MX2017001980A - Derivado de quinolina muy puro y metodo para su produccion. - Google Patents

Derivado de quinolina muy puro y metodo para su produccion.

Info

Publication number
MX2017001980A
MX2017001980A MX2017001980A MX2017001980A MX2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A MX 2017001980 A MX2017001980 A MX 2017001980A
Authority
MX
Mexico
Prior art keywords
manufacturing same
quinoline derivative
purity
purity quinoline
formula
Prior art date
Application number
MX2017001980A
Other languages
English (en)
Inventor
Nakamura Taiju
Abe Taichi
Miyashita Yusuke
Kuroda Hirofumi
Ayata Yusuke
Akao Atsushi
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55399727&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2017001980(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of MX2017001980A publication Critical patent/MX2017001980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Abstract

Se proporciona un compuesto representado por la fórmula (IV) o una de sus sales, donde el contenido del compuesto representado por la fórmula (I) es menor o igual a 350 ppm en masa. (ver Fórmulas).
MX2017001980A 2014-08-28 2015-08-26 Derivado de quinolina muy puro y metodo para su produccion. MX2017001980A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2014174062 2014-08-28
JP2015034729 2015-02-25
PCT/JP2015/073946 WO2016031841A1 (ja) 2014-08-28 2015-08-26 高純度キノリン誘導体およびその製造方法

Publications (1)

Publication Number Publication Date
MX2017001980A true MX2017001980A (es) 2017-05-04

Family

ID=55399727

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017001980A MX2017001980A (es) 2014-08-28 2015-08-26 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009299A MX2022009299A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009300A MX2022009300A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2022009299A MX2022009299A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.
MX2022009300A MX2022009300A (es) 2014-08-28 2017-02-13 Derivado de quinolina muy puro y metodo para su produccion.

Country Status (23)

Country Link
US (5) US10259791B2 (es)
EP (4) EP4089076A1 (es)
JP (1) JP6659554B2 (es)
KR (3) KR102329681B1 (es)
CN (2) CN106660964B (es)
AU (1) AU2015309862C1 (es)
BR (1) BR112017002827B1 (es)
CA (1) CA2957005C (es)
DK (1) DK3524595T3 (es)
ES (1) ES2926687T3 (es)
HR (1) HRP20221047T1 (es)
HU (1) HUE059606T2 (es)
IL (2) IL302218A (es)
JO (2) JO3783B1 (es)
LT (1) LT3524595T (es)
MX (3) MX2017001980A (es)
PL (1) PL3524595T3 (es)
PT (1) PT3524595T (es)
RS (1) RS63559B1 (es)
SG (2) SG11201700855XA (es)
SI (1) SI3524595T1 (es)
TW (1) TWI721954B (es)
WO (1) WO2016031841A1 (es)

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US9945862B2 (en) 2011-06-03 2018-04-17 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
CA2957005C (en) * 2014-08-28 2021-10-12 Eisai R&D Management Co., Ltd. High-purity quinoline derivative and method for manufacturing same
PL3263106T3 (pl) 2015-02-25 2024-04-02 Eisai R&D Management Co., Ltd. Sposób tłumienia goryczy pochodnej chinoliny
KR20170122809A (ko) 2015-03-04 2017-11-06 머크 샤프 앤드 돔 코포레이션 암을 치료하기 위한 pd-1 길항제 및 vegfr/fgfr/ret 티로신 키나제 억제제의 조합
WO2016204193A1 (ja) 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
CN105801481A (zh) * 2016-05-20 2016-07-27 湖南欧亚生物有限公司 一种乐伐替尼的合成方法
CN108299294A (zh) * 2017-01-11 2018-07-20 江苏恒瑞医药股份有限公司 一种乐伐替尼杂质的制备方法
CN112204011A (zh) * 2018-06-01 2021-01-08 成都苑东生物制药股份有限公司 一种甲磺酸乐伐替尼新晶型及其制备方法
CN111320580B (zh) * 2018-12-14 2022-12-20 江苏先声药业有限公司 一种仑伐替尼中间体的制备方法
CN111377864B (zh) * 2018-12-27 2022-03-18 江苏先声药业有限公司 一种仑伐替尼杂质及其制备方法和应用
CN109824590B (zh) * 2019-02-21 2022-03-22 扬子江药业集团有限公司 仑伐替尼及其盐的制备方法
CN109851556A (zh) * 2019-03-18 2019-06-07 扬子江药业集团有限公司 仑伐替尼或其甲磺酸盐药物杂质的制备方法
CN110283122B (zh) * 2019-06-26 2021-05-25 石药集团中奇制药技术（石家庄）有限公司 一种高纯度仑伐替尼及其盐的制备方法
CN110229103A (zh) * 2019-06-27 2019-09-13 尚科生物医药（上海）有限公司 一种乐伐替尼甲磺酸盐晶型b的制备方法
CN110563644A (zh) * 2019-10-30 2019-12-13 北京赛思源生物医药技术有限公司 一种仑伐替尼甲磺酸盐的新晶型
CN113045491A (zh) * 2019-12-26 2021-06-29 罗欣药业(上海)有限公司 一种仑伐替尼及中间体的制备方法
WO2021217537A1 (zh) * 2020-04-30 2021-11-04 天津睿创康泰生物技术有限公司 一种乐伐替尼游离碱晶型及其制备方法
CN115397416B (zh) * 2020-05-09 2023-12-05 北京睿创康泰医药研究院有限公司 包含仑伐替尼的分子水平的药物组合物及其制备方法和应用
CN113999173A (zh) * 2020-07-28 2022-02-01 药源药物化学（上海）有限公司 一种高纯度结晶的制备方法
CN112142662B (zh) * 2020-10-27 2022-03-08 南京法恩化学有限公司 一种甲磺酸乐伐替尼的制备方法
KR102576608B1 (ko) 2020-12-16 2023-09-12 쌍용씨앤이 주식회사 칼슘설포알루미네이트를 함유한 수경성 조성물 및 이를 포함하는 페이스트, 모르타르 및 콘크리트의 유동성 유지방법
WO2022208784A1 (ja) * 2021-03-31 2022-10-06 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 湿度に敏感な医薬用途物質を安定化する方法及び安定製剤
CN115322149A (zh) * 2022-08-22 2022-11-11 思科(深圳)药物研发有限公司 一种甲磺酸仑伐替尼杂质及其制备方法

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