UY35620A - Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso - Google Patents
Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de usoInfo
- Publication number
- UY35620A UY35620A UY0001035620A UY35620A UY35620A UY 35620 A UY35620 A UY 35620A UY 0001035620 A UY0001035620 A UY 0001035620A UY 35620 A UY35620 A UY 35620A UY 35620 A UY35620 A UY 35620A
- Authority
- UY
- Uruguay
- Prior art keywords
- methods
- antibodies
- lexined
- oxidated
- receiver
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4726—Lectins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a anticuerpos monoclonales que se unen al receptor 1 de LDL (lipop roteína de baja densidad) oxidado similar a la lectina humana (en lo sucesivo, denominado a veces como "LOX- 1"), y composiciones farmacéuticas y métodos de tratamiento que comprenden los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361837765P | 2013-06-21 | 2013-06-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY35620A true UY35620A (es) | 2015-01-30 |
Family
ID=51177197
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY0001035620A UY35620A (es) | 2013-06-21 | 2014-06-18 | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
Country Status (13)
Country | Link |
---|---|
US (2) | US9562101B2 (es) |
EP (1) | EP3010936B1 (es) |
JP (1) | JP2016523257A (es) |
KR (1) | KR20160021849A (es) |
CN (1) | CN105518026A (es) |
AR (1) | AR096651A1 (es) |
AU (1) | AU2014281294A1 (es) |
CA (1) | CA2915831A1 (es) |
EA (1) | EA201690064A1 (es) |
MX (1) | MX2015017853A (es) |
TW (1) | TW201536802A (es) |
UY (1) | UY35620A (es) |
WO (1) | WO2014205302A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
UY35620A (es) | 2013-06-21 | 2015-01-30 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
SG11201702385TA (en) * | 2014-10-01 | 2017-04-27 | Medimmune Ltd | Binding proteins specific for lox1 and uses thereof |
US20160367474A1 (en) * | 2015-06-17 | 2016-12-22 | Anthony Pignataro | Treatment process for skin imperfections |
WO2017011394A1 (en) * | 2015-07-10 | 2017-01-19 | Baylor College Of Medicine | Human monoclonal antibodies for human norovirus and epitope discovery |
MA43342A (fr) * | 2015-09-30 | 2018-08-08 | Medimmune Ltd | Compositions et procédé d'inhibition de cellules souches cancéreuses |
WO2017210360A1 (en) | 2016-05-31 | 2017-12-07 | Cardiovax, Llc | Methods for diagnosing and treating systemic lupus erythematosus |
US10858422B2 (en) | 2016-05-31 | 2020-12-08 | Abcentra, Llc | Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody |
CN107216390B (zh) * | 2017-07-05 | 2020-08-21 | 吉林大学 | 抗lox-1人源单链抗体及其制备方法和应用 |
GB2569144B (en) * | 2017-12-06 | 2021-06-16 | Proimmune Ltd | Method for screening the activity of mutated expressed polypeptides |
CN111171147B (zh) * | 2020-02-11 | 2021-07-20 | 北京康普美特创新医药科技有限责任公司 | 一种抗补体c3分子的全人源单克隆抗体及应用 |
CN115477704B (zh) * | 2021-06-16 | 2024-02-23 | 四川大学华西医院 | 一种基于lox1构建的嵌合抗原受体免疫细胞制备及其应用 |
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UY35620A (es) | 2013-06-21 | 2015-01-30 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
AR096601A1 (es) | 2013-06-21 | 2016-01-20 | Novartis Ag | Anticuerpos del receptor 1 de ldl oxidado similar a lectina y métodos de uso |
JP6362209B2 (ja) | 2013-12-27 | 2018-07-25 | 国立研究開発法人国立循環器病研究センター | 抗血液凝固剤 |
SG11201702385TA (en) | 2014-10-01 | 2017-04-27 | Medimmune Ltd | Binding proteins specific for lox1 and uses thereof |
-
2014
- 2014-06-18 UY UY0001035620A patent/UY35620A/es not_active Application Discontinuation
- 2014-06-18 US US14/307,519 patent/US9562101B2/en active Active
- 2014-06-19 AR ARP140102313A patent/AR096651A1/es unknown
- 2014-06-20 AU AU2014281294A patent/AU2014281294A1/en not_active Abandoned
- 2014-06-20 MX MX2015017853A patent/MX2015017853A/es unknown
- 2014-06-20 CN CN201480046090.6A patent/CN105518026A/zh active Pending
- 2014-06-20 EP EP14738994.4A patent/EP3010936B1/en active Active
- 2014-06-20 JP JP2016521832A patent/JP2016523257A/ja active Pending
- 2014-06-20 EA EA201690064A patent/EA201690064A1/ru unknown
- 2014-06-20 CA CA2915831A patent/CA2915831A1/en not_active Abandoned
- 2014-06-20 TW TW103121444A patent/TW201536802A/zh unknown
- 2014-06-20 KR KR1020167001385A patent/KR20160021849A/ko not_active Application Discontinuation
- 2014-06-20 WO PCT/US2014/043317 patent/WO2014205302A2/en active Application Filing
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2016
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US20170260272A1 (en) | 2017-09-14 |
AU2014281294A1 (en) | 2015-12-24 |
CN105518026A (zh) | 2016-04-20 |
KR20160021849A (ko) | 2016-02-26 |
EA201690064A1 (ru) | 2016-05-31 |
EP3010936A2 (en) | 2016-04-27 |
WO2014205302A2 (en) | 2014-12-24 |
JP2016523257A (ja) | 2016-08-08 |
AR096651A1 (es) | 2016-01-27 |
US9562101B2 (en) | 2017-02-07 |
US20140377281A1 (en) | 2014-12-25 |
MX2015017853A (es) | 2016-05-10 |
EP3010936B1 (en) | 2021-03-24 |
AU2014281294A2 (en) | 2016-02-04 |
US9988455B2 (en) | 2018-06-05 |
CA2915831A1 (en) | 2014-12-24 |
TW201536802A (zh) | 2015-10-01 |
WO2014205302A3 (en) | 2015-04-23 |
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