ATE291097T1 - Expressionsprofile in adulten und fötalen organen - Google Patents

Expressionsprofile in adulten und fötalen organen

Info

Publication number
ATE291097T1
ATE291097T1 AT98956326T AT98956326T ATE291097T1 AT E291097 T1 ATE291097 T1 AT E291097T1 AT 98956326 T AT98956326 T AT 98956326T AT 98956326 T AT98956326 T AT 98956326T AT E291097 T1 ATE291097 T1 AT E291097T1
Authority
AT
Austria
Prior art keywords
adult
expression profiles
probes
fetal
organs
Prior art date
Application number
AT98956326T
Other languages
English (en)
Inventor
David J Lockhart
Archana Nair
Janet A Warrington
Original Assignee
Affymetrix Inc A Delaware Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc A Delaware Corp filed Critical Affymetrix Inc A Delaware Corp
Application granted granted Critical
Publication of ATE291097T1 publication Critical patent/ATE291097T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6834Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809Methods for determination or identification of nucleic acids involving differential detection
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
AT98956326T 1997-10-31 1998-10-30 Expressionsprofile in adulten und fötalen organen ATE291097T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6385797P 1997-10-31 1997-10-31
PCT/US1998/022966 WO1999023254A1 (en) 1997-10-31 1998-10-30 Expression profiles in adult and fetal organs

Publications (1)

Publication Number Publication Date
ATE291097T1 true ATE291097T1 (de) 2005-04-15

Family

ID=22051981

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98956326T ATE291097T1 (de) 1997-10-31 1998-10-30 Expressionsprofile in adulten und fötalen organen

Country Status (7)

Country Link
US (1) US6033860A (de)
EP (1) EP1027456B1 (de)
JP (2) JP2001521753A (de)
AT (1) ATE291097T1 (de)
AU (1) AU1287799A (de)
DE (1) DE69829402T2 (de)
WO (1) WO1999023254A1 (de)

Families Citing this family (202)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960439B2 (en) 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
EP1198585B1 (de) * 1999-06-28 2007-06-13 Source Precision Medicine, Inc. Verfahren zum Charakterisieren von biologischen Bedingungen, die kalibrierte Genexpressionsprofile verwenden
US6958225B2 (en) 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
CA2388511A1 (en) * 1999-11-04 2001-05-10 Incyte Genomics, Inc. Tissue specific genes of diagnostic import
AU1466001A (en) * 1999-11-05 2001-05-14 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
US6372431B1 (en) * 1999-11-19 2002-04-16 Incyte Genomics, Inc. Mammalian toxicological response markers
GB2396351B (en) * 2000-02-04 2004-08-25 Aeomica Inc Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human lung
WO2001057251A2 (en) * 2000-02-04 2001-08-09 Aeomica, Inc. Methods and apparatus for predicting, confirming, and displaying functional information derived from genomic sequence
GB2396352B (en) * 2000-02-04 2004-08-25 Aeomica Inc Human genome-derived single exon nucleic acid probes useful for analysis of gene expression in human bone marrow
US6884578B2 (en) * 2000-03-31 2005-04-26 Affymetrix, Inc. Genes differentially expressed in secretory versus proliferative endometrium
WO2001084149A2 (en) 2000-04-29 2001-11-08 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
US20020012905A1 (en) * 2000-06-14 2002-01-31 Snodgrass H. Ralph Toxicity typing using liver stem cells
DE10048633A1 (de) * 2000-09-25 2002-04-18 Schering Ag Methode zur in vitro Diagnostik von Endometriose
US6780594B2 (en) 2000-09-25 2004-08-24 Schering Aktiengesellschaft Method for in vitro diagnosis of endometriosis
WO2002027321A2 (en) 2000-09-26 2002-04-04 Health Research Incorporated Analysis of hiv-1 coreceptor use in the clinical care of hiv-1-infected patients
US7135278B1 (en) 2000-09-29 2006-11-14 University Of Rochester Method of screening for therapeutics for infectious diseases
WO2002057414A2 (en) * 2000-10-20 2002-07-25 Expression Diagnostics, Inc. Leukocyte expression profiling
WO2003008647A2 (en) * 2000-11-28 2003-01-30 University Of Cincinnati Blood assessment of injury
US20020142328A1 (en) * 2000-12-01 2002-10-03 Danenberg Kathleen D. Method of determining a chemotherapeutic regimen by assaying gene expression in primary tumors
US7341717B2 (en) * 2001-04-13 2008-03-11 Gpc Biotech Ag Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor
EP1385999B1 (de) * 2001-04-30 2012-12-12 Ventana Medical Systems, Inc. Automatisiertes in situ oder mikroarray hybridisierungsverfahren und reagenzien dafür
US6905827B2 (en) * 2001-06-08 2005-06-14 Expression Diagnostics, Inc. Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
US7235358B2 (en) 2001-06-08 2007-06-26 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
US7026121B1 (en) * 2001-06-08 2006-04-11 Expression Diagnostics, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
CA2356540A1 (en) * 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
JP2005515757A (ja) * 2001-08-30 2005-06-02 エモリー・ユニバーシティ ミトコンドリア生物学発現アレイ
US20030068621A1 (en) * 2001-10-04 2003-04-10 Jonathan Briggs Method and device for producing oligonucleotide arrays
EP1451340B1 (de) 2001-11-09 2014-01-08 Life Technologies Corporation Identifizierung, überwachung und behandlung einer krankheit sowie charakterisierung eines biologischen zustands unter verwendung von genexpressionsprofilen
WO2003053586A1 (en) * 2001-12-19 2003-07-03 Affymetrix, Inc. Array plates and method for constructing array plates
US7504215B2 (en) 2002-07-12 2009-03-17 Affymetrix, Inc. Nucleic acid labeling methods
EP2194147B1 (de) 2002-12-04 2015-07-22 Applied Biosystems, LLC Multiplexverstärkung von Polynucleotiden
US20080014579A1 (en) * 2003-02-11 2008-01-17 Affymetrix, Inc. Gene expression profiling in colon cancers
US7892745B2 (en) 2003-04-24 2011-02-22 Xdx, Inc. Methods and compositions for diagnosing and monitoring transplant rejection
GB0310270D0 (en) * 2003-05-03 2003-06-11 Univ Edinburgh Biomolecular devices
EP2327796A1 (de) 2003-06-10 2011-06-01 The Trustees Of Boston University Nachweismethoden für Lungenerkrankungen
US20040259100A1 (en) 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US8131475B2 (en) 2003-09-03 2012-03-06 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for identifying, diagnosing, and predicting survival of lymphomas
EP2157524A3 (de) 2003-09-03 2010-12-08 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Verfahren zur Identifizierung und Diagnose von sowie vohersage des Überlebens bei Lymphomen
WO2005054516A2 (en) 2003-11-26 2005-06-16 Advandx, Inc. Peptide nucleic acid probes for analysis of certain staphylococcus species
EP1564306B1 (de) 2004-02-17 2013-08-07 Affymetrix, Inc. Verfahren zur Fragmentierung und Markierung von DNS
WO2005082110A2 (en) * 2004-02-26 2005-09-09 Illumina Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
KR20080075045A (ko) 2004-03-24 2008-08-13 트리패스 이미징, 인코포레이티드 자궁경부 질환의 검사 방법 및 조성물
WO2006029184A2 (en) * 2004-09-08 2006-03-16 Expression Diagnostics, Inc. Genes useful for diagnosing and monitoring inflammation related disorders
EP1647600A3 (de) 2004-09-17 2006-06-28 Affymetrix, Inc. (A US Entity) Verfahren zur Kennzeichnung von biologischen Proben durch Hinzufügung von Nukleinsäre "bar-code" Markierungen
US20060073511A1 (en) 2004-10-05 2006-04-06 Affymetrix, Inc. Methods for amplifying and analyzing nucleic acids
US7682782B2 (en) 2004-10-29 2010-03-23 Affymetrix, Inc. System, method, and product for multiple wavelength detection using single source excitation
EP1652580A1 (de) 2004-10-29 2006-05-03 Affymetrix, Inc. Mikroarray mit hohem Durchsatz, Arrayanordnung und Herstellungsverfahren für Arrays
US7647186B2 (en) * 2004-12-07 2010-01-12 Illumina, Inc. Oligonucleotide ordering system
JP2008537120A (ja) 2005-04-14 2008-09-11 ザ トラスティーズ オブ ボストン ユニバーシティ 分類予測を使用した肺障害についての診断
EP1885889A4 (de) * 2005-05-11 2010-01-20 Expression Diagnostics Inc Verfahren zur überwachung des betriebsstatus von transplantaten über genlisten
US20070072175A1 (en) * 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
ES2429564T3 (es) 2005-05-18 2013-11-15 Novartis Ag Procedimientos para el diagnóstico y tratamiento de enfermedades que tienen un componente autoinmune y/o inflamatorio
WO2006138257A2 (en) 2005-06-15 2006-12-28 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20070054168A1 (en) * 2005-09-06 2007-03-08 Hao Chang Zinc/air cell
EP1941057A4 (de) * 2005-10-07 2009-11-11 Baylor Res Inst Diagnose des systemischen ausbruchs juveniler idiopathischer arthritis über blutleukozyten-mikroarrayanalyse
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
US7634363B2 (en) * 2005-12-07 2009-12-15 Affymetrix, Inc. Methods for high throughput genotyping
US20090215055A1 (en) * 2005-12-13 2009-08-27 Erasmus University Medical Center Rotterdam Genetic Brain Tumor Markers
US20070161031A1 (en) * 2005-12-16 2007-07-12 The Board Of Trustees Of The Leland Stanford Junior University Functional arrays for high throughput characterization of gene expression regulatory elements
EP1989326A4 (de) 2006-01-17 2009-09-30 Health Research Inc Heteroduplex-verfolgungstest
US20070212721A1 (en) 2006-01-27 2007-09-13 Tripath Imaging, Inc. Methods for identifying patients with an increased likelihood of having ovarian cancer and compositions therefor
WO2007103541A2 (en) 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
WO2007109376A2 (en) 2006-03-23 2007-09-27 Novartis Ag Anti-tumor cell antigen antibody therapeutics
US7914988B1 (en) 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
CA2648580A1 (en) * 2006-04-07 2008-05-02 Xdx, Inc. Steroid responsive nucleic acid expression and prediction of disease activity
US20070259346A1 (en) * 2006-05-03 2007-11-08 Agilent Technologies, Inc. Analysis of arrays
US20080058218A1 (en) * 2006-05-03 2008-03-06 Gordon David B Arrays of compound probes and methods using the same
EP2057465A4 (de) 2006-08-09 2010-04-21 Homestead Clinical Corp Organspezifische proteine und anwendungsverfahren dafür
WO2008021431A2 (en) * 2006-08-14 2008-02-21 Xdx, Inc. Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders
WO2008048986A2 (en) * 2006-10-17 2008-04-24 Children's Hospital Medical Center Gene array technique for predicting response in inflammatory bowel diseases
US9845494B2 (en) 2006-10-18 2017-12-19 Affymetrix, Inc. Enzymatic methods for genotyping on arrays
CA2704288A1 (en) 2006-11-03 2008-08-21 Baylor Research Institute Diagnosis of metastatic melanoma and monitoring indicators of immunosuppression through blood leukocyte microarray analysis
US8148067B2 (en) * 2006-11-09 2012-04-03 Xdx, Inc. Methods for diagnosing and monitoring the status of systemic lupus erythematosus
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
US8293684B2 (en) * 2006-11-29 2012-10-23 Exiqon Locked nucleic acid reagents for labelling nucleic acids
EP2135080A4 (de) * 2007-03-08 2010-12-01 Switchgear Genomics Funktionelle arrays zur charakterisierung mit hohem durchsatz von regulatorischen elementen in nichttranslatierten bereichen von genen
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
WO2008127710A2 (en) 2007-04-13 2008-10-23 Dana Farber Cancer Institute Methods for treating cancer resistant to erbb therapeutics
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
WO2009113779A2 (ko) 2008-03-11 2009-09-17 국립암센터 Snp 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법
GB0809069D0 (en) 2008-05-19 2008-06-25 Univ Leuven Kath Gene signatures
US8039817B2 (en) 2008-05-05 2011-10-18 Illumina, Inc. Compensator for multiple surface imaging
EP2294214A2 (de) * 2008-05-07 2011-03-16 Illumina, Inc. Zusammensetzungen und verfahren zur bereitstellung von substanzen an und aus einem array
JP2009268665A (ja) * 2008-05-07 2009-11-19 Canon Inc 吸入装置
EP2664679B1 (de) 2008-05-30 2017-11-08 The University of North Carolina At Chapel Hill Genexpressionsprofile zur Vorhersage des Ausgangs von Brustkrebserkrankungen
US20110195064A1 (en) 2008-06-06 2011-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv Survival predictor for diffuse large b cell lymphoma
US20100087325A1 (en) * 2008-10-07 2010-04-08 Illumina, Inc. Biological sample temperature control system and method
EP2340314B8 (de) 2008-10-22 2015-02-18 Illumina, Inc. Erhaltung von informationen in verbindung mit genomischer dna-methylierung
EP3722810A3 (de) 2009-02-11 2021-01-13 Caris MPI, Inc. Molekulare profilierung von tumoren
EP3255146B1 (de) 2009-03-16 2019-05-15 Pangu Biopharma Limited Zusammensetzungen und verfahren mit histidyl-trna-synthetase-spleissvarianten mit nicht-kanonischen biologischen aktivitäten
US20100310576A1 (en) 2009-03-31 2010-12-09 Adams Ryan A COMPOSITIONS AND METHODS COMPRISING ASPARTYL-tRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES
US8815779B2 (en) 2009-09-16 2014-08-26 SwitchGear Genomics, Inc. Transcription biomarkers of biological responses and methods
EP2488873B1 (de) 2009-10-16 2015-08-05 Novartis AG Biomarker für pharmakodynamische tumorreaktionen
CA2779223A1 (en) 2009-10-27 2011-05-12 Caris Mpi, Inc. Molecular profiling for personalized medicine
US20120282276A1 (en) 2009-11-05 2012-11-08 The Regents Of The University Of Michigan Biomarkers predictive of progression of fibrosis
US8501122B2 (en) 2009-12-08 2013-08-06 Affymetrix, Inc. Manufacturing and processing polymer arrays
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
AU2010336392B2 (en) 2009-12-23 2014-01-23 Hill's Pet Nutrition, Inc. Compositions and methods for diagnosing and treating kidney disorders in a canine
ES2596655T3 (es) 2010-02-01 2017-01-11 Illumina Inc. Procedimientos de enfoque y sistemas y conjuntos ópticos que usan los mismos
JP2013519869A (ja) 2010-02-10 2013-05-30 ノバルティス アーゲー 筋肉成長のための方法および化合物
WO2011112465A1 (en) 2010-03-06 2011-09-15 Illumina, Inc. Systems, methods, and apparatuses for detecting optical signals from a sample
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
JP6066900B2 (ja) 2010-04-26 2017-01-25 エータイアー ファーマ, インコーポレイテッド システイニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103096911B (zh) 2010-04-27 2018-05-29 Atyr 医药公司 与异亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
US8993723B2 (en) 2010-04-28 2015-03-31 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
EP2566515B1 (de) 2010-05-03 2017-08-02 aTyr Pharma, Inc. Innovative entdeckung von therapeutischen und diagnostischen mitteln sowie antikörperzusammensetzungen im zusammenhang mit proteinfragmenten von arginyl-trna-synthetasen
AU2011248230B2 (en) 2010-05-03 2016-10-06 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases
ES2623805T3 (es) 2010-05-03 2017-07-12 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de fenilalanil-alfa-ARNt sintetasas
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ, インコーポレイテッド p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
JP6396656B2 (ja) 2010-05-14 2018-09-26 エータイアー ファーマ, インコーポレイテッド フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US9034598B2 (en) 2010-05-17 2015-05-19 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases
JP6046607B2 (ja) 2010-05-27 2016-12-21 エータイアー ファーマ, インコーポレイテッド グルタミニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
US8962560B2 (en) 2010-06-01 2015-02-24 Atyr Pharma Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases
CN107898791A (zh) 2010-06-03 2018-04-13 药品循环有限责任公司 布鲁顿酪氨酸激酶(btk)抑制剂的应用
JP2013529089A (ja) 2010-06-07 2013-07-18 エフ.ホフマン−ラ ロシュ アーゲー インターロイキン−6受容体を阻害するモノクローナル抗体による薬剤治療に対する応答を予測するための遺伝子発現マーカー
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
CN103118695B (zh) 2010-07-12 2016-08-03 Atyr医药公司 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现
CN103167876B (zh) 2010-08-12 2016-08-31 菲特治疗公司 改进的造血干细胞和祖细胞疗法
US9029506B2 (en) 2010-08-25 2015-05-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-tRNA synthetases
WO2012050920A1 (en) 2010-09-29 2012-04-19 Illumina, Inc. Compositions and methods for sequencing nucleic acids
EP2633069B1 (de) 2010-10-26 2015-07-01 Illumina, Inc. Sequenzierungsverfahren
JP6163104B2 (ja) 2010-11-15 2017-07-12 アクセラレイテッド・バイオサイエンシズ・コーポレーション ヒト・トロホブラスト幹細胞からの神経幹細胞の生成
CA2819378A1 (en) 2010-12-02 2012-06-07 Katholieke Universiteit Leuven, K.U.Leuven R&D Irak-related interventions and diagnosis
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
JP5808825B2 (ja) 2011-02-24 2015-11-10 ヒルズ・ペット・ニュートリシャン・インコーポレーテッド ネコの腎障害を診断および治療する組成物および方法
MX358408B (es) 2011-03-02 2018-08-20 Berg Llc Ensayos interrogatorios basados en celulas y usos de los mismos.
WO2012119077A1 (en) 2011-03-02 2012-09-07 Morphotek Inc. Co -administration of eribulin and farletuzumab for the treatment of breast cancer
CA2830240A1 (en) 2011-03-15 2012-09-20 The University Of North Carolina At Chapell Hill Methods of treating breast cancer with anthracycline therapy
JP2014509515A (ja) 2011-03-18 2014-04-21 エーザイ・アール・アンド・ディー・マネジメント株式会社 エリブリンに対する応答を予測するための方法及び組成物
US9777332B2 (en) 2011-03-31 2017-10-03 St. Jude Children's Research Hospital Methods and compositions for identifying minimal residual disease in acute lymphoblastic leukemia
WO2012170936A2 (en) 2011-06-09 2012-12-13 Illumina, Inc. Patterned flow-cells useful for nucleic acid analysis
BR112013032354A2 (pt) 2011-06-15 2017-01-03 Hills Pet Nutrition Inc Composições e métodos para diagnóstico e monitoração de hipertireoidismo em um felino
AU2012328662B2 (en) 2011-10-28 2015-12-17 Illumina, Inc. Microarray fabrication system and method
EP2786156A2 (de) 2011-11-30 2014-10-08 AbbVie Deutschland GmbH & Co KG Verfahren und zusammensetzungen zur bestimmung des ansprechens auf eine behandlung mit einem tnf-alpha-hemmer
EP2794649B1 (de) 2011-12-19 2016-04-27 Hill's Pet Nutrition, Inc. Zusammensetzungen und verfahren zur diagnose von schilddrüsenüberfunktion bei haustieren
RU2659423C2 (ru) 2012-02-16 2018-07-02 ЭйТИР ФАРМА, ИНК. ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ
WO2013123125A1 (en) 2012-02-17 2013-08-22 President And Fellows Of Harvard College Assembly of nucleic acid sequences in emulsions
ES2663234T3 (es) 2012-02-27 2018-04-11 Cellular Research, Inc Composiciones y kits para recuento molecular
EP2820174B1 (de) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Verfahren und verwendung für molekulare tags
SG10201608234UA (en) 2012-04-02 2016-11-29 Berg Llc Interrogatory cell-based assays and uses thereof
EP2834371B1 (de) 2012-04-05 2019-01-09 The Regents of The University of California Genexpressionspaneel für brustkrebsprognose
MX369628B (es) 2012-05-22 2019-11-14 Nanostring Technologies Inc Genes nano46 y metodos para predecir el resultado del cancer de mama.
KR20150032340A (ko) 2012-07-24 2015-03-25 파마시클릭스, 인코포레이티드 브루톤 티로신 키나제(btk)의 억제제에 대한 내성과 관련된 돌연변이
CA2881823C (en) 2012-08-20 2019-06-11 Illumina, Inc. Method and system for fluorescence lifetime based sequencing
NZ709167A (en) 2012-11-27 2020-03-27 Univ Pontificia Catolica Chile Compositions and methods for diagnosing thyroid tumors
US9457053B2 (en) 2012-11-30 2016-10-04 Accelerated Biosciences Corp. Methods of differentiating stem cells by modulating MIR-124
BR112015017403A2 (pt) 2013-01-21 2017-11-21 Abbvie Inc biomarcadores de terapia de combinação de anti-tnf e anti-il17 para doença inflamatória
JP6416793B2 (ja) 2013-02-28 2018-10-31 カプリオン プロテオミクス インコーポレーテッド 結核のバイオマーカー及びその使用
GB2584364A (en) 2013-03-15 2020-12-02 Abvitro Llc Single cell bar-coding for antibody discovery
ES2751402T3 (es) 2013-03-27 2020-03-31 Bluegnome Ltd Evaluación del riesgo de aneuploidía
EP3842542A1 (de) 2013-08-28 2021-06-30 Becton, Dickinson and Company Massiv parallele einzelzellanalyse
JP2016537010A (ja) 2013-09-09 2016-12-01 ブリティッシュ コロンビア キャンサー エージェンシー ブランチ 予後を予測するための方法及びキット、並びに、放射線照射療法を用いた乳癌の治療方法及びキット
US9352315B2 (en) 2013-09-27 2016-05-31 Taiwan Semiconductor Manufacturing Company, Ltd. Method to produce chemical pattern in micro-fluidic structure
AU2014329547B2 (en) 2013-10-02 2019-05-16 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
AU2014346788B8 (en) 2013-11-06 2021-01-28 Arizona Board Of Regents On Behalf Of The Unviersity Of Arizona Method for subtyping lymphoma types by means of expression profiling
CN112322735A (zh) 2014-01-16 2021-02-05 启迪公司 用于***癌复发的预后的基因表达面板
US10704097B2 (en) 2014-02-27 2020-07-07 Katholieke Universiteit Leuven Oxidative stress and cardiovascular disease events
WO2015127517A1 (en) 2014-02-27 2015-09-03 Katholieke Universiteit Leuven Oxidative stress and cardiovascular disease events
US9885086B2 (en) 2014-03-20 2018-02-06 Pharmacyclics Llc Phospholipase C gamma 2 and resistance associated mutations
JP2017516501A (ja) 2014-05-30 2017-06-22 ジーンセントリック ダイアグノスティクス, インコーポレイテッド 肺がんのタイピング法
US20160000936A1 (en) 2014-06-10 2016-01-07 Abbvie Inc. Biomarkers for inflammatory disease and methods of using same
EP3194593B1 (de) 2014-09-15 2019-02-06 AbVitro LLC Nukleotidbibliotheksequenzierung mit hohem durchsatz
CA3148687A1 (en) 2014-11-26 2016-06-02 Accelerated Biosciences Corp. Induced hepatocytes and uses thereof
EP3604556A1 (de) 2014-12-12 2020-02-05 Medivation Prostate Therapeutics LLC Verfahren zur vorhersage der reaktion auf brustkrebstherapeutika und verfahren zur behandlung von brustkrebs
CN107208057A (zh) 2014-12-19 2017-09-26 Vrije布鲁塞尔大学 哺乳动物卵丘***复合体的体外成熟
WO2016130572A2 (en) 2015-02-10 2016-08-18 Dana-Farber Cancer Institute, Inc. Methods of determining levels of exposure to radiation and uses thereof
EP3274692B1 (de) 2015-03-24 2022-08-10 Illumina, Inc. Verfahren zur bildgebung von proben zur biologischen oder chemischen analyse
AU2016271049B9 (en) 2015-05-29 2019-07-18 Illumina, Inc. Sample carrier and assay system for conducting designated reactions
JP6923509B2 (ja) 2015-07-28 2021-08-18 オトノミ—,インク. 切断型のtrkbおよびtrkcのアンタゴニストを使用する処置
US10976334B2 (en) 2015-08-24 2021-04-13 Illumina, Inc. In-line pressure accumulator and flow-control system for biological or chemical assays
WO2018057051A1 (en) 2016-09-24 2018-03-29 Abvitro Llc Affinity-oligonucleotide conjugates and uses thereof
KR20180085717A (ko) 2015-09-24 2018-07-27 에이비비트로, 엘엘씨 친화성-올리고뉴클레오타이드 콘쥬게이트 및 그것의 사용
AU2016326734B2 (en) 2015-09-25 2022-07-07 Abvitro Llc High throughput process for T cell receptor target identification of natively-paired T cell receptor sequences
CN108138226B (zh) 2015-10-18 2022-02-11 阿费梅特里克斯公司 单核苷酸多态性和***缺失的多等位基因基因分型
AU2017246334C1 (en) 2016-04-04 2022-11-17 Sinopia Biosciences, Inc. Treating extrapyramidal syndrome using Trapidil
US11725248B2 (en) 2016-04-20 2023-08-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Evaluation of mantle cell lymphoma and methods related thereto
WO2017201164A1 (en) 2016-05-17 2017-11-23 Genecentric Diagnostics, Inc. Methods for subtyping of lung squamous cell carcinoma
EP3458612B1 (de) 2016-05-17 2023-11-15 Genecentric Therapeutics, Inc. Verfahren zur subtypisierung von lungenadenokarzinomen
EP3260552A1 (de) 2016-06-20 2017-12-27 Istituto Europeo di Oncologia (IEO) Verfahren und kits mit gensignaturen zur stratifizierung von brustkrebspatienten
WO2018013883A1 (en) 2016-07-14 2018-01-18 Caprion Proteomics Inc. Biomarkers of latent tuberculosis infection
WO2018064116A1 (en) 2016-09-28 2018-04-05 Illumina, Inc. Methods and systems for data compression
WO2018213803A1 (en) 2017-05-19 2018-11-22 Neon Therapeutics, Inc. Immunogenic neoantigen identification
EP3638814B8 (de) 2017-06-14 2023-06-21 The United States of America, as Represented by The Secretary, Department of Health and Human Services Verfahren zur bestimmung des lymphomtyps
WO2018237327A1 (en) 2017-06-22 2018-12-27 Triact Therapeutics, Inc. METHODS OF TREATING GLIOBLASTOMA
WO2019018764A1 (en) 2017-07-21 2019-01-24 Genecentric Therapeutics, Inc. METHODS OF DETERMINING RESPONSE TO PARP INHIBITORS
EP3687501A4 (de) 2017-09-29 2021-06-23 Triact Therapeutics, Inc. Iniparib-formulierungen und verwendungen davon
ES2960914T3 (es) 2018-03-16 2024-03-07 Gopath Laboratories Llc Métodos para la detección personalizada de la reaparición del cáncer o de la metástasis y/o evaluación de la respuesta al tratamiento
EP3847261A1 (de) 2018-09-05 2021-07-14 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Verfahren zum engineering von synthetischer cis-regulierender dna
US20210388449A1 (en) 2018-10-09 2021-12-16 Genecentric Therapeutics, Inc. Detecting cancer cell of origin
WO2020104482A1 (en) 2018-11-20 2020-05-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting metastatic potential in patients suffering from sdhb-mutated paraganglioma
JP7462632B2 (ja) 2018-11-30 2024-04-05 カリス エムピーアイ インコーポレイテッド 次世代分子プロファイリング
EP3956476A1 (de) 2019-04-17 2022-02-23 Igenomix S.L. Verbesserte verfahren zur frühdiagnose von uterinen leiomyomen und leiomyosarkomen
WO2021112918A1 (en) 2019-12-02 2021-06-10 Caris Mpi, Inc. Pan-cancer platinum response predictor
EP4121534A1 (de) 2020-03-18 2023-01-25 Alnylam Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur behandlung von patienten mit einer heterozygoten alaninglyoxylat-aminotransferase-genvariante (agxt)
EP3907301A1 (de) 2020-05-08 2021-11-10 Istituto Europeo di Oncologia S.r.l. Methoden und kits zur bestimmung des risikos eines erneuten auftretens von brustkrebs
WO2023122758A1 (en) 2021-12-22 2023-06-29 Cornell University Prognostic/predictive epigenetic breast cancer signature
WO2023122363A1 (en) 2021-12-23 2023-06-29 Illumina Software, Inc. Dynamic graphical status summaries for nucelotide sequencing
US20230215515A1 (en) 2021-12-23 2023-07-06 Illumina Software, Inc. Facilitating secure execution of external workflows for genomic sequencing diagnostics
WO2023129764A1 (en) 2021-12-29 2023-07-06 Illumina Software, Inc. Automatically switching variant analysis model versions for genomic analysis applications
CN115814060A (zh) * 2022-08-30 2023-03-21 长春科技学院 胸腺素β10在制备修复肝损伤药物中的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506131A (en) * 1987-06-05 1996-04-09 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450 genes
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US5750367A (en) * 1993-11-08 1998-05-12 Baylor College Of Medicine Human and mouse very low density lipoprotein receptors and methods for use of such receptors
JPH089969A (ja) * 1994-06-30 1996-01-16 Eisai Co Ltd 電位依存性カルシウムチャネル遺伝子安定発現細胞
US6177242B1 (en) * 1994-12-14 2001-01-23 Institut Pasteur Genomic DNA fragments containing regulatory and coding sequences for the β2-subunit of the neuronal nicotinic acetylcholine receptor and transgenic animals made using these fragments or mutated fragments
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
JP2002515738A (ja) * 1996-01-23 2002-05-28 アフィメトリックス,インコーポレイティド 核酸分析法

Also Published As

Publication number Publication date
EP1027456A1 (de) 2000-08-16
EP1027456B1 (de) 2005-03-16
DE69829402T2 (de) 2006-04-13
US6033860A (en) 2000-03-07
AU1287799A (en) 1999-05-24
JP2006246892A (ja) 2006-09-21
DE69829402D1 (en) 2005-04-21
WO1999023254A1 (en) 1999-05-14
JP2001521753A (ja) 2001-11-13

Similar Documents

Publication Publication Date Title
ATE291097T1 (de) Expressionsprofile in adulten und fötalen organen
FR13C0062I2 (fr) Compositions pharmaceutiques comprenant du dextromethorphan et de la quinidine pour traiter des troubles neurologiques
BR9712523A (pt) Novos derivados de pirazol heterociclilmetil-substituìdos
DE69604653T2 (de) Taxol derivate, deren herstellung und diese enthaltende pharmazeutischen zusammenstellungen
DE59609487D1 (de) Kaskaden-polymer-komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
TR199902803T2 (xx) VCAM-1' in te�hisinin daralt�lmas� i�in bile�ikler ve metodlar.
TR200102817T2 (tr) Antiinflamatuar ajanlar olarak faydalı bileşikler
EE200100507A (et) Hüdroksümatairesinool vähkkasvaja vältimises
WO2002028999A3 (en) Gene expression profiles in granulocytic cells
FI972287A (fi) Uudenlaisia polysubstituoituja DTPA-johdoksia ja niiden metallikomplekseja, kyseisiä komplekseja sisältäviä farmaseuttisia aineita, niiden käyttö diagnosoinnissa ja terapiassa sekä menetelmiä kyseisten kompleksinmuodostajien ja kompleksien valmistamiseksi ja menetelmiä kyseisten.
FI963221A0 (fi) 6-substituoitu mykofenolihappo ja sen johdannaiset, joilla on immunosuppressiivista aktiivisuutta
DE69905368T2 (de) Oxydiertes thymosin beta 4
PT902789E (pt) Derivados de androsteno
ES2138729T3 (es) Metodos de diagnostico de la preeclampsia.
BR0010702A (pt) Novas quinonas como terapias de doenças
TR200001040T2 (tr) Kaşıntıyı önleme etkisi için bileşiklerin yeni bir kullanımı
BR0311866A (pt) Composições de saponinas ou sapogeninas para terapia de câncer
NO20050216L (no) Steroidkonjugater samt fremstilling og anvendelse derav
DE59107336D1 (de) Oligosaccharidderivate und deren Verwendung in Heilmitteln
BG101126A (en) The use of muramylpeptide compounds
DE69612056T2 (de) Terpenderivate (sarcodictyine) als antikrebsmittel
DE60322228D1 (de) Schnell zerfallende tablette
PT1097140E (pt) Derivados de imidazole substituidos com bifenilsulfonilo processo para a sua preparacao sua aplicacao como medicamento ou meio de diagnostico asim como medicamento neles incluido
ATE223214T1 (de) Von milchsäure abgeleitete butyrat-prodrugs
EA200100802A1 (ru) Применение тианептина при приготовлении лекарственных средств, предназначенных для лечения нейродегенеративных патологий

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties