CN101475632B - 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 - Google Patents
具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 Download PDFInfo
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- CN101475632B CN101475632B CN200810050206XA CN200810050206A CN101475632B CN 101475632 B CN101475632 B CN 101475632B CN 200810050206X A CN200810050206X A CN 200810050206XA CN 200810050206 A CN200810050206 A CN 200810050206A CN 101475632 B CN101475632 B CN 101475632B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/375—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Basidiomycetes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims (3)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200810050206XA CN101475632B (zh) | 2008-01-03 | 2008-01-03 | 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 |
CN201110222012.5A CN102274487B (zh) | 2008-01-03 | 2008-01-03 | 重组灵芝免疫蛋白在制备治疗白细胞减少症药物中的应用 |
AU2008349094A AU2008349094B8 (en) | 2008-01-03 | 2008-12-30 | Recombinant Ganoderma lucidium immunomodulatory protein (rLZ-8) and uses thereof |
EP08871843.2A EP2246064B1 (en) | 2008-01-03 | 2008-12-30 | Recombinant ganoderma lucidium immunomodulatory protein (rlz-8) and uses thereof |
PCT/CN2008/002142 WO2009094850A1 (en) | 2008-01-03 | 2008-12-30 | Recombinant ganoderma lucidium immunomodulatory protein (rlz-8) and uses thereof |
CA2711207A CA2711207C (en) | 2008-01-03 | 2008-12-30 | Recombinant ganoderma lucidium immunomodulatory protein (rlz-8) and uses thereof |
JP2010541002A JP5735280B2 (ja) | 2008-01-03 | 2008-12-30 | 組換えマンネンタケ(Ganodermalucidium)免疫調節タンパク質(rLZ−8)およびその使用 |
US12/829,653 US20110009597A1 (en) | 2008-01-03 | 2010-07-02 | RECOMBINANT GANODERMA LUCIDIUM IMMUNOMODULATORY PROTEIN (rLZ-8) AND USES THEREOF |
US14/511,781 US20150023994A1 (en) | 2008-01-03 | 2014-10-10 | RECOMBINANT GANODERMA LUCIDIUM IMMUNOMODULATORY PROTEIN (rLZ-8) AND USES THEREOF |
JP2014245808A JP6040212B2 (ja) | 2008-01-03 | 2014-12-04 | 組換えマンネンタケ(Ganodermalucidium)免疫調節タンパク質(rLZ−8)およびその使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200810050206XA CN101475632B (zh) | 2008-01-03 | 2008-01-03 | 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201110222012.5A Division CN102274487B (zh) | 2008-01-03 | 2008-01-03 | 重组灵芝免疫蛋白在制备治疗白细胞减少症药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101475632A CN101475632A (zh) | 2009-07-08 |
CN101475632B true CN101475632B (zh) | 2012-01-04 |
Family
ID=40836415
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200810050206XA Expired - Fee Related CN101475632B (zh) | 2008-01-03 | 2008-01-03 | 具有抗肿瘤作用的重组灵芝免疫调节蛋白及其药物制剂 |
Country Status (7)
Country | Link |
---|---|
US (2) | US20110009597A1 (zh) |
EP (1) | EP2246064B1 (zh) |
JP (2) | JP5735280B2 (zh) |
CN (1) | CN101475632B (zh) |
AU (1) | AU2008349094B8 (zh) |
CA (1) | CA2711207C (zh) |
WO (1) | WO2009094850A1 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ772688A (en) | 2010-06-03 | 2022-09-30 | Pharmacyclics Llc | The use of inhibitors of bruton’s tyrosine kinase (btk) |
EA032463B1 (ru) * | 2011-10-19 | 2019-05-31 | Фармасайкликс Элэлси | Применение ингибиторов тирозинкиназы брутона (втк) |
CN102731632B (zh) * | 2012-07-16 | 2014-03-12 | 张喜田 | 重组灵芝免疫调节蛋白单甲氧基聚乙二醇丙酸琥珀酰亚胺酯修饰物、制备方法和用途 |
KR20180088926A (ko) | 2012-07-24 | 2018-08-07 | 파마싸이클릭스 엘엘씨 | 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이 |
CN103417953B (zh) * | 2013-08-16 | 2015-06-17 | 张喜田 | 重组灵芝免疫调节蛋白(rLZ-8)在制备治疗黑色素瘤药物中的应用 |
CN103463618B (zh) * | 2013-09-06 | 2014-09-03 | 张喜田 | 重组灵芝免疫调节蛋白在制备治疗局灶性脑缺血药物中的应用 |
CN103524628B (zh) * | 2013-10-15 | 2015-01-07 | 张喜田 | 重组灵芝免疫调节蛋白与人血清白蛋白融合蛋白及其制备方法与应用 |
CN103536901A (zh) * | 2013-10-25 | 2014-01-29 | 张喜田 | 重组灵芝免疫调节蛋白在制备治疗帕金森病药物中的应用 |
CN103751765B (zh) * | 2014-02-12 | 2015-02-25 | 张喜田 | 重组灵芝免疫调节蛋白(rLZ-8)在制备治疗组织纤维化药物中的应用 |
TWI608846B (zh) | 2014-03-13 | 2017-12-21 | 益生生技開發股份有限公司 | 用於改善化學治療所造成之不良副作用的組合療法 |
CN103816532B (zh) * | 2014-03-18 | 2015-04-29 | 张喜田 | 重组灵芝免疫调节蛋白(rLZ-8)在制备治疗慢性心力衰竭药物中的应用 |
CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
CN103990109B (zh) * | 2014-06-17 | 2015-03-25 | 张喜田 | 重组灵芝免疫调节蛋白(rLZ-8)在制备治疗骨质疏松药物中的应用 |
CN104043105A (zh) * | 2014-06-18 | 2014-09-17 | 张喜田 | 重组灵芝免疫调节蛋白rLZ-8在治疗肺癌,喉癌和脑胶质瘤中的应用 |
CN107118263B (zh) | 2017-04-08 | 2020-07-03 | 张喜田 | 重组灵芝免疫调节蛋白突变体及其应用 |
CA3223071A1 (en) * | 2021-08-09 | 2023-02-16 | Xin Zhang | Novel mutant of recombinant ganoderma lucidum immunomodulatory protein and use thereof |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0288959B1 (en) * | 1987-04-28 | 1994-01-12 | Meiji Milk Products Company Limited | Novel glycoprotein, production process thereof and immunosuppressive agent containing same as effective ingredient |
JPH02124899A (ja) * | 1988-11-01 | 1990-05-14 | Meiji Milk Prod Co Ltd | 新規な蛋白質とその製造法及びこれを有効成分とする免疫抑制剤 |
TWI351963B (en) * | 2003-09-17 | 2011-11-11 | Yeastern Biotech Co Ltd | Fungal immunomodulatory protein (fip) prepared by |
US20070071766A1 (en) * | 2005-09-23 | 2007-03-29 | Ko Jiunn L | Compositions comprising fungal immunomodulatory protein and use thereof |
CN101205553A (zh) * | 2007-12-13 | 2008-06-25 | 吉林大学 | 一种重组灵芝免疫调节蛋白制备方法 |
-
2008
- 2008-01-03 CN CN200810050206XA patent/CN101475632B/zh not_active Expired - Fee Related
- 2008-12-30 CA CA2711207A patent/CA2711207C/en not_active Expired - Fee Related
- 2008-12-30 EP EP08871843.2A patent/EP2246064B1/en not_active Not-in-force
- 2008-12-30 JP JP2010541002A patent/JP5735280B2/ja not_active Expired - Fee Related
- 2008-12-30 WO PCT/CN2008/002142 patent/WO2009094850A1/zh active Application Filing
- 2008-12-30 AU AU2008349094A patent/AU2008349094B8/en not_active Ceased
-
2010
- 2010-07-02 US US12/829,653 patent/US20110009597A1/en not_active Abandoned
-
2014
- 2014-10-10 US US14/511,781 patent/US20150023994A1/en not_active Abandoned
- 2014-12-04 JP JP2014245808A patent/JP6040212B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2711207A1 (en) | 2009-08-06 |
EP2246064A4 (en) | 2011-05-18 |
EP2246064A1 (en) | 2010-11-03 |
US20110009597A1 (en) | 2011-01-13 |
AU2008349094B8 (en) | 2014-10-16 |
EP2246064B1 (en) | 2018-08-08 |
JP2015078211A (ja) | 2015-04-23 |
AU2008349094B2 (en) | 2014-10-02 |
WO2009094850A1 (en) | 2009-08-06 |
JP5735280B2 (ja) | 2015-06-17 |
AU2008349094A8 (en) | 2014-10-16 |
JP2011508749A (ja) | 2011-03-17 |
US20150023994A1 (en) | 2015-01-22 |
CN101475632A (zh) | 2009-07-08 |
AU2008349094A1 (en) | 2009-08-06 |
CA2711207C (en) | 2019-02-12 |
JP6040212B2 (ja) | 2016-12-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
ASS | Succession or assignment of patent right |
Owner name: ZHANG XITIAN Free format text: FORMER OWNER: SUN FEI Effective date: 20090626 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20090626 Address after: Shanghai City, Fengxian District Jinhui Tang Road No. 369 building 30 Applicant after: Zhang Xitian Address before: Institute of regenerative medicine, Jilin University, 1163 Xinmin Street, Jilin, Changchun, China Applicant before: Sun Fei |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai wisdom Biotechnology Co., Ltd. Assignor: Zhang Xitian Contract record no.: 2010310000049 Denomination of invention: Recombinant Ganoderma lucidum immunoregulation protein with antineoplastic function and medicinal preparation thereof License type: Exclusive License Open date: 20090708 Record date: 20100510 |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120104 Termination date: 20190103 |
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CF01 | Termination of patent right due to non-payment of annual fee |