EA201892619A1 - Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 - Google Patents

Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2

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Publication number
EA201892619A1
EA201892619A1 EA201892619A EA201892619A EA201892619A1 EA 201892619 A1 EA201892619 A1 EA 201892619A1 EA 201892619 A EA201892619 A EA 201892619A EA 201892619 A EA201892619 A EA 201892619A EA 201892619 A1 EA201892619 A1 EA 201892619A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mutant
polypeptide
affinity
immunoconjugate
polypetips
Prior art date
Application number
EA201892619A
Other languages
English (en)
Inventor
Оливер Аст
Петер Брюнкер
Анне Фраймозер-Грундшобер
Зильвия Хертер
Томас У. Хофер
Ральф Хоссе
Кристиан Клайн
Эккехард Мёсснер
Валерия Г. Николини
Пабло Умана
Original Assignee
Роше Гликарт Аг
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46022216&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201892619(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Роше Гликарт Аг filed Critical Роше Гликарт Аг
Publication of EA201892619A1 publication Critical patent/EA201892619A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor

Abstract

В заявке описан иммуноконъюгат, содержащий мутантный полипептид интерлейкина-2 (IL-2) с тремя аминокислотными мутациями, соответствующими аминокислотным заменам F42A, Y45A и L72G в последовательности человеческого IL-2 (SEQ ID NO:1), где указанные мутации аннулируют или снижают аффинность мутантного полипептида IL-2 к высокоаффинному рецептору IL-2 и сохраняют аффинность мутантного полипептида IL-2 к рецептору IL-2 с промежуточной аффинностью по сравнению с полипептидом IL-2 дикого типа. Кроме того, в заявке описаны выделенный полинуклеотид, кодирующий, указанный иммуноконъюгат, эксперессионный вектор и клетки-хозяева, содержащие этот выделенный полинуклеотид. В ней также раскрыты способ получения иммуноконъюгата, содержащие его фармацевтические композиции, способы лечения рака и стимуляции иммунной системы, в которых применяются эти композиции.
EA201892619A 2011-04-29 2012-02-07 Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 EA201892619A1 (ru)

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