MX2019000159A - Pirrolo[2,3-d]piridazin-4-onas sustituidas y pirazolo[3,4-d]pirida zin-4-onas como inhibidores de la proteina quinasa. - Google Patents

Pirrolo[2,3-d]piridazin-4-onas sustituidas y pirazolo[3,4-d]pirida zin-4-onas como inhibidores de la proteina quinasa.

Info

Publication number
MX2019000159A
MX2019000159A MX2019000159A MX2019000159A MX2019000159A MX 2019000159 A MX2019000159 A MX 2019000159A MX 2019000159 A MX2019000159 A MX 2019000159A MX 2019000159 A MX2019000159 A MX 2019000159A MX 2019000159 A MX2019000159 A MX 2019000159A
Authority
MX
Mexico
Prior art keywords
pyridazin
ones
pyrazolo
protein kinase
kinase inhibitors
Prior art date
Application number
MX2019000159A
Other languages
English (en)
Inventor
Yang Lijun
Zhao Xingdong
Tan Haohan
Wang Xianlong
Li Zhifu
Lin Min
Chen Zhifang
Wang Weibo
Chen Ling
Tan Rui
Liu Bin
Sun Jing
Zhang Weipeng
Ran Kai
Zou Zongyao
Original Assignee
Shanghai Fochon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Fochon Pharmaceutical Co Ltd filed Critical Shanghai Fochon Pharmaceutical Co Ltd
Publication of MX2019000159A publication Critical patent/MX2019000159A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Se proporcionan ciertos compuestos o sales farmacéuticamente aceptables de los mismos que pueden inhibir la actividad quinasa de la tirosina quinasa de Bruton (BTK) y pueden ser útiles para el tratamiento de enfermedades como el cáncer, las enfermedades inmunológicas y la inflamación.
MX2019000159A 2016-06-22 2017-06-20 Pirrolo[2,3-d]piridazin-4-onas sustituidas y pirazolo[3,4-d]pirida zin-4-onas como inhibidores de la proteina quinasa. MX2019000159A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662353535P 2016-06-22 2016-06-22
US201662412768P 2016-10-25 2016-10-25
PCT/CN2017/089123 WO2017219955A1 (en) 2016-06-22 2017-06-20 Substituted pyrrolo [2, 3-d] pyridazin-4-ones and pyrazolo [3, 4-d] pyridazin-4-ones as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2019000159A true MX2019000159A (es) 2019-05-30

Family

ID=60783194

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000159A MX2019000159A (es) 2016-06-22 2017-06-20 Pirrolo[2,3-d]piridazin-4-onas sustituidas y pirazolo[3,4-d]pirida zin-4-onas como inhibidores de la proteina quinasa.

Country Status (12)

Country Link
US (1) US10800785B2 (es)
EP (1) EP3475286A4 (es)
JP (1) JP6966044B2 (es)
KR (1) KR102489537B1 (es)
CN (1) CN109476666B (es)
AU (1) AU2017280412B2 (es)
BR (1) BR112018076622A2 (es)
CA (1) CA3028824C (es)
MX (1) MX2019000159A (es)
RU (1) RU2749038C2 (es)
TW (1) TWI791444B (es)
WO (1) WO2017219955A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116096720A (zh) * 2020-08-27 2023-05-09 上海和誉生物医药科技有限公司 二氢吡咯并[2,3-d]哒嗪-7-酮衍生物，其制备方法和应用
WO2022228387A1 (en) * 2021-04-26 2022-11-03 Fochon Biosciences, Ltd. Compounds as parp inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
WO2014113932A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
WO2014113942A1 (en) * 2013-01-23 2014-07-31 Merck Sharp & Dohme Corp. Btk inhibitors
TW201441234A (zh) * 2013-01-23 2014-11-01 Merck Sharp & Dohme Ｂｔｋ抑制劑
EP3082809B1 (en) * 2013-12-20 2021-01-20 Merck Sharp & Dohme Corp. Btk inhibitors
CN106573001B (zh) * 2014-07-07 2019-01-29 江苏恒瑞医药股份有限公司 作为蛋白激酶抑制剂的氨基哒嗪酮化合物
CN105837576B (zh) * 2015-01-14 2019-03-26 湖北生物医药产业技术研究院有限公司 Btk抑制剂

Also Published As

Publication number Publication date
KR102489537B1 (ko) 2023-01-17
TWI791444B (zh) 2023-02-11
RU2749038C2 (ru) 2021-06-03
EP3475286A4 (en) 2019-11-06
AU2017280412A1 (en) 2019-01-17
RU2019101016A3 (es) 2020-07-22
CN109476666B (zh) 2021-10-15
CA3028824C (en) 2023-12-12
KR20190026754A (ko) 2019-03-13
AU2017280412B2 (en) 2021-02-25
CN109476666A (zh) 2019-03-15
JP2019522651A (ja) 2019-08-15
BR112018076622A2 (pt) 2019-04-02
US20190161489A1 (en) 2019-05-30
RU2019101016A (ru) 2020-07-22
WO2017219955A1 (en) 2017-12-28
EP3475286A1 (en) 2019-05-01
CA3028824A1 (en) 2017-12-28
JP6966044B2 (ja) 2021-11-10
US10800785B2 (en) 2020-10-13
TW201811792A (zh) 2018-04-01

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