PE20010306A1 - Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa - Google Patents

Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa

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Publication number
PE20010306A1
PE20010306A1 PE2000000663A PE0006632000A PE20010306A1 PE 20010306 A1 PE20010306 A1 PE 20010306A1 PE 2000000663 A PE2000000663 A PE 2000000663A PE 0006632000 A PE0006632000 A PE 0006632000A PE 20010306 A1 PE20010306 A1 PE 20010306A1
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PE
Peru
Prior art keywords
heteroaryl
useful
aryl
inhibition
pharmaceutical compositions
Prior art date
Application number
PE2000000663A
Other languages
English (en)
Inventor
Steven Lee Bender
Michael Brennan Wallace
John F Braganza
Stephan James Cripps
Ye Hua
Michael David Johnson
Theodore Otto Johnson Jr
Robert Steven Kania
Hiep The Luu
Cynthia Louise Palmer
Siegfried Heinz Reich
Anna Maria Tempczyk-Russell
Min Teng
Christine Thomas
Michael David Varney
Allen J Borchardt
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22498654&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20010306(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of PE20010306A1 publication Critical patent/PE20010306A1/es

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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P35/00—Antineoplastic agents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

SE REFIERE A COMPUESTOS DE INDAZOL DE FORMULA I DONDE R1 ES ARILO, HETEROARILO, CH=CH-R3, CH=N-R3; R3 ES ALQUILO, ALQUENILO, CICLOALQUILO, HETEROCICLOALQUILO, ARILO, HETEROARILO; R2 ES UN ARILO, HETEROARILO, Y-X; Y ES O, S, C=CH2, C=O, S=O, SO2, ALQUILIDENO, NH, N-(ALQUILO C1-C8); X ES Ar, HETEROARILO, NH-(ALQUILO), NH-(CICLOALQUILO), NH-(HETEROCICLOALQUILO), NH(ARILO), NH(HETEROARILO), NH(ALCOXILO), NH(DIALQUILOAMIDA). UN COMPUESTO PREFERIDO DE FORMULA II. EL COMPUESTO ES UN MODULADOR DEL RECEPTOR DE PROTEINQUINASA DE PREFERENCIA EL RECEPTOR DEL FACTOR DE CRECIMIENTO ENDOTELIAL VASCULAR VEGF Y PUEDE SER UTIL PARA INHIBIR EL CRECIMIENTO DE TUMORES, ANGIOGENESIS, PROLIFERACION DE LAS CELULAS
PE2000000663A 1999-07-02 2000-06-28 Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa PE20010306A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14213099P 1999-07-02 1999-07-02

Publications (1)

Publication Number Publication Date
PE20010306A1 true PE20010306A1 (es) 2001-03-29

Family

ID=22498654

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PE2000000663A PE20010306A1 (es) 1999-07-02 2000-06-28 Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa

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EP (2) EP1614683B1 (es)
JP (2) JP3878849B2 (es)
KR (1) KR100529639B1 (es)
CN (2) CN1137884C (es)
AP (1) AP1486A (es)
AR (2) AR035554A1 (es)
AT (1) ATE376543T1 (es)
AU (1) AU777701B2 (es)
BE (1) BE2013C015I2 (es)
BG (1) BG66070B1 (es)
BR (1) BRPI0012352B8 (es)
CA (1) CA2383630C (es)
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CR (2) CR6517A (es)
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DE (2) DE60037211T2 (es)
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DZ (1) DZ3191A1 (es)
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GT (1) GT200000107A (es)
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HR (1) HRP20020109B1 (es)
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