MX351513B - Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo. - Google Patents

Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo.

Info

Publication number
MX351513B
MX351513B MX2014008605A MX2014008605A MX351513B MX 351513 B MX351513 B MX 351513B MX 2014008605 A MX2014008605 A MX 2014008605A MX 2014008605 A MX2014008605 A MX 2014008605A MX 351513 B MX351513 B MX 351513B
Authority
MX
Mexico
Prior art keywords
salt
disubstituted
alkynylbenzene
compound
alkynylbenzene compound
Prior art date
Application number
MX2014008605A
Other languages
English (en)
Other versions
MX2014008605A (es
Inventor
Takeshi Sagara
Sachie Otsuki
Satoru Ito
Hiroshi Sootome
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of MX2014008605A publication Critical patent/MX2014008605A/es
Publication of MX351513B publication Critical patent/MX351513B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

La presente invención provee un compuesto representado por la fórmula (I): (ver Fórmula) (en donde R1, X1, X2, Y y Z son como se define en la especificación), o una sal del mismo.
MX2014008605A 2012-01-19 2013-01-17 Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo. MX351513B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012009467 2012-01-19
PCT/JP2013/050740 WO2013108809A1 (ja) 2012-01-19 2013-01-17 ３，５－二置換ベンゼンアルキニル化合物及びその塩

Publications (2)

Publication Number Publication Date
MX2014008605A MX2014008605A (es) 2014-08-27
MX351513B true MX351513B (es) 2017-10-17

Family

ID=48799233

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014008605A MX351513B (es) 2012-01-19 2013-01-17 Compuesto de alquinilbenceno 3,5-disustituido y sales del mismo.

Country Status (24)

Country Link
US (1) US9108973B2 (es)
EP (1) EP2657233B1 (es)
JP (1) JP5355825B1 (es)
KR (1) KR101623286B1 (es)
CN (1) CN103958512B (es)
AU (1) AU2013210403B2 (es)
BR (1) BR112014017749B1 (es)
CA (1) CA2854093C (es)
DK (1) DK2657233T3 (es)
ES (1) ES2516392T3 (es)
FI (1) FIC20230038I1 (es)
FR (1) FR23C1050I1 (es)
HK (1) HK1198164A1 (es)
HU (1) HUS2300043I1 (es)
MX (1) MX351513B (es)
MY (1) MY171055A (es)
NL (1) NL301254I2 (es)
NO (1) NO2023046I1 (es)
PL (1) PL2657233T3 (es)
PT (1) PT2657233E (es)
RU (1) RU2576384C1 (es)
SG (1) SG2014009286A (es)
TW (1) TWI508964B (es)
WO (1) WO2013108809A1 (es)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012088266A2 (en) 2010-12-22 2012-06-28 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3
JP5873656B2 (ja) 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
DK3176170T3 (en) 2012-06-13 2019-01-28 Incyte Holdings Corp SUBSTITUTED TRICYCLIC RELATIONS AS FGFR INHIBITORS
RS62233B1 (sr) 2012-07-11 2021-09-30 Blueprint Medicines Corp Inhibitori receptora fibroblast faktora rasta
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
AR094812A1 (es) 2013-02-20 2015-08-26 Eisai R&D Man Co Ltd Derivado de piridina monocíclico como inhibidor del fgfr
ES2893725T3 (es) 2013-04-19 2022-02-09 Incyte Holdings Corp Heterocíclicos bicíclicos como inhibidores del FGFR
JP6084292B2 (ja) * 2013-07-18 2017-02-22 大鵬薬品工業株式会社 Ｆｇｆｒ阻害剤耐性癌の治療薬
AU2014291161B2 (en) * 2013-07-18 2018-04-26 Taiho Pharmaceutical Co., Ltd. Antitumor drug for intermittent administration of FGFR inhibitor
US9580432B2 (en) * 2013-08-12 2017-02-28 Taiho Pharmaceutical Co., Ltd. Fused pyrimidine compound or salt thereof
CA2928042C (en) 2013-10-25 2022-05-10 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
ES2756175T3 (es) * 2013-12-27 2020-04-27 Chugai Pharmaceutical Co Ltd Genes mutantes guardián de fgfr y fármacos que se dirigen a los mismos
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
KR101947289B1 (ko) * 2014-06-24 2019-02-12 다이호야쿠힌고교 가부시키가이샤 신규 피롤로피리미딘 화합물 또는 그의 염, 및 이것을 함유하는 의약 조성물, 특히 nae 저해 작용에 기초하는 종양 등의 예방제 및/또는 치료제
AU2015304465B2 (en) 2014-08-18 2019-05-09 Eisai R&D Management Co., Ltd. Salt of monocyclic pyridine derivative and crystal thereof
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
CN105837575B (zh) 2015-01-13 2019-01-15 四川大学 3-乙炔基吡唑并嘧啶衍生物及其制备方法和用途
TWI638817B (zh) * 2015-01-30 2018-10-21 大鵬藥品工業股份有限公司 免疫疾病之預防及／或治療劑
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
CN107438607B (zh) 2015-02-20 2021-02-05 因赛特公司 作为fgfr抑制剂的双环杂环
HUE051074T2 (hu) 2015-03-31 2021-03-01 Taiho Pharmaceutical Co Ltd 3,5-diszubsztituált benzol alkinil vegyület kristálya
JP6762300B2 (ja) 2015-06-17 2020-09-30 中外製薬株式会社 アミノピラゾール誘導体
CA2997051C (en) * 2015-09-01 2020-03-24 Taiho Pharmaceutical Co., Ltd. Novel pyrazolo[3,4-d]pyrimidine compound or salt thereof
TWI623316B (zh) * 2015-12-22 2018-05-11 Taiho Pharmaceutical Co Ltd Antitumor effect enhancer derived from pyrrolopyrimidine compound
EP3269370B1 (en) * 2016-02-23 2020-01-08 Taiho Pharmaceutical Co., Ltd. Novel condensed pyrimidine compound or salt thereof
US11883404B2 (en) 2016-03-04 2024-01-30 Taiho Pharmaceuticals Co., Ltd. Preparation and composition for treatment of malignant tumors
MA43807A (fr) 2016-03-04 2018-11-28 Taiho Pharmaceutical Co Ltd Préparation et composition de traitement de tumeurs malignes
CN107344940B (zh) * 2016-05-06 2020-04-21 广东东阳光药业有限公司 Btk抑制剂及其用途
CN107698593A (zh) * 2016-08-09 2018-02-16 南京天印健华医药科技有限公司 作为fgfr抑制剂的杂环化合物
JP7223684B2 (ja) * 2017-02-28 2023-02-16 大鵬薬品工業株式会社 ピラゾロ［３，４－ｄ］ピリミジン化合物を用いた抗腫瘍効果増強剤
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
JOP20180094A1 (ar) 2017-10-18 2019-04-18 Hk Inno N Corp مركب حلقي غير متجانس كمثبط بروتين كيناز
CN109776544B (zh) * 2017-11-15 2022-02-01 上海医药工业研究院 吡唑并[3,4-d]嘧啶类化合物及其制备方法和用途
MA52093A (fr) 2018-03-19 2021-01-27 Taiho Pharmaceutical Co Ltd Composition pharmaceutique comprenant du sulfate d'alkyle de sodium
BR112020017922A2 (pt) 2018-03-28 2020-12-22 Eisai R&D Management Co., Ltd. Agente terapêutico para carcinoma hepatocelular
MA52493A (fr) 2018-05-04 2021-03-10 Incyte Corp Sels d'un inhibiteur de fgfr
BR112020022392A2 (pt) 2018-05-04 2021-02-02 Incyte Corporation formas sólidas de um inibidor de fgfr e processos para preparação das mesmas
EP3795571A4 (en) 2018-07-02 2021-04-28 Shenzhen TargetRx, Inc. ALCYNYL (HETERO) AROMATIC COMPOUND FOR INHIBITION OF PROTEIN KINASE ACTIVITY
AU2018448845B2 (en) * 2018-11-09 2022-03-24 Taiho Pharmaceutical Co., Ltd. Method for producing dimethoxybenzene compound
WO2020096042A1 (ja) * 2018-11-09 2020-05-14 大鵬薬品工業株式会社 ジメトキシベンゼン化合物の製造方法
US20220023300A1 (en) * 2018-11-26 2022-01-27 Taiho Pharmaceutical Co., Ltd. Therapeutic and prophylactic method for tumor treatable with endocrine therapy by combined use of fibroblast growth factor receptor inhibitor with endocrine therapy
WO2020170355A1 (ja) * 2019-02-20 2020-08-27 大鵬薬品工業株式会社 Ｆｇｆｒ１変異腫瘍の治療方法
EP3932427A4 (en) * 2019-02-28 2022-12-07 Taiho Pharmaceutical Co., Ltd. CANCER THERAPY WITH 3,5-DISUBSTITUTED BENZENE-ALKYNYL COMPOUND AND PEMBROLIZUMAB
WO2020185532A1 (en) 2019-03-08 2020-09-17 Incyte Corporation Methods of treating cancer with an fgfr inhibitor
WO2020188015A1 (en) 2019-03-21 2020-09-24 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
AU2020274083A1 (en) * 2019-05-13 2021-11-18 D.E. Shaw Research, Llc FGFR inhibitors and methods of use thereof
AU2020278566A1 (en) * 2019-05-17 2021-12-23 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
TW202114691A (zh) 2019-06-21 2021-04-16 日商大鵬藥品工業股份有限公司 惡性腫瘤之治療方法
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CR20220169A (es) 2019-10-14 2022-10-27 Incyte Corp Heterociclos bicíclicos como inhibidores de fgfr
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
WO2021089005A1 (zh) * 2019-11-08 2021-05-14 石药集团中奇制药技术（石家庄）有限公司 一种fgfr抑制剂的用途
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
JP2023505258A (ja) 2019-12-04 2023-02-08 インサイト・コーポレイション Ｆｇｆｒ阻害剤としての三環式複素環
WO2021113462A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Derivatives of an fgfr inhibitor
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202140025A (zh) 2020-01-31 2021-11-01 國立大學法人京都大學 軟骨發育異常症之治療
EP4183395A1 (en) * 2020-07-15 2023-05-24 Taiho Pharmaceutical Co., Ltd. Pyrimidine compound-containing combination to be used in tumor treatment
TWI797711B (zh) * 2020-08-13 2023-04-01 大陸商上海和譽生物醫藥科技有限公司 一種fgfr及其突變抑制劑，其製備方法和應用
CN114805359B (zh) * 2021-01-28 2023-10-27 药雅科技(上海)有限公司 炔代杂环化合物fgfr抑制剂的制备方法和用途
CN115028634B (zh) * 2021-03-08 2023-11-28 药雅科技(上海)有限公司 一种炔代吡嗪并杂环类fgfr抑制剂及其制备方法和用途
WO2022261160A1 (en) 2021-06-09 2022-12-15 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
CN115785103A (zh) * 2022-12-28 2023-03-14 北京康立生医药技术开发有限公司 一种治疗胆管癌药物福巴替尼的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659274B2 (en) 2006-01-25 2010-02-09 Osi Pharmaceuticals, Inc. Unsaturated mTOR inhibitors
CA3143428A1 (en) * 2007-03-28 2008-10-09 Pharmacyclics Llc 8-amino-3-substituted-imidazo[1,5-a]pyrazine and use thereof as inhibitors of bruton's tyrosine kinase
GB0819105D0 (en) * 2008-10-17 2008-11-26 Chroma Therapeutics Ltd Pyrrolo-pyrimidine compounds
KR101483215B1 (ko) 2010-01-29 2015-01-16 한미약품 주식회사 단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
CA3007787C (en) * 2010-06-03 2020-03-10 Pharmacyclics Llc The use of inhibitors of bruton's tyrosine kinase (btk)

Also Published As

Publication number Publication date
JPWO2013108809A1 (ja) 2015-05-11
BR112014017749A8 (pt) 2017-07-11
RU2576384C1 (ru) 2016-03-10
EP2657233B1 (en) 2014-08-27
CN103958512B (zh) 2016-01-20
AU2013210403A1 (en) 2014-06-26
JP5355825B1 (ja) 2013-11-27
TW201335156A (zh) 2013-09-01
EP2657233A1 (en) 2013-10-30
HK1198164A1 (zh) 2015-03-13
AU2013210403B2 (en) 2016-01-14
BR112014017749A2 (pt) 2017-06-20
CA2854093A1 (en) 2013-07-25
HUS2300043I1 (hu) 2024-01-28
US20140343035A1 (en) 2014-11-20
DK2657233T3 (da) 2014-09-22
MX2014008605A (es) 2014-08-27
BR112014017749B1 (pt) 2021-08-03
KR101623286B1 (ko) 2016-05-20
FIC20230038I1 (fi) 2023-12-18
TWI508964B (zh) 2015-11-21
KR20140080551A (ko) 2014-06-30
CA2854093C (en) 2016-07-05
PT2657233E (pt) 2014-10-24
MY171055A (en) 2019-09-23
NL301254I1 (es) 2023-12-20
PL2657233T3 (pl) 2015-01-30
US9108973B2 (en) 2015-08-18
NL301254I2 (nl) 2024-01-10
SG2014009286A (en) 2014-04-28
ES2516392T3 (es) 2014-10-30
FR23C1050I1 (fr) 2024-01-26
EP2657233A4 (en) 2013-12-04
WO2013108809A1 (ja) 2013-07-25
CN103958512A (zh) 2014-07-30
NO2023046I1 (no) 2023-12-20

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