SG11201900546UA - Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof - Google Patents
Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereofInfo
- Publication number
- SG11201900546UA SG11201900546UA SG11201900546UA SG11201900546UA SG11201900546UA SG 11201900546U A SG11201900546U A SG 11201900546UA SG 11201900546U A SG11201900546U A SG 11201900546UA SG 11201900546U A SG11201900546U A SG 11201900546UA SG 11201900546U A SG11201900546U A SG 11201900546UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- spiro
- lactam
- pct
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIP0 I PCT 01E1°1°1a °nolo III 11010111010111100100 ow (10) International Publication Number WO 2018/026792 Al (51) International Patent Classification: CO7D 487/20 (2006.01) A61P 25/00 (2006.01) A61K 31/4747 (2006.01) (21) International Application Number: PCT/US2017/044861 (22) International Filing Date: 01 August 2017 (01.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/369,534 01 August 2016 (01.08.2016) US (71) Applicant: APTINYX INC. [US/US]; 1801 Maple Av- enue, Suite 4300, Evanston, IL 60201 (US). (72) Inventor: KHAN, Amin, M.; 720 Oakton Street, #3A, Evanston, IL 60202 (US). (74) Agent: BRODOWSKI, Michael, H. et al.; Goodwin Proc- ter LLP, 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — Published: with international search report (Art. 21(3)) N © (54) Title: SPIRO-LACTAM AND BIS-SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF (57) : Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be O used in the treatment of conditions such as depression and related disorders. Orally delivered formulations and other pharmaceutically N acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662369534P | 2016-08-01 | 2016-08-01 | |
PCT/US2017/044861 WO2018026792A1 (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201900546UA true SG11201900546UA (en) | 2019-02-27 |
Family
ID=59593195
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201900546UA SG11201900546UA (en) | 2016-08-01 | 2017-08-01 | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
Country Status (16)
Country | Link |
---|---|
US (2) | US11028095B2 (en) |
EP (1) | EP3490994B8 (en) |
JP (1) | JP2019527235A (en) |
KR (1) | KR102462288B1 (en) |
CN (1) | CN109661398B (en) |
AU (1) | AU2017306158B2 (en) |
BR (1) | BR112019001926A2 (en) |
CA (1) | CA3031562A1 (en) |
CL (1) | CL2019000249A1 (en) |
CO (1) | CO2019000944A2 (en) |
EA (1) | EA201990425A1 (en) |
IL (1) | IL264496B (en) |
MX (1) | MX2019001322A (en) |
PE (1) | PE20190502A1 (en) |
SG (1) | SG11201900546UA (en) |
WO (1) | WO2018026792A1 (en) |
Families Citing this family (10)
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KR101769999B1 (en) | 2008-09-18 | 2017-08-21 | 노오쓰웨스턴 유니버시티 | Nmda receptor modulators and uses thereof |
LT2951183T (en) | 2013-01-29 | 2019-05-27 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3031539C (en) | 2016-08-01 | 2023-11-28 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CA3031537A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
KR102462288B1 (en) | 2016-08-01 | 2022-11-01 | 앱티닉스 인크. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
CN109843889B (en) | 2016-08-01 | 2022-03-15 | 阿普廷伊克斯股份有限公司 | Spiro-lactam NMDA modulators and methods of using the same |
KR102503590B1 (en) | 2016-08-01 | 2023-02-24 | 앱티닉스 인크. | Spiro-lactam NMDA receptor modulators and uses thereof |
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WO2019152681A1 (en) * | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof |
CN112204031A (en) | 2018-01-31 | 2021-01-08 | 阿普廷伊克斯股份有限公司 | Spiro-lactam NMDA receptor modulators and uses thereof |
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KR102462288B1 (en) | 2016-08-01 | 2022-11-01 | 앱티닉스 인크. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
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2017
- 2017-08-01 KR KR1020197005664A patent/KR102462288B1/en active IP Right Grant
- 2017-08-01 SG SG11201900546UA patent/SG11201900546UA/en unknown
- 2017-08-01 MX MX2019001322A patent/MX2019001322A/en unknown
- 2017-08-01 BR BR112019001926A patent/BR112019001926A2/en active Search and Examination
- 2017-08-01 AU AU2017306158A patent/AU2017306158B2/en not_active Ceased
- 2017-08-01 CA CA3031562A patent/CA3031562A1/en active Pending
- 2017-08-01 EA EA201990425A patent/EA201990425A1/en unknown
- 2017-08-01 WO PCT/US2017/044861 patent/WO2018026792A1/en unknown
- 2017-08-01 CN CN201780054216.8A patent/CN109661398B/en active Active
- 2017-08-01 JP JP2019505250A patent/JP2019527235A/en not_active Ceased
- 2017-08-01 PE PE2019000295A patent/PE20190502A1/en unknown
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- 2017-08-01 IL IL264496A patent/IL264496B/en unknown
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2019
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2021
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US11028095B2 (en) | 2021-06-08 |
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AU2017306158B2 (en) | 2021-10-14 |
EA201990425A1 (en) | 2019-08-30 |
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CN109661398A (en) | 2019-04-19 |
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CL2019000249A1 (en) | 2019-06-21 |
AU2017306158A1 (en) | 2019-01-31 |
US20200181159A1 (en) | 2020-06-11 |
PE20190502A1 (en) | 2019-04-10 |
CO2019000944A2 (en) | 2019-02-08 |
US20220098211A1 (en) | 2022-03-31 |
IL264496A (en) | 2019-03-31 |
JP2019527235A (en) | 2019-09-26 |
CA3031562A1 (en) | 2018-02-08 |
KR102462288B1 (en) | 2022-11-01 |
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