JOP20190134A1 - بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها - Google Patents
بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامهاInfo
- Publication number
- JOP20190134A1 JOP20190134A1 JOP/2019/0134A JOP20190134A JOP20190134A1 JO P20190134 A1 JOP20190134 A1 JO P20190134A1 JO P20190134 A JOP20190134 A JO P20190134A JO P20190134 A1 JOP20190134 A1 JO P20190134A1
- Authority
- JO
- Jordan
- Prior art keywords
- methods
- antigen
- binding proteins
- neuropilin
- abps
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
يتعلق الاختراع الحالي بتوفير في الطلب الحالي بروتينات رابطة لمولد الضد (ABPs) ترتبط انتقائياً بـ NRP-1 وصوره المتماثلة ونظائره، وتركيبات تشتمل على ABPs. ويتم أيضا تقديم طرق لاستخدام ABPs، مثل الطرق العلاجية والتشخيصية.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662438733P | 2016-12-23 | 2016-12-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
JOP20190134A1 true JOP20190134A1 (ar) | 2019-06-02 |
Family
ID=61025050
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2019/0134A JOP20190134A1 (ar) | 2016-12-23 | 2017-06-16 | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
Country Status (21)
Country | Link |
---|---|
US (3) | US10227413B2 (ar) |
EP (1) | EP3558365B1 (ar) |
JP (1) | JP2020511947A (ar) |
KR (1) | KR20190099254A (ar) |
CN (1) | CN110167590A (ar) |
AR (1) | AR110659A1 (ar) |
AU (1) | AU2017379062A1 (ar) |
BR (1) | BR112019012796A2 (ar) |
CA (1) | CA3046313A1 (ar) |
CO (1) | CO2019007846A2 (ar) |
EA (1) | EA201991546A1 (ar) |
ES (1) | ES2963746T3 (ar) |
IL (1) | IL267097A (ar) |
JO (1) | JOP20190134A1 (ar) |
MA (1) | MA47113A (ar) |
MX (1) | MX2019007554A (ar) |
PH (1) | PH12019501405A1 (ar) |
SG (1) | SG10201913855TA (ar) |
TW (1) | TWI797100B (ar) |
WO (1) | WO2018119171A1 (ar) |
ZA (1) | ZA202003695B (ar) |
Families Citing this family (10)
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JOP20190134A1 (ar) * | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
CA3221995A1 (en) | 2017-02-08 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
EP4273258A3 (en) | 2017-02-20 | 2024-01-17 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
MX2020008336A (es) | 2018-02-08 | 2020-09-21 | Dragonfly Therapeutics Inc | Dominios variables de anticuerpos que se dirigen al receptor nkg2d. |
EA202091888A1 (ru) * | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
WO2020109627A1 (en) * | 2018-11-30 | 2020-06-04 | Institut Gustave Roussy | Anti-neuropilin-1 and anti-programmed cell death-1 combination therapy for treating cancer |
EP3906415A1 (en) * | 2019-01-03 | 2021-11-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
TW202126685A (zh) * | 2019-09-24 | 2021-07-16 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
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US20240068004A1 (en) * | 2022-08-15 | 2024-02-29 | Mbrace Therapeutics, Inc. | Cell-free methods of producing antibodies to intracellular targets |
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JOP20190134A1 (ar) * | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
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2017
- 2017-06-16 JO JOP/2019/0134A patent/JOP20190134A1/ar unknown
- 2017-12-21 ES ES17835532T patent/ES2963746T3/es active Active
- 2017-12-21 MA MA047113A patent/MA47113A/fr unknown
- 2017-12-21 CA CA3046313A patent/CA3046313A1/en active Pending
- 2017-12-21 BR BR112019012796A patent/BR112019012796A2/pt unknown
- 2017-12-21 SG SG10201913855TA patent/SG10201913855TA/en unknown
- 2017-12-21 AU AU2017379062A patent/AU2017379062A1/en active Pending
- 2017-12-21 AR ARP170103623A patent/AR110659A1/es unknown
- 2017-12-21 MX MX2019007554A patent/MX2019007554A/es unknown
- 2017-12-21 TW TW106145004A patent/TWI797100B/zh active
- 2017-12-21 KR KR1020197020999A patent/KR20190099254A/ko not_active Application Discontinuation
- 2017-12-21 EP EP17835532.7A patent/EP3558365B1/en active Active
- 2017-12-21 CN CN201780079177.7A patent/CN110167590A/zh active Pending
- 2017-12-21 WO PCT/US2017/067782 patent/WO2018119171A1/en unknown
- 2017-12-21 JP JP2019533631A patent/JP2020511947A/ja active Pending
- 2017-12-21 EA EA201991546A patent/EA201991546A1/ru unknown
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2018
- 2018-02-20 US US15/900,158 patent/US10227413B2/en active Active
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2019
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2020
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AR110659A1 (es) | 2019-04-17 |
AU2017379062A1 (en) | 2019-06-20 |
BR112019012796A2 (pt) | 2019-12-03 |
ES2963746T3 (es) | 2024-04-01 |
CA3046313A1 (en) | 2018-06-28 |
EA201991546A1 (ru) | 2020-01-17 |
US10227413B2 (en) | 2019-03-12 |
PH12019501405A1 (en) | 2019-10-28 |
MX2019007554A (es) | 2019-11-18 |
CO2019007846A2 (es) | 2019-08-20 |
WO2018119171A1 (en) | 2018-06-28 |
EP3558365A1 (en) | 2019-10-30 |
MA47113A (fr) | 2019-10-30 |
US11186644B2 (en) | 2021-11-30 |
SG10201913855TA (en) | 2020-03-30 |
US20220098312A1 (en) | 2022-03-31 |
JP2020511947A (ja) | 2020-04-23 |
US20190119389A1 (en) | 2019-04-25 |
EP3558365B1 (en) | 2023-09-13 |
TWI797100B (zh) | 2023-04-01 |
KR20190099254A (ko) | 2019-08-26 |
CN110167590A (zh) | 2019-08-23 |
IL267097A (en) | 2019-08-29 |
US20180186886A1 (en) | 2018-07-05 |
TW201829466A (zh) | 2018-08-16 |
ZA202003695B (en) | 2023-01-25 |
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