BR112015032414A2 - agente terapêutico compreendendo anticorpo antiepirregulina humanizado como ingrediente ativo para carcinoma de pulmão de célula não pequena excluindo adenocarcinoma - Google Patents
agente terapêutico compreendendo anticorpo antiepirregulina humanizado como ingrediente ativo para carcinoma de pulmão de célula não pequena excluindo adenocarcinomaInfo
- Publication number
- BR112015032414A2 BR112015032414A2 BR112015032414A BR112015032414A BR112015032414A2 BR 112015032414 A2 BR112015032414 A2 BR 112015032414A2 BR 112015032414 A BR112015032414 A BR 112015032414A BR 112015032414 A BR112015032414 A BR 112015032414A BR 112015032414 A2 BR112015032414 A2 BR 112015032414A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- pyrregulin
- antiepyrregulin
- humanized
- active ingredient
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3023—Lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Abstract
a presente invenção refere-se a agentes terapêuticos para câncer de pulmão de célula não pequena exceto adenocarcinoma compreendendo como ingrediente ativo um anticorpo antiepirregulina que mostra reatividade entre espécies cruzada entre o animal humano e cinomolgo que é um animal não humano, um anticorpo antiepirregulina com degradação química suprimida, um anticorpo antiepirregulina com ponto isoelétrico reduzido, um anticorpo antiepirregulina com temperatura de ponto média aumentada de desnaturação térmica ou um anticorpo antiepirregulina com quantidade reduzida de agregados, gerado substituindo apropriadamente resíduos de aminoácido nas sequências de região variável de um anticorpo ep27 humanizado que inibe proliferação de célula de câncer através do exercício de uma cito-toxicidade e uma atividade de neutralização contra células de câncer expressando epirregulina humana.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013131249 | 2013-06-24 | ||
PCT/JP2014/066512 WO2014208482A1 (ja) | 2013-06-24 | 2014-06-23 | ヒト化抗Epiregulin抗体を有効成分として含む腺癌以外の非小細胞肺癌の治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015032414A2 true BR112015032414A2 (pt) | 2017-11-07 |
Family
ID=52141818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015032414A BR112015032414A2 (pt) | 2013-06-24 | 2014-06-23 | agente terapêutico compreendendo anticorpo antiepirregulina humanizado como ingrediente ativo para carcinoma de pulmão de célula não pequena excluindo adenocarcinoma |
Country Status (13)
Country | Link |
---|---|
US (1) | US20160159919A1 (pt) |
EP (1) | EP3015115A4 (pt) |
JP (1) | JPWO2014208482A1 (pt) |
KR (1) | KR20160022354A (pt) |
CN (1) | CN105517571A (pt) |
AU (1) | AU2014299916A1 (pt) |
BR (1) | BR112015032414A2 (pt) |
CA (1) | CA2916362A1 (pt) |
HK (1) | HK1223567A1 (pt) |
MX (1) | MX2015017852A (pt) |
RU (1) | RU2016101716A (pt) |
TW (1) | TW201542591A (pt) |
WO (1) | WO2014208482A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120141501A1 (en) | 2009-05-29 | 2012-06-07 | Forerunner Pharma Research Co. Ltd | Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component |
TWI593705B (zh) | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
WO2017072310A1 (en) * | 2015-10-30 | 2017-05-04 | Medimmune Limited | Prevention of n-terminal truncation in igg light chains |
TW201834688A (zh) | 2017-02-24 | 2018-10-01 | 日商中外製藥股份有限公司 | 藥學組成物、抗原結合分子、治療方法以及篩選方法 |
US11667713B2 (en) | 2017-12-28 | 2023-06-06 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
CN111072772B (zh) * | 2019-12-31 | 2023-08-04 | 上海良润生物医药科技有限公司 | 一种肽标签及其在检测或纯化融合蛋白质的应用 |
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AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
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CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
US20030003097A1 (en) | 2001-04-02 | 2003-01-02 | Idec Pharmaceutical Corporation | Recombinant antibodies coexpressed with GnTIII |
US20050171339A1 (en) | 2001-12-28 | 2005-08-04 | Izumi Sugo | Method of stabilizing protein |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
EP1514928B1 (en) | 2002-06-05 | 2013-07-31 | Chugai Seiyaku Kabushiki Kaisha | Method for producing antibodies using baculoviruses |
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EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
JP5687822B2 (ja) * | 2006-10-12 | 2015-03-25 | 中外製薬株式会社 | 抗ereg抗体を用いる癌の診断および治療 |
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GB0909904D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Product |
GB0909906D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
EP2626414B1 (en) | 2010-10-06 | 2020-07-15 | Chugai Seiyaku Kabushiki Kaisha | Cancer stem cell mass and process for production thereof |
JP5997151B2 (ja) * | 2011-06-30 | 2016-09-28 | 中外製薬株式会社 | ヘテロ二量化ポリペプチド |
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TWI593705B (zh) * | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
US10766960B2 (en) * | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
-
2014
- 2014-06-23 KR KR1020167001353A patent/KR20160022354A/ko not_active Application Discontinuation
- 2014-06-23 WO PCT/JP2014/066512 patent/WO2014208482A1/ja active Application Filing
- 2014-06-23 US US14/900,928 patent/US20160159919A1/en not_active Abandoned
- 2014-06-23 TW TW103121504A patent/TW201542591A/zh unknown
- 2014-06-23 JP JP2015524031A patent/JPWO2014208482A1/ja active Pending
- 2014-06-23 BR BR112015032414A patent/BR112015032414A2/pt not_active Application Discontinuation
- 2014-06-23 EP EP14818552.3A patent/EP3015115A4/en not_active Withdrawn
- 2014-06-23 MX MX2015017852A patent/MX2015017852A/es unknown
- 2014-06-23 AU AU2014299916A patent/AU2014299916A1/en not_active Abandoned
- 2014-06-23 CN CN201480046749.8A patent/CN105517571A/zh active Pending
- 2014-06-23 CA CA2916362A patent/CA2916362A1/en not_active Abandoned
- 2014-06-23 RU RU2016101716A patent/RU2016101716A/ru not_active Application Discontinuation
-
2016
- 2016-10-18 HK HK16111984.7A patent/HK1223567A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
KR20160022354A (ko) | 2016-02-29 |
RU2016101716A (ru) | 2017-07-27 |
TW201542591A (zh) | 2015-11-16 |
CN105517571A (zh) | 2016-04-20 |
US20160159919A1 (en) | 2016-06-09 |
EP3015115A1 (en) | 2016-05-04 |
EP3015115A4 (en) | 2017-02-22 |
AU2014299916A1 (en) | 2015-12-24 |
HK1223567A1 (zh) | 2017-08-04 |
CA2916362A1 (en) | 2014-12-31 |
JPWO2014208482A1 (ja) | 2017-02-23 |
WO2014208482A1 (ja) | 2014-12-31 |
MX2015017852A (es) | 2016-08-11 |
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