EA201270793A8 - Применение ингибиторов тирозинкиназы брутона (втк) - Google Patents

Применение ингибиторов тирозинкиназы брутона (втк)

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Publication number
EA201270793A8
EA201270793A8 EA201270793A EA201270793A EA201270793A8 EA 201270793 A8 EA201270793 A8 EA 201270793A8 EA 201270793 A EA201270793 A EA 201270793A EA 201270793 A EA201270793 A EA 201270793A EA 201270793 A8 EA201270793 A8 EA 201270793A8
Authority
EA
Eurasian Patent Office
Prior art keywords
bruton
btc
kinase inhibitors
thyrosine kinase
expression profile
Prior art date
Application number
EA201270793A
Other languages
English (en)
Other versions
EA031737B1 (ru
EA201270793A2 (ru
Inventor
Джозеф Дж. Баги
Лоренс Элиас
Гвен Файф
Эрик Хедрик
Дэвид Дж. Лаури
Тарак Д. Моди
Original Assignee
Фармасайкликс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45067334&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201270793(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Фармасайкликс, Инк. filed Critical Фармасайкликс, Инк.
Publication of EA201270793A2 publication Critical patent/EA201270793A2/ru
Publication of EA201270793A8 publication Critical patent/EA201270793A8/ru
Publication of EA031737B1 publication Critical patent/EA031737B1/ru

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Описанное в настоящем документе представляет собой способы лечения рака, включающие: а) введение ингибитора Btk субъекту, достаточного, чтобы привести к увеличению или появлению в крови субпопуляции лимфоцитов, определяемую иммунофенотипированием; б) определение профиля экспрессии одного или более биомаркеров из одной или более субпопуляции лимфоцитов; и в) введение второго агента на основании определенного профиля экспрессии.
EA201270793A 2010-06-03 2011-06-03 Применение ингибиторов тирозинкиназы брутона (btk) для лечения лейкоза и лимфомы EA031737B1 (ru)

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US41976410P 2010-12-03 2010-12-03
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