GB9603256D0 - Antibodies - Google Patents

Antibodies

Info

Publication number
GB9603256D0
GB9603256D0 GBGB9603256.0A GB9603256A GB9603256D0 GB 9603256 D0 GB9603256 D0 GB 9603256D0 GB 9603256 A GB9603256 A GB 9603256A GB 9603256 D0 GB9603256 D0 GB 9603256D0
Authority
GB
United Kingdom
Prior art keywords
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GBGB9603256.0A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GBGB9603256.0A priority Critical patent/GB9603256D0/en
Publication of GB9603256D0 publication Critical patent/GB9603256D0/en
Priority to PCT/GB1997/000423 priority patent/WO1997030087A1/en
Pending legal-status Critical Current

Links

GBGB9603256.0A 1996-02-16 1996-02-16 Antibodies Pending GB9603256D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB9603256.0A GB9603256D0 (en) 1996-02-16 1996-02-16 Antibodies
PCT/GB1997/000423 WO1997030087A1 (en) 1996-02-16 1997-02-14 Preparation of glycosylated antibodies

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9603256.0A GB9603256D0 (en) 1996-02-16 1996-02-16 Antibodies

Publications (1)

Publication Number Publication Date
GB9603256D0 true GB9603256D0 (en) 1996-04-17

Family

ID=10788859

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9603256.0A Pending GB9603256D0 (en) 1996-02-16 1996-02-16 Antibodies

Country Status (2)

Country Link
GB (1) GB9603256D0 (en)
WO (1) WO1997030087A1 (en)

Families Citing this family (651)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU759779B2 (en) * 1997-10-31 2003-05-01 Genentech Inc. Methods and compositions comprising glycoprotein glycoforms
EP2180007B2 (en) * 1998-04-20 2017-08-30 Roche Glycart AG Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
EP2264166B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
US7449308B2 (en) 2000-06-28 2008-11-11 Glycofi, Inc. Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
NZ581474A (en) 2001-08-03 2011-04-29 Glycart Biotechnology Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
US7691810B2 (en) 2003-10-09 2010-04-06 Kyowa Hakko Kirin Co., Ltd Method of producing recombinant antithrombin III composition
DK1716181T3 (en) 2004-02-19 2010-03-01 Genentech Inc CDR repaired antibodies
MXPA06014069A (en) 2004-06-04 2007-04-25 Genentech Inc Method for treating multiple sclerosis.
RU2411956C2 (en) 2004-10-05 2011-02-20 Дженентек, Инк. Method of treating vasculitis
JO3000B1 (en) 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
JP2008528486A (en) 2005-01-21 2008-07-31 ジェネンテック・インコーポレーテッド Fixed dose of HER antibody
ZA200707078B (en) 2005-02-23 2008-11-26 Genentech Inc Extending time to disease progression or survival in cancer patients
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
KR101453570B1 (en) 2005-12-02 2014-10-22 제넨테크, 인크. Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r
CA2638785C (en) 2006-01-05 2017-02-21 Genentech, Inc. Anti-ephb4 antibodies and methods using same
AR059851A1 (en) 2006-03-16 2008-04-30 Genentech Inc ANTIBODIES OF EGFL7 AND METHODS OF USE
MX2008015132A (en) 2006-05-30 2008-12-10 Genentech Inc Antibodies and immunoconjugates and uses therefor.
KR20090027227A (en) 2006-06-06 2009-03-16 제넨테크, 인크. Anti-dll4 antibodies and methods using same
EP2046809B1 (en) 2006-07-19 2016-12-07 The Trustees Of The University Of Pennsylvania Wsx-1/il-27 as a target for anti-inflammatory responses
RS53861B1 (en) * 2006-09-10 2015-08-31 Glycotope Gmbh Use of human cells of myeloid leukaemia origin for expression of antibodies
LT2845866T (en) 2006-10-27 2017-07-10 Genentech, Inc. Antibodies and immunoconjugates and uses therefor
PL1920781T3 (en) 2006-11-10 2015-06-30 Glycotope Gmbh Compositions comprising a core-1 positive microorganism and their use for the treatment or prophylaxis of tumors
BRPI0806403A2 (en) 2007-02-09 2011-09-06 Genentech Inc anti-robo4 antibody, use an antibody and imaging method
PL2132573T3 (en) 2007-03-02 2014-09-30 Genentech Inc Predicting response to a her dimerisation inhbitor based on low her3 expression
ES2417148T3 (en) 2007-06-08 2013-08-06 Genentech, Inc. Gene expression markers of tumor resistance to HER2 inhibitor treatment
KR101922788B1 (en) 2007-09-26 2018-11-27 추가이 세이야쿠 가부시키가이샤 Modified antibody constant region
PT2514436T (en) 2007-11-07 2018-03-21 Genentech Inc Il-22 for use in treating microbial disorders
AR069501A1 (en) 2007-11-30 2010-01-27 Genentech Inc ANTI-VEGF ANTIBODIES (VASCULAR ENDOTELIAL GROWTH FACTOR)
TWI472339B (en) 2008-01-30 2015-02-11 Genentech Inc Composition comprising antibody that binds to domain ii of her2 and acidic variants thereof
TW201438738A (en) 2008-09-16 2014-10-16 Genentech Inc Methods for treating progressive multiple sclerosis
SG10201605250SA (en) 2008-10-14 2016-08-30 Genentech Inc Immunoglobulin variants and uses thereof
DK2752189T3 (en) 2008-11-22 2017-01-16 Hoffmann La Roche APPLICATION OF ANTI-VEGF ANTIBODY IN COMBINATION WITH CHEMOTHERY TO TREAT CANCER CANCER
WO2010075249A2 (en) 2008-12-22 2010-07-01 Genentech, Inc. A method for treating rheumatoid arthritis with b-cell antagonists
CN102264759B (en) 2008-12-23 2016-05-11 弗·哈夫曼-拉罗切有限公司 Immunoglobulin variants with the Binding change of albumin A
US8597652B2 (en) 2009-03-20 2013-12-03 Genentech, Inc. Multispecific anti-HER antibodies
BRPI1006270B1 (en) 2009-03-25 2022-08-16 Genentech, Inc ANTI-A5SS1 ANTIBODY, IMMUNOCONJUGATE, PHARMACEUTICAL COMPOSITION, IN VITRO OR EX VIVO METHOD TO DETECT A5SS1 PROTEIN, USE OF AN ANTIBODY AND KIT TO DETECT A5SS1 PROTEIN
HRP20221471T1 (en) 2009-03-25 2023-02-03 Genentech, Inc. Anti-fgfr3 antibodies and methods using same
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
WO2011014457A1 (en) 2009-07-27 2011-02-03 Genentech, Inc. Combination treatments
US20110027275A1 (en) 2009-07-31 2011-02-03 Napoleone Ferrara Inhibition of tumor metastasis
AR077848A1 (en) 2009-08-15 2011-09-28 Genentech Inc ANTI-ANGIOGENESIS THERAPY FOR THE TREATMENT OF BREAST CANCER PREVIOUSLY TREATED
WO2011028950A1 (en) 2009-09-02 2011-03-10 Genentech, Inc. Mutant smoothened and methods of using the same
JP5814925B2 (en) 2009-10-22 2015-11-17 ジェネンテック, インコーポレイテッド Anti-hepsin antibody and method of use thereof
WO2011056502A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Bone morphogenetic protein receptor type ii compositions and methods of use
WO2011056497A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor type iib compositions and methods of use
WO2011056494A1 (en) 2009-10-26 2011-05-12 Genentech, Inc. Activin receptor-like kinase-1 antagonist and vegfr3 antagonist combinations
WO2011056997A1 (en) 2009-11-04 2011-05-12 Fabrus Llc Methods for affinity maturation-based antibody optimization
CA2780143A1 (en) 2009-11-05 2011-05-12 Genentech, Inc. Methods and composition for secretion of heterologous polypeptides
WO2011071577A1 (en) 2009-12-11 2011-06-16 Genentech, Inc. Anti-vegf-c antibodies and methods using same
DK2516465T3 (en) 2009-12-23 2016-06-06 Hoffmann La Roche ANTI-BV8 ANTIBODIES AND APPLICATIONS THEREOF
JP5841072B2 (en) 2010-02-10 2016-01-06 イミュノジェン・インコーポレーテッド CD20 antibody and use thereof
SG183333A1 (en) 2010-02-18 2012-09-27 Genentech Inc Neuregulin antagonists and use thereof in treating cancer
EP2539367A2 (en) 2010-02-23 2013-01-02 F. Hoffmann-La Roche AG Anti-angiogenesis therapy for the treatment of ovarian cancer
EP2550295A1 (en) 2010-03-24 2013-01-30 F. Hoffmann-La Roche AG Anti-lrp6 antibodies
WO2011146568A1 (en) 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
WO2011147834A1 (en) 2010-05-26 2011-12-01 Roche Glycart Ag Antibodies against cd19 and uses thereof
WO2011153243A2 (en) 2010-06-02 2011-12-08 Genentech, Inc. Anti-angiogenesis therapy for treating gastric cancer
CA2795972A1 (en) 2010-06-03 2011-12-08 Genentech, Inc. Immuno-pet imaging of antibodies and immunoconjugates and uses therefor
MX336001B (en) 2010-06-18 2016-01-07 Genentech Inc Anti-axl antibodies and methods of use.
WO2011161119A1 (en) 2010-06-22 2011-12-29 F. Hoffmann-La Roche Ag Antibodies against insulin-like growth factor i receptor and uses thereof
WO2011161189A1 (en) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anti-hepsin antibodies and methods of use
AU2011274528B2 (en) 2010-07-09 2015-04-23 Genentech, Inc. Anti-neuropilin antibodies and methods of use
WO2012010582A1 (en) 2010-07-21 2012-01-26 Roche Glycart Ag Anti-cxcr5 antibodies and methods of use
WO2012012750A1 (en) 2010-07-23 2012-01-26 Trustees Of Boston University ANTI-DEsupR INHIBITORS AS THERAPEUTICS FOR INHIBITION OF PATHOLOGICAL ANGIOGENESIS AND TUMOR CELL INVASIVENESS AND FOR MOLECULAR IMAGING AND TARGETED DELIVERY
JP2013541501A (en) 2010-08-03 2013-11-14 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Biomarkers for chronic lymphocytic leukemia (CLL)
CA2805564A1 (en) 2010-08-05 2012-02-09 Stefan Jenewein Anti-mhc antibody anti-viral cytokine fusion protein
NZ703653A (en) 2010-08-13 2016-09-30 Roche Glycart Ag Anti-fap antibodies and methods of use
KR101653030B1 (en) 2010-08-13 2016-08-31 로슈 글리카트 아게 Anti-tenascin-c a2 antibodies and methods of use
NZ604510A (en) 2010-08-17 2013-10-25 Csl Ltd Dilutable biocidal compositions and methods of use
JP5813114B2 (en) 2010-08-25 2015-11-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Antibodies against IL-18R1 and uses thereof
CA2808236A1 (en) 2010-08-31 2012-03-08 Genentech, Inc. Biomarkers and methods of treatment
AU2011312205B2 (en) 2010-10-05 2015-08-13 Curis, Inc. Mutant smoothened and methods of using the same
JP2013541594A (en) 2010-11-08 2013-11-14 ジェネンテック, インコーポレイテッド Anti-IL-6 receptor antibody administered subcutaneously
PE20140238A1 (en) 2010-11-10 2014-03-07 Genentech Inc METHODS AND COMPOSITIONS FOR IMMUNOTHERAPY FOR NEURAL DISEASE
CN110251668A (en) 2010-11-30 2019-09-20 霍夫曼-拉罗奇有限公司 Low-affinity blood-brain barrier receptor antibody and application thereof
MY188365A (en) 2010-12-16 2021-12-06 Genentech Inc Diagnosis and treatments relating to th2 inhibition
UA115641C2 (en) 2010-12-20 2017-11-27 Дженентек, Інк. DETERMINED ANTIBODY Binds Mesothelin and Immunoconjugate Containing It
KR20130118925A (en) 2010-12-22 2013-10-30 제넨테크, 인크. Anti-pcsk9 antibodies and methods of use
WO2012092539A2 (en) 2010-12-31 2012-07-05 Takeda Pharmaceutical Company Limited Antibodies to dll4 and uses thereof
CA2824824A1 (en) 2011-02-28 2012-09-07 F. Hoffmann-La Roche Ag Monovalent antigen binding proteins
CA2825081A1 (en) 2011-02-28 2012-09-07 Birgit Bossenmaier Antigen binding proteins
EP2691417B1 (en) 2011-03-29 2018-08-01 Roche Glycart AG Antibody fc variants
KR20140021589A (en) 2011-04-07 2014-02-20 제넨테크, 인크. Anti-fgfr4 antibodies and methods of use
WO2012146630A1 (en) 2011-04-29 2012-11-01 F. Hoffmann-La Roche Ag N-terminal acylated polypeptides, methods for their production and uses thereof
WO2012155019A1 (en) 2011-05-12 2012-11-15 Genentech, Inc. Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature pepides
LT2710035T (en) 2011-05-16 2017-06-26 F. Hoffmann-La Roche Ag Fgfr1 agonists and methods of use
EP2721067B1 (en) 2011-06-15 2019-07-31 F.Hoffmann-La Roche Ag Anti-human epo receptor antibodies and methods of use
EA201400046A1 (en) 2011-06-22 2014-07-30 Ф. Хоффманн-Ля Рош Аг REMOVAL OF TARGET CELLS WITH THE HELP OF CIRCULATING VIRUS-SPECIFIC CYTOTOXIC T-CELLS USING THE CONTAINING GCGS CLASS I COMPLEX
CN107090038A (en) 2011-06-30 2017-08-25 霍夫曼-拉罗奇有限公司 Anti- C MET antibody formulations
US20130022551A1 (en) 2011-07-22 2013-01-24 Trustees Of Boston University DEspR ANTAGONISTS AND AGONISTS AS THERAPEUTICS
MX2014001766A (en) 2011-08-17 2014-05-01 Genentech Inc Neuregulin antibodies and uses thereof.
MX2014001736A (en) 2011-08-17 2014-03-31 Genentech Inc Inhibition of angiogenesis in refractory tumors.
EP2748302B1 (en) 2011-08-22 2018-08-15 Glycotope GmbH Microorganisms carrying a tumor antigen
CA2844141A1 (en) 2011-08-23 2013-02-28 Roche Glycart Ag Anti-mcsp antibodies
WO2013040433A1 (en) 2011-09-15 2013-03-21 Genentech, Inc. Methods of promoting differentiation
AR087918A1 (en) 2011-09-19 2014-04-23 Genentech Inc COMBINED TREATMENTS INCLUDING C-MET ANTAGONISTS AND B-RAF ANTAGONISTS
JP2014531210A (en) 2011-09-30 2014-11-27 テバ・ファーマシューティカルズ・オーストラリア・ピーティワイ・リミテッド Antibodies against TL1a and uses thereof
AU2012319150B2 (en) 2011-10-05 2017-08-17 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
JP5854535B2 (en) * 2011-10-05 2016-02-09 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Methods for the production of antibody G1 glycoforms
ES2687951T3 (en) 2011-10-14 2018-10-30 F. Hoffmann-La Roche Ag Anti-HtrA1 antibodies and procedures for use
MX2014004426A (en) 2011-10-15 2014-07-09 Genentech Inc Scd1 antagonists for treating cancer.
WO2013059531A1 (en) 2011-10-20 2013-04-25 Genentech, Inc. Anti-gcgr antibodies and uses thereof
IN2014CN03062A (en) 2011-10-28 2015-07-31 Hoffmann La Roche
JP2015504413A (en) 2011-10-28 2015-02-12 パトリス リミテッド PAT-LM1 epitope and methods for using the same
RU2014124842A (en) 2011-11-21 2015-12-27 Дженентек, Инк. CLEANING ANTI-C-MET ANTIBODIES
EP2788024A1 (en) 2011-12-06 2014-10-15 F.Hoffmann-La Roche Ag Antibody formulation
SG11201403223PA (en) 2011-12-22 2014-07-30 Hoffmann La Roche Expression vector organization, novel production cell generation methods and their use for the recombinant production of polypeptides
CN113896787A (en) 2011-12-22 2022-01-07 弗·哈夫曼-拉罗切有限公司 Expression vector element combinations, novel production cell production methods and their use in the recombinant production of polypeptides
MX2014007262A (en) 2011-12-22 2014-08-01 Hoffmann La Roche Full length antibody display system for eukaryotic cells and its use.
WO2013096791A1 (en) 2011-12-23 2013-06-27 Genentech, Inc. Process for making high concentration protein formulations
WO2013101771A2 (en) 2011-12-30 2013-07-04 Genentech, Inc. Compositions and method for treating autoimmune diseases
US10774132B2 (en) 2012-01-09 2020-09-15 The Scripps Research Instittue Ultralong complementarity determining regions and uses thereof
CN104411717A (en) 2012-01-09 2015-03-11 斯克利普斯研究所 Humanized antibodies with ultralong CDR3S
EP2804630B1 (en) 2012-01-18 2017-10-18 F. Hoffmann-La Roche AG Methods of using fgf19 modulators
PE20141561A1 (en) 2012-01-18 2014-11-12 Genentech Inc ANTI-LRP5 ANTIBODIES AND METHODS OF USE
EP2812350B1 (en) 2012-02-11 2019-04-03 F.Hoffmann-La Roche Ag R-spondin translocations and methods using the same
TR201808458T4 (en) 2012-02-15 2018-07-23 Hoffmann La Roche FC-receptor based affinity chromatography.
SG11201406079TA (en) 2012-03-27 2014-10-30 Genentech Inc Diagnosis and treatments relating to her3 inhibitors
AR090549A1 (en) 2012-03-30 2014-11-19 Genentech Inc ANTI-LGR5 AND IMMUNOCATE PLAYERS
KR20150006000A (en) 2012-05-01 2015-01-15 제넨테크, 인크. Anti-pmel17 antibodies and immunoconjugates
WO2013170191A1 (en) 2012-05-11 2013-11-14 Genentech, Inc. Methods of using antagonists of nad biosynthesis from nicotinamide
CA2873646C (en) 2012-05-18 2022-04-26 Genentech, Inc. High-concentration monoclonal antibody formulations
BR112014028838A2 (en) 2012-05-21 2020-05-12 Genentech Inc USES OF AN ANTIBODY, METHOD FOR MAKING AN ANTIBODY AND ANTIBODIES
WO2013177470A1 (en) 2012-05-23 2013-11-28 Genentech, Inc. Selection method for therapeutic agents
WO2013181568A2 (en) * 2012-06-01 2013-12-05 Momenta Pharmaceuticals, Inc. Methods related to alemtuzumab
US9695244B2 (en) 2012-06-01 2017-07-04 Momenta Pharmaceuticals, Inc. Methods related to denosumab
EP2861624A1 (en) 2012-06-15 2015-04-22 F. Hoffmann-La Roche AG Anti-pcsk9 antibodies, formulations, dosing, and methods of use
PL2869837T3 (en) 2012-07-04 2017-03-31 F.Hoffmann-La Roche Ag Anti-theophylline antibodies and methods of use
EP3138580B1 (en) 2012-07-04 2021-03-03 F. Hoffmann-La Roche AG Covalently linked antigen-antibody conjugates
KR20150030755A (en) 2012-07-04 2015-03-20 에프. 호프만-라 로슈 아게 Anti-biotin antibodies and methods of use
JP6309518B2 (en) 2012-07-05 2018-04-11 ジェネンテック, インコーポレイテッド Expression and secretion system
KR20150030753A (en) 2012-07-09 2015-03-20 제넨테크, 인크. Immunoconjugates comprising anti-cd79b antibodies
EA201590173A1 (en) 2012-07-09 2015-09-30 Дженентек, Инк. IMMUNOCONGUTS CONTAINING ANTIBODIES TO CD22
EP2869849A1 (en) 2012-07-09 2015-05-13 Genentech, Inc. Immunoconjugates comprising anti-cd22 antibodies
MX2015000314A (en) 2012-07-09 2015-04-10 Genentech Inc Immunoconjugates comprising anti - cd79b antibodies.
SI3495387T1 (en) 2012-07-13 2021-12-31 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
KR20190121874A (en) 2012-08-29 2019-10-28 에프. 호프만-라 로슈 아게 Blood brain barrier shuttle
CA2890207A1 (en) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Novel ntrk1 fusion molecules and uses thereof
PE20150956A1 (en) 2012-11-08 2015-06-20 Hoffmann La Roche HER3 FORK BINDING HER3 ANTIGEN BINDING PROTEINS
EA201590731A1 (en) 2012-11-13 2015-11-30 Дженентек, Инк. ANTIBODIES TO HEMAGGLUTININ AND METHODS OF APPLICATION
JP6475167B2 (en) 2012-12-21 2019-02-27 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Multifunctional protein containing disulfide-linked multivalent MHC class I
CA2898326C (en) 2013-01-18 2022-05-17 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
WO2014116749A1 (en) 2013-01-23 2014-07-31 Genentech, Inc. Anti-hcv antibodies and methods of using thereof
KR102204127B1 (en) 2013-02-01 2021-01-20 키라 바이오테크 피티와이 리미티드 Anti-cd83 antibodies and use thereof
DK2953971T3 (en) 2013-02-07 2023-05-01 Csl Ltd IL-11R BINDING PROTEINS AND USES THEREOF
CN104994879A (en) 2013-02-22 2015-10-21 霍夫曼-拉罗奇有限公司 Methods of treating cancer and preventing drug resistance
CA2896259A1 (en) 2013-02-26 2014-09-04 Roche Glycart Ag Anti-mcsp antibodies
CA2902263A1 (en) 2013-03-06 2014-09-12 Genentech, Inc. Methods of treating and preventing cancer drug resistance
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
RU2015139054A (en) 2013-03-14 2017-04-19 Дженентек, Инк. METHODS FOR TREATING CANCER AND PREVENTION OF DRUG RESISTANCE OF CANCER
KR20150127199A (en) 2013-03-14 2015-11-16 제넨테크, 인크. Anti-b7-h4 antibodies and immunoconjugates
AU2014239903A1 (en) 2013-03-14 2015-09-17 Genentech, Inc. Combinations of a MEK inhibitor compound with an HER3/EGFR inhibitor compound and methods of use
MX2015012326A (en) 2013-03-15 2016-03-08 Genentech Inc Anti-crth2 antibodies and their use.
KR20150128707A (en) 2013-03-15 2015-11-18 제넨테크, 인크. Compositions and methods for diagnosis and treatment of hepatic cancers
EP2968537A1 (en) 2013-03-15 2016-01-20 Genentech, Inc. Methods of treating cancer and preventing cancer drug resistance
SI2970422T1 (en) 2013-03-15 2018-07-31 F. Hoffmann-La Roche Ag Il-22 polypeptides and il-22 fc fusion proteins and methods of use
SG11201507333XA (en) 2013-03-15 2015-10-29 Genentech Inc Biomarkers and methods of treating pd-1 and pd-l1 related conditions
US9598485B2 (en) 2013-03-15 2017-03-21 Ac Immune S.A. Anti-tau antibodies and methods of use
UA118028C2 (en) 2013-04-03 2018-11-12 Рош Глікарт Аг Bispecific antibodies specific for fap and dr5, antibodies specific for dr5 and methods of use
TWI747803B (en) 2013-04-29 2021-12-01 瑞士商赫孚孟拉羅股份公司 Human fcrn-binding modified antibodies and methods of use
MX2015015060A (en) 2013-04-29 2016-02-25 Hoffmann La Roche Fc-receptor binding modified asymmetric antibodies and methods of use.
EP3327034A1 (en) 2013-04-29 2018-05-30 F. Hoffmann-La Roche AG Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases
PL3594240T3 (en) 2013-05-20 2024-04-02 F. Hoffmann-La Roche Ag Anti-transferrin receptor antibodies and methods of use
US20160168231A1 (en) 2013-07-18 2016-06-16 Fabrus, Inc. Antibodies with ultralong complementarity determining regions
CN111518199A (en) 2013-07-18 2020-08-11 图鲁斯生物科学有限责任公司 Humanized antibodies with ultralong complementarity determining regions
MX2016001236A (en) 2013-08-01 2016-05-24 Five Prime Therapeutics Inc Afucosylated anti-fgfr2iiib antibodies.
SG11201601044XA (en) 2013-08-12 2016-03-30 Genentech Inc Compositions and method for treating complement-associated conditions
CA2922889A1 (en) 2013-09-17 2015-03-26 Genentech, Inc. Methods of using anti-lgr5 antibodies
JP2016537965A (en) 2013-10-11 2016-12-08 ジェネンテック, インコーポレイテッド NSP4 inhibitors and methods of use
KR20160044060A (en) 2013-10-11 2016-04-22 에프. 호프만-라 로슈 아게 Multispecific domain exchanged common variable light chain antibodies
MX2016003744A (en) 2013-10-11 2016-08-11 Us Health Tem8 antibodies and their use.
CA2925598A1 (en) 2013-10-18 2015-04-23 Genentech, Inc. Anti-rspo antibodies and methods of use
MX2016005159A (en) 2013-10-23 2016-07-05 Genentech Inc Methods of diagnosing and treating eosinophilic disorders.
RU2697098C1 (en) 2013-11-21 2019-08-12 Ф.Хоффманн-Ля Рош Аг Antibodies to alpha-synuclein and methods of using
SG10201808835QA (en) 2013-12-09 2018-11-29 Allakos Inc Anti-siglec-8 antibodies and methods of use thereof
US20160333063A1 (en) 2013-12-13 2016-11-17 The General Hospital Corporation Soluble high molecular weight (hmw) tau species and applications thereof
MX2016007576A (en) 2013-12-13 2016-10-03 Genentech Inc Anti-cd33 antibodies and immunoconjugates.
RU2719487C2 (en) 2013-12-17 2020-04-17 Дженентек, Инк. Methods of treating cancer using antagonists binding to components of the signal path pd-1, and taxanes
PE20210107A1 (en) 2013-12-17 2021-01-19 Genentech Inc ANTI-CD3 ANTIBODIES AND METHODS OF USE
EP3527587A1 (en) 2013-12-17 2019-08-21 F. Hoffmann-La Roche AG Combination therapy comprising ox40 binding agonists and pd-l1 binding antagonists
CN105899535A (en) 2013-12-17 2016-08-24 豪夫迈·罗氏有限公司 Methods of treating cancer using pd-1 axis binding antagonists and an anti-cd20 antibody
TWI728373B (en) 2013-12-23 2021-05-21 美商建南德克公司 Antibodies and methods of use
CN105873616B (en) 2014-01-03 2020-06-05 豪夫迈·罗氏有限公司 Covalently linked polypeptide toxin-antibody conjugates
CN105873615B (en) 2014-01-03 2020-12-25 豪夫迈·罗氏有限公司 Covalently linked helicar-anti-helicar antibody conjugates and uses thereof
WO2015103549A1 (en) 2014-01-03 2015-07-09 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Neutralizing antibodies to hiv-1 env and their use
JP6476194B2 (en) 2014-01-03 2019-02-27 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Bispecific anti-hapten / anti-blood brain barrier receptor antibodies, complexes thereof, and their use as blood brain barrier shuttles
MX2016008190A (en) 2014-01-06 2016-10-21 Hoffmann La Roche Monovalent blood brain barrier shuttle modules.
KR20160107190A (en) 2014-01-15 2016-09-13 에프. 호프만-라 로슈 아게 Fc-region variants with modified fcrn- and maintained protein a-binding properties
US20170043034A1 (en) 2014-01-24 2017-02-16 Genentech, Inc. Methods of using anti-steap1 antibodies and immunoconjugates
CA2937539A1 (en) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened and methods of using the same
AU2015214058B2 (en) 2014-02-08 2020-07-09 Genentech, Inc. Methods of treating Alzheimer's Disease
EP3102230B1 (en) 2014-02-08 2021-04-28 F. Hoffmann-La Roche AG Methods of treating alzheimer's disease
ES2685424T3 (en) 2014-02-12 2018-10-09 F. Hoffmann-La Roche Ag Anti-Jagged1 antibodies and procedures for use
WO2015127405A2 (en) 2014-02-21 2015-08-27 Genentech, Inc. Anti-il-13/il-17 bispecific antibodies and uses thereof
EP3110446B1 (en) 2014-02-28 2021-12-01 Allakos Inc. Methods and compositions for treating siglec-8 associated diseases
CN106103730B (en) 2014-03-14 2021-06-08 豪夫迈·罗氏有限公司 Methods and compositions for secretion of heterologous polypeptides
WO2015140591A1 (en) 2014-03-21 2015-09-24 Nordlandssykehuset Hf Anti-cd14 antibodies and uses thereof
BR112016021383A2 (en) 2014-03-24 2017-10-03 Genentech Inc METHOD TO IDENTIFY A PATIENT WITH CANCER WHO IS LIKE OR LESS LIKELY TO RESPOND TO TREATMENT WITH A CMET ANTAGONIST, METHOD TO IDENTIFY A PATIENT WITH PREVIOUSLY TREATED CANCER, METHOD TO DETERMINE THE EXPRESSION OF THE HGF BIOMARKER, ANTI-C-MET ANTAGONIST AND ITS USE, DIAGNOSTIC KIT AND ITS PREPARATION METHOD
JP6588461B2 (en) 2014-03-31 2019-10-09 ジェネンテック, インコーポレイテッド Combination therapy comprising an anti-angiogenic agent and an OX40 binding agonist
UA121112C2 (en) 2014-03-31 2020-04-10 Дженентек, Інк. Anti-ox40 antibodies and methods of use
WO2015164615A1 (en) 2014-04-24 2015-10-29 University Of Oslo Anti-gluten antibodies and uses thereof
KR20170003582A (en) 2014-05-22 2017-01-09 제넨테크, 인크. Anti-gpc3 antibodies and immunoconjugates
JP2017524371A (en) 2014-05-23 2017-08-31 ジェネンテック, インコーポレイテッド MIT biomarkers and methods of use
WO2015191715A1 (en) 2014-06-11 2015-12-17 Genentech, Inc. Anti-lgr5 antibodies and uses thereof
US20230190750A1 (en) 2014-06-13 2023-06-22 Genentech, Inc. Methods of treating and preventing cancer drug resistance
MX2016015280A (en) 2014-06-26 2017-03-03 Hoffmann La Roche Anti-brdu antibodies and methods of use.
AU2015288232B2 (en) 2014-07-11 2020-10-15 Ventana Medical Systems, Inc. Anti-PD-L1 antibodies and diagnostic uses thereof
WO2016007775A1 (en) 2014-07-11 2016-01-14 Genentech, Inc. Notch pathway inhibition
TWI751102B (en) 2014-08-28 2022-01-01 美商奇諾治療有限公司 Antibodies and chimeric antigen receptors specific for cd19
EP4074735A1 (en) 2014-08-28 2022-10-19 BioAtla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
EP3191527B1 (en) * 2014-09-10 2020-01-15 F.Hoffmann-La Roche Ag Galactoengineered immunoglobulin 1 antibodies
SG10201804931QA (en) 2014-09-12 2018-07-30 Genentech Inc Anti-cll-1 antibodies and immunoconjugates
PE20170935A1 (en) 2014-09-12 2017-07-13 Genentech Inc ANTI-HER2 AND IMMUNOCONJUGATED ANTIBODIES
AR101848A1 (en) 2014-09-12 2017-01-18 Genentech Inc ANTI-B7-H4 AND IMMUNOCATE PLAYERS
CA2957148A1 (en) 2014-09-17 2016-03-24 Genentech, Inc. Immunoconjugates comprising anti-her2 antibodies and pyrrolobenzodiazepines
DK3262071T3 (en) 2014-09-23 2020-06-15 Hoffmann La Roche Method of using anti-CD79b immune conjugates
CN107074938A (en) 2014-10-16 2017-08-18 豪夫迈·罗氏有限公司 Anti alpha synapse nucleoprotein antibody and application method
AU2015336931B2 (en) 2014-10-23 2021-04-29 Kira Biotech Pty Limited CD83 binding proteins and uses thereof
EP3223865A4 (en) 2014-10-31 2018-10-03 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
BR112017009159A2 (en) 2014-11-03 2018-03-06 Genentech, Inc. methods and biomarkers to predict efficacy and evaluation of ox40 agonist treatment
CA2966523A1 (en) 2014-11-03 2016-05-12 Genentech, Inc. Assays for detecting t cell immune subsets and methods of use thereof
US10208120B2 (en) 2014-11-05 2019-02-19 Genentech, Inc. Anti-FGFR2/3 antibodies and methods using same
US20160152720A1 (en) 2014-11-06 2016-06-02 Genentech, Inc. Combination therapy comprising ox40 binding agonists and tigit inhibitors
MX2017005150A (en) 2014-11-06 2017-08-08 Hoffmann La Roche Fc-region variants with modified fcrn- and protein a-binding properties.
RS59340B1 (en) 2014-11-06 2019-10-31 Hoffmann La Roche Fc-region variants with modified fcrn-binding and methods of use
JP6929771B2 (en) 2014-11-10 2021-09-01 ジェネンテック, インコーポレイテッド Anti-interleukin-33 antibody and its use
WO2016077369A1 (en) 2014-11-10 2016-05-19 Genentech, Inc. Animal model for nephropathy and agents for treating the same
US10160795B2 (en) 2014-11-14 2018-12-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to Ebola virus glycoprotein and their use
WO2016075278A1 (en) 2014-11-14 2016-05-19 F. Hoffmann-La Roche Ag Antigen binding molecules comprising a tnf family ligand trimer
EP3221360A1 (en) 2014-11-17 2017-09-27 F. Hoffmann-La Roche AG Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
WO2016081643A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
EP3221364B1 (en) 2014-11-19 2020-12-16 Genentech, Inc. Antibodies against bace1 and use thereof for neural disease immunotherapy
PL3221349T3 (en) 2014-11-19 2021-05-17 Axon Neuroscience Se Humanized tau antibodies in alzheimer's disease
RU2753902C2 (en) 2014-11-20 2021-08-24 Ф.Хоффманн-Ля Рош Аг Combination therapy based on t-cell-activating bispecific antigen-binding molecules against cd3 and folate receptor 1 (folr1) and antagonists binding to pd-1 axis
JP6721590B2 (en) 2014-12-03 2020-07-15 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Multispecific antibody
CN107108739B (en) 2014-12-05 2022-01-04 豪夫迈·罗氏有限公司 anti-CD 79b antibodies and methods of use
CN107207591A (en) 2014-12-10 2017-09-26 豪夫迈·罗氏有限公司 Blood-brain barrier receptor antibody and application method
SI3233921T1 (en) 2014-12-19 2022-01-31 Chugai Seiyaku Kabushiki Kaisha Anti-c5 antibodies and methods of use
WO2016111947A2 (en) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Antibodies that inhibit tim-3:lilrb2 interactions and uses thereof
CN107428833B (en) 2015-01-16 2021-11-02 朱诺治疗学股份有限公司 ROR 1-specific antibodies and chimeric antigen receptors
CN113956354A (en) 2015-01-22 2022-01-21 中外制药株式会社 Combinations and methods of use of two or more anti-C5 antibodies
CN107407677B (en) 2015-01-28 2020-07-17 豪夫迈·罗氏有限公司 Gene expression markers and treatment of multiple sclerosis
CN107636170A (en) 2015-02-04 2018-01-26 健泰科生物技术公司 Saltant type Smoothened and its application method
KR20170110129A (en) 2015-02-05 2017-10-10 추가이 세이야쿠 가부시키가이샤 Antibodies comprising ionic concentration dependent antigen binding domains, Fc region variants, antibodies that bind to IL-8, and their use
KR20170140180A (en) 2015-02-24 2017-12-20 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use
WO2016149276A1 (en) 2015-03-16 2016-09-22 Genentech, Inc. Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
WO2016146833A1 (en) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
US10562960B2 (en) 2015-03-20 2020-02-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to gp120 and their use
PT3274370T (en) 2015-03-23 2020-01-30 Bayer Pharma AG Anti-ceacam6 antibodies and uses thereof
JP6944924B2 (en) 2015-03-23 2021-10-06 ジョンス セラピューティクス, インコーポレイテッド Antibodies to ICOS
MY186708A (en) 2015-04-03 2021-08-11 Eureka Therapeutics Inc Constructs targeting afp peptide/mhc complexes and uses thereof
EP3286315B1 (en) 2015-04-24 2021-05-26 F. Hoffmann-La Roche AG Methods of identifying bacteria comprising binding polypeptides
EP3288981A1 (en) 2015-05-01 2018-03-07 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
WO2016179194A1 (en) 2015-05-04 2016-11-10 Jounce Therapeutics, Inc. Lilra3 and method of using the same
EP3936524A3 (en) 2015-05-11 2022-06-15 F. Hoffmann-La Roche AG Compositions and methods of treating lupus nephritis
SI3294770T1 (en) 2015-05-12 2021-01-29 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
AU2016270625B2 (en) 2015-05-29 2022-10-06 Genentech, Inc. Therapeutic and diagnostic methods for cancer
EP3763827A1 (en) 2015-05-29 2021-01-13 F. Hoffmann-La Roche AG Pd-l1 promoter methylation in cancer
JP2018520658A (en) 2015-05-29 2018-08-02 ジェネンテック, インコーポレイテッド Humanized anti-Ebola virus glycoprotein antibodies and uses thereof
WO2016196679A1 (en) 2015-06-02 2016-12-08 Genentech, Inc. Compositions and methods for using anti-il-34 antibodies to treat neurological diseases
WO2016196975A1 (en) 2015-06-03 2016-12-08 The United States Of America, As Represented By The Secretary Department Of Health & Human Services Neutralizing antibodies to hiv-1 env and their use
ES2834823T3 (en) 2015-06-04 2021-06-18 Ospedale San Raffaele Srl IGFBP3 and its uses
WO2016193497A1 (en) 2015-06-04 2016-12-08 Ospedale San Raffaele Srl Inhibitor of igfbp3/tmem219 axis and diabetes
SG10201911349YA (en) 2015-06-05 2020-01-30 Genentech Inc Anti-tau antibodies and methods of use
CN107810011A (en) 2015-06-08 2018-03-16 豪夫迈·罗氏有限公司 Use the method for anti-OX40 antibodies for treating cancer
AU2016274584A1 (en) 2015-06-08 2018-01-04 Genentech, Inc. Methods of treating cancer using anti-OX40 antibodies and PD-1 axis binding antagonists
AR104987A1 (en) 2015-06-15 2017-08-30 Genentech Inc ANTIBODY-DRUG IMMUNOCUJADOS UNITED BY NON-PEPTIDIC LINKERS
WO2016205200A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Anti-cll-1 antibodies and methods of use
LT3310814T (en) 2015-06-16 2023-10-10 F. Hoffmann-La Roche Ag Humanized and affinity matured antibodies to fcrh5 and methods of use
WO2016204966A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Anti-cd3 antibodies and methods of use
CN107771076A (en) 2015-06-17 2018-03-06 豪夫迈·罗氏有限公司 Use the axle binding antagonists of PD 1 and the method for Taxane treatment Locally Advanced or metastatic breast cancer
MX2017016169A (en) 2015-06-17 2018-08-15 Genentech Inc Anti-her2 antibodies and methods of use.
CA2987797A1 (en) 2015-06-17 2016-12-22 Christopher Robert Bebbington Methods and compositions for treating fibrotic diseases
ES2908009T3 (en) 2015-06-24 2022-04-27 Hoffmann La Roche Affinity-matched anti-transferrin receptor antibodies
MX2017016645A (en) 2015-06-29 2018-11-09 Genentech Inc Type ii anti-cd20 antibody for use in organ transplantation.
ES2898065T3 (en) 2015-06-29 2022-03-03 Ventana Med Syst Inc Materials and Procedures for Performing Histochemical Assays for Human Proepiregulin and Amphiregulin
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
JP6914919B2 (en) 2015-08-28 2021-08-04 ジェネンテック, インコーポレイテッド Anti-hypusine antibody and its use
CA2999369C (en) 2015-09-22 2023-11-07 Spring Bioscience Corporation Anti-ox40 antibodies and diagnostic uses thereof
IL257565B1 (en) 2015-09-23 2024-04-01 Genentech Inc Optimized variants of anti-vegf antibodies
EP3662930A1 (en) 2015-09-24 2020-06-10 AbVitro LLC Hiv antibody compositions and methods of use
AR106188A1 (en) 2015-10-01 2017-12-20 Hoffmann La Roche ANTI-CD19 HUMANIZED HUMAN ANTIBODIES AND METHODS OF USE
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
AR106189A1 (en) 2015-10-02 2017-12-20 Hoffmann La Roche BIESPECTIFIC ANTIBODIES AGAINST HUMAN A-b AND THE HUMAN TRANSFERRINE RECEIVER AND METHODS OF USE
EP3150636A1 (en) 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Tetravalent multispecific antibodies
AU2016329120B2 (en) 2015-10-02 2023-04-13 F. Hoffmann-La Roche Ag Bispecific antibodies specific for a costimulatory TNF receptor
DK3356411T3 (en) 2015-10-02 2021-09-06 Hoffmann La Roche Bispecific antibodies specific for PD1 and TIM3
JP6657392B2 (en) 2015-10-02 2020-03-04 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Bispecific anti-human CD20 / human transferrin receptor antibodies and methods of use
JP2018529747A (en) 2015-10-06 2018-10-11 ジェネンテック, インコーポレイテッド Methods for treating multiple sclerosis
CR20180171A (en) 2015-10-07 2018-05-03 Hoffmann La Roche BIESPECTIFIC ANTIBODIES WITH TETRAVALENCE FOR A FNT CO-STIMULATOR RECEIVER
US10392441B2 (en) 2015-10-07 2019-08-27 United States Of America, As Represented By The Secretary, Department Of Health And Human Services IL-7R-alpha specific antibodies for treating acute lymphoblastic leukemia
EP3365372A1 (en) 2015-10-22 2018-08-29 Jounce Therapeutics, Inc. Gene signatures for determining icos expression
US10604577B2 (en) 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
MX2018005036A (en) 2015-10-29 2018-08-01 Hoffmann La Roche Anti-variant fc-region antibodies and methods of use.
EP3184547A1 (en) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anti-tpbg antibodies and methods of use
EP3368074A2 (en) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anti-factor d antibodies and conjugates
CN115160439A (en) 2015-10-30 2022-10-11 豪夫迈·罗氏有限公司 anti-HtrA 1 antibodies and methods of use thereof
EP4011911A1 (en) 2015-11-03 2022-06-15 The United States of America as represented by The Secretary Department of Health and Human Services Neutralizing antibodies to hiv-1 gp41 and their use
EP3371217A1 (en) 2015-11-08 2018-09-12 H. Hoffnabb-La Roche Ag Methods of screening for multispecific antibodies
SG11201804134YA (en) 2015-11-23 2018-06-28 Five Prime Therapeutics Inc Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
AU2016372930B2 (en) 2015-12-18 2020-10-08 Chugai Seiyaku Kabushiki Kaisha Anti-C5 antibodies and methods of use
WO2017118675A1 (en) 2016-01-08 2017-07-13 F. Hoffmann-La Roche Ag Methods of treating cea-positive cancers using pd-1 axis binding antagonists and anti-cea/anti-cd3 bispecific antibodies
BR112018014762A2 (en) 2016-01-20 2018-12-26 Genentech Inc method of treating (early) alzheimer's disease
AU2017213826A1 (en) 2016-02-04 2018-08-23 Curis, Inc. Mutant smoothened and methods of using the same
CN109196121B (en) 2016-02-29 2022-01-04 基因泰克公司 Methods for treatment and diagnosis of cancer
CA3016552A1 (en) 2016-03-15 2017-09-21 Genentech, Inc. Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies
US20170315132A1 (en) 2016-03-25 2017-11-02 Genentech, Inc. Multiplexed total antibody and antibody-conjugated drug quantification assay
EP3443004A1 (en) 2016-04-14 2019-02-20 H. Hoffnabb-La Roche Ag Anti-rspo3 antibodies and methods of use
CA3021086C (en) 2016-04-15 2023-10-17 Bioatla, Llc Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
EP3443120A2 (en) 2016-04-15 2019-02-20 H. Hoffnabb-La Roche Ag Methods for monitoring and treating cancer
KR20190003958A (en) 2016-04-15 2019-01-10 제넨테크, 인크. Treatment and monitoring of cancer
WO2017192589A1 (en) 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to influenza ha and their use and identification
MA56474A (en) 2016-05-02 2022-05-11 Hoffmann La Roche CONTORSBODY - SINGLE CHAIN TARGET BINDER
JP7089483B2 (en) 2016-05-11 2022-06-22 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Modified anti-tenascin antibody and usage
EP3455254B1 (en) 2016-05-11 2021-07-07 F. Hoffmann-La Roche AG Antigen binding molecules comprising a tnf family ligand trimer and a tenascin binding moiety
EP3243836A1 (en) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG C-terminally fused tnf family ligand trimer-containing antigen binding molecules
HRP20221298T1 (en) 2016-05-13 2022-12-23 Bioatla, Inc. Anti-ror2 antibodies, antibody fragments, their immunoconjugates and uses thereof
EP3243832A1 (en) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety
EP3458101B1 (en) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Protac antibody conjugates and methods of use
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
CN116143918A (en) 2016-06-24 2023-05-23 豪夫迈·罗氏有限公司 Anti-polyubiquitin multispecific antibodies
JP6983824B2 (en) 2016-07-04 2021-12-17 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft New antibody format
WO2018014260A1 (en) 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
KR102553195B1 (en) 2016-07-29 2023-07-07 주노 쎄러퓨티크스 인코퍼레이티드 Anti-idiotypic antibodies to anti-CD19 antibodies
MX2018015721A (en) 2016-07-29 2019-05-27 Chugai Pharmaceutical Co Ltd Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity.
EP3494991A4 (en) 2016-08-05 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of il-8 related diseases
CN109476748B (en) 2016-08-08 2023-05-23 豪夫迈·罗氏有限公司 Methods for treatment and diagnosis of cancer
AU2017321973A1 (en) 2016-09-02 2019-03-07 Dana-Farber Cancer Institute, Inc. Composition and methods of treating B cell disorders
EP3510046A4 (en) 2016-09-07 2020-05-06 The Regents of the University of California Antibodies to oxidation-specific epitopes
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
EP3515932B1 (en) 2016-09-19 2023-11-22 F. Hoffmann-La Roche AG Complement factor based affinity chromatography
SI3528838T1 (en) 2016-09-23 2023-10-30 F. Hoffmann-La Roche Ag Uses of il-13 antagonists for treating atopic dermatitis
EP3519433A1 (en) 2016-10-03 2019-08-07 Juno Therapeutics, Inc. Hpv-specific binding molecules
JP7050770B2 (en) 2016-10-05 2022-04-08 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Method for preparing antibody drug conjugate
TWI775781B (en) 2016-10-06 2022-09-01 美商建南德克公司 Therapeutic and diagnostic methods for cancer
WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
US11555076B2 (en) 2016-10-29 2023-01-17 Genentech, Inc. Anti-MIC antibodies and methods of use
HUE057559T2 (en) 2016-11-02 2022-06-28 Jounce Therapeutics Inc Antibodies to pd-1 and uses thereof
AU2017361081A1 (en) 2016-11-15 2019-05-23 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
JOP20190100A1 (en) 2016-11-19 2019-05-01 Potenza Therapeutics Inc Anti-gitr antigen-binding proteins and methods of use thereof
EP4015532A1 (en) 2016-11-21 2022-06-22 cureab GmbH Anti-gp73 antibodies and immunoconjugates
AU2017373889A1 (en) 2016-12-07 2019-06-06 Ac Immune Sa Anti-Tau antibodies and methods of use
AU2017373884A1 (en) 2016-12-07 2019-05-30 Ac Immune Sa Anti-tau antibodies and methods of their use
KR20190095921A (en) 2016-12-12 2019-08-16 제넨테크, 인크. How to Treat Cancer Using Anti-PD-L1 Antibody and Antiandrogen
KR20190097039A (en) 2016-12-19 2019-08-20 에프. 호프만-라 로슈 아게 Combination Therapy with Targeted 4-1BB (CD137) Agonists
CA3039446A1 (en) 2016-12-20 2018-06-28 F. Hoffmann-La Roche Ag Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists
JOP20190134A1 (en) 2016-12-23 2019-06-02 Potenza Therapeutics Inc Anti-neuropilin antigen-binding proteins and methods of use thereof
MX2019007795A (en) 2017-01-03 2019-08-16 Hoffmann La Roche Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9.
WO2018129029A1 (en) 2017-01-04 2018-07-12 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
EP3568468A4 (en) 2017-01-12 2020-12-30 Eureka Therapeutics, Inc. Constructs targeting histone h3 peptide/mhc complexes and uses thereof
US11021535B2 (en) 2017-02-10 2021-06-01 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
CA3051700A1 (en) 2017-02-10 2018-08-16 Genentech, Inc. Anti-tryptase antibodies, compositions thereof, and uses thereof
CN110546277A (en) 2017-03-01 2019-12-06 豪夫迈·罗氏有限公司 Methods for diagnosis and treatment of cancer
EP3600442A1 (en) 2017-03-22 2020-02-05 Genentech, Inc. Optimized antibody compositions for treatment of ocular disorders
EP3601337A1 (en) 2017-03-28 2020-02-05 Genentech, Inc. Methods of treating neurodegenerative diseases
JP7196094B2 (en) 2017-03-29 2022-12-26 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Bispecific Antigen Binding Molecules for Costimulatory TNF Receptors
EP3601346A1 (en) 2017-03-29 2020-02-05 H. Hoffnabb-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
JOP20190203A1 (en) 2017-03-30 2019-09-03 Potenza Therapeutics Inc Anti-tigit antigen-binding proteins and methods of use thereof
CN110494452B (en) 2017-04-03 2023-08-25 豪夫迈·罗氏有限公司 Antibodies that bind STEAP-1
CR20190427A (en) 2017-04-04 2019-11-01 Hoffmann La Roche Novel bispecific antigen binding molecules capable of specific binding to cd40 and to fap
JP6997212B2 (en) 2017-04-05 2022-02-04 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Bispecific antibodies that specifically bind to PD1 and LAG3
CN110392698B (en) 2017-04-05 2022-01-25 豪夫迈·罗氏有限公司 anti-LAG 3 antibodies
CA3058478A1 (en) 2017-04-14 2018-10-18 Genentech, Inc. Diagnostic and therapeutic methods for cancer
CA3059615A1 (en) 2017-04-21 2018-10-25 Genentech, Inc. Use of klk5 antagonists for treatment of a disease
KR20200012860A (en) 2017-04-26 2020-02-05 유레카 쎄라퓨틱스, 인코포레이티드 Constructs that specifically recognize glypican 3 and uses thereof
US20220135670A1 (en) 2017-04-27 2022-05-05 Tesaro, Inc. Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
EA201992626A1 (en) 2017-05-05 2020-04-24 Аллакос Инк. METHODS AND COMPOSITIONS FOR TREATMENT OF ALLERGIC EYE DISEASES
CA3062177A1 (en) 2017-05-16 2018-11-22 Five Prime Therapeutics, Inc. Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
JP2020527351A (en) 2017-07-21 2020-09-10 ジェネンテック, インコーポレイテッド Cancer treatment and diagnosis
AU2018308364C1 (en) 2017-07-26 2023-02-16 Forty Seven, Inc. Anti-SIRP-alpha antibodies and related methods
WO2019059411A1 (en) 2017-09-20 2019-03-28 Chugai Seiyaku Kabushiki Kaisha Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent
KR20200104284A (en) 2017-10-03 2020-09-03 주노 쎄러퓨티크스 인코퍼레이티드 HPV-specific binding molecule
EP3694890A4 (en) 2017-10-12 2021-11-03 Immunowake Inc. Vegfr-antibody light chain fusion protein
CN111246884A (en) 2017-11-01 2020-06-05 豪夫迈·罗氏有限公司 Novel antigen binding molecules comprising trimers of TNF family ligands
AU2018359506A1 (en) 2017-11-01 2020-04-23 F. Hoffmann-La Roche Ag Combination therapy with targeted OX40 agonists
AU2018357923A1 (en) 2017-11-01 2020-03-05 F. Hoffmann-La Roche Ag Bispecific 2+1 contorsbodies
MX2020004243A (en) 2017-11-01 2020-09-25 Juno Therapeutics Inc Antibodies and chimeric antigen receptors specific for b-cell maturation antigen.
TW201923089A (en) 2017-11-06 2019-06-16 美商建南德克公司 Diagnostic and therapeutic methods for cancer
CN111615520A (en) 2017-12-01 2020-09-01 辉瑞大药厂 anti-CXCR 5 antibodies and compositions and uses thereof
KR20200110745A (en) 2017-12-15 2020-09-25 주노 쎄러퓨티크스 인코퍼레이티드 Anti-CCT5 binding molecule and method of use thereof
EP3502140A1 (en) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules
AU2018390881A1 (en) 2017-12-21 2020-07-02 F. Hoffmann-La Roche Ag Antibodies binding to HLA-A2/WT1
TW201929907A (en) 2017-12-22 2019-08-01 美商建南德克公司 Use of PILRA binding agents for treatment of a Disease
EP4219559A3 (en) 2017-12-22 2023-10-18 Jounce Therapeutics, Inc. Antibodies for lilrb2
US20220135687A1 (en) 2017-12-28 2022-05-05 Nanjing Legend Biotech Co., Ltd. Antibodies and variants thereof against pd-l1
EP3732202A4 (en) 2017-12-28 2022-06-15 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against tigit
WO2019129679A1 (en) 2017-12-29 2019-07-04 F. Hoffmann-La Roche Ag Method for improving vegf-receptor blocking selectivity of an anti-vegf antibody
WO2019136029A1 (en) 2018-01-02 2019-07-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to ebola virus glycoprotein and their use
KR20200106525A (en) 2018-01-05 2020-09-14 에이씨 이뮨 에스.에이. Misfolded TDP-43 binding molecule
CA3084518A1 (en) 2018-01-15 2019-07-18 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against pd-1
CA3088649A1 (en) 2018-01-16 2019-07-25 Lakepharma, Inc. Bispecific antibody that binds cd3 and another target
ES2932861T3 (en) 2018-01-26 2023-01-27 Hoffmann La Roche IL-22 Fc Compositions and Procedures for Use
CR20200327A (en) 2018-01-26 2020-11-05 Genentech Inc Il-22 fc fusion proteins and methods of use
JP7438953B2 (en) 2018-02-01 2024-02-27 イノベント バイオロジックス (スウツォウ) カンパニー,リミテッド Fully humanized anti-B cell maturation antigen (BCMA) single chain antibody and its applications
SG11202007390YA (en) 2018-02-08 2020-08-28 Genentech Inc Bispecific antigen-binding molecules and methods of use
TWI829667B (en) 2018-02-09 2024-01-21 瑞士商赫孚孟拉羅股份公司 Antibodies binding to gprc5d
KR102417088B1 (en) 2018-02-09 2022-07-07 제넨테크, 인크. Methods of treatment and diagnosis for mast cell-mediated inflammatory diseases
EP3752530A1 (en) 2018-02-14 2020-12-23 ABBA Therapeutics AG Anti-human pd-l2 antibodies
RU2020130795A (en) 2018-02-21 2022-03-21 Дзе Юнайтед Стэйтс Оф Америка, Эс Репрезентед Бай Дзе Секретэри, Департмент Оф Хелт Энд Хьюман Сервисиз NEUTRALIZING ANTIBODIES TO ENV HIV-1 AND THEIR USE
EP3755364A1 (en) 2018-02-21 2020-12-30 F. Hoffmann-La Roche AG Dosing for treatment with il-22 fc fusion proteins
TW202000702A (en) 2018-02-26 2020-01-01 美商建南德克公司 Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies
KR20200132913A (en) 2018-03-13 2020-11-25 에프. 호프만-라 로슈 아게 Therapeutic combination of 4-1BB agonist and anti-CD20 antibody
TW202003561A (en) 2018-03-13 2020-01-16 瑞士商赫孚孟拉羅股份公司 Combination therapy with targeted 4-1BB (CD137) agonists
AU2019235033A1 (en) 2018-03-14 2020-07-30 Beijing Xuanyi Pharmasciences Co., Ltd. Anti-claudin 18.2 antibodies
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
CA3093729A1 (en) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies having cross-reactivity to zika virus and methods of use
PE20210290A1 (en) 2018-03-21 2021-02-11 Five Prime Therapeutics Inc SIGHT BINDING ANTIBODIES AT ACID pH
AU2019245243A1 (en) 2018-03-29 2020-09-03 Genentech, Inc Modulating lactogenic activity in mammalian cells
TW202011029A (en) 2018-04-04 2020-03-16 美商建南德克公司 Methods for detecting and quantifying FGF21
MA52193A (en) 2018-04-05 2021-02-17 Juno Therapeutics Inc T-LYMPHOCYTE RECEPTORS AND MODIFIED CELLS EXPRESSING THEM
JP7418346B2 (en) 2018-04-13 2024-01-19 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Her2-targeted antigen-binding molecule including 4-1BBL
WO2019222294A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable cytokine polypeptides and methods of use thereof
CA3100007A1 (en) 2018-05-14 2019-11-21 Werewolf Therapeutics, Inc. Activatable interleukin-2 polypeptides and methods of use thereof
HRP20230787T1 (en) 2018-05-18 2023-10-27 Glycotope Gmbh Anti-muc1 antibody
EP3805400A4 (en) 2018-06-04 2022-06-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule showing changed half-life in cytoplasm
WO2019246557A1 (en) 2018-06-23 2019-12-26 Genentech, Inc. Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor
JP2021528988A (en) 2018-07-04 2021-10-28 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト New bispecific agonist 4-1BB antigen-binding molecule
SG11202100096XA (en) 2018-07-09 2021-02-25 Five Prime Therapeutics Inc Antibodies binding to ilt4
WO2020014306A1 (en) 2018-07-10 2020-01-16 Immunogen, Inc. Met antibodies and immunoconjugates and uses thereof
BR112021000303A2 (en) 2018-07-11 2021-04-13 Five Prime Therapeutics, Inc. ANTIBODIES THAT BIND THE SIGHT IN ACID PH
KR20210034622A (en) 2018-07-18 2021-03-30 제넨테크, 인크. Lung cancer treatment method using PD-1 axis binding antagonist, anti-metabolite, and platinum agent
TW202017944A (en) 2018-07-20 2020-05-16 美商表面腫瘤學公司 Anti-cd112r compositions and methods
SG11202101152QA (en) 2018-08-03 2021-03-30 Chugai Pharmaceutical Co Ltd Antigen-binding molecule containing two antigen-binding domains that are linked to each other
EP3608674A1 (en) 2018-08-09 2020-02-12 Regeneron Pharmaceuticals, Inc. Methods for assessing binding affinity of an antibody variant to the neonatal fc receptor
SG11202003531WA (en) 2018-08-10 2020-05-28 Chugai Pharmaceutical Co Ltd Anti-cd137 antigen-binding molecule and utilization thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
AU2019342099A1 (en) 2018-09-19 2021-04-08 Genentech, Inc. Therapeutic and diagnostic methods for bladder cancer
EP4249917A3 (en) 2018-09-21 2023-11-08 F. Hoffmann-La Roche AG Diagnostic methods for triple-negative breast cancer
CN113286812A (en) 2018-09-27 2021-08-20 西里欧发展公司 Masked cytokine polypeptides
SG11202102477QA (en) 2018-10-01 2021-04-29 Hoffmann La Roche Bispecific antigen binding molecules comprising anti-fap clone 212
CN112654641A (en) 2018-10-01 2021-04-13 豪夫迈·罗氏有限公司 Bispecific antigen binding molecules with trivalent binding to CD40
EP3632929A1 (en) 2018-10-02 2020-04-08 Ospedale San Raffaele S.r.l. Antibodies and uses thereof
US20220010020A1 (en) 2018-10-05 2022-01-13 Five Prime Therapeutics, Inc. Anti-FGFR2 Antibody Formulations
WO2020081493A1 (en) 2018-10-16 2020-04-23 Molecular Templates, Inc. Pd-l1 binding proteins
CN113196061A (en) 2018-10-18 2021-07-30 豪夫迈·罗氏有限公司 Methods of diagnosis and treatment of sarcoma-like renal cancer
US20210395390A1 (en) 2018-10-31 2021-12-23 Bayer Aktiengesellschaft Reversal agents for neutralizing the therapeutic activity of anti-fxia antibodies
SG11202105010UA (en) 2018-11-16 2021-06-29 Memorial Sloan Kettering Cancer Center Antibodies to mucin-16 and methods of use thereof
MX2021006578A (en) 2018-12-05 2021-07-07 Genentech Inc Diagnostic methods and compositions for cancer immunotherapy.
BR112021010908A2 (en) 2018-12-06 2021-08-31 Genentech, Inc. METHOD FOR TREATMENT OF DIFFUSED LARGE B-CELL LYMPHOMA, KIT AND IMMUNOCONJUGATE
CN113227119A (en) 2018-12-10 2021-08-06 基因泰克公司 Photocrosslinked peptides for site-specific conjugation to Fc-containing proteins
EP3898667A2 (en) 2018-12-20 2021-10-27 F. Hoffmann-La Roche AG Modified antibody fcs and methods of use
US20220089694A1 (en) 2018-12-20 2022-03-24 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof
WO2020127618A1 (en) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted agonistic cd28 antigen binding molecules
EP3898671A1 (en) 2018-12-21 2021-10-27 F. Hoffmann-La Roche AG Antibody that binds to vegf and il-1beta and methods of use
SG11202102859TA (en) 2018-12-21 2021-04-29 Hoffmann La Roche Antibodies binding to cd3
AR117728A1 (en) 2018-12-21 2021-08-25 Hoffmann La Roche CD28 ANTIGEN BINDING SUPERAGONIST MOLECULES WITH TUMOR TARGET
MX2021007769A (en) 2018-12-26 2021-09-23 Xilio Dev Inc Activatable masked anti-ctla4 binding proteins.
JP2022515543A (en) 2018-12-30 2022-02-18 エフ.ホフマン-ラ ロシュ アーゲー Anti-rabbit CD19 antibody and how to use
CN115120716A (en) 2019-01-14 2022-09-30 健泰科生物技术公司 Methods of treating cancer with PD-1 axis binding antagonists and RNA vaccines
CA3126778A1 (en) 2019-01-17 2020-07-23 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
CN113329770A (en) 2019-01-24 2021-08-31 中外制药株式会社 Novel cancer antigen and antibody against said antigen
US20220096651A1 (en) 2019-01-29 2022-03-31 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for receptor tyrosine kinase like orphan receptor 1 (ror1)
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
CA3130695A1 (en) 2019-02-27 2020-09-03 Genentech, Inc. Dosing for treatment with anti-tigit and anti-cd20 or anti-cd38 antibodies
MX2021010565A (en) 2019-03-08 2021-10-13 Genentech Inc Methods for detecting and quantifying membrane-associated proteins on extracellular vesicles.
TW202100556A (en) 2019-03-14 2021-01-01 美商建南德克公司 Treatment with her2 t cell-dependent bispecific antibodies
WO2020208049A1 (en) 2019-04-12 2020-10-15 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules comprising lipocalin muteins
AU2020257748A1 (en) 2019-04-19 2021-11-18 Chugai Seiyaku Kabushiki Kaisha Chimeric receptor recognizing modification site of antibody
AU2020258480A1 (en) 2019-04-19 2021-10-21 Genentech, Inc. Anti-mertk antibodies and their methods of use
CN114269376A (en) 2019-05-03 2022-04-01 豪夫迈·罗氏有限公司 Methods of treating cancer with anti-PD-L1 antibodies
WO2020227228A2 (en) 2019-05-03 2020-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
CN114450022A (en) 2019-05-14 2022-05-06 狼人治疗公司 Separation fraction and method of use thereof
CN114206340A (en) 2019-05-14 2022-03-18 豪夫迈·罗氏有限公司 Methods of treating follicular lymphoma using anti-CD 79B immunoconjugates
US20230085439A1 (en) 2019-05-21 2023-03-16 University Of Georgia Research Foundation, Inc. Antibodies that bind human metapneumovirus fusion protein and their use
AU2020278907A1 (en) 2019-05-23 2022-01-20 Ac Immune Sa Anti-TDP-43 binding molecules and uses thereof
JP2022538075A (en) 2019-06-26 2022-08-31 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Fusion of antibody-bound CEA and 4-1BBL
WO2020260326A1 (en) 2019-06-27 2020-12-30 F. Hoffmann-La Roche Ag Novel icos antibodies and tumor-targeted antigen binding molecules comprising them
WO2021003297A1 (en) 2019-07-02 2021-01-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind egfrviii and their use
US20220267452A1 (en) 2019-07-12 2022-08-25 Chugai Seiyaku Kabushiki Kaisha Anti-mutation type fgfr3 antibody and use therefor
AR119382A1 (en) 2019-07-12 2021-12-15 Hoffmann La Roche PRE-TARGETING ANTIBODIES AND METHODS OF USE
AR119393A1 (en) 2019-07-15 2021-12-15 Hoffmann La Roche ANTIBODIES THAT BIND NKG2D
CA3144524A1 (en) 2019-07-31 2021-02-04 F. Hoffmann-La Roche Ag Antibodies binding to gprc5d
CN114174338A (en) 2019-07-31 2022-03-11 豪夫迈·罗氏有限公司 Antibodies that bind to GPRC5D
KR102509648B1 (en) 2019-08-06 2023-03-15 아프리노이아 테라퓨틱스 리미티드 Antibodies that bind to pathological Tau species and uses thereof
CN114340675A (en) 2019-09-12 2022-04-12 豪夫迈·罗氏有限公司 Compositions and methods for treating lupus nephritis
CA3150999A1 (en) 2019-09-18 2021-03-25 James Thomas Koerber Anti-klk7 antibodies, anti-klk5 antibodies, multispecific anti-klk5/klk7 antibodies, and methods of use
JP2022548292A (en) 2019-09-19 2022-11-17 ブリストル-マイヤーズ スクイブ カンパニー Antibodies that bind VISTA at acidic pH
JP2022549218A (en) 2019-09-20 2022-11-24 ジェネンテック, インコーポレイテッド Anti-tryptase antibody medication
MX2022003610A (en) 2019-09-27 2022-04-20 Genentech Inc Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies.
CN114945386A (en) 2019-10-18 2022-08-26 基因泰克公司 Methods of treating diffuse large B-cell lymphoma using anti-CD 79B immunoconjugates
KR20220092580A (en) 2019-11-06 2022-07-01 제넨테크, 인크. Diagnosis and treatment methods for the treatment of blood cancer
JP2023501229A (en) 2019-11-15 2023-01-18 エンテラ・エッセ・エッレ・エッレ TMEM219 antibody and its therapeutic use
JP2023503105A (en) 2019-11-21 2023-01-26 エンテラ・エッセ・エッレ・エッレ IGFBP3 Antibodies and Their Therapeutic Uses
KR20220122653A (en) 2019-12-06 2022-09-02 주노 쎄러퓨티크스 인코퍼레이티드 Anti-idiotypic Antibodies and Related Compositions and Methods Against BPCMA-Target Binding Domains
EP4069742A1 (en) 2019-12-06 2022-10-12 Juno Therapeutics, Inc. Anti-idiotypic antibodies to gprc5d-targeted binding domains and related compositions and methods
CR20220330A (en) 2019-12-13 2022-08-04 Genentech Inc Anti-ly6g6d antibodies and methods of use
PE20221282A1 (en) 2019-12-18 2022-09-05 Hoffmann La Roche ANTIBODIES THAT BIND HLA-A2/MAGE-A4
CN113045655A (en) 2019-12-27 2021-06-29 高诚生物医药(香港)有限公司 anti-OX 40 antibodies and uses thereof
PE20221585A1 (en) 2019-12-27 2022-10-06 Chugai Pharmaceutical Co Ltd ANTI-ANTIGEN-4 ANTIBODY ASSOCIATED WITH THE CYTOTOXIC T LYMPHOCYTE (CTLA-4) AND USE THEREOF
AU2021206523A1 (en) 2020-01-09 2022-05-26 F. Hoffmann-La Roche Ag New 4-1BBL trimer-containing antigen binding molecules
CN110818795B (en) 2020-01-10 2020-04-24 上海复宏汉霖生物技术股份有限公司 anti-TIGIT antibodies and methods of use
WO2022050954A1 (en) 2020-09-04 2022-03-10 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
WO2021194481A1 (en) 2020-03-24 2021-09-30 Genentech, Inc. Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
JP2023513059A (en) 2020-01-31 2023-03-30 ザ クリーブランド クリニック ファウンデーション Anti-Mullerian hormone receptor 2 antibody and method of use
JP2023512654A (en) 2020-01-31 2023-03-28 ジェネンテック, インコーポレイテッド Methods for Inducing Neoepitope-Specific T Cells Using PD-1 Axis Binding Antagonists and RNA Vaccines
TW202144395A (en) 2020-02-12 2021-12-01 日商中外製藥股份有限公司 Anti-CD137 antigen-binding molecule for use in cancer treatment
IL295023A (en) 2020-02-14 2022-09-01 Jounce Therapeutics Inc Antibodies and fusion proteins that bind to ccr8 and uses thereof
EP3868396A1 (en) 2020-02-20 2021-08-25 Enthera S.R.L. Inhibitors and uses thereof
EP4093762A1 (en) 2020-02-20 2022-11-30 The United States of America, as represented by the Secretary, Department of Health and Human Services Epstein-barr virus monoclonal antibodies and uses thereof
CA3169910A1 (en) 2020-02-28 2021-09-02 Shanghai Henlius Biotech, Inc. Anti-cd137 constructs, multispecific antibody and uses thereof
AU2021225920A1 (en) 2020-02-28 2022-09-15 Shanghai Henlius Biotech, Inc. Anti-CD137 construct and use thereof
CN115605507A (en) 2020-03-13 2023-01-13 基因泰克公司(Us) Anti-interleukin-33 antibodies and uses thereof
CN117510630A (en) 2020-03-19 2024-02-06 基因泰克公司 Isotype selective anti-TGF-beta antibodies and methods of use
EP4107185A1 (en) 2020-03-23 2022-12-28 Genentech, Inc. Biomarkers for predicting response to il-6 antagonist in covid-19 pneumonia
JP2023518815A (en) 2020-03-23 2023-05-08 ジェネンテック, インコーポレイテッド Methods of treating pneumonia, including COVID-19 pneumonia, with an IL6 antagonist
US20230174656A1 (en) 2020-03-23 2023-06-08 Genentech, Inc. Tocilizumab and remdesivir combination therapy for covid-19 pneumonia
CR20220489A (en) 2020-03-24 2022-10-31 Genentech Inc Tie2-binding agents and methods of use
EP4127153A2 (en) 2020-03-26 2023-02-08 Genentech, Inc. Modified mammalian cells having reduced host cell proteins
AR121706A1 (en) 2020-04-01 2022-06-29 Hoffmann La Roche OX40 AND FAP-TARGETED BSPECIFIC ANTIGEN-BINDING MOLECULES
WO2021202959A1 (en) 2020-04-03 2021-10-07 Genentech, Inc. Therapeutic and diagnostic methods for cancer
WO2021207662A1 (en) 2020-04-10 2021-10-14 Genentech, Inc. Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome
IL297541A (en) 2020-04-24 2022-12-01 Genentech Inc Methods of using anti-cd79b immunoconjugates
JP2023523145A (en) 2020-04-27 2023-06-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Isotype-independent antibody against lipoprotein (a)
EP4143345A1 (en) 2020-04-28 2023-03-08 Genentech, Inc. Methods and compositions for non-small cell lung cancer immunotherapy
EP4146283A1 (en) 2020-05-03 2023-03-15 Levena (Suzhou) Biopharma Co., Ltd. Antibody-drug conjugates (adcs) comprising an anti-trop-2 antibody, compositions comprising such adcs, as well as methods of making and using the same
US20230220057A1 (en) 2020-05-27 2023-07-13 Staidson (Beijing) Biopharmaceuticals Co., Ltd. Antibodies specifically recognizing nerve growth factor and uses thereof
CN116529260A (en) 2020-06-02 2023-08-01 当康生物技术有限责任公司 anti-CD 93 constructs and uses thereof
AU2021283345A1 (en) 2020-06-02 2023-02-02 Dynamicure Biotechnology Llc Anti-CD93 constructs and uses thereof
AU2021288916A1 (en) 2020-06-08 2022-11-24 F.Hoffmann-La Roche Ag Anti-HBV antibodies and methods of use
WO2021252977A1 (en) 2020-06-12 2021-12-16 Genentech, Inc. Methods and compositions for cancer immunotherapy
WO2021257503A1 (en) 2020-06-16 2021-12-23 Genentech, Inc. Methods and compositions for treating triple-negative breast cancer
MX2022015881A (en) 2020-06-18 2023-01-24 Genentech Inc Treatment with anti-tigit antibodies and pd-1 axis binding antagonists.
KR20230025673A (en) 2020-06-19 2023-02-22 에프. 호프만-라 로슈 아게 Antibodies that bind to CD3 and FolR1
WO2021255146A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cea
WO2021255155A1 (en) 2020-06-19 2021-12-23 F. Hoffmann-La Roche Ag Antibodies binding to cd3 and cd19
IL296089A (en) 2020-06-19 2022-11-01 Hoffmann La Roche Antibodies binding to cd3
US20220017637A1 (en) 2020-06-23 2022-01-20 Hoffmann-La Roche Inc. Agonistic cd28 antigen binding molecules targeting her2
TW202216756A (en) 2020-06-24 2022-05-01 美商建南德克公司 Apoptosis resistant cell lines
WO2021260064A1 (en) 2020-06-25 2021-12-30 F. Hoffmann-La Roche Ag Anti-cd3/anti-cd28 bispecific antigen binding molecules
KR20230037578A (en) 2020-07-10 2023-03-16 에프. 호프만-라 로슈 아게 Antibodies that bind to cancer cells and target radionuclides to those cells
TW202216780A (en) 2020-07-17 2022-05-01 美商建南德克公司 Anti-notch2 antibodies and methods of use
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
KR20230133832A (en) 2020-07-29 2023-09-19 다이내믹큐어 바이오테크놀로지 엘엘씨 Anti-CD93 constructs and uses thereof
WO2022031749A1 (en) 2020-08-03 2022-02-10 Genentech, Inc. Diagnostic and therapeutic methods for lymphoma
WO2022029660A1 (en) 2020-08-05 2022-02-10 Juno Therapeutics, Inc. Anti-idiotypic antibodies to ror1-targeted binding domains and related compositions and methods
AU2021322239A1 (en) 2020-08-07 2023-02-23 Genentech, Inc. Flt3 ligand fusion proteins and methods of use
AR123254A1 (en) 2020-08-14 2022-11-16 Ac Immune Sa HUMANIZED ANTI-TDP-43 BINDING MOLECULES AND THEIR USES
WO2022043517A2 (en) 2020-08-27 2022-03-03 Cureab Gmbh Anti-golph2 antibodies for macrophage and dendritic cell differentiation
CA3192344A1 (en) 2020-08-28 2022-03-03 Genentech, Inc. Crispr/cas9 multiplex knockout of host cell proteins
EP4208201A1 (en) 2020-09-04 2023-07-12 F. Hoffmann-La Roche AG Antibody that binds to vegf-a and ang2 and methods of use
CN116249719A (en) 2020-09-15 2023-06-09 拜耳公司 Novel anti-A2 AP antibodies and uses thereof
EP4213877A1 (en) 2020-09-17 2023-07-26 Genentech, Inc. Results of empacta: a randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of tocilizumab in hospitalized patients with covid-19 pneumonia
JP2023544407A (en) 2020-10-05 2023-10-23 ジェネンテック, インコーポレイテッド Administration for treatment with anti-FcRH5/anti-CD3 bispecific antibodies
KR20230091871A (en) 2020-10-20 2023-06-23 에프. 호프만-라 로슈 아게 Combination therapy of a PD-1 axis binding antagonist and a LRRK2 inhibitor
AR123855A1 (en) 2020-10-20 2023-01-18 Genentech Inc PEG-CONJUGATED ANTI-MERTK ANTIBODIES AND METHODS OF USE
EP4232475A1 (en) 2020-10-20 2023-08-30 Kantonsspital St. Gallen Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof
WO2022093981A1 (en) 2020-10-28 2022-05-05 Genentech, Inc. Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists
WO2022098638A2 (en) 2020-11-04 2022-05-12 Genentech, Inc. Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
IL302400A (en) 2020-11-04 2023-06-01 Genentech Inc Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
EP4240493A2 (en) 2020-11-04 2023-09-13 Genentech, Inc. Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
WO2022101458A1 (en) 2020-11-16 2022-05-19 F. Hoffmann-La Roche Ag Combination therapy with fap-targeted cd40 agonists
TW202237639A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
TW202237638A (en) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 Compositions of guanylyl cyclase c (gcc) antigen binding agents and methods of use thereof
WO2022132904A1 (en) 2020-12-17 2022-06-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies targeting sars-cov-2
JP2024503826A (en) 2021-01-06 2024-01-29 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Combination therapy using PD1-LAG3 bispecific antibody and CD20 T cell bispecific antibody
EP4277705A1 (en) 2021-01-12 2023-11-22 F. Hoffmann-La Roche AG Split antibodies which bind to cancer cells and target radionuclides to said cells
AU2022207624A1 (en) 2021-01-13 2023-07-13 F. Hoffmann-La Roche Ag Combination therapy
WO2022162587A1 (en) 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
CN117120084A (en) 2021-01-28 2023-11-24 维肯芬特有限责任公司 Methods and means for modulating B cell mediated immune responses
WO2022162203A1 (en) 2021-01-28 2022-08-04 Vaccinvent Gmbh Method and means for modulating b-cell mediated immune responses
EP4284422A1 (en) 2021-01-28 2023-12-06 Vaccinvent GmbH Method and means for modulating b-cell mediated immune responses
EP4288458A1 (en) 2021-02-03 2023-12-13 Genentech, Inc. Multispecific binding protein degrader platform and methods of use
CN117396502A (en) 2021-02-09 2024-01-12 佐治亚大学研究基金会有限公司 Human monoclonal antibodies to pneumococcal antigens
IL304955A (en) 2021-02-09 2023-10-01 Us Health Antibodies targeting the spike protein of coronaviruses
CA3208365A1 (en) 2021-02-15 2022-08-18 Chantal KUHN Cell therapy compositions and methods for modulating tgf-b signaling
IL305131A (en) 2021-02-26 2023-10-01 Bayer Ag INHIBITORS OF IL-11 OR IL-11Ra FOR USE IN THE TREATMENT OF ABNORMAL UTERINE BLEEDING
CA3209364A1 (en) 2021-03-01 2022-09-09 Jennifer O'neil Combination of masked ctla4 and pd1/pdl1 antibodies for treating cancer
US20220306743A1 (en) 2021-03-01 2022-09-29 Xilio Development, Inc. Combination of ctla4 and pd1/pdl1 antibodies for treating cancer
JP2024509169A (en) 2021-03-03 2024-02-29 ソレント・セラピューティクス・インコーポレイテッド Antibody-drug conjugates including anti-BCMA antibodies
JP2024509191A (en) 2021-03-05 2024-02-29 ダイナミキュア バイオテクノロジー エルエルシー Anti-VISTA constructs and their uses
AR125074A1 (en) 2021-03-12 2023-06-07 Genentech Inc ANTI-KLK7 ANTIBODIES, ANTI-KLK5 ANTIBODIES, ANTI-KLK5/KLK7 MULTI-SPECIFIC ANTIBODIES AND METHODS OF USE
CA3213599A1 (en) 2021-03-15 2022-09-22 Genentech, Inc. Compositions and methods of treating lupus nephritis
WO2022197877A1 (en) 2021-03-19 2022-09-22 Genentech, Inc. Methods and compositions for time delayed bio-orthogonal release of cytotoxic agents
TW202300648A (en) 2021-03-25 2023-01-01 美商當康生物科技有限公司 Anti-igfbp7 constructs and uses thereof
US20220389096A1 (en) 2021-03-30 2022-12-08 Bayer Aktiengesellschaft Novel anti-sema3a antibodies and uses thereof
AR125344A1 (en) 2021-04-15 2023-07-05 Chugai Pharmaceutical Co Ltd ANTI-C1S ANTIBODY
TW202305122A (en) 2021-04-19 2023-02-01 美商建南德克公司 Modified mammalian cells
WO2022228705A1 (en) 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
CA3218170A1 (en) 2021-05-12 2022-11-17 Jamie Harue HIRATA Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
US20220389097A1 (en) 2021-05-14 2022-12-08 Genentech Inc. Agonists of TREM2
WO2022243261A1 (en) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Agonistic cd40 antigen binding molecules targeting cea
KR20240010469A (en) 2021-05-21 2024-01-23 제넨테크, 인크. Modified cells for production of recombinant products of interest
AR126009A1 (en) 2021-06-02 2023-08-30 Hoffmann La Roche CD28 ANTIGEN-BINDING AGONIST MOLECULES THAT TARGET EPCAM
TW202306994A (en) 2021-06-04 2023-02-16 日商中外製藥股份有限公司 Anti-ddr2 antibodies and uses thereof
CA3216220A1 (en) 2021-06-09 2022-12-15 F. Hoffmann-La Roche Ag Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer
CA3221924A1 (en) 2021-06-11 2022-12-15 Genentech, Inc. Method for treating chronic obstructive pulmonary disease with an st2 antagonist
WO2022266660A1 (en) 2021-06-17 2022-12-22 Amberstone Biosciences, Inc. Anti-cd3 constructs and uses thereof
WO2022263638A1 (en) 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
BR112023023480A2 (en) 2021-06-25 2024-01-30 Chugai Pharmaceutical Co Ltd USE OF ANTI-CTLA-4 ANTIBODY
WO2022270611A1 (en) 2021-06-25 2022-12-29 中外製薬株式会社 Anti–ctla-4 antibody
TW202317633A (en) 2021-07-08 2023-05-01 美商舒泰神(加州)生物科技有限公司 Antibodies specifically recognizing tnfr2 and uses thereof
WO2023288182A1 (en) 2021-07-12 2023-01-19 Genentech, Inc. Structures for reducing antibody-lipase binding
US20230049152A1 (en) 2021-07-14 2023-02-16 Genentech, Inc. Anti-c-c motif chemokine receptor 8 (ccr8) antibodies and methods of use
CN115812082A (en) 2021-07-14 2023-03-17 舒泰神(北京)生物制药股份有限公司 Antibody specifically recognizing CD40 and application thereof
WO2023004386A1 (en) 2021-07-22 2023-01-26 Genentech, Inc. Brain targeting compositions and methods of use thereof
WO2023001884A1 (en) 2021-07-22 2023-01-26 F. Hoffmann-La Roche Ag Heterodimeric fc domain antibodies
CN117794953A (en) 2021-08-03 2024-03-29 豪夫迈·罗氏有限公司 Bispecific antibodies and methods of use
WO2023019092A1 (en) 2021-08-07 2023-02-16 Genentech, Inc. Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma
WO2023019239A1 (en) 2021-08-13 2023-02-16 Genentech, Inc. Dosing for anti-tryptase antibodies
WO2023021055A1 (en) 2021-08-19 2023-02-23 F. Hoffmann-La Roche Ag Multivalent anti-variant fc-region antibodies and methods of use
AU2022332285A1 (en) 2021-08-23 2024-02-15 Immunitas Therapeutics, Inc. Anti-cd161 antibodies and uses thereof
IL310382A (en) 2021-08-27 2024-03-01 Genentech Inc Methods of treating tau pathologies
WO2023034750A1 (en) 2021-08-30 2023-03-09 Genentech, Inc. Anti-polyubiquitin multispecific antibodies
AU2022345251A1 (en) 2021-09-17 2024-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies
WO2023056403A1 (en) 2021-09-30 2023-04-06 Genentech, Inc. Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
WO2023081818A1 (en) 2021-11-05 2023-05-11 American Diagnostics & Therapy, Llc (Adxrx) Monoclonal antibodies against carcinoembryonic antigens, and their uses
WO2023086807A1 (en) 2021-11-10 2023-05-19 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
TW202337494A (en) 2021-11-16 2023-10-01 美商建南德克公司 Methods and compositions for treating systemic lupus erythematosus (sle) with mosunetuzumab
WO2023088959A1 (en) 2021-11-16 2023-05-25 Ac Immune Sa Novel molecules for therapy and diagnosis
WO2023094569A1 (en) 2021-11-26 2023-06-01 F. Hoffmann-La Roche Ag Combination therapy of anti-tyrp1/anti-cd3 bispecific antibodies and tyrp1-specific antibodies
AR127887A1 (en) 2021-12-10 2024-03-06 Hoffmann La Roche ANTIBODIES THAT BIND CD3 AND PLAP
TW202340248A (en) 2021-12-20 2023-10-16 瑞士商赫孚孟拉羅股份公司 Agonistic ltbr antibodies and bispecific antibodies comprising them
US20230227545A1 (en) 2022-01-07 2023-07-20 Johnson & Johnson Enterprise Innovation Inc. Materials and methods of il-1beta binding proteins
US20230322958A1 (en) 2022-01-19 2023-10-12 Genentech, Inc. Anti-Notch2 Antibodies and Conjugates and Methods of Use
WO2023154824A1 (en) 2022-02-10 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies that broadly target coronaviruses
WO2023156549A1 (en) 2022-02-16 2023-08-24 Ac Immune Sa Humanized anti-tdp-43 binding molecules and uses thereof
WO2023159182A1 (en) 2022-02-18 2023-08-24 Rakuten Medical, Inc. Anti-programmed death-ligand 1 (pd-l1) antibody molecules, encoding polynucleotides, and methods of use
WO2023173026A1 (en) 2022-03-10 2023-09-14 Sorrento Therapeutics, Inc. Antibody-drug conjugates and uses thereof
TW202346365A (en) 2022-03-23 2023-12-01 瑞士商赫孚孟拉羅股份公司 Combination treatment of an anti-cd20/anti-cd3 bispecific antibody and chemotherapy
WO2023192827A1 (en) 2022-03-26 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bispecific antibodies to hiv-1 env and their use
WO2023192881A1 (en) 2022-03-28 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to hiv-1 env and their use
WO2023186756A1 (en) 2022-03-28 2023-10-05 F. Hoffmann-La Roche Ag Interferon gamma variants and antigen binding molecules comprising these
WO2023191816A1 (en) 2022-04-01 2023-10-05 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2023194565A1 (en) 2022-04-08 2023-10-12 Ac Immune Sa Anti-tdp-43 binding molecules
WO2023198727A1 (en) 2022-04-13 2023-10-19 F. Hoffmann-La Roche Ag Pharmaceutical compositions of anti-cd20/anti-cd3 bispecific antibodies and methods of use
WO2023201299A1 (en) 2022-04-13 2023-10-19 Genentech, Inc. Pharmaceutical compositions of therapeutic proteins and methods of use
WO2023203177A1 (en) 2022-04-20 2023-10-26 Kantonsspital St. Gallen Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof
WO2023215737A1 (en) 2022-05-03 2023-11-09 Genentech, Inc. Anti-ly6e antibodies, immunoconjugates, and uses thereof
WO2023217933A1 (en) 2022-05-11 2023-11-16 F. Hoffmann-La Roche Ag Antibody that binds to vegf-a and il6 and methods of use
WO2023219613A1 (en) 2022-05-11 2023-11-16 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2023235699A1 (en) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Antibodies to lilrb4 and uses thereof
WO2023240058A2 (en) 2022-06-07 2023-12-14 Genentech, Inc. Prognostic and therapeutic methods for cancer
WO2023237706A2 (en) 2022-06-08 2023-12-14 Institute For Research In Biomedicine (Irb) Cross-specific antibodies, uses and methods for discovery thereof
WO2024015897A1 (en) 2022-07-13 2024-01-18 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2024020432A1 (en) 2022-07-19 2024-01-25 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2024020407A1 (en) 2022-07-19 2024-01-25 Staidson Biopharma Inc. Antibodies specifically recognizing b- and t-lymphocyte attenuator (btla) and uses thereof
WO2024020564A1 (en) 2022-07-22 2024-01-25 Genentech, Inc. Anti-steap1 antigen-binding molecules and uses thereof
WO2024020579A1 (en) 2022-07-22 2024-01-25 Bristol-Myers Squibb Company Antibodies binding to human pad4 and uses thereof
WO2024030829A1 (en) 2022-08-01 2024-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind to the underside of influenza viral neuraminidase
WO2024028732A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Cd98 binding constructs for treating brain tumors
WO2024028731A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Transferrin receptor binding proteins for treating brain tumors
WO2024044779A2 (en) 2022-08-26 2024-02-29 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for delta-like ligand 3 (dll3)
WO2024049949A1 (en) 2022-09-01 2024-03-07 Genentech, Inc. Therapeutic and diagnostic methods for bladder cancer
WO2024054822A1 (en) 2022-09-07 2024-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Engineered sars-cov-2 antibodies with increased neutralization breadth
WO2024054929A1 (en) 2022-09-07 2024-03-14 Dynamicure Biotechnology Llc Anti-vista constructs and uses thereof
WO2024064826A1 (en) 2022-09-22 2024-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
WO2024068996A1 (en) 2022-09-30 2024-04-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272066A (en) * 1986-03-07 1993-12-21 Massachusetts Institute Of Technology Synthetic method for enhancing glycoprotein stability
SE466403B (en) * 1988-03-24 1992-02-10 Kurt G I Nilsson SAID TO SYNTHETIZE Oligosaccharides
AU4751990A (en) * 1988-12-13 1990-07-10 La Jolla Cancer Research Foundation Nucleotides encoding human b1, 4-galactosyltransferase and uses thereof
US5047335A (en) * 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
GB9022547D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Purified immunoglobulin

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