UA117901C2 - Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування - Google Patents
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосуванняInfo
- Publication number
- UA117901C2 UA117901C2 UAA201401075A UAA201401075A UA117901C2 UA 117901 C2 UA117901 C2 UA 117901C2 UA A201401075 A UAA201401075 A UA A201401075A UA A201401075 A UAA201401075 A UA A201401075A UA 117901 C2 UA117901 C2 UA 117901C2
- Authority
- UA
- Ukraine
- Prior art keywords
- polypeptide
- effector function
- human igg1
- antibody variants
- human
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Винахід стосується способу посилення ефекторної функції вихідного поліпептиду, який містить Fc-домен імуноглобуліну і з'єднувальну ділянку, де ефекторна функція є зв'язуванням Clq, який передбачає введення мутації у вихідний поліпептид в амінокислотному залишку, який відповідає Е430 в Fc-ділянці важкого ланцюга людського IgG1, пронумерований відповідно до нумерації EU, в антитілі IgG1 людини; варіанта такого поліпептиду; композиції, що його містить; та способу його застосування для лікування раку у людини.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161504994P | 2011-07-06 | 2011-07-06 | |
DKPA201100519 | 2011-07-06 | ||
DKPA201200371 | 2012-05-30 | ||
PCT/EP2012/063339 WO2013004842A2 (en) | 2011-07-06 | 2012-07-06 | Antibody variants and uses thereof |
Publications (1)
Publication Number | Publication Date |
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UA117901C2 true UA117901C2 (uk) | 2018-10-25 |
Family
ID=47437504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201401075A UA117901C2 (uk) | 2011-07-06 | 2012-06-07 | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
Country Status (21)
Country | Link |
---|---|
US (2) | US10759867B2 (uk) |
EP (2) | EP3970746A3 (uk) |
JP (2) | JP6243330B2 (uk) |
KR (2) | KR20220158849A (uk) |
CN (3) | CN104220093B (uk) |
AU (4) | AU2012280222B8 (uk) |
BR (1) | BR112014000264A2 (uk) |
CA (1) | CA2840147A1 (uk) |
DK (1) | DK2729170T3 (uk) |
EA (1) | EA201400108A1 (uk) |
ES (1) | ES2908876T3 (uk) |
IN (1) | IN2014CN00807A (uk) |
MX (1) | MX357944B (uk) |
PL (1) | PL2729170T3 (uk) |
PT (1) | PT2729170T (uk) |
RS (1) | RS63044B1 (uk) |
SG (1) | SG10201605572TA (uk) |
SI (1) | SI2729170T1 (uk) |
UA (1) | UA117901C2 (uk) |
WO (1) | WO2013004842A2 (uk) |
ZA (1) | ZA201309499B (uk) |
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- 2012-07-06 CN CN202010835726.2A patent/CN112239496A/zh active Pending
- 2012-07-06 CA CA2840147A patent/CA2840147A1/en active Pending
- 2012-07-06 JP JP2014517839A patent/JP6243330B2/ja active Active
- 2012-07-06 WO PCT/EP2012/063339 patent/WO2013004842A2/en active Application Filing
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2013
- 2013-12-17 ZA ZA2013/09499A patent/ZA201309499B/en unknown
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2017
- 2017-08-04 JP JP2017151418A patent/JP6586442B2/ja active Active
- 2017-12-04 AU AU2017272140A patent/AU2017272140B2/en active Active
-
2019
- 2019-12-17 AU AU2019283809A patent/AU2019283809A1/en not_active Abandoned
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2020
- 2020-07-06 US US16/921,154 patent/US20210163619A1/en active Pending
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2022
- 2022-02-10 AU AU2022200869A patent/AU2022200869A1/en active Pending
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