MX2021003214A - Metodos terapeuticos y de diagnostico para el cancer de vejiga. - Google Patents

Metodos terapeuticos y de diagnostico para el cancer de vejiga.

Info

Publication number
MX2021003214A
MX2021003214A MX2021003214A MX2021003214A MX2021003214A MX 2021003214 A MX2021003214 A MX 2021003214A MX 2021003214 A MX2021003214 A MX 2021003214A MX 2021003214 A MX2021003214 A MX 2021003214A MX 2021003214 A MX2021003214 A MX 2021003214A
Authority
MX
Mexico
Prior art keywords
bladder cancer
methods
therapeutic
patient suffering
diagnostic methods
Prior art date
Application number
MX2021003214A
Other languages
English (en)
Inventor
Sanjeev Mariathasan
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2021003214A publication Critical patent/MX2021003214A/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3

Abstract

La presente invención proporciona métodos y composiciones terapéuticos y de diagnóstico para el cáncer de vejiga (por ejemplo, carcinoma urotelial localmente avanzado o metastásico). La invención proporciona métodos para tratar el cáncer de vejiga, métodos para determinar si un paciente que tiene cáncer de vejiga es propenso a responder a un tratamiento que comprende un antagonista de unión al eje de PD-L1, métodos para prever la sensibilidad de un paciente que tiene cáncer de vejiga al tratamiento que comprende un antagonista de unión al eje de PD-L1 y métodos para seleccionar un tratamiento para un paciente que tiene cáncer de vejiga, en función de niveles de expresión de un biomarcador de la invención (por ejemplo, niveles de expresión de PD-L1 en células inmunitarias que infiltran los tumores en una muestra tumoral obtenida del paciente).
MX2021003214A 2018-09-19 2019-09-17 Metodos terapeuticos y de diagnostico para el cancer de vejiga. MX2021003214A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862733573P 2018-09-19 2018-09-19
PCT/US2019/051530 WO2020061060A1 (en) 2018-09-19 2019-09-17 Therapeutic and diagnostic methods for bladder cancer

Publications (1)

Publication Number Publication Date
MX2021003214A true MX2021003214A (es) 2021-05-12

Family

ID=68084975

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021003214A MX2021003214A (es) 2018-09-19 2019-09-17 Metodos terapeuticos y de diagnostico para el cancer de vejiga.

Country Status (11)

Country Link
US (1) US20210208143A1 (es)
EP (1) EP3853611A1 (es)
JP (1) JP2022501332A (es)
KR (1) KR20210063330A (es)
CN (1) CN112955747A (es)
AU (1) AU2019342099A1 (es)
CA (1) CA3111401A1 (es)
IL (1) IL281486A (es)
MX (1) MX2021003214A (es)
TW (1) TW202023617A (es)
WO (1) WO2020061060A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL302006A (en) * 2020-10-11 2023-06-01 Agensys Inc Methods for treating cancer with antibody-drug conjugates (ADC) that bind to proteins 191P4D12
CN112481380B (zh) * 2020-12-02 2022-10-21 上海市第一人民医院 一种评估晚期膀胱癌抗肿瘤免疫治疗反应性和预后生存的标志物及其应用
CN114854863A (zh) * 2022-06-02 2022-08-05 中国人民解放军空军军医大学 基于生物标志物构建的模型在预测癌症免疫疗效中的应用

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