HUE056365T2 - 2-(2,4,5-Helyettesített-anilino)pirimidin származékok - Google Patents
2-(2,4,5-Helyettesített-anilino)pirimidin származékokInfo
- Publication number
- HUE056365T2 HUE056365T2 HUE20157927A HUE20157927A HUE056365T2 HU E056365 T2 HUE056365 T2 HU E056365T2 HU E20157927 A HUE20157927 A HU E20157927A HU E20157927 A HUE20157927 A HU E20157927A HU E056365 T2 HUE056365 T2 HU E056365T2
- Authority
- HU
- Hungary
- Prior art keywords
- anilino
- substituted
- pyrimidine compounds
- pyrimidine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161512061P | 2011-07-27 | 2011-07-27 | |
US201261591363P | 2012-01-27 | 2012-01-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE056365T2 true HUE056365T2 (hu) | 2022-02-28 |
Family
ID=46875901
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12759801A HUE026429T2 (hu) | 2011-07-27 | 2012-07-25 | Rák kezelésében hasznos 2-(2,4,5-szubsztituált-anilino)-pirimidin származékok mint EGFR modulátorok |
HUE20157927A HUE056365T2 (hu) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-Helyettesített-anilino)pirimidin származékok |
HUE17194307A HUE049060T2 (hu) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-Helyettesített-anilino)pirimidin származékok mint rák kezelésére alkalmas EGFR modulátorok |
HUE15192658A HUE037645T2 (hu) | 2011-07-27 | 2012-07-25 | Rák kezelésére alkalmas 2.(2,4,5-helyettesített-anilino)pirimidin származékok mint EGFR modulátorok |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE12759801A HUE026429T2 (hu) | 2011-07-27 | 2012-07-25 | Rák kezelésében hasznos 2-(2,4,5-szubsztituált-anilino)-pirimidin származékok mint EGFR modulátorok |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE17194307A HUE049060T2 (hu) | 2011-07-27 | 2012-07-25 | 2-(2,4,5-Helyettesített-anilino)pirimidin származékok mint rák kezelésére alkalmas EGFR modulátorok |
HUE15192658A HUE037645T2 (hu) | 2011-07-27 | 2012-07-25 | Rák kezelésére alkalmas 2.(2,4,5-helyettesített-anilino)pirimidin származékok mint EGFR modulátorok |
Country Status (39)
Country | Link |
---|---|
US (6) | US8946235B2 (hu) |
EP (7) | EP3333161B1 (hu) |
JP (3) | JP5427321B2 (hu) |
KR (3) | KR101422619B1 (hu) |
CN (7) | CN104109161B (hu) |
AR (1) | AR087336A1 (hu) |
AU (1) | AU2012288626C1 (hu) |
BR (4) | BR122014026114B1 (hu) |
CA (5) | CA2843109C (hu) |
CL (1) | CL2013003281A1 (hu) |
CO (1) | CO6811863A2 (hu) |
CR (1) | CR20130629A (hu) |
CY (4) | CY1117431T1 (hu) |
DK (5) | DK2736895T3 (hu) |
DO (1) | DOP2013000263A (hu) |
EA (3) | EA033733B1 (hu) |
EC (1) | ECSP13013033A (hu) |
ES (5) | ES2564671T3 (hu) |
GT (1) | GT201300288A (hu) |
HK (4) | HK1192549A1 (hu) |
HR (4) | HRP20211682T1 (hu) |
HU (4) | HUE026429T2 (hu) |
IL (6) | IL229199A (hu) |
LT (3) | LT3686194T (hu) |
ME (3) | ME03785B (hu) |
MX (2) | MX2014000528A (hu) |
MY (2) | MY161925A (hu) |
NI (1) | NI201300134A (hu) |
PE (1) | PE20141700A1 (hu) |
PH (1) | PH12015501326B1 (hu) |
PL (5) | PL3333161T3 (hu) |
PT (4) | PT3333161T (hu) |
RS (4) | RS62542B1 (hu) |
SG (5) | SG10201402857QA (hu) |
SI (4) | SI3686194T1 (hu) |
SM (1) | SMT201600070B (hu) |
TW (3) | TWI465445B (hu) |
UY (1) | UY34219A (hu) |
WO (1) | WO2013014448A1 (hu) |
Families Citing this family (209)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2645689T3 (es) | 2008-05-21 | 2017-12-07 | Ariad Pharmaceuticals, Inc. | Derivados de fósforo como inhibidores de quinasas |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
WO2011021038A1 (en) | 2009-08-20 | 2011-02-24 | Karus Therapeutics Limited | Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors |
KR101884010B1 (ko) | 2011-05-04 | 2018-07-31 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 화합물 |
AU2012288626C1 (en) | 2011-07-27 | 2015-09-17 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as EGFR modulators useful for treating cancer |
GB201204125D0 (en) | 2012-03-08 | 2012-04-25 | Karus Therapeutics Ltd | Compounds |
JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
US9512134B2 (en) | 2013-01-29 | 2016-12-06 | Aptinyx, Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
US9828384B2 (en) * | 2013-01-29 | 2017-11-28 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
CN108283644B (zh) | 2013-03-15 | 2022-03-18 | G1治疗公司 | 在化学疗法期间对正常细胞的瞬时保护 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
WO2014210354A1 (en) * | 2013-06-28 | 2014-12-31 | Genentech, Inc. | Azaindazole compounds as inhibitors of t790m containing egfr mutants |
CN104292142B (zh) * | 2013-07-17 | 2019-05-14 | 天津大地康和医药技术有限公司 | 一种n-芳基杂环丁烷脱芳基方法 |
PH12019500143A1 (en) | 2013-08-23 | 2020-03-02 | Neupharma Inc | Certain chemical entities, compositions, and methods |
RU2703301C2 (ru) * | 2013-10-21 | 2019-10-16 | Мерк Патент Гмбх | Соединения гетероарила в качестве ингибиторов btk и их применение |
GB201400034D0 (en) * | 2014-01-02 | 2014-02-19 | Astrazeneca Ab | Pharmaceutical Compositions comprising AZD9291 |
CN104761544B (zh) * | 2014-01-03 | 2019-03-15 | 北京轩义医药科技有限公司 | Egfr酪氨酸激酶的临床重要突变体的选择性抑制剂 |
GB201402431D0 (en) | 2014-02-12 | 2014-03-26 | Karus Therapeutics Ltd | Compounds |
CN104860941B (zh) * | 2014-02-25 | 2017-03-22 | 上海海雁医药科技有限公司 | 2,4‑二取代苯‑1,5‑二胺衍生物及其应用以及由其制备的药物组合物和药用组合物 |
KR102456088B1 (ko) | 2014-04-04 | 2022-10-19 | 델 마 파마슈티컬스 | 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체 |
PL3125885T3 (pl) * | 2014-04-04 | 2021-12-06 | Astrazeneca Ab | Kombinacja inhibitora EGFR i inhibitora MEK do zastosowania w leczeniu nowotworu złośliwego z mutacją NRAS |
JP6468611B2 (ja) * | 2014-05-13 | 2019-02-13 | アリアド ファーマシューティカルズ, インコーポレイテッド | キナーゼ阻害のためのヘテロアリール化合物 |
CN106660993B (zh) * | 2014-06-12 | 2020-09-11 | 上海复尚慧创医药研究有限公司 | 一类激酶抑制剂 |
CA2949793C (en) * | 2014-06-19 | 2024-02-27 | Ariad Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
CN105254615B (zh) * | 2014-07-11 | 2017-02-22 | 杭州华东医药集团新药研究院有限公司 | 苯胺嘧啶衍生物及其在制备抗恶性肿瘤药物中的用途 |
CN105315285B (zh) * | 2014-07-25 | 2017-12-08 | 上海海雁医药科技有限公司 | 2,4‑二取代7H‑吡咯并[2,3‑d]嘧啶衍生物、其制法与医药上的用途 |
CN105315259B (zh) * | 2014-07-29 | 2018-03-09 | 上海艾力斯医药科技有限公司 | 吡啶胺基嘧啶衍生物、其制备方法及应用 |
JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
CN104140418B (zh) * | 2014-08-15 | 2016-08-24 | 常州润诺生物科技有限公司 | 2-(2,4,5-取代苯胺)嘧啶衍生物及其用途 |
WO2016029839A1 (zh) * | 2014-08-25 | 2016-03-03 | 四川海思科制药有限公司 | 一种(取代的苯基)(取代的嘧啶)胺基衍生物及其制备方法和药物用途 |
CN104356040A (zh) * | 2014-09-17 | 2015-02-18 | 爱斯特(成都)生物制药有限公司 | 一种1-二苯甲基-3-羟基氮杂环丁烷盐酸盐的制备方法 |
CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
CN105524068B (zh) * | 2014-09-30 | 2017-11-24 | 上海海雁医药科技有限公司 | 氮杂双环衍生物、其制法与医药上的用途 |
CN105237515B (zh) * | 2014-10-10 | 2018-06-05 | 益方生物科技(上海)有限公司 | 氘代嘧啶类化合物、其制备方法、药物组合物和用途 |
BR112017006713B1 (pt) | 2014-10-11 | 2023-11-21 | Shanghai Hansoh Biomedical Co., Ltd. | Inibidores de egfr, seus usos e seu processo de preparação, e composição farmacêutica |
EP3604294B1 (en) * | 2014-10-13 | 2021-05-05 | Yuhan Corporation | Compounds and compositions for modulating egfr mutant kinase activities |
CN111170998B (zh) | 2014-11-05 | 2023-04-11 | 益方生物科技(上海)股份有限公司 | 嘧啶或吡啶类化合物、其制备方法和医药用途 |
WO2016090174A1 (en) * | 2014-12-03 | 2016-06-09 | Auckland Uniservices, Ltd. | Kinase inhibitor prodrug for the treatment of cancer |
MX2017007664A (es) | 2014-12-11 | 2018-01-23 | Beta Pharma Inc | Derivados de 2-anilinopirimidina sustituida como moduladores de egfr. |
US10266517B2 (en) | 2014-12-23 | 2019-04-23 | Dana-Farber Cancer Institute, Inc. | Pyrimidines as EGFR inhibitors and methods of treating disorders |
CN104961731A (zh) * | 2015-02-05 | 2015-10-07 | 苏州晶云药物科技有限公司 | 一种表皮生长因子受体抑制剂的磷酸盐、其晶型及制备方法 |
CN104788427B (zh) * | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
CA2976227C (en) | 2015-02-17 | 2023-10-24 | Neupharma, Inc. | Quinazoline derivatives and their use in treatment of cancer |
CN107973791B (zh) * | 2015-04-29 | 2020-04-07 | 南京圣和药业股份有限公司 | 稠环或三环芳基嘧啶化合物用作激酶抑制剂 |
TWI685494B (zh) * | 2015-04-29 | 2020-02-21 | 大陸商廣東眾生藥業股份有限公司 | 稠環或三環芳基嘧啶化合物用作激酶抑制劑 |
CN104817541B (zh) * | 2015-05-11 | 2017-06-16 | 苏州东南药业股份有限公司 | 一种抗肿瘤药物的合成方法 |
JP6863901B2 (ja) * | 2015-05-13 | 2021-04-28 | アリアド ファーマシューティカルズ, インコーポレイテッド | キナーゼ阻害のためのヘテロアリール化合物 |
JP6949726B2 (ja) | 2015-05-15 | 2021-10-13 | ノバルティス アーゲー | Egfr変異癌を治療する方法 |
CN104910049B (zh) | 2015-06-16 | 2016-06-29 | 苏州明锐医药科技有限公司 | Azd9291中间体及其制备方法 |
WO2017008761A1 (zh) * | 2015-07-16 | 2017-01-19 | 正大天晴药业集团股份有限公司 | 苯胺嘧啶衍生物及其用途 |
EP3325469A4 (en) * | 2015-07-20 | 2019-01-23 | Dana Farber Cancer Institute, Inc. | NOVEL PYRIMIDINES USEFUL AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS |
EP3327014A4 (en) * | 2015-07-24 | 2019-01-02 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd. | Egfr inhibitor and pharmaceutically acceptable salt and polymorph thereof, and use thereof |
CN105001208A (zh) * | 2015-08-06 | 2015-10-28 | 南京雷科星生物技术有限公司 | 一种表皮生长因子受体egfr抑制剂及其制备方法与用途 |
GB201514758D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Formulation |
GB201514760D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds and method of use |
GB201514751D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
GB201514754D0 (en) | 2015-08-19 | 2015-09-30 | Karus Therapeutics Ltd | Compounds |
CN106117185B (zh) * | 2015-08-31 | 2017-11-07 | 广州必贝特医药技术有限公司 | 2,4‑二含氮基团取代嘧啶类化合物及其制备方法和应用 |
AU2015407300B2 (en) * | 2015-08-31 | 2019-06-20 | Wuxi Shuangliang Biotechnology Co., Ltd. | 2-Arylamino pyridine, pyridine or triazine derivative, preparation method and use thereof |
CN110483485A (zh) * | 2015-09-02 | 2019-11-22 | 益方生物科技(上海)有限公司 | 嘧啶类化合物、其制备方法和医药用途 |
RU2603960C1 (ru) * | 2015-11-19 | 2016-12-10 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Дихлорацетат n1,n2-дизамещенного n4-[4-(1-метил-1н-индол-3-ил)-пиримидин-2-ил]-5-метоксибензол-1,2,4-триамина в качестве модулятора egfr для лечения рака |
RU2606949C9 (ru) * | 2015-11-19 | 2018-03-14 | ЗАО "Р-Фарм" | Замещенные N-{ 3-[4-(1-метил-1Н-индол-3-ил)пиримидин-2-иламино]-4-метоксифенил} -амиды в качестве модуляторов EGFR, предназначенные для лечения рака |
TW201718583A (zh) * | 2015-11-23 | 2017-06-01 | Nanjing Sanhome Pharmaceutical Co Ltd | 新的表皮生長因子受體抑制劑及其應用 |
CN106810553B (zh) * | 2015-11-30 | 2020-03-17 | 江苏正大丰海制药有限公司 | 3-(4,5-取代氨基嘧啶)苯基衍生物及其应用 |
CA3007110A1 (en) * | 2015-12-03 | 2017-06-08 | Shanghai Aeon Biotech Co., Ltd. | Heterocycle compounds and uses thereof |
WO2017096095A1 (en) * | 2015-12-03 | 2017-06-08 | Shanghai Aeon Biotech Co., Ltd. | Thieno-pyrimidine derivatives and uses thereof |
CN105601620A (zh) * | 2015-12-25 | 2016-05-25 | 北京康立生医药技术开发有限公司 | 一种甲磺酸迈瑞替尼的制备方法 |
CN106928150B (zh) | 2015-12-31 | 2020-07-31 | 恩瑞生物医药科技(上海)有限公司 | 丙烯酰胺苯胺衍生物及其药学上的应用 |
WO2017120429A1 (en) | 2016-01-07 | 2017-07-13 | CS Pharmasciences, Inc. | Selective inhibitors of clinically important mutants of the egfr tyrosine kinase |
CN105646454B (zh) * | 2016-01-19 | 2018-05-08 | 浙江大学 | 含异羟肟酸片段的2-芳胺基嘧啶类衍生物及制备和应用 |
CN108610331A (zh) * | 2016-01-22 | 2018-10-02 | 焦玉奇 | 2-(2,4,5-取代苯胺)嘧啶衍生物 |
CN106995437A (zh) * | 2016-01-22 | 2017-08-01 | 齐鲁制药有限公司 | 取代吲哚或吲唑嘧啶衍生物及其制备方法和用途 |
TWI745345B (zh) * | 2016-02-01 | 2021-11-11 | 瑞典商阿斯特捷利康公司 | 製備奧希替尼(osimertinib,azd9291)或其鹽及「azd9291苯胺」或其鹽的改良方法 |
CN107043368B (zh) * | 2016-02-05 | 2020-07-31 | 齐鲁制药有限公司 | 芳胺嘧啶化合物及其盐的结晶 |
CN107043369A (zh) * | 2016-02-06 | 2017-08-15 | 焦玉奇 | 2‑(2,4,5‑取代苯胺)嘧啶衍生物 |
CN107098887B (zh) * | 2016-02-22 | 2019-08-09 | 复旦大学 | 嘧啶类化合物 |
CN105646467B (zh) * | 2016-02-25 | 2018-07-20 | 黄燕鸽 | 一种抗癌化合物奥美替尼及其合成方法 |
CN105585557B (zh) * | 2016-02-25 | 2018-06-22 | 清华大学 | 用于靶向治疗癌症的egfr抑制剂及其制备方法与应用 |
CN105777716B (zh) * | 2016-02-25 | 2018-04-10 | 清华大学 | 一种用于靶向治疗癌症的egfr抑制剂及其制备方法与应用 |
CN110590749B (zh) * | 2016-03-07 | 2020-11-06 | 上海艾力斯医药科技股份有限公司 | 吡啶胺基嘧啶衍生物甲磺酸盐的结晶形式及其制备和应用 |
CN107163026B (zh) * | 2016-03-07 | 2019-07-02 | 上海艾力斯医药科技有限公司 | 吡啶胺基嘧啶衍生物的盐及其制备方法和应用 |
CN107188888A (zh) * | 2016-03-15 | 2017-09-22 | 罗欣生物科技(上海)有限公司 | 一种制备甲磺酸迈瑞替尼的方法 |
JP7007287B2 (ja) * | 2016-03-22 | 2022-01-24 | ジエンス ハンセン ファーマセウティカル グループ カンパニー リミテッド | Egfr阻害薬フリー塩基または酸性塩の多結晶形、その製造方法、および応用 |
EA201892311A1 (ru) | 2016-05-11 | 2019-06-28 | Бета Фарма, Инк. | Производные 2-анилинопиримидина в качестве терапевтических агентов для лечения рака мозга |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112018073663A2 (pt) | 2016-05-19 | 2019-04-30 | Aptinyx Inc. | moduladores de receptores nmda spiro-lactâmicos e seus usos |
CA3023176A1 (en) * | 2016-05-26 | 2017-11-30 | Zeno Royalties & Milestones, LLC | Egfr inhibitor compounds |
US10844045B2 (en) * | 2016-06-17 | 2020-11-24 | Beta Pharma, Inc. | Pharmaceutical salts N-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and crystalline forms thereof |
CN107522690B (zh) * | 2016-06-20 | 2022-08-05 | 海南先声药业有限公司 | 一种Osimertinib的制备方法 |
CN107540661A (zh) * | 2016-06-24 | 2018-01-05 | 正大天晴药业集团股份有限公司 | 作为egfr抑制剂的苯胺嘧啶化合物的结晶 |
CN107663208B (zh) * | 2016-07-27 | 2021-10-15 | 南京圣和药业股份有限公司 | 一种新型egfr激酶抑制剂的药用盐及其制备方法与用途 |
CN107663207B (zh) * | 2016-07-27 | 2021-07-30 | 南京圣和药业股份有限公司 | 一种egfr激酶抑制剂的甲磺酸盐结晶及制备方法 |
PE20190500A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda spiro-lactam y uso de los mismos |
SG11201900546UA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
SG11201900554YA (en) | 2016-08-01 | 2019-02-27 | Aptinyx Inc | Spiro-lactam nmda modulators and methods of using same |
CN109890825B (zh) | 2016-08-01 | 2022-03-11 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺nmda受体调节剂及其用途 |
PE20190503A1 (es) | 2016-08-01 | 2019-04-10 | Aptinyx Inc | Moduladores del receptor nmda espiro-lactam y uso de los mismos |
CA3033370A1 (en) | 2016-08-15 | 2018-02-22 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN106366022B (zh) * | 2016-08-19 | 2018-03-13 | 上海工程技术大学 | 一种用于制备azd9291的中间体及其制备方法和应用 |
CN106366072B (zh) * | 2016-08-19 | 2018-12-07 | 上海工程技术大学 | 一种azd9291的制备方法 |
CN106397407B (zh) * | 2016-08-31 | 2018-09-04 | 浙江科聚化工有限公司 | 抗肿瘤药物azd9291衍生物的制备方法 |
CN106432231B (zh) * | 2016-09-09 | 2018-06-12 | 无锡佰翱得生物科学有限公司 | Azd9291的药用盐、及其晶型和制备方法 |
ES2863925T3 (es) * | 2016-09-19 | 2021-10-13 | Nanjing Chuangte Pharmaceutical Tech Co Ltd | Derivados de 3-(pirimidinamina 4,5-sustituida)fenilo deuterados y aplicaciones de los mismos |
CN107955019B (zh) * | 2016-10-17 | 2021-09-14 | 广东众生药业股份有限公司 | 一种egfr抑制剂的盐型、晶型及其制备方法 |
WO2018073839A1 (en) | 2016-10-18 | 2018-04-26 | Mylan Laboratories Limited | Amorphous osimertinib mesylate, processes for its preparation and solid amorphous dispersions thereof |
AU2017345574A1 (en) * | 2016-10-19 | 2019-05-23 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for treating cancer |
CN106496196B (zh) * | 2016-10-20 | 2019-07-02 | 南京雷科星生物技术有限公司 | 一种喹唑啉、吡啶并嘧啶或则双并嘧啶衍生物表皮生长因子抑制剂及其制备方法与用途 |
CN106543060B (zh) * | 2016-10-31 | 2018-11-06 | 湖南欧亚药业有限公司 | 一种奥斯替尼甲磺酸盐的制备方法 |
CN108299419B (zh) * | 2017-01-11 | 2022-04-26 | 南京圣和药业股份有限公司 | 一种新型egfr激酶抑制剂的几种新晶型及其制备方法 |
SG11201906435SA (en) | 2017-01-26 | 2019-08-27 | Hanmi Pharmaceutical Co Ltd | Pyrimidine compound and pharmaceutical use thereof |
US11395821B2 (en) | 2017-01-30 | 2022-07-26 | G1 Therapeutics, Inc. | Treatment of EGFR-driven cancer with fewer side effects |
EP3585389A4 (en) * | 2017-02-22 | 2020-12-23 | G1 Therapeutics, Inc. | TREATMENT OF EGFR MEDIATED CANCER WITH LESS SIDE EFFECTS |
TWI796326B (zh) * | 2017-03-24 | 2023-03-21 | 日商第一三共股份有限公司 | 含有axl抑制劑與egfr酪胺酸激酶抑制藥的醫藥品及其用途 |
CN106883216B (zh) * | 2017-04-06 | 2020-03-13 | 张家港威胜生物医药有限公司 | 一种奥希替尼的制备方法 |
CN108503627A (zh) * | 2017-04-19 | 2018-09-07 | 郑州泰基鸿诺医药股份有限公司 | 用作egfr抑制剂的2,4-二取代苯-1,5-二胺衍生物及其应用 |
AR111469A1 (es) * | 2017-04-21 | 2019-07-17 | Yuhan Corp | Sal de un compuesto del derivado de aminopiridina, una forma cristalina de la misma, y un proceso para preparar la misma |
CN106967050A (zh) * | 2017-05-11 | 2017-07-21 | 北京工业大学 | 一种azd9291的制备方法 |
CN108929311B (zh) * | 2017-05-22 | 2020-07-28 | 焦玉奇 | 2-(2,4,5-取代苯胺)嘧啶衍生物 |
CN108558835A (zh) * | 2017-05-24 | 2018-09-21 | 浙江同源康医药股份有限公司 | 一种氘代azd9291的晶型、制备方法及用途 |
CN107176954B (zh) * | 2017-06-02 | 2019-01-11 | 无锡双良生物科技有限公司 | 一种egfr抑制剂的药用盐及其晶型、制备方法和应用 |
EP3640248B8 (en) * | 2017-06-13 | 2023-11-29 | Beijing Avistone Biotechnology Co., Ltd. | Aminopyrimidine derivatives, preparation method therefor and use thereof |
WO2018232235A1 (en) | 2017-06-16 | 2018-12-20 | Beta Pharma, Inc. | Pharmaceutical formulations of n-(2-(2-(dimethylamino)ethoxy)-4-methoxy-5-((4-(1-methyl-1h-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide and salts thereof |
WO2019001425A1 (zh) * | 2017-06-27 | 2019-01-03 | 浙江同源康医药股份有限公司 | 一种氘代奥斯替尼衍生物及其应用 |
CN107095873A (zh) * | 2017-06-28 | 2017-08-29 | 卢凯华 | 具有低耐药性的抗肺癌靶向药物组合物 |
CN107216313B (zh) * | 2017-06-29 | 2019-11-19 | 山东四环药业股份有限公司 | 一种抗肿瘤药物azd9291的制备方法 |
WO2019010619A1 (zh) * | 2017-07-10 | 2019-01-17 | 焦玉奇 | 2-(2,4,5-取代苯胺)嘧啶衍生物 |
NZ761156A (en) * | 2017-07-28 | 2024-01-26 | Yuhan Corp | Improved process for preparing aminopyrimidine derivatives |
PL3658547T3 (pl) | 2017-07-28 | 2024-01-03 | Yuhan Corporation | Sposób wytwarzania n-(5-(4-(4-formylo-3-fenylo-1h-pirazol-1-ilo)pirymidyn-2-yloamino)-4-metoksy-2-morfolinofenylo)akrylamidu |
CN107266426A (zh) * | 2017-08-15 | 2017-10-20 | 南通因诺威医药科技有限公司 | 2‑氨烃基嘧啶类化合物及其制备方法和用途 |
EP3672633A1 (en) | 2017-08-21 | 2020-07-01 | Eli Lilly and Company | Combinations of egfr inhibitors and anti-human vegfr-2 antibodies |
CN109485638B (zh) * | 2017-09-12 | 2020-07-17 | 新发药业有限公司 | 一种奥希替尼中间体的制备方法 |
CN107915725B (zh) * | 2017-10-20 | 2023-06-27 | 复旦大学 | Azd9291的药用盐及其制备方法 |
SG11202004384YA (en) * | 2017-11-17 | 2020-06-29 | Univ Illinois | Cancer therapy by degrading dual mek signaling |
MX2020007312A (es) | 2018-01-08 | 2021-01-08 | G1 Therapeutics Inc | Regimenes de dosificacion superior de g1t38. |
WO2019152696A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
JP7210599B2 (ja) | 2018-01-31 | 2023-01-23 | アプティニックス インコーポレイテッド | スピロラクタム系nmda受容体修飾因子およびその使用 |
WO2019157225A2 (en) * | 2018-02-08 | 2019-08-15 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US20200368231A1 (en) | 2018-02-12 | 2020-11-26 | Astrazeneca Ab | Osimertinib for use in the treatment of non-small cell lung cancer |
US20210085688A1 (en) * | 2018-02-20 | 2021-03-25 | Dana-Farber Cancer Institute, Inc. | Pharmaceutical combinations of egfr inhibitors and methods of use thereof |
US20210077469A1 (en) * | 2018-02-20 | 2021-03-18 | Dana-Farber Cancer Institute, Inc. | Pharmaceutical combinations of egfr inhibitors and methods of use thereof |
CN108250187B (zh) * | 2018-03-01 | 2021-01-05 | 中国科学院上海药物研究所 | 吲哚-1-碳酸酯类化合物、其制备方法和应用 |
CN108191861B (zh) * | 2018-03-01 | 2020-10-02 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-反式-2,4-戊二烯酰胺 |
WO2019175093A1 (en) | 2018-03-12 | 2019-09-19 | Astrazeneca Ab | Method for treating lung cancer |
CN109666024A (zh) * | 2018-03-20 | 2019-04-23 | 兰州大学 | 2-氧嘧啶类化合物及其制备方法和用途 |
CN108218839A (zh) * | 2018-03-20 | 2018-06-29 | 上药康丽(常州)药业有限公司 | 一种抗肿瘤药物azd9291的制备方法 |
CN108484579A (zh) * | 2018-03-28 | 2018-09-04 | 黑龙江鑫创生物科技开发有限公司 | 一种微通道反应器合成奥希替尼中间体的方法 |
CN108530450B (zh) * | 2018-05-03 | 2021-03-30 | 赖建智 | 具有egfr抑制活性的化合物、制备方法及其在疾病治疗中的应用 |
US11639344B2 (en) | 2018-05-15 | 2023-05-02 | InventisBio Co., Ltd. | EGFR inhibitors |
CN110606842B (zh) * | 2018-06-15 | 2021-06-01 | 上海艾力斯医药科技股份有限公司 | 吡啶胺基嘧啶衍生物的制备方法及其中间体 |
CN110698461B (zh) * | 2018-07-09 | 2024-04-05 | 上海翰森生物医药科技有限公司 | 第三代egfr抑制剂的制备方法 |
CN109134435B (zh) * | 2018-10-29 | 2023-01-03 | 湖南大学 | 一种奥希替尼azd9291的合成方法 |
CN111233774B (zh) * | 2018-11-28 | 2023-04-14 | 鲁南制药集团股份有限公司 | 一种胺基嘧啶类化合物 |
TW202038957A (zh) | 2018-12-21 | 2020-11-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與激酶抑制劑之組合 |
CN111410651B (zh) * | 2019-01-05 | 2021-06-04 | 山东轩竹医药科技有限公司 | 酪氨酸激酶抑制剂的盐及其晶型 |
WO2020140934A1 (zh) * | 2019-01-05 | 2020-07-09 | 山东轩竹医药科技有限公司 | Egfr酪氨酸激酶的选择性抑制剂的盐及其晶型 |
CN111606889B (zh) * | 2019-02-25 | 2023-03-07 | 上海翰森生物医药科技有限公司 | 4-(1-环丙基-1h-吲哚-3-基)-n-苯基嘧啶-2-胺衍生物的制备方法 |
CN113773304B (zh) * | 2019-02-25 | 2023-03-10 | 江苏豪森药业集团有限公司 | 抗耐药抗肿瘤egfr抑制剂的制备方法 |
CN109928956B (zh) * | 2019-02-27 | 2020-10-13 | 杭州偶联医药科技有限公司 | 一种靶向泛素化降解egfr蛋白的化合物及其药物组合物和应用 |
WO2020192302A1 (zh) * | 2019-03-27 | 2020-10-01 | 广州必贝特医药技术有限公司 | 含嘧啶的三取代咪唑类化合物及其应用 |
CN111747931A (zh) * | 2019-03-29 | 2020-10-09 | 深圳福沃药业有限公司 | 用于治疗癌症的氮杂芳环酰胺衍生物 |
CA3133766A1 (en) | 2019-03-29 | 2020-10-08 | Astrazeneca Ab | Osimertinib for use in the treatment of non-small cell lung cancer |
WO2020206603A1 (zh) * | 2019-04-09 | 2020-10-15 | 河南真实生物科技有限公司 | 2-(2,4,5-取代苯氨基)嘧啶衍生物及其晶形b |
CN109942550A (zh) * | 2019-04-15 | 2019-06-28 | 广州医科大学附属第一医院(广州呼吸中心) | 11c标记的egfr正电子示踪剂及其制备方法和应用 |
JP2022531116A (ja) | 2019-05-01 | 2022-07-06 | クレキシオ バイオサイエンシーズ エルティーディー. | そう痒症を治療する方法 |
CA3138648A1 (en) * | 2019-05-22 | 2020-11-26 | Shanghai Hansoh Biomedical Co., Ltd. | Indole derivative-containing inhibitor, preparation method therefor and application thereof |
CN110283162B (zh) * | 2019-07-09 | 2022-04-05 | 辽宁大学 | 一种表皮生长因子受体抑制剂及其应用 |
CN110483486B (zh) * | 2019-09-17 | 2024-01-26 | 鲁南制药集团股份有限公司 | 一种奥西替尼酮咯酸盐晶型及其制备方法 |
US20210161897A1 (en) | 2019-11-12 | 2021-06-03 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
WO2021111462A1 (en) * | 2019-12-02 | 2021-06-10 | Natco Pharma Limited | An improved process for the preparation of osimertinib mesylate |
EP4076667A1 (en) | 2019-12-20 | 2022-10-26 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
CA3166980A1 (en) | 2020-01-20 | 2021-07-29 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
CN113372332B (zh) * | 2020-03-10 | 2023-09-12 | 鲁南制药集团股份有限公司 | 一种奥希替尼新晶型 |
CN113372331B (zh) * | 2020-03-10 | 2023-09-12 | 鲁南制药集团股份有限公司 | 一种奥希替尼一水合物新晶型 |
CN111303123B (zh) * | 2020-03-31 | 2021-08-31 | 南京雷正医药科技有限公司 | 2-(2,4,5-取代苯胺基)嘧啶化合物及其应用 |
CN111285852A (zh) * | 2020-04-02 | 2020-06-16 | 广州博济医药生物技术股份有限公司 | 氘代奥希替尼药用盐的晶型及其制备方法 |
CN111303124A (zh) * | 2020-04-08 | 2020-06-19 | 北京赛思源生物医药技术有限公司 | 一种甲磺酸奥希替尼的新晶体 |
US20210369709A1 (en) | 2020-05-27 | 2021-12-02 | Astrazeneca Ab | EGFR TKIs FOR USE IN THE TREATMENT OF NON-SMALL CELL LUNG CANCER |
CN113801101A (zh) * | 2020-06-15 | 2021-12-17 | 鲁南制药集团股份有限公司 | Azd9291-2-酮戊二酸盐及其制备方法 |
US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
CN113929663A (zh) * | 2020-06-29 | 2022-01-14 | 鲁南制药集团股份有限公司 | Azd9291-2-吲哚甲酸盐及其制备方法 |
CN113929664A (zh) * | 2020-07-13 | 2022-01-14 | 鲁南制药集团股份有限公司 | Azd9291-3,5-吡啶二羧酸盐及其制备方法 |
CN113968845A (zh) * | 2020-07-24 | 2022-01-25 | 鲁南制药集团股份有限公司 | Azd9291-没食子酸盐及其制备方法 |
US20230321098A1 (en) | 2020-08-25 | 2023-10-12 | Loxo Oncology, Inc. | Osimertinib and selpercatinib combinations for the treatment of egfr- and ret-associated cancers |
EP4217071A1 (en) | 2020-09-23 | 2023-08-02 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
CN112430231B (zh) * | 2020-11-06 | 2022-09-30 | 德州德药制药有限公司 | 一种azd9291的工业化制备方法 |
CN112358468B (zh) * | 2020-11-10 | 2022-03-22 | 德州德药制药有限公司 | 一种工业化合成azd9291的方法 |
CN116018141A (zh) * | 2020-11-19 | 2023-04-25 | 上海翰森生物医药科技有限公司 | 一种含吲哚类衍生物的盐、晶型及其制备方法和应用 |
US11780824B2 (en) | 2020-12-16 | 2023-10-10 | Scinopharm Taiwan, Ltd. | Process for preparing osimertinib or a salt thereof |
WO2022133345A1 (en) | 2020-12-18 | 2022-06-23 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
CN117479943A (zh) | 2021-06-15 | 2024-01-30 | 基因泰克公司 | 组合疗法中的egfr抑制剂和perk活化剂及其用于治疗癌症的用途 |
CN113387935B (zh) * | 2021-07-23 | 2022-06-10 | 苏州雅深智慧科技有限公司 | 抑制三突变表皮生长因子受体酪氨酸激酶的化合物及用途 |
CN117440945A (zh) * | 2021-08-06 | 2024-01-23 | 上海和誉生物医药科技有限公司 | 嘧啶或吡啶衍生物及其制备方法和在药学上的应用 |
CA3229553A1 (en) | 2021-09-02 | 2023-03-09 | Synthon B.V. | A process for making osimertinib |
CN113683612B (zh) * | 2021-09-07 | 2022-06-17 | 山东铂源药业股份有限公司 | 一种帕布昔利布的制备方法 |
JP2023043050A (ja) * | 2021-09-15 | 2023-03-28 | 株式会社東芝 | 新規アミン化合物、酸性ガス吸収剤、酸性ガスの除去方法及び酸性ガス除去 |
CN114014847B (zh) * | 2021-12-08 | 2023-11-03 | 滨州医学院 | 一种含苯并噻吩嘧啶衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
CN114380806B (zh) * | 2022-03-24 | 2022-06-10 | 中国药科大学 | 2-氨基-4-吲哚基嘧啶类化合物及其制备方法与应用 |
WO2023187037A1 (en) | 2022-03-31 | 2023-10-05 | Astrazeneca Ab | Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer |
WO2023194531A1 (en) | 2022-04-07 | 2023-10-12 | Astrazeneca Ab | Improved process for the manufacture of osimertinib |
WO2023209090A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their application in the treatment of cancer |
US20240116926A1 (en) | 2022-04-28 | 2024-04-11 | Astrazeneca Ab | Heteroaromatic compounds |
WO2023209084A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Condensed bicyclic heteroaromatic compounds and their use in the treatment of cancer |
WO2023209088A1 (en) | 2022-04-28 | 2023-11-02 | Astrazeneca Ab | Bicyclic heteroaromatic compounds and their use in the treatment of cancer |
WO2023213850A1 (en) * | 2022-05-03 | 2023-11-09 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Inhibitors of tau proteins |
WO2024002938A1 (en) | 2022-06-27 | 2024-01-04 | Astrazeneca Ab | Combinations involving epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of cancer |
WO2024003241A1 (en) | 2022-06-30 | 2024-01-04 | Astrazeneca Ab | Treatment for immuno-oncology resistant subjects with an anti pd-l1 antibody an antisense targeted to stat3 and an inhibitor of ctla-4 |
WO2024008929A1 (en) | 2022-07-08 | 2024-01-11 | Astrazeneca Ab | Epidermal growth factor receptor tyrosine kinase inhibitors in combination with hgf-receptor inhibitors for the treatment of cancer |
CN115650974A (zh) * | 2022-08-04 | 2023-01-31 | 天津大学 | N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-顺式戊二烯酰胺衍生物及应用 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9523675D0 (en) | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Vegfインヒビターとしてのキナゾリン誘導体 |
PT885198E (pt) | 1996-03-05 | 2002-06-28 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
KR100838617B1 (ko) | 1999-02-10 | 2008-06-16 | 아스트라제네카 아베 | 혈관형성 억제제로서의 퀴나졸린 유도체 |
BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
AU2001266233B2 (en) | 2000-07-07 | 2006-06-29 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as vascular damaging agents |
CZ200331A3 (cs) | 2000-07-07 | 2003-04-16 | Angiogene Pharmaceuticals Limited | Deriváty kolchinolu jako inhibitory angiogeneze, způsob jejich přípravy a farmaceutická kompozice, která je obsahuje |
US6881737B2 (en) * | 2001-04-11 | 2005-04-19 | Amgen Inc. | Substituted triazinyl acrylamide derivatives and methods of use |
DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
EP1828185B1 (en) * | 2004-12-21 | 2009-05-06 | SmithKline Beecham Corporation | 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors |
GB0500492D0 (en) | 2005-01-11 | 2005-02-16 | Cyclacel Ltd | Compound |
CN113952338A (zh) | 2005-02-03 | 2022-01-21 | 综合医院公司 | 治疗吉非替尼耐药性癌症的方法 |
AU2006311830B2 (en) | 2005-11-03 | 2013-03-14 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
GB0524436D0 (en) | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
CN101326182B (zh) * | 2005-12-05 | 2011-09-28 | 史密丝克莱恩比彻姆公司 | 2-嘧啶基吡唑并吡啶ErbB激酶抑制剂 |
JP2009541318A (ja) | 2006-06-22 | 2009-11-26 | メルク エンド カムパニー インコーポレーテッド | チロシンキナーゼ阻害剤 |
JP2009544592A (ja) * | 2006-07-21 | 2009-12-17 | ノバルティス アクチエンゲゼルシャフト | Jakキナーゼ阻害剤としての2,4−ジ(アリールアミノ)−ピリミジン−5−カルボキサミド化合物 |
TWI552752B (zh) | 2007-10-19 | 2016-10-11 | 賽基艾維洛米斯研究股份有限公司 | 雜芳基化合物及其用途 |
US7989465B2 (en) * | 2007-10-19 | 2011-08-02 | Avila Therapeutics, Inc. | 4,6-disubstituted pyrimidines useful as kinase inhibitors |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
RU2536584C2 (ru) * | 2008-06-27 | 2014-12-27 | Авила Терапьютикс, Инк. | Гетероарильные соединения и их применение |
CN105574346A (zh) | 2008-09-05 | 2016-05-11 | 新基阿维罗米克斯研究公司 | 多肽偶联物与不可逆抑制剂的设计方法和检测方法 |
US20110183975A1 (en) | 2008-10-07 | 2011-07-28 | Yasuhiro Goto | Novel 6-azaindole aminopyrimidine derivatives having nik inhibitory activity |
CN101723936B (zh) | 2008-10-27 | 2014-01-15 | 上海睿星基因技术有限公司 | 激酶抑制剂及其在药学中的用途 |
KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
KR101256018B1 (ko) * | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물 |
IN2012DN02534A (hu) | 2009-09-16 | 2015-08-28 | Avila Therapeutics Inc | |
CN102725292A (zh) * | 2009-11-02 | 2012-10-10 | 雅培制药有限公司 | 作为用于多靶激酶抑制的新构建物的咪唑并吡啶化合物 |
US20110207736A1 (en) | 2009-12-23 | 2011-08-25 | Gatekeeper Pharmaceuticals, Inc. | Compounds that modulate egfr activity and methods for treating or preventing conditions therewith |
WO2011140338A1 (en) | 2010-05-05 | 2011-11-10 | Gatekeeper Pharmaceuticals, Inc. | Compounds that modulate egfr activity and methods for treating or preventing conditions therewith |
LT2585470T (lt) | 2010-06-23 | 2017-04-10 | Hanmi Science Co., Ltd. | Nauji kondensuoti pirimidino dariniai tirozino kinazės aktyvumo slopinimui |
UY33539A (es) | 2010-08-02 | 2012-02-29 | Astrazeneca Ab | Compuestos químicos alk |
KR101884010B1 (ko) * | 2011-05-04 | 2018-07-31 | 어리어드 파마슈티칼스, 인코포레이티드 | Egfr-유도된 암의 세포 증식을 억제하는 화합물 |
AU2012288626C1 (en) | 2011-07-27 | 2015-09-17 | Astrazeneca Ab | 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as EGFR modulators useful for treating cancer |
-
2012
- 2012-07-25 AU AU2012288626A patent/AU2012288626C1/en active Active
- 2012-07-25 SI SI201231963T patent/SI3686194T1/sl unknown
- 2012-07-25 BR BR122014026114-4A patent/BR122014026114B1/pt active IP Right Grant
- 2012-07-25 EP EP17194307.9A patent/EP3333161B1/en active Active
- 2012-07-25 EP EP20157798.8A patent/EP3686193B1/en active Active
- 2012-07-25 SG SG10201402857QA patent/SG10201402857QA/en unknown
- 2012-07-25 CN CN201410287156.2A patent/CN104109161B/zh active Active
- 2012-07-25 ES ES12759801.9T patent/ES2564671T3/es active Active
- 2012-07-25 MY MYPI2013702541A patent/MY161925A/en unknown
- 2012-07-25 EP EP15192658.1A patent/EP3009431B1/en active Active
- 2012-07-25 ME MEP-2020-87A patent/ME03785B/me unknown
- 2012-07-25 CN CN201510641921.0A patent/CN105198862B/zh active Active
- 2012-07-25 SG SG10201910984XA patent/SG10201910984XA/en unknown
- 2012-07-25 SI SI201231771T patent/SI3333161T1/sl unknown
- 2012-07-25 ES ES20157927T patent/ES2900230T3/es active Active
- 2012-07-25 CA CA2843109A patent/CA2843109C/en active Active
- 2012-07-25 EA EA201792394A patent/EA033733B1/ru unknown
- 2012-07-25 SI SI201230455T patent/SI2736895T1/sl unknown
- 2012-07-25 CN CN201280033773.9A patent/CN103702990B/zh active Active
- 2012-07-25 PL PL17194307T patent/PL3333161T3/pl unknown
- 2012-07-25 HU HUE12759801A patent/HUE026429T2/hu unknown
- 2012-07-25 BR BR122014026094-6A patent/BR122014026094B1/pt active IP Right Grant
- 2012-07-25 ME MEP-2016-34A patent/ME02382B/me unknown
- 2012-07-25 PT PT171943079T patent/PT3333161T/pt unknown
- 2012-07-25 DK DK12759801.9T patent/DK2736895T3/da active
- 2012-07-25 PL PL20157798T patent/PL3686193T3/pl unknown
- 2012-07-25 LT LTEP20157927.3T patent/LT3686194T/lt unknown
- 2012-07-25 RS RS20211378A patent/RS62542B1/sr unknown
- 2012-07-25 CA CA2881987A patent/CA2881987C/en active Active
- 2012-07-25 DK DK15192658.1T patent/DK3009431T3/en active
- 2012-07-25 JP JP2013541431A patent/JP5427321B2/ja active Active
- 2012-07-25 MY MYPI2019007672A patent/MY194532A/en unknown
- 2012-07-25 LT LTEP15192658.1T patent/LT3009431T/lt unknown
- 2012-07-25 KR KR1020147008572A patent/KR101422619B1/ko active Protection Beyond IP Right Term
- 2012-07-25 HU HUE20157927A patent/HUE056365T2/hu unknown
- 2012-07-25 BR BR112014001768-9A patent/BR112014001768B1/pt active IP Right Grant
- 2012-07-25 CA CA2881991A patent/CA2881991C/en active Active
- 2012-07-25 CN CN201410287447.1A patent/CN104109151B/zh active Active
- 2012-07-25 HU HUE17194307A patent/HUE049060T2/hu unknown
- 2012-07-25 CN CN201510639096.0A patent/CN105348266B/zh active Active
- 2012-07-25 EA EA201391491A patent/EA024421B1/ru active Protection Beyond IP Right Term
- 2012-07-25 HU HUE15192658A patent/HUE037645T2/hu unknown
- 2012-07-25 PL PL15192658T patent/PL3009431T3/pl unknown
- 2012-07-25 PT PT201577988T patent/PT3686193T/pt unknown
- 2012-07-25 EA EA201690328A patent/EA029488B1/ru not_active IP Right Cessation
- 2012-07-25 SI SI201231167T patent/SI3009431T1/en unknown
- 2012-07-25 SG SG10201402860QA patent/SG10201402860QA/en unknown
- 2012-07-25 BR BR122014026150-0A patent/BR122014026150B1/pt active IP Right Grant
- 2012-07-25 SG SG2013081716A patent/SG194783A1/en unknown
- 2012-07-25 PL PL12759801T patent/PL2736895T3/pl unknown
- 2012-07-25 ME MEP-2017-290A patent/ME02887B/me unknown
- 2012-07-25 US US13/557,871 patent/US8946235B2/en active Active
- 2012-07-25 DK DK20157927.3T patent/DK3686194T3/da active
- 2012-07-25 LT LTEP17194307.9T patent/LT3333161T/lt unknown
- 2012-07-25 PT PT201579273T patent/PT3686194T/pt unknown
- 2012-07-25 ES ES15192658.1T patent/ES2654177T3/es active Active
- 2012-07-25 CA CA2882018A patent/CA2882018C/en active Active
- 2012-07-25 CA CA2881993A patent/CA2881993C/en active Active
- 2012-07-25 WO PCT/GB2012/051783 patent/WO2013014448A1/en active Application Filing
- 2012-07-25 EP EP20157927.3A patent/EP3686194B1/en active Active
- 2012-07-25 KR KR1020147011325A patent/KR101691268B1/ko active IP Right Grant
- 2012-07-25 RS RS20160094A patent/RS54653B1/en unknown
- 2012-07-25 SG SG10201910986QA patent/SG10201910986QA/en unknown
- 2012-07-25 PL PL20157927T patent/PL3686194T3/pl unknown
- 2012-07-25 ES ES17194307T patent/ES2791308T3/es active Active
- 2012-07-25 CN CN201510639051.3A patent/CN105254616B/zh active Active
- 2012-07-25 DK DK17194307.9T patent/DK3333161T3/da active
- 2012-07-25 MX MX2014000528A patent/MX2014000528A/es unknown
- 2012-07-25 PT PT151926581T patent/PT3009431T/pt unknown
- 2012-07-25 CN CN201510507888.2A patent/CN105175396B/zh active Active
- 2012-07-25 DK DK20157798.8T patent/DK3686193T3/da active
- 2012-07-25 PE PE2013002532A patent/PE20141700A1/es active IP Right Grant
- 2012-07-25 RS RS20171309A patent/RS56679B1/sr unknown
- 2012-07-25 EP EP12759801.9A patent/EP2736895B1/en active Active
- 2012-07-25 EP EP22189028.8A patent/EP4119551A1/en active Pending
- 2012-07-25 EP EP22158770.2A patent/EP4086246A1/en active Pending
- 2012-07-25 ES ES20157798T patent/ES2914854T3/es active Active
- 2012-07-25 KR KR1020137003097A patent/KR101410902B1/ko active Protection Beyond IP Right Term
- 2012-07-25 RS RS20200459A patent/RS60190B1/sr unknown
- 2012-07-25 HR HRP20211682TT patent/HRP20211682T1/hr unknown
- 2012-07-26 TW TW101127018A patent/TWI465445B/zh active
- 2012-07-26 TW TW103124452A patent/TWI555743B/zh active
- 2012-07-26 UY UY34219A patent/UY34219A/es not_active Application Discontinuation
- 2012-07-26 AR ARP120102716 patent/AR087336A1/es active IP Right Grant
- 2012-07-26 TW TW105130486A patent/TWI583386B/zh active
-
2013
- 2013-06-05 JP JP2013118744A patent/JP5537704B2/ja active Active
- 2013-10-31 IL IL229199A patent/IL229199A/en active IP Right Grant
- 2013-11-13 DO DO2013000263A patent/DOP2013000263A/es unknown
- 2013-11-14 CL CL2013003281A patent/CL2013003281A1/es unknown
- 2013-11-19 EC ECSP13013033 patent/ECSP13013033A/es unknown
- 2013-11-20 GT GT201300288A patent/GT201300288A/es unknown
- 2013-11-28 CO CO13279940A patent/CO6811863A2/es active IP Right Grant
- 2013-11-29 CR CR20130629A patent/CR20130629A/es unknown
- 2013-12-06 NI NI201300134A patent/NI201300134A/es unknown
-
2014
- 2014-01-10 MX MX2020013020A patent/MX2020013020A/es unknown
- 2014-03-31 JP JP2014071530A patent/JP5977779B2/ja active Active
- 2014-06-18 HK HK14105766.5A patent/HK1192549A1/zh unknown
- 2014-06-19 HK HK14105842.3A patent/HK1192554A1/xx unknown
- 2014-12-19 US US14/576,721 patent/US9732058B2/en active Active
-
2015
- 2015-06-15 PH PH12015501326A patent/PH12015501326B1/en unknown
- 2015-10-26 IL IL242285A patent/IL242285A/en active IP Right Grant
- 2015-10-26 IL IL242286A patent/IL242286A/en active IP Right Grant
- 2015-10-26 IL IL242284A patent/IL242284A/en active IP Right Grant
- 2015-10-26 IL IL242278A patent/IL242278A/en active IP Right Grant
- 2015-10-26 IL IL242279A patent/IL242279A/en active IP Right Grant
-
2016
- 2016-02-05 HR HRP20160135TT patent/HRP20160135T1/hr unknown
- 2016-03-01 CY CY20161100168T patent/CY1117431T1/el unknown
- 2016-03-10 SM SM201600070T patent/SMT201600070B/xx unknown
- 2016-08-03 HK HK16109232.1A patent/HK1221216A1/zh unknown
-
2017
- 2017-07-13 US US15/649,068 patent/US10017493B2/en active Active
- 2017-12-18 HR HRP20171957TT patent/HRP20171957T1/hr unknown
-
2018
- 2018-01-03 CY CY20181100002T patent/CY1120072T1/el unknown
- 2018-05-29 US US15/991,578 patent/US20190092746A1/en not_active Abandoned
- 2018-12-04 HK HK18115460.9A patent/HK1256370A1/zh unknown
-
2019
- 2019-06-19 US US16/445,709 patent/US10858336B2/en active Active
-
2020
- 2020-04-20 HR HRP20200624TT patent/HRP20200624T1/hr unknown
- 2020-05-12 CY CY20201100434T patent/CY1123210T1/el unknown
- 2020-11-12 US US17/096,167 patent/US11524951B2/en active Active
-
2021
- 2021-11-17 CY CY20211100994T patent/CY1125405T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUE056365T2 (hu) | 2-(2,4,5-Helyettesített-anilino)pirimidin származékok | |
IL269977B (en) | Compounds 2-(1-isopropyl-pyrazol-5-yl)-3-(hydroxy/chloro)methyl pyridine | |
IL286152A (en) | Modified imidazopyridinyl-aminopyridine compounds | |
SI2694508T1 (sl) | Soli substituiranega 2,3-dihidroimidazo(1,2-C)kinazolina | |
EP2699091A4 (en) | 2 ', 6'-dioxo-3'-deutero-PIPERIDIN-3-YL-isoindoline COMPOUNDS | |
IL229007A0 (en) | Dihydroisoxazole compounds kill parasites | |
EP2762476A4 (en) | 1,2,4-triazine-6-carboxamide derivative | |
GB201012105D0 (en) | Novel pyrimidine compounds | |
EP2709609A4 (en) | HETEROCYCLIC COMPOUNDS | |
HK1192757A1 (zh) | 取代的 -芳基- -苯基- -三嗪- -胺 | |
IL233800A0 (en) | Pyrimidine compounds are fungicidal | |
IL231468A0 (en) | 3,1-diaryl-converted heterocyclic pesticides | |
EP2758058A4 (en) | SUBSTITUTED PYRIMIDINES | |
IL233799A0 (en) | Pyrimidine compounds are fungicidal | |
EP2735567A4 (en) | HETEROCYCLIC SUBSTITUTED PYRIMIDINE COMPOUND | |
EP2758059A4 (en) | SUBSTITUTED PYRIMIDINES | |
GB2501403B (en) | 3-arylethynyl substituted quinazolinone compounds | |
GB201102024D0 (en) | Novel heterocyclic compounds 3 | |
GB201101821D0 (en) | Novel heterocyclic compounds 1 | |
GB201101822D0 (en) | Novel heterocyclic compounds 2 | |
GB201101823D0 (en) | Novel heterocyclic compounds 4 | |
GB201113441D0 (en) | Novel compounds 64 | |
GB201113450D0 (en) | Novel compounds 60 | |
GB201113448D0 (en) | Novel compounds 61 | |
GB201113443D0 (en) | Novel compounds 62 |