PL2099442T3 - Sposób stosowania inhibitorów deacetylazy histonów i monitoringu biomarkerów w terapii skojarzonej - Google Patents

Sposób stosowania inhibitorów deacetylazy histonów i monitoringu biomarkerów w terapii skojarzonej

Info

Publication number
PL2099442T3
PL2099442T3 PL07869059T PL07869059T PL2099442T3 PL 2099442 T3 PL2099442 T3 PL 2099442T3 PL 07869059 T PL07869059 T PL 07869059T PL 07869059 T PL07869059 T PL 07869059T PL 2099442 T3 PL2099442 T3 PL 2099442T3
Authority
PL
Poland
Prior art keywords
combination therapy
histone deacetylase
deacetylase inhibitors
monitoring biomarkers
biomarkers
Prior art date
Application number
PL07869059T
Other languages
English (en)
Inventor
Shanthi Adimoolam
Joseph J Buggy
Darren Magda
Richard Miller
Original Assignee
Pharmacyclics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacyclics Inc filed Critical Pharmacyclics Inc
Publication of PL2099442T3 publication Critical patent/PL2099442T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PL07869059T 2006-12-26 2007-12-07 Sposób stosowania inhibitorów deacetylazy histonów i monitoringu biomarkerów w terapii skojarzonej PL2099442T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87190006P 2006-12-26 2006-12-26
EP07869059.1A EP2099442B1 (en) 2006-12-26 2007-12-07 Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
PCT/US2007/086874 WO2008082856A1 (en) 2006-12-26 2007-12-07 Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy

Publications (1)

Publication Number Publication Date
PL2099442T3 true PL2099442T3 (pl) 2015-04-30

Family

ID=39588962

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07869059T PL2099442T3 (pl) 2006-12-26 2007-12-07 Sposób stosowania inhibitorów deacetylazy histonów i monitoringu biomarkerów w terapii skojarzonej

Country Status (17)

Country Link
US (1) US9408816B2 (pl)
EP (2) EP2099442B1 (pl)
JP (2) JP2010514777A (pl)
KR (2) KR20120090100A (pl)
CN (1) CN101674820B (pl)
AU (1) AU2007340129B2 (pl)
CA (1) CA2674084C (pl)
CY (1) CY1116019T1 (pl)
DK (1) DK2099442T3 (pl)
ES (1) ES2529147T3 (pl)
NZ (1) NZ578428A (pl)
PL (1) PL2099442T3 (pl)
PT (1) PT2099442E (pl)
RU (2) RU2446796C2 (pl)
SI (1) SI2099442T1 (pl)
WO (1) WO2008082856A1 (pl)
ZA (1) ZA200905060B (pl)

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JP2014139181A (ja) 2014-07-31
KR20120090100A (ko) 2012-08-16
US9408816B2 (en) 2016-08-09
CA2674084C (en) 2013-05-14
CA2674084A1 (en) 2008-07-10
RU2446796C2 (ru) 2012-04-10
WO2008082856A1 (en) 2008-07-10
EP2099442A1 (en) 2009-09-16
SI2099442T1 (sl) 2015-03-31
US20080153877A1 (en) 2008-06-26
EP2626067A1 (en) 2013-08-14
RU2009126655A (ru) 2011-02-10
JP2010514777A (ja) 2010-05-06
EP2099442A4 (en) 2010-06-16
KR20090101362A (ko) 2009-09-25
JP5827706B2 (ja) 2015-12-02
NZ578428A (en) 2012-03-30
CN101674820A (zh) 2010-03-17
AU2007340129B2 (en) 2012-02-02
ZA200905060B (en) 2010-07-28
PT2099442E (pt) 2015-02-10
ES2529147T3 (es) 2015-02-17
DK2099442T3 (en) 2015-02-16
AU2007340129A1 (en) 2008-07-10
CN101674820B (zh) 2013-09-25
RU2011148293A (ru) 2013-06-10
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