MX2020004438A - El uso de inhibidores de la tirosina quinasa de bruton (btk). - Google Patents

El uso de inhibidores de la tirosina quinasa de bruton (btk).

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Publication number
MX2020004438A
MX2020004438A MX2020004438A MX2020004438A MX2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A MX 2020004438 A MX2020004438 A MX 2020004438A
Authority
MX
Mexico
Prior art keywords
btk
bruton
inhibitors
tyrosine kinase
subpopulation
Prior art date
Application number
MX2020004438A
Other languages
English (en)
Inventor
Joseph J Buggy
David J Loury
Tarak D Mody
Laurence Elias
Gwen Fyfe
Eric Hedrick
Original Assignee
Pharmacyclics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45067334&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2020004438(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacyclics Llc filed Critical Pharmacyclics Llc
Publication of MX2020004438A publication Critical patent/MX2020004438A/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

Se divulgan aquí métodos para tratar un cáncer que comprenden: a. administrar un inhibidor de Btk a un sujeto suficiente para dar como resultado un incremento o aparición en la sangre de una subpoblación de linfocitos definida por inmunofenotipificación; b. determinar el perfil de expresión de uno o más biomarcadores a partir de una o más subpoblaciones de linfocitos; y c. administrar un segundo agente con base en el perfil de expresión determinado.
MX2020004438A 2010-06-03 2011-06-03 El uso de inhibidores de la tirosina quinasa de bruton (btk). MX2020004438A (es)

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US41976410P 2010-12-03 2010-12-03
US201161472138P 2011-04-05 2011-04-05
PCT/US2011/039190 WO2011153514A2 (en) 2010-06-03 2011-06-03 The use of inhibitors of bruton's tyrosine kinase (btk)

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MX2012014049A MX342405B (es) 2010-06-03 2011-06-03 El uso de inhibidores de la tirosina quinasa de bruton (btk).
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