DK 10180043T DK 2270150 T3 DK2270150 T3 DK 2270150T3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
- C07K16/3084—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated gangliosides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
Claims (7)
1. Fremgangsmåde til at kontrollere den antistof-afhængige cellulære cytotoxicitet (ADCC) af et IgG-antistofmolekyle, fremgangsmåden omfattende at regulere tilstedeværelsen eller fraværet af binding af fucose til /V-acetylglucosaminen af den reducerende terminus (1) af en biantennær kompleks-type N-glycosidbundet sukkerkæde ved at deletere et gen, der koder for en a-l,6-fucosyltransferase i en værtscelle, ikke-menneskelig dyre eller plante, eller ved at addere en mutation til genet for at reducere eller eliminere enzymaktiviteten i en værtscelle, ikke-menneskelig dyre eller plante, hvor sukkerkæden binder til antistoffet og hovedsageligt har den følgende struktur:
(l) hvor reguleringen omfatter at binde en sukkerkæde, hvor fucose ikke er bundet til N-acetylglucosaminen af den reducerende terminus af en kompleks-type N-glycosidbundet sukkerkæde til antistofmolekylet, for derved at aktivere ADCC af antistofmolekylet.
2. Fremgangsmåde ifølge krav 1, hvor antistofmolekylet er et humant antistof, et humaniseret antistof, et humant kimærisk antistof eller et humant CDR-grafted antistof.
3. Fremgangsmåde til fremstilling af et IgG-antistofmolekyle, fremgangsmåden omfattende at regulere tilstedeværelsen eller fraværet af binding af fucose til N-acetylglucosaminen af den reducerende terminus (1) af en biantennær kompleks-type N-glycosidbundet sukkerkæde, ved at deletere et gen, der koder for en a-1,6-fucosyltransferase i en værtscelle, ikke-menneskelig dyre eller plante, eller ved at addere en mutation til genet for at reducere eller eliminere enzymaktiviteten i en værtscelle, ikke-menneskelig dyre eller plante, hvor sukkerkæden binder til antistoffet og hovedsageligt har den følgende struktur:
(l)
4. Fremgangsmåde ifølge et hvilket som helst af de foregående krav, yderligere omfattende at tilvejebringe antistofmolekylet.
5. Flumaniseret IgG-antistofmolekyle, der kan tilvejebringes ved fremgangsmåden ifølge et hvilket som helst af krav 1-4, fremgangsmåden omfattende at regulere tilstedeværelsen eller fraværet af binding af fucose til N-acetylglucosaminen af den reducerende terminus (1) af en biantennær kompleks-type N-glycosidbundet sukkerkæde, ved at deletere et gen, der koder for en a-l,6-fucosyltransferase i værtscellen, ikke-menneskelig dyre eller plante, eller ved at addere en mutation til genet for at eliminere enzymaktiviteten i værtscellen, ikke-menneskelig dyre eller plante, hvor sukkerkæden binder til antistoffet og hovedsageligt har den følgende struktur:
(l)
6. Lægemiddel omfattende IgG-antistofmolekylet ifølge krav 5.
7. IgG-antistofmolekyle ifølge krav 5 til anvendelse i diagnosticering, forebyggelse eller behandling af en cancer, en allergi, en cardiovaskulær sygdom, en viral infektion eller en bakteriel infektion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10315899 | 1999-04-09 | ||
EP00915403.0A EP1176195B1 (en) | 1999-04-09 | 2000-04-07 | Method for controlling the activity of immunologically functional molecule |
Publications (2)
Publication Number | Publication Date |
---|---|
DK2270150T3 true DK2270150T3 (da) | 2016-06-20 |
DK2270150T4 DK2270150T4 (da) | 2019-08-26 |
Family
ID=14346708
Family Applications (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10180041.5T DK2270149T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK10181015.8T DK2275541T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK10180036.5T DK2278003T4 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til regulering af aktiviteten af et immunologisk funktionelt molekyle |
DK10180034.0T DK2270147T4 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
DK10180045.6T DK2275540T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK08002266.8T DK1914244T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at modulere aktiviteten af funktionelle immunmolekyler. |
DK10180043.1T DK2270150T4 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK00915403.0T DK1176195T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
Family Applications Before (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10180041.5T DK2270149T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK10181015.8T DK2275541T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK10180036.5T DK2278003T4 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til regulering af aktiviteten af et immunologisk funktionelt molekyle |
DK10180034.0T DK2270147T4 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
DK10180045.6T DK2275540T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle. |
DK08002266.8T DK1914244T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at modulere aktiviteten af funktionelle immunmolekyler. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00915403.0T DK1176195T3 (da) | 1999-04-09 | 2000-04-07 | Fremgangsmåde til at kontrollere aktiviteten af immunologisk funktionelt molekyle |
Country Status (14)
Country | Link |
---|---|
US (15) | US7214775B2 (da) |
EP (11) | EP3031917A1 (da) |
JP (3) | JP4368530B2 (da) |
AU (1) | AU3672800A (da) |
BE (1) | BE2018C020I2 (da) |
CA (2) | CA2704600C (da) |
CY (4) | CY1114164T1 (da) |
DK (8) | DK2270149T3 (da) |
ES (9) | ES2568899T3 (da) |
FR (1) | FR18C1021I2 (da) |
LU (1) | LUC00074I2 (da) |
NL (1) | NL300939I2 (da) |
PT (2) | PT1914244E (da) |
WO (1) | WO2000061739A1 (da) |
Families Citing this family (1610)
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