AU589917B2
(en)
|
1984-10-04 |
1989-10-26 |
Novartis Ag |
Monoclonal antibodies to cyclosporins
|
EP0194972B1
(en)
|
1985-03-11 |
1992-07-29 |
Sandoz Ag |
Novel cyclosporins
|
US6905680B2
(en)
|
1988-11-23 |
2005-06-14 |
Genetics Institute, Inc. |
Methods of treating HIV infected subjects
|
US6534055B1
(en)
|
1988-11-23 |
2003-03-18 |
Genetics Institute, Inc. |
Methods for selectively stimulating proliferation of T cells
|
US6352694B1
(en)
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
GB8827305D0
(en)
|
1988-11-23 |
1988-12-29 |
British Bio Technology |
Compounds
|
US5858358A
(en)
|
1992-04-07 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for selectively stimulating proliferation of T cells
|
JP2762522B2
(ja)
|
1989-03-06 |
1998-06-04 |
藤沢薬品工業株式会社 |
血管新生阻害剤
|
CA2014590C
(en)
|
1989-04-15 |
1999-12-14 |
Mitsuo Masaki |
Novel peptides, and antidementia agents containing the same
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
US5892112A
(en)
|
1990-11-21 |
1999-04-06 |
Glycomed Incorporated |
Process for preparing synthetic matrix metalloprotease inhibitors
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
ES2108120T3
(es)
|
1991-05-10 |
1997-12-16 |
Rhone Poulenc Rorer Int |
Compuestos bis arilicos y heteroarilicos mono- y biciclicos que inhiben tirosina quinasa receptora de egf y/o pdgf.
|
US5118677A
(en)
|
1991-05-20 |
1992-06-02 |
American Home Products Corporation |
Amide esters of rapamycin
|
NZ243082A
(en)
|
1991-06-28 |
1995-02-24 |
Ici Plc |
4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
GB9125660D0
(en)
|
1991-12-03 |
1992-01-29 |
Smithkline Beecham Plc |
Novel compound
|
AU661533B2
(en)
|
1992-01-20 |
1995-07-27 |
Astrazeneca Ab |
Quinazoline derivatives
|
ES2089723T3
(es)
|
1992-03-27 |
1996-10-01 |
American Home Prod |
29-demetoxirapamicina para inducir la inmunodepresion.
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
ZA935112B
(en)
|
1992-07-17 |
1994-02-08 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
ZA935111B
(en)
|
1992-07-17 |
1994-02-04 |
Smithkline Beecham Corp |
Rapamycin derivatives
|
US5256790A
(en)
|
1992-08-13 |
1993-10-26 |
American Home Products Corporation |
27-hydroxyrapamycin and derivatives thereof
|
GB9221220D0
(en)
|
1992-10-09 |
1992-11-25 |
Sandoz Ag |
Organic componds
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
JP3560609B2
(ja)
|
1992-11-13 |
2004-09-02 |
イミュネックス・コーポレーション |
Elkリガンドと呼ばれる新規なサイトカイン
|
US5455258A
(en)
|
1993-01-06 |
1995-10-03 |
Ciba-Geigy Corporation |
Arylsulfonamido-substituted hydroxamic acids
|
US5629327A
(en)
|
1993-03-01 |
1997-05-13 |
Childrens Hospital Medical Center Corp. |
Methods and compositions for inhibition of angiogenesis
|
US5516658A
(en)
|
1993-08-20 |
1996-05-14 |
Immunex Corporation |
DNA encoding cytokines that bind the cell surface receptor hek
|
WO1995008548A1
(en)
|
1993-09-20 |
1995-03-30 |
The Leland Stanford Junior University |
Recombinant production of novel polyketides
|
AU693475B2
(en)
|
1993-10-01 |
1998-07-02 |
Novartis Ag |
Pyrimidineamine derivatives and processes for the preparation thereof
|
US5656643A
(en)
|
1993-11-08 |
1997-08-12 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
|
CA2175215C
(en)
|
1993-11-19 |
2008-06-03 |
Yat Sun Or |
Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
|
DK0734389T3
(da)
|
1993-12-17 |
2000-08-21 |
Novartis Ag |
Rapamycinderivater, som er anvendelige som immunosuppressive midler
|
US5700823A
(en)
|
1994-01-07 |
1997-12-23 |
Sugen, Inc. |
Treatment of platelet derived growth factor related disorders such as cancers
|
IL112248A0
(en)
|
1994-01-25 |
1995-03-30 |
Warner Lambert Co |
Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
|
IL112249A
(en)
|
1994-01-25 |
2001-11-25 |
Warner Lambert Co |
Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
|
WO1995024190A2
(en)
|
1994-03-07 |
1995-09-14 |
Sugen, Inc. |
Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
|
IL112873A
(en)
|
1994-03-08 |
2005-03-20 |
Wyeth Corp |
Rapamycin-fkbp12 binding proteins, their isolation and their use
|
EP1464706A3
(en)
|
1994-04-15 |
2004-11-03 |
Amgen Inc., |
HEK5, HEK7, HEK8, HEK11, EPH-like receptor protein tyrosine kinases
|
ATE159257T1
(de)
|
1994-05-03 |
1997-11-15 |
Ciba Geigy Ag |
Pyrrolopyrimidinderivate mit antiproliferativer wirkung
|
GB9410142D0
(en)
|
1994-05-20 |
1994-07-06 |
Univ Warwick |
Carbapenems
|
US7175843B2
(en)
|
1994-06-03 |
2007-02-13 |
Genetics Institute, Llc |
Methods for selectively stimulating proliferation of T cells
|
US6303769B1
(en)
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
US5919905A
(en)
|
1994-10-05 |
1999-07-06 |
Immunex Corporation |
Cytokine designated LERK-6
|
GB9524630D0
(en)
|
1994-12-24 |
1996-01-31 |
Zeneca Ltd |
Chemical compounds
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
US5863949A
(en)
|
1995-03-08 |
1999-01-26 |
Pfizer Inc |
Arylsulfonylamino hydroxamic acid derivatives
|
DK0817775T3
(da)
|
1995-03-30 |
2001-11-19 |
Pfizer |
Quinazolinderivater
|
PT819129E
(pt)
|
1995-04-03 |
2001-01-31 |
Novartis Ag |
Derivados pirazole e processos para a sua preparacao
|
WO1996033172A1
(en)
|
1995-04-20 |
1996-10-24 |
Pfizer Inc. |
Arylsulfonyl hydroxamic acid derivatives as mmp and tnf inhibitors
|
GB9508538D0
(en)
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
US7067318B2
(en)
|
1995-06-07 |
2006-06-27 |
The Regents Of The University Of Michigan |
Methods for transfecting T cells
|
US6692964B1
(en)
|
1995-05-04 |
2004-02-17 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for transfecting T cells
|
US5747498A
(en)
|
1996-05-28 |
1998-05-05 |
Pfizer Inc. |
Alkynyl and azido-substituted 4-anilinoquinazolines
|
US5880141A
(en)
|
1995-06-07 |
1999-03-09 |
Sugen, Inc. |
Benzylidene-Z-indoline compounds for the treatment of disease
|
US5650415A
(en)
|
1995-06-07 |
1997-07-22 |
Sugen, Inc. |
Quinoline compounds
|
CZ292233B6
(cs)
|
1995-06-09 |
2003-08-13 |
Novartis Ag |
Deriváty rapamycinu a jejich použití jako léčiv
|
US5624677A
(en)
|
1995-06-13 |
1997-04-29 |
Pentech Pharmaceuticals, Inc. |
Controlled release of drugs delivered by sublingual or buccal administration
|
US6124453A
(en)
|
1995-07-04 |
2000-09-26 |
Novartis Ag |
Macrolides
|
IL122855A
(en)
|
1995-07-06 |
2004-08-31 |
Novartis Ag |
History of N-Phenyl (Alkyl) - 7H-Pyrolo [-3,2d] Pyrimidine - 4 Amine, their preparation and pharmaceutical preparations containing them
|
DE19534177A1
(de)
|
1995-09-15 |
1997-03-20 |
Merck Patent Gmbh |
Cyclische Adhäsionsinhibitoren
|
AR004010A1
(es)
|
1995-10-11 |
1998-09-30 |
Glaxo Group Ltd |
Compuestos heterociclicos
|
GB9523675D0
(en)
|
1995-11-20 |
1996-01-24 |
Celltech Therapeutics Ltd |
Chemical compounds
|
PT780386E
(pt)
|
1995-12-20 |
2003-02-28 |
Hoffmann La Roche |
Inibidores de metaloprotease de matriz
|
US6140317A
(en)
|
1996-01-23 |
2000-10-31 |
Novartis Ag |
Pyrrolopyrimidines and processes for their preparation
|
JP3406763B2
(ja)
|
1996-01-30 |
2003-05-12 |
東レ・ダウコーニング・シリコーン株式会社 |
シリコーンゴム組成物
|
GB9603097D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline compounds
|
GB9603095D0
(en)
|
1996-02-14 |
1996-04-10 |
Zeneca Ltd |
Quinazoline derivatives
|
DE19608588A1
(de)
|
1996-03-06 |
1997-09-11 |
Thomae Gmbh Dr K |
Pyrimido [5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
DE19629652A1
(de)
|
1996-03-06 |
1998-01-29 |
Thomae Gmbh Dr K |
4-Amino-pyrimidin-Derivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
|
DK0888353T3
(da)
|
1996-03-15 |
2003-10-27 |
Novartis Ag |
N-7-Heterocyclyl-pyrrolo[2,3-d]pyrimidiner og deres anvendelse
|
PT892789E
(pt)
|
1996-04-12 |
2002-07-31 |
Warner Lambert Co |
Inibidores irreversiveis de quinases de tirosina
|
GB9607729D0
(en)
|
1996-04-13 |
1996-06-19 |
Zeneca Ltd |
Quinazoline derivatives
|
EP0907642B1
(en)
|
1996-06-24 |
2005-11-02 |
Pfizer Inc. |
Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
|
ES2244001T3
(es)
|
1996-07-05 |
2005-12-01 |
Biotica Technology Limited |
Eritromicinas y procedimiento para su preparacion.
|
US6258823B1
(en)
|
1996-07-12 |
2001-07-10 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
EP0818442A3
(en)
|
1996-07-12 |
1998-12-30 |
Pfizer Inc. |
Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor
|
US6391874B1
(en)
|
1996-07-13 |
2002-05-21 |
Smithkline Beecham Corporation |
Fused heterocyclic compounds as protein tyrosine kinase inhibitors
|
HRP970371A2
(en)
|
1996-07-13 |
1998-08-31 |
Kathryn Jane Smith |
Heterocyclic compounds
|
PL331154A1
(en)
|
1996-07-13 |
1999-06-21 |
Glaxo Group Ltd |
Bicyclic heteroaromatic compounds as inhibitors of proteinous tyrosine kinase
|
KR20000067904A
(ko)
|
1996-07-18 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
매트릭스 메탈로프로테아제의 포스피네이트계 억제제
|
DK0920505T3
(da)
|
1996-08-16 |
2008-09-08 |
Schering Corp |
Pattedyrcelleoverfladeantigener og tilhörende reagenser
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
DK0938486T3
(da)
|
1996-08-23 |
2008-07-07 |
Novartis Ag |
Substituerede pyrrolopyrimidiner og fremgangsmåder til deres fremstilling
|
KR20000068248A
(ko)
|
1996-08-23 |
2000-11-25 |
디. 제이. 우드, 스피겔 알렌 제이 |
아릴설포닐아미노 하이드록삼산 유도체
|
SE9603465D0
(sv)
|
1996-09-23 |
1996-09-23 |
Astra Ab |
New compounds
|
ES2239779T3
(es)
|
1996-10-02 |
2005-10-01 |
Novartis Ag |
Derivados de pirimidina y procedimientos para la preparacion de los mismos.
|
WO1998014449A1
(en)
|
1996-10-02 |
1998-04-09 |
Novartis Ag |
Fused pyrazole derivatives and processes for their preparation
|
ID18494A
(id)
|
1996-10-02 |
1998-04-16 |
Novartis Ag |
Turunan pirazola leburan dan proses pembuatannya
|
EP0837063A1
(en)
|
1996-10-17 |
1998-04-22 |
Pfizer Inc. |
4-Aminoquinazoline derivatives
|
GB9621757D0
(en)
|
1996-10-18 |
1996-12-11 |
Ciba Geigy Ag |
Phenyl-substituted bicyclic heterocyclyl derivatives and their use
|
ES2224277T3
(es)
|
1997-01-06 |
2005-03-01 |
Pfizer Inc. |
Derivados de sulfonas ciclicas.
|
ES2202796T3
(es)
|
1997-02-03 |
2004-04-01 |
Pfizer Products Inc. |
Derivados de acidos arilsulfonilaminohidroxamicos.
|
BR9807305A
(pt)
|
1997-02-05 |
2000-05-02 |
Warner Lambert Co |
Pirido [2,3-d] pirimidinas e 4-aminopirimidinas como inibidores de proliferação celular.
|
WO1998034915A1
(en)
|
1997-02-07 |
1998-08-13 |
Pfizer Inc. |
N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
|
HUP0000657A3
(en)
|
1997-02-11 |
2000-10-30 |
Pfizer |
N-arylsulfonyl-piperidine, -morpholine hydroxamic acid derivatives and pharmaceutical compositions containing them
|
CO4950519A1
(es)
|
1997-02-13 |
2000-09-01 |
Novartis Ag |
Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
|
US6902913B2
(en)
|
1997-04-30 |
2005-06-07 |
Kosan Biosciences, Inc. |
Recombinant narbonolide polyketide synthase
|
US6150395A
(en)
|
1997-05-30 |
2000-11-21 |
The Regents Of The University Of California |
Indole-3-carbinol (I3C) derivatives and methods
|
US6329375B1
(en)
|
1997-08-05 |
2001-12-11 |
Sugen, Inc. |
Tricyclic quinoxaline derivatives as protein tyrosine kinase inhibitors
|
CA2299355C
(en)
|
1997-08-08 |
2005-09-27 |
Pfizer Products Inc. |
Aryloxyarylsulfonylamino hydroxamic acid derivatives
|
US6509173B1
(en)
|
1997-10-21 |
2003-01-21 |
Human Genome Sciences, Inc. |
Human tumor necrosis factor receptor-like proteins TR11, TR11SV1, and TR11SV2
|
GB9725782D0
(en)
|
1997-12-05 |
1998-02-04 |
Pfizer Ltd |
Therapeutic agents
|
US6153383A
(en)
|
1997-12-09 |
2000-11-28 |
Verdine; Gregory L. |
Synthetic transcriptional modulators and uses thereof
|
RS49779B
(sr)
|
1998-01-12 |
2008-06-05 |
Glaxo Group Limited, |
Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
|
GB9800575D0
(en)
|
1998-01-12 |
1998-03-11 |
Glaxo Group Ltd |
Heterocyclic compounds
|
JP2002502607A
(ja)
|
1998-02-09 |
2002-01-29 |
ジェネンテク・インコーポレイテッド |
新規な腫瘍壊死因子レセプター相同体及びそれをコードする核酸
|
AU756838B2
(en)
|
1998-03-04 |
2003-01-23 |
Bristol-Myers Squibb Company |
Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors
|
PA8469401A1
(es)
|
1998-04-10 |
2000-05-24 |
Pfizer Prod Inc |
Derivados biciclicos del acido hidroxamico
|
PA8469501A1
(es)
|
1998-04-10 |
2000-09-29 |
Pfizer Prod Inc |
Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
|
AU4093799A
(en)
|
1998-05-22 |
1999-12-13 |
Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and therapies based thereon
|
CA2314156C
(en)
|
1998-05-29 |
2010-05-25 |
Sugen, Inc. |
Pyrrole substituted 2-indolinone protein kinase inhibitors
|
UA60365C2
(uk)
|
1998-06-04 |
2003-10-15 |
Пфайзер Продактс Інк. |
Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
|
EP1097147A4
(en)
|
1998-07-10 |
2001-11-21 |
Merck & Co Inc |
NEW ANGIOGENESIS INHIBITORS
|
CA2341409A1
(en)
|
1998-08-31 |
2000-03-09 |
Merck And Co., Inc. |
Novel angiogenesis inhibitors
|
MXPA01003376A
(es)
|
1998-10-02 |
2002-11-07 |
Kosan Biosciences Inc |
Enzimas policetido sintetasa y construcciones de acido desoxirribonucleico recombinante para las mismas.
|
US6686454B1
(en)
|
1998-10-09 |
2004-02-03 |
Isotechnika, Inc. |
Antibodies to specific regions of cyclosporine related compounds
|
ES2213985T3
(es)
|
1998-11-05 |
2004-09-01 |
Pfizer Products Inc. |
Derivados de hidroxiamida de acido 5-oxo-pirrolidin-2-carboxilico.
|
CA2359801A1
(en)
|
1999-02-09 |
2000-08-17 |
Rajesh S. Gokhale |
Methods to mediate polyketide synthase module effectiveness
|
EP1165085B1
(en)
|
1999-03-30 |
2006-06-14 |
Novartis AG |
Phthalazine derivatives for treating inflammatory diseases
|
GB9912961D0
(en)
|
1999-06-03 |
1999-08-04 |
Pfizer Ltd |
Metalloprotease inhibitors
|
DE60027564T3
(de)
|
1999-06-07 |
2009-07-23 |
Immunex Corp., Thousand Oaks |
Tek-antagonisten
|
US6521424B2
(en)
|
1999-06-07 |
2003-02-18 |
Immunex Corporation |
Recombinant expression of Tek antagonists
|
ES2295040T3
(es)
|
1999-07-12 |
2008-04-16 |
Genentech, Inc. |
Promocion o inhibicion de la angiogenesis y cardiovascularizacion mediante homologos del ligando / receptor del factor de necrosis del tumor.
|
ES2219388T3
(es)
|
1999-08-24 |
2004-12-01 |
Ariad Gene Therapeutics, Inc. |
28-epi-rapalogos.
|
BR0015203A
(pt)
|
1999-11-05 |
2002-07-16 |
Astrazeneca Ab |
Derivado de quinazolina, processo para a preparação de um derivado de quinazolina, composição farmacêutica, uso de um composto, e, processo para a produção de um efeito antiangiogênico e/ou redutor de permeabilidade vascular em um animal de sangue quente
|
GB9927191D0
(en)
|
1999-11-17 |
2000-01-12 |
Angeletti P Ist Richerche Bio |
Methods and means for regulation of gene expression
|
AU1776501A
(en)
|
1999-11-19 |
2001-05-30 |
Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and their use in the disruption of protein-protein interactions
|
US7220552B1
(en)
|
1999-11-19 |
2007-05-22 |
The Board Of Trustees Of The Leland Stanford Junior University |
Bifunctional molecules and their use in the disruption of protein-protein interactions
|
JP5336686B2
(ja)
|
1999-11-24 |
2013-11-06 |
スージェン, インク. |
遊離酸または遊離塩基としてイオン化可能な医薬品のための処方
|
US6515004B1
(en)
|
1999-12-15 |
2003-02-04 |
Bristol-Myers Squibb Company |
N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
|
US6727225B2
(en)
|
1999-12-20 |
2004-04-27 |
Immunex Corporation |
TWEAK receptor
|
EP1255840A2
(en)
|
2000-02-08 |
2002-11-13 |
Norges Teknisk Naturvitenskapelige Universitet |
Gene cluster encoding a nystatin polyketide synthase and its manipulation and utility
|
US6797514B2
(en)
|
2000-02-24 |
2004-09-28 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
AU4328801A
(en)
|
2000-02-24 |
2001-09-03 |
Xcyte Therapies Inc |
Simultaneous stimulation and concentration of cells
|
US6867041B2
(en)
|
2000-02-24 |
2005-03-15 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
US7572631B2
(en)
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
CA2400040A1
(en)
|
2000-02-25 |
2001-08-30 |
Immunex Corporation |
Integrin antagonists
|
AR028619A1
(es)
|
2000-05-23 |
2003-05-14 |
Vertex Pharma |
Un compuesto inhibidor de caspasas
|
US7176037B2
(en)
|
2000-07-13 |
2007-02-13 |
The Scripps Research Institute |
Labeled peptides, proteins and antibodies and processes and intermediates useful for their preparation
|
US6630500B2
(en)
|
2000-08-25 |
2003-10-07 |
Cephalon, Inc. |
Selected fused pyrrolocarbazoles
|
CN1307173C
(zh)
|
2000-12-21 |
2007-03-28 |
葛兰素集团有限公司 |
作为血管生成调节剂的嘧啶胺
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US6878714B2
(en)
|
2001-01-12 |
2005-04-12 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
US7105682B2
(en)
|
2001-01-12 |
2006-09-12 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
US7102009B2
(en)
|
2001-01-12 |
2006-09-05 |
Amgen Inc. |
Substituted amine derivatives and methods of use
|
US20020147198A1
(en)
|
2001-01-12 |
2002-10-10 |
Guoqing Chen |
Substituted arylamine derivatives and methods of use
|
WO2003014311A2
(en)
|
2001-08-06 |
2003-02-20 |
Kosan Biosciences, Inc. |
Methods for altering polyketide synthase genes
|
US6809077B2
(en)
|
2001-10-12 |
2004-10-26 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogs for the treatment of autoimmune diseases
|
US20050026868A1
(en)
|
2003-07-11 |
2005-02-03 |
Metcalf Chester A. |
Phosphorus-containing macrocycles
|
US6987090B2
(en)
|
2002-05-09 |
2006-01-17 |
Lg Household & Health Care Ltd. |
Use of 3-position cyclosporin derivatives for hair growth
|
US7307088B2
(en)
|
2002-07-09 |
2007-12-11 |
Amgen Inc. |
Substituted anthranilic amide derivatives and methods of use
|
TWI329112B
(en)
|
2002-07-19 |
2010-08-21 |
Bristol Myers Squibb Co |
Novel inhibitors of kinases
|
US7012065B2
(en)
|
2003-02-07 |
2006-03-14 |
Enanta Pharmaceuticals, Inc. |
Cyclosporins for the treatment of immune disorders
|
EP1477563A3
(en)
|
2003-05-16 |
2004-11-24 |
Wyeth |
Cloning genes from streptomyces cyaneogriseus subsp.noncyanogenus for biosynthesis of antibiotics and methods of use
|
BRPI0410785A
(pt)
|
2003-05-23 |
2006-06-20 |
Wyeth Corp |
molécula de ácido nucleico isolada, célula hospedeira, animal transgênico não humano, proteìna isolada, oligonucleotìdeo anti-sentido, molécula de sirna, anticorpo isolado, métodos de triagem quanto aos compostos de teste capazes de inibir, de intensificar ou imitar a interação do gitrl com o gitr, para diagnosticar doenças, para tratar um paciente em risco ou diagnosticado com uma doença, para induzir e para inibir a proliferação de uma população celular contendo células t efetoras, de bloquear a supressão e de supressão de uma população celular que inclua células t efetoras na presença de células t reguladoras cd4+cd25+, e para tratar uma doença, composição farmacêutica, e, adjuvante de vacina
|
JP4755981B2
(ja)
|
2003-07-08 |
2011-08-24 |
ノバルティス アーゲー |
骨減少の処置のための、ラパマイシンおよびラパマイシン誘導体の使用
|
WO2005007190A1
(en)
|
2003-07-11 |
2005-01-27 |
Schering Corporation |
Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer
|
AR045134A1
(es)
|
2003-07-29 |
2005-10-19 |
Smithkline Beecham Plc |
Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic
|
WO2005016894A1
(en)
|
2003-08-15 |
2005-02-24 |
Novartis Ag |
2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders
|
EP1692318A4
(en)
|
2003-12-02 |
2008-04-02 |
Genzyme Corp |
COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LUNG CANCER
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
WO2006083289A2
(en)
|
2004-06-04 |
2006-08-10 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
CA2578066C
(en)
|
2004-08-26 |
2011-10-11 |
Pfizer Inc. |
Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
|
BRPI0516592A
(pt)
|
2004-10-13 |
2008-09-23 |
Wyeth Corp |
composto de fórmula
|
DK2343320T3
(da)
|
2005-03-25 |
2018-01-29 |
Gitr Inc |
Anti-gitr-antistoffer og anvendelser deraf
|
DK2161336T4
(en)
|
2005-05-09 |
2017-04-24 |
Ono Pharmaceutical Co |
Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
BRPI0616202A2
(pt)
|
2005-09-20 |
2011-06-14 |
Pfizer Prod Inc |
formas de dosagem e uso de um inibidor da tirosina quinase
|
WO2007133822A1
(en)
|
2006-01-19 |
2007-11-22 |
Genzyme Corporation |
Gitr antibodies for the treatment of cancer
|
US8653238B2
(en)
|
2006-02-27 |
2014-02-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for transport of molecules with enhanced release properties across biological barriers
|
US20070203168A1
(en)
|
2006-02-28 |
2007-08-30 |
Zhao Jonathon Z |
Isomers of rapamycin and 42-Epi-rapamycin, methods of making and using the same
|
US7601852B2
(en)
|
2006-05-11 |
2009-10-13 |
Kosan Biosciences Incorporated |
Macrocyclic kinase inhibitors
|
NZ578162A
(en)
|
2006-12-07 |
2011-12-22 |
Genentech Inc |
Phosphoinositide 3-kinase inhibitor compounds and methods of use
|
PT2175884T
(pt)
|
2007-07-12 |
2016-09-21 |
Gitr Inc |
Terapias de combinação empregando moléculas de ligação a gitr
|
BRPI0816769A2
(pt)
|
2007-09-12 |
2016-11-29 |
Hoffmann La Roche |
combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
|
ES2439705T3
(es)
|
2007-10-25 |
2014-01-24 |
Genentech, Inc. |
Proceso para la preparación de compuestos de tienopirimidina
|
KR100945483B1
(ko)
|
2007-10-25 |
2010-03-05 |
이화여자대학교 산학협력단 |
pikD 조절유전자의 발현벡터를 이용한 스트렙토미세스베네주엘라에(Streptomycesvenezuelae)에서폴리케타이드(polyketide)의 생산성 증가방법
|
GB0805363D0
(en)
|
2008-03-20 |
2008-04-30 |
Sinvent As |
Novel NRPS-PKS gene cluster and its manipulation and utility
|
WO2010003118A1
(en)
|
2008-07-02 |
2010-01-07 |
Trubion Pharmaceuticals, Inc. |
Tgf-b antagonist multi-target binding proteins
|
CN102149820B
(zh)
|
2008-09-12 |
2014-07-23 |
国立大学法人三重大学 |
能够表达外源gitr配体的细胞
|
EP2352526A1
(en)
|
2008-09-19 |
2011-08-10 |
Protox Therapeutics Inc. |
Treating cancer stem cells using targeted cargo proteins
|
ES2556211T3
(es)
|
2008-09-24 |
2016-01-14 |
Shanghai Institute Of Organic Chemistry, Chinese Academy Of Sciences |
Agrupación de genes novedosa
|
US8367618B2
(en)
|
2009-01-30 |
2013-02-05 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogues for preventing or treating hepatitis C infection
|
WO2011008260A2
(en)
|
2009-07-13 |
2011-01-20 |
President And Fellows Of Harvard College |
Bifunctional stapled polypeptides and uses thereof
|
EP2456777A2
(en)
|
2009-07-24 |
2012-05-30 |
Université Henri Poincaré - Nancy 1 |
Stambomycin and derivatives, their production and their use as drugs
|
KR101790802B1
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-gitr 항체
|
WO2011038049A1
(en)
|
2009-09-22 |
2011-03-31 |
Aileron Therapeutics, Inc. |
Peptidomimetic macrocycles
|
WO2011049157A1
(ja)
|
2009-10-22 |
2011-04-28 |
ペプチドリーム株式会社 |
ペプチド翻訳合成におけるrapidディスプレイ法
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
EP2519544A1
(en)
|
2009-12-29 |
2012-11-07 |
Emergent Product Development Seattle, LLC |
Polypeptide heterodimers and uses thereof
|
CN103282362B
(zh)
|
2010-11-30 |
2016-06-29 |
约翰·霍普金斯大学 |
杂交环状文库和其筛选
|
AR084217A1
(es)
|
2010-12-10 |
2013-05-02 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
US9428845B1
(en)
|
2010-12-28 |
2016-08-30 |
Warp Drive Bio, Inc. |
Identifying new therapeutic agents
|
MY161199A
(en)
|
2011-03-23 |
2017-04-14 |
Amgen Inc |
Fused tricyclic dual inhibitors of cdk 4/6 and flt3
|
NZ618157A
(en)
|
2011-05-19 |
2015-07-31 |
Fundación Ct Nac De Investigaciones Oncológicas Carlos Iii |
Macrocyclic compounds as protein kinase inhibitors
|
WO2012174489A2
(en)
|
2011-06-15 |
2012-12-20 |
The Ohio State University |
Small molecule composite surfaces as inhibitors of protein-protein interactions
|
TW201311689A
(zh)
|
2011-08-05 |
2013-03-16 |
必治妥美雅史谷比公司 |
作為因子xia抑制劑之新穎巨環化合物
|
DE102011111991A1
(de)
|
2011-08-30 |
2013-02-28 |
Lead Discovery Center Gmbh |
Neue Cyclosporin-Derivate
|
WO2013039954A1
(en)
|
2011-09-14 |
2013-03-21 |
Sanofi |
Anti-gitr antibodies
|
JP6399660B2
(ja)
|
2012-04-10 |
2018-10-03 |
ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア |
癌治療用組成物および方法
|
AR091279A1
(es)
|
2012-06-08 |
2015-01-21 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
NZ724616A
(en)
|
2012-06-08 |
2018-06-29 |
Gilead Sciences Inc |
Macrocyclic inhibitors of flaviviridae viruses
|
WO2013185103A1
(en)
|
2012-06-08 |
2013-12-12 |
Gilead Sciences, Inc. |
Macrocyclic inhibitors of flaviviridae viruses
|
DK2872157T3
(da)
|
2012-07-12 |
2020-03-30 |
Hangzhou Dac Biotech Co Ltd |
Konjugater af cellbindende molekyler med cytotoxiske midler
|
CN105849086B
(zh)
|
2012-11-24 |
2018-07-31 |
杭州多禧生物科技有限公司 |
亲水性链接体及其在药物分子和细胞结合分子共轭反应上的应用
|
US20150352131A1
(en)
|
2013-01-16 |
2015-12-10 |
Rhode Island Hospital |
Compositions and Methods for the Prevention and Treatment of Osteolysis and Osteoporosis
|
WO2014143659A1
(en)
|
2013-03-15 |
2014-09-18 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the gtpase k-ras g12c
|
MX364438B
(es)
|
2013-03-15 |
2019-04-26 |
Araxes Pharma Llc |
Inhibidores covalentes de kras g12c.
|
CA2944198C
(en)
|
2013-04-26 |
2021-11-16 |
Indiana University Research & Technology Corporation |
Hydroxyindole carboxylic acid based inhibitors for oncogenic src homology-2 domain containing protein tyrosine phosphatase-2 (shp2)
|
EP2806274A1
(en)
|
2013-05-24 |
2014-11-26 |
AIT Austrian Institute of Technology GmbH |
Lung cancer diagnostic method and means
|
BR112016008016B8
(pt)
|
2013-10-10 |
2023-09-26 |
Araxes Pharma Llc |
Compostos inibidores de kras g12c, composição farmacêutica compreendendo ditos compostos, métodos para regular a atividade e para preparar uma proteína mutante kras, hras ou nras g12c, método para inibir a proliferação de uma população de células e usos terapêuticos dos ditos compostos
|
CN105899493B
(zh)
|
2014-01-17 |
2019-03-29 |
诺华股份有限公司 |
用于抑制shp2活性的1-(三嗪-3-基/哒嗪-3-基)-哌(-嗪)啶衍生物及其组合物
|
ES2699351T3
(es)
|
2014-01-17 |
2019-02-08 |
Novartis Ag |
Derivados de 1-piridazin/triazin-3-il-piper(-azina)/idina/pirolidina y composiciones de las mismas para inhibir la actividad de SHP2
|
JO3517B1
(ar)
|
2014-01-17 |
2020-07-05 |
Novartis Ag |
ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
|
US10233431B2
(en)
|
2014-02-26 |
2019-03-19 |
The Regents Of The University Of California |
Producing 3-hydroxycarboxylic acid and ketone using polyketide synthases
|
CN106255882A
(zh)
|
2014-03-03 |
2016-12-21 |
耶路撒冷希伯来大学伊森姆研究发展公司 |
用于检测铜绿假单胞菌的方法和装置
|
US10011600B2
(en)
|
2014-09-25 |
2018-07-03 |
Araxes Pharma Llc |
Methods and compositions for inhibition of Ras
|
US9862701B2
(en)
|
2014-09-25 |
2018-01-09 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
TW201629069A
(zh)
|
2015-01-09 |
2016-08-16 |
霍普驅動生物科技股份有限公司 |
參與協同結合之化合物及其用途
|
EP4289950A3
(en)
|
2015-01-09 |
2024-01-24 |
Revolution Medicines, Inc. |
Macrocyclic compounds that participate in cooperative binding and medical uses thereof
|
WO2016160362A1
(en)
|
2015-03-31 |
2016-10-06 |
Allergan, Inc. |
Cyclosporins modified on the mebmt sidechain by heterocyclic rings
|
KR20180005178A
(ko)
|
2015-04-10 |
2018-01-15 |
아락세스 파마 엘엘씨 |
치환된 퀴나졸린 화합물 및 이의 사용방법
|
WO2016168540A1
(en)
|
2015-04-15 |
2016-10-20 |
Araxes Pharma Llc |
Fused-tricyclic inhibitors of kras and methods of use thereof
|
WO2016191328A1
(en)
|
2015-05-22 |
2016-12-01 |
Allosta Pharmaceuticals |
Methods to prepare and employ binding site models for modulation of phosphatase activity and selectivity determination
|
WO2016196569A1
(en)
|
2015-06-01 |
2016-12-08 |
Indiana University Research & Technology Corporation |
Small molecule inhibitors of protein tyrosine phosphatases and uses thereof
|
JP6878316B2
(ja)
|
2015-06-19 |
2021-05-26 |
ノバルティス アーゲー |
Shp2の活性を阻害するための化合物および組成物
|
JP6718889B2
(ja)
|
2015-06-19 |
2020-07-08 |
ノバルティス アーゲー |
Shp2の活性を阻害するための化合物および組成物
|
EP3310779B1
(en)
|
2015-06-19 |
2019-05-08 |
Novartis AG |
Compounds and compositions for inhibiting the activity of shp2
|
CA2993013A1
(en)
|
2015-07-22 |
2017-01-26 |
Araxes Pharma Llc |
Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins
|
US10875842B2
(en)
|
2015-09-28 |
2020-12-29 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
EP3356353A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
US10882847B2
(en)
|
2015-09-28 |
2021-01-05 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
EP3356349A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
WO2017058768A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
US10730867B2
(en)
|
2015-09-28 |
2020-08-04 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
US10689356B2
(en)
|
2015-09-28 |
2020-06-23 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
AU2016329064B2
(en)
|
2015-10-01 |
2023-10-19 |
Warp Drive Bio, Inc. |
Methods and reagents for analyzing protein-protein interfaces
|
WO2017078499A2
(ko)
|
2015-11-06 |
2017-05-11 |
경북대학교 산학협력단 |
단백질 타이로신 탈인산화효소 억제제를 포함하는 신경염증성 질환의 예방 또는 치료용 조성물
|
WO2017079723A1
(en)
|
2015-11-07 |
2017-05-11 |
Board Of Regents, The University Of Texas System |
Targeting proteins for degradation
|
TW201726656A
(zh)
|
2015-11-16 |
2017-08-01 |
亞瑞克西斯製藥公司 |
包含經取代雜環基團之2-經取代喹唑啉化合物及其使用方法
|
WO2017100279A1
(en)
|
2015-12-09 |
2017-06-15 |
West Virginia University |
Chemical compound for inhibition of shp2 function and for use as an anti-cancer agent
|
WO2017100546A1
(en)
|
2015-12-09 |
2017-06-15 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
WO2017156397A1
(en)
|
2016-03-11 |
2017-09-14 |
Board Of Regents, The University Of Texas Sysytem |
Heterocyclic inhibitors of ptpn11
|
US10822312B2
(en)
|
2016-03-30 |
2020-11-03 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
CA3024523A1
(en)
|
2016-05-18 |
2017-11-23 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitors
|
CA3024706A1
(en)
|
2016-05-31 |
2017-12-07 |
Board Of Regents, The University Of Texas System |
Heterocyclic inhibitors of ptpn11
|
PL3464272T3
(pl)
|
2016-06-07 |
2022-03-28 |
Jacobio Pharmaceuticals Co., Ltd. |
Nowe pochodne heterocykliczne użyteczne jako inhibitory SHP2
|
PL3468972T3
(pl)
|
2016-06-14 |
2020-11-16 |
Novartis Ag |
Związki i kompozycje do hamowania aktywności shp2
|
IL264186B1
(en)
|
2016-07-12 |
2024-04-01 |
Revolution Medicines Inc |
2,5-dimutomers of 3-methylpyrazines and 2,5,6-dimutomers of 3-methylpyrazines as allosteric SHP2 inhibitors
|
EP3515916B1
(en)
|
2016-09-22 |
2023-06-07 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
US10280172B2
(en)
|
2016-09-29 |
2019-05-07 |
Araxes Pharma Llc |
Inhibitors of KRAS G12C mutant proteins
|
US10377743B2
(en)
|
2016-10-07 |
2019-08-13 |
Araxes Pharma Llc |
Inhibitors of RAS and methods of use thereof
|
TW201819386A
(zh)
|
2016-10-24 |
2018-06-01 |
美商傳達治療有限公司 |
Shp2磷酸酶抑制劑及其使用方法
|
CA3042231A1
(en)
|
2016-10-28 |
2018-05-03 |
Ginkgo Bioworks, Inc. |
Compositions and methods for the production of compounds
|
CA3043131A1
(en)
|
2016-11-18 |
2018-05-24 |
Neurovive Pharmaceutical Ab |
Use of sanglifehrin macrocyclic analogues as anticancer compounds
|
RU2019121922A
(ru)
|
2016-12-15 |
2021-01-18 |
Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния |
Композиции и способы лечения рака
|
SG11201906223TA
(en)
|
2016-12-22 |
2019-08-27 |
Amgen Inc |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
EP3558979B1
(en)
|
2016-12-22 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
|
US10988766B2
(en)
|
2017-01-06 |
2021-04-27 |
Oregon Health & Science University |
Compositions and methods used in diagnosing and treating colorectal cancer
|
RU2769132C2
(ru)
|
2017-01-10 |
2022-03-28 |
Новартис Аг |
Фармацевтическая комбинация, содержащая ингибитор alk и ингибитор shp2
|
CN110446709B
(zh)
|
2017-01-23 |
2023-09-12 |
锐新医药公司 |
作为变构shp2抑制剂的二环化合物
|
JP7240320B2
(ja)
|
2017-01-23 |
2023-03-15 |
レヴォリューション・メディスンズ,インコーポレイテッド |
アロステリックshp2阻害剤としてのピリジン化合物
|
EP3573971A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
|
EP3573954A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
WO2018140598A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Fused n-heterocyclic compounds and methods of use thereof
|
JP7327802B2
(ja)
|
2017-01-26 |
2023-08-16 |
アラクセス ファーマ エルエルシー |
縮合ヘテロ-ヘテロ二環式化合物およびその使用方法
|
EP3573970A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
|
US11358959B2
(en)
|
2017-01-26 |
2022-06-14 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
WO2018160731A1
(en)
|
2017-02-28 |
2018-09-07 |
Novartis Ag |
Shp inhibitor compositions and uses for chimeric antigen receptor therapy
|
WO2018172250A1
(en)
|
2017-03-21 |
2018-09-27 |
Bayer Pharma Aktiengesellschaft |
2-methyl-quinazolines
|
EA202190196A1
(ru)
|
2017-03-23 |
2021-08-31 |
Джакобио Фармасьютикалс Ко., Лтд. |
Новые гетероциклические производные, применимые в качестве ингибиторов shp2
|
CN110831632A
(zh)
|
2017-04-05 |
2020-02-21 |
锐新医药公司 |
参与协同结合的化合物及其用途
|
KR20200003802A
(ko)
|
2017-04-05 |
2020-01-10 |
레볼루션 메디슨즈, 인크. |
단백질-단백질 계면을 분석하기 위한 방법 및 시약
|
JP7348071B2
(ja)
|
2017-05-02 |
2023-09-20 |
レヴォリューション・メディスンズ,インコーポレイテッド |
mTOR阻害剤としてのラパマイシン類似体
|
CA3061650A1
(en)
|
2017-05-11 |
2018-11-15 |
Astrazeneca Ab |
Heteroaryl compounds that inhibit g12c mutant ras proteins
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
WO2018218071A1
(en)
|
2017-05-25 |
2018-11-29 |
Araxes Pharma Llc |
Compounds and methods of use thereof for treatment of cancer
|
AU2018271990A1
(en)
|
2017-05-25 |
2019-12-12 |
Araxes Pharma Llc |
Covalent inhibitors of KRAS
|
WO2018218069A1
(en)
|
2017-05-25 |
2018-11-29 |
Araxes Pharma Llc |
Quinazoline derivatives as modulators of mutant kras, hras or nras
|
US11591336B2
(en)
|
2017-05-26 |
2023-02-28 |
D. E. Shaw Research, Llc |
Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors
|
CN111344017A
(zh)
|
2017-09-07 |
2020-06-26 |
锐新医药公司 |
治疗癌症的shp2抑制剂组合物和方法
|
EP3679040B1
(en)
|
2017-09-08 |
2022-08-03 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
TW201912639A
(zh)
|
2017-09-11 |
2019-04-01 |
美商克魯松藥物公司 |
Shp2之八氫環戊烷并[c]吡咯別構抑制劑
|
AU2018369759B2
(en)
|
2017-11-15 |
2022-11-24 |
Array Biopharma Inc. |
KRas G12C inhibitors
|
TW201938561A
(zh)
|
2017-12-08 |
2019-10-01 |
瑞典商阿斯特捷利康公司 |
化學化合物
|
FI3728254T3
(fi)
|
2017-12-21 |
2023-05-05 |
Boehringer Ingelheim Int |
Bentsyyliaminosubstituoidut pyridopyrimidinonit ja johdannaiset SOS1-estäjinä
|
WO2019152454A1
(en)
|
2018-01-30 |
2019-08-08 |
Research Development Foundation |
Shp2 inhibitors and methods of use thereof
|
TW201942115A
(zh)
|
2018-02-01 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌藥之經取代的喹唑啉和吡啶並嘧啶衍生物
|
TW201942116A
(zh)
|
2018-02-09 |
2019-11-01 |
美商輝瑞股份有限公司 |
作為抗癌劑之四氫喹唑啉衍生物
|
KR102614939B1
(ko)
|
2018-02-13 |
2023-12-19 |
블루레이 테라퓨틱스 (상하이) 컴퍼니 리미티드 |
피리미딘-융합고리 화합물 및 그의 제조방법과 용도
|
US11044675B2
(en)
|
2018-02-13 |
2021-06-22 |
Idac Holdings, Inc. |
Methods, apparatuses and systems for adaptive uplink power control in a wireless network
|
WO2019165073A1
(en)
|
2018-02-21 |
2019-08-29 |
Relay Therapeutics, Inc. |
Shp2 phosphatase inhibitors and methods of use thereof
|
WO2019167000A1
(en)
|
2018-03-02 |
2019-09-06 |
Otsuka Pharmaceutical Co., Ltd. |
Pharmaceutical compounds
|
US20210069188A1
(en)
|
2018-03-21 |
2021-03-11 |
Relay Therapeutics, Inc. |
Pyrazolo[3,4-b]pyrazine shp2 phosphatase inhibitors and methods of use thereof
|
SG11202009245TA
(en)
|
2018-03-21 |
2020-10-29 |
Relay Therapeutics Inc |
Shp2 phosphatase inhibitors and methods of use thereof
|
CN112368272B
(zh)
|
2018-03-21 |
2023-04-21 |
苏州浦合医药科技有限公司 |
Shp2抑制剂及其用途
|
US20220274979A1
(en)
|
2018-04-18 |
2022-09-01 |
Bayer Pharma Aktiengesellschaft |
2-methyl-aza-quinazolines
|
CA3098698A1
(en)
|
2018-05-01 |
2019-11-07 |
Revolution Medicines, Inc. |
C26-linked rapamycin analogs as mtor inhibitors
|
PL3788049T3
(pl)
|
2018-05-01 |
2023-06-19 |
Revolution Medicines, Inc. |
Połączone z C40, C28 i C32 analogi rapamycyny jako inhibitory mTOR
|
CA3099151A1
(en)
|
2018-05-02 |
2019-11-07 |
Navire Pharma, Inc. |
Substituted heterocyclic inhibitors of ptpn11
|
MA52501A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
JP7361722B2
(ja)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤及び同一物の使用方法
|
EP3790551A4
(en)
|
2018-05-07 |
2022-03-09 |
Mirati Therapeutics, Inc. |
KRAS G12C INHIBITORS
|
TW202012415A
(zh)
|
2018-05-08 |
2020-04-01 |
瑞典商阿斯特捷利康公司 |
化學化合物
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
US20210230300A1
(en)
|
2018-06-04 |
2021-07-29 |
Bayer Aktiengesellschaft |
Inhibitors of shp2
|
US20190375749A1
(en)
|
2018-06-11 |
2019-12-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
MX2020012261A
(es)
|
2018-06-12 |
2021-03-31 |
Amgen Inc |
Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer.
|
WO2020022323A1
(en)
|
2018-07-24 |
2020-01-30 |
Taiho Pharmaceutical Co., Ltd. |
Heterobicyclic compounds for inhibiting the activity of shp2
|
AU2019312670A1
(en)
|
2018-08-01 |
2021-02-04 |
Araxes Pharma Llc |
Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer
|
WO2020033286A1
(en)
|
2018-08-06 |
2020-02-13 |
Purdue Research Foundation |
Novel sesquiterpenoid analogs
|
CA3109181A1
(en)
|
2018-08-10 |
2020-02-13 |
Navire Pharma, Inc. |
6-(4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3h)-one derivatives and related compounds as ptpn11 (shp2) inhibitors for treating cancer
|
WO2020035031A1
(en)
|
2018-08-16 |
2020-02-20 |
Genentech, Inc. |
Fused ring compounds
|
ES2961253T3
(es)
|
2018-08-31 |
2024-03-11 |
Mirati Therapeutics Inc |
Inhibidores de KRas G12C
|
US20200115389A1
(en)
|
2018-09-18 |
2020-04-16 |
Nikang Therapeutics, Inc. |
Fused tricyclic ring derivatives as src homology-2 phosphatase inhibitors
|
WO2020063760A1
(en)
|
2018-09-26 |
2020-04-02 |
Jacobio Pharmaceuticals Co., Ltd. |
Novel heterocyclic derivatives useful as shp2 inhibitors
|
IL281726B2
(en)
|
2018-09-29 |
2024-03-01 |
Novartis Ag |
Production of compounds and preparations to inhibit the activity of SHP2
|
JP2022502385A
(ja)
|
2018-09-29 |
2022-01-11 |
ノバルティス アーゲー |
Shp2の活性を阻害するための化合物の製造方法
|
EP3860717A1
(en)
|
2018-10-03 |
2021-08-11 |
Gilead Sciences, Inc. |
Imidozopyrimidine derivatives
|
TW202028183A
(zh)
|
2018-10-10 |
2020-08-01 |
大陸商江蘇豪森藥業集團有限公司 |
含氮雜芳類衍生物調節劑、其製備方法和應用
|
CN111295384B
(zh)
|
2018-10-10 |
2022-08-12 |
江苏豪森药业集团有限公司 |
双环类衍生物抑制剂、其制备方法和应用
|
CN114341124A
(zh)
|
2018-10-17 |
2022-04-12 |
Array生物制药公司 |
蛋白质酪氨酸磷酸酶抑制剂
|
CN117143079A
(zh)
|
2018-11-06 |
2023-12-01 |
上海奕拓医药科技有限责任公司 |
一种螺芳环化合物及其应用
|
CN114751903B
(zh)
|
2018-11-07 |
2023-09-15 |
上海凌达生物医药有限公司 |
一类含氮稠杂环类shp2抑制剂化合物、制备方法和用途
|
US11053226B2
(en)
|
2018-11-19 |
2021-07-06 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
US20220000869A1
(en)
|
2018-11-23 |
2022-01-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Use of shp2 inhibitors for the treatment of insulin resistance
|
TW202039498A
(zh)
|
2018-11-30 |
2020-11-01 |
大陸商上海拓界生物醫藥科技有限公司 |
嘧啶並五員氮雜環類衍生物、其製備方法及其在醫藥上的應用
|
CN113498342A
(zh)
|
2018-12-21 |
2021-10-12 |
锐新医药公司 |
参与协同结合的化合物和其用途
|
EP3908306A1
(en)
|
2019-01-08 |
2021-11-17 |
Yale University |
Phosphatase binding compounds and methods of using same
|
JP2022517222A
(ja)
|
2019-01-10 |
2022-03-07 |
ミラティ セラピューティクス, インコーポレイテッド |
Kras g12c阻害剤
|
WO2020156242A1
(zh)
|
2019-01-31 |
2020-08-06 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
CN113365988B
(zh)
|
2019-01-31 |
2023-10-03 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
CN113382731A
(zh)
|
2019-02-12 |
2021-09-10 |
诺华股份有限公司 |
包含tno155和瑞博西尼的药物组合
|
CN113395967A
(zh)
|
2019-02-12 |
2021-09-14 |
诺华股份有限公司 |
包含tno155和pd-1抑制剂的药物组合
|
US20220152026A1
(en)
|
2019-02-12 |
2022-05-19 |
Novartis Ag |
Pharmaceutical combination comprising tno155 and a krasg12c inhibitor
|
EP3931188B1
(en)
|
2019-02-26 |
2023-08-30 |
Boehringer Ingelheim International GmbH |
New isoindolinone substituted indoles and derivatives as ras inhibitors
|
CN113727758A
(zh)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
双环杂环基化合物及其用途
|
US20230148450A9
(en)
|
2019-03-01 |
2023-05-11 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
CN111647000B
(zh)
|
2019-03-04 |
2021-10-12 |
勤浩医药(苏州)有限公司 |
吡嗪类衍生物及其在抑制shp2中的应用
|
AU2020232026A1
(en)
|
2019-03-07 |
2021-09-02 |
Merck Patent Gmbh |
Carboxamide-pyrimidine derivatives as shp2 antagonists
|
WO2020201991A1
(en)
|
2019-04-02 |
2020-10-08 |
Array Biopharma Inc. |
Protein tyrosine phosphatase inhibitors
|
US11001561B2
(en)
|
2019-04-08 |
2021-05-11 |
Merck Patent Gmbh |
Pyrimidinone derivatives as SHP2 antagonists
|
JP7335003B2
(ja)
|
2019-06-14 |
2023-08-29 |
北京盛諾基医薬科技股▲フン▼有限公司 |
Shp2ホスファターゼアロステリック阻害物質
|
BR112021024674A2
(pt)
|
2019-06-28 |
2022-05-31 |
Tuojie Biotech Shanghai Co Ltd |
Derivado heterocíclico de nitrogênio com cinco membros de pirimidina, método de preparação do mesmo e uso farmacêutico do mesmo
|
CN112300160A
(zh)
|
2019-08-01 |
2021-02-02 |
上海奕拓医药科技有限责任公司 |
一种螺芳环化合物、其制备及应用
|
EP3772513A1
(en)
|
2019-08-09 |
2021-02-10 |
C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening |
Shp2 inhibitors
|
GB201911928D0
(en)
|
2019-08-20 |
2019-10-02 |
Otsuka Pharma Co Ltd |
Pharmaceutical compounds
|
WO2021043077A1
(zh)
|
2019-09-06 |
2021-03-11 |
四川科伦博泰生物医药股份有限公司 |
一种取代吡嗪化合物、其制备方法和用途
|
WO2021061515A1
(en)
|
2019-09-23 |
2021-04-01 |
Synblia Therapeutics, Inc. |
Shp2 inhibitors and uses thereof
|
US11890281B2
(en)
|
2019-09-24 |
2024-02-06 |
Relay Therapeutics, Inc. |
SHP2 phosphatase inhibitors and methods of making and using the same
|
CN112724145A
(zh)
|
2019-10-14 |
2021-04-30 |
杭州雷索药业有限公司 |
用于抑制shp2活性的吡嗪衍生物
|
WO2021074227A1
(en)
|
2019-10-15 |
2021-04-22 |
Bayer Aktiengesellschaft |
2-methyl-aza-quinazolines
|
BR112022008534A2
(pt)
|
2019-11-04 |
2022-08-09 |
Revolution Medicines Inc |
Compostos, composição farmacêutica, conjugado e métodos para tratar câncer e para tratar um distúrbio relacionado à proteína ras
|
PE20221278A1
(es)
|
2019-11-04 |
2022-09-05 |
Revolution Medicines Inc |
Inhibidores de ras
|
KR20220109407A
(ko)
*
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
Ras 억제제
|
CR20220200A
(es)
|
2019-11-08 |
2022-07-28 |
Revolution Medicines Inc |
Compuestos de heteroarilo bicíclicos y usos de estos
|
EP4056563A4
(en)
|
2019-11-08 |
2024-02-21 |
Nanjing Sanhome Pharmaceutical Co Ltd |
COMPOUND USED AS SHP2 INHIBITOR AND ITS USE
|
AU2020393205A1
(en)
|
2019-11-29 |
2022-06-30 |
Lupin Limited |
Substituted tricyclic compounds
|
WO2021110796A1
(en)
|
2019-12-04 |
2021-06-10 |
Bayer Aktiengesellschaft |
Inhibitors of shp2
|
WO2021115286A1
(zh)
|
2019-12-10 |
2021-06-17 |
成都倍特药业股份有限公司 |
一种可用作shp2抑制剂的含氮杂原子的六元并五元芳环衍生物
|
WO2021119525A1
(en)
|
2019-12-11 |
2021-06-17 |
Tiaki Therapeutics Inc. |
Shp1 and shp2 inhibitors and their methods of use
|
US20230028414A1
(en)
|
2019-12-16 |
2023-01-26 |
Amgen Inc. |
Dosing regimen of kras g12c inhibitor
|
WO2021120045A1
(en)
|
2019-12-18 |
2021-06-24 |
InventisBio Co., Ltd. |
Heterocyclic compounds, preparation methods and uses thereof
|
US20230083431A1
(en)
|
2019-12-18 |
2023-03-16 |
Merck Sharp & Dohme Llc |
Macrocyclic peptides as potent inhibitors of k-ras g12d mutant
|
CN113651814B
(zh)
|
2019-12-19 |
2022-06-17 |
北京加科思新药研发有限公司 |
Kras突变蛋白抑制剂
|
WO2021121397A1
(zh)
|
2019-12-19 |
2021-06-24 |
首药控股(北京)股份有限公司 |
取代的炔基杂环化合物
|
CN114761408B
(zh)
|
2019-12-19 |
2023-09-15 |
贝达药业股份有限公司 |
Kras g12c抑制剂及其在医药上的应用
|
TW202136276A
(zh)
|
2019-12-20 |
2021-10-01 |
美商艾瑞斯卡公司 |
三環吡啶酮及嘧啶酮
|
WO2021120890A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Pyrazolyl derivatives useful as anti-cancer agents
|
AU2020405170A1
(en)
|
2019-12-20 |
2022-06-30 |
Mirati Therapeutics, Inc. |
SOS1 inhibitors
|
CR20220363A
(es)
|
2019-12-27 |
2022-09-23 |
Lupin Ltd |
Compuestos tricíclicos sustituidos
|
CN113045565A
(zh)
|
2019-12-27 |
2021-06-29 |
微境生物医药科技(上海)有限公司 |
新型K-Ras G12C抑制剂
|
EP4083042A1
(en)
|
2019-12-27 |
2022-11-02 |
Wigen Biomedicine Technology (Shanghai) Co., Ltd. |
Spiro ring-containing quinazoline compound
|
WO2021139678A1
(zh)
|
2020-01-07 |
2021-07-15 |
广州百霆医药科技有限公司 |
吡啶并嘧啶类kras g12c突变蛋白抑制剂
|
CN113087700B
(zh)
|
2020-01-08 |
2023-03-14 |
苏州亚盛药业有限公司 |
螺环四氢喹唑啉
|
CA3163216A1
(en)
|
2020-01-10 |
2021-07-15 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
EP4092026A4
(en)
|
2020-01-13 |
2024-03-06 |
Suzhou Zelgen Biopharmaceutical Co Ltd |
ARYL OR HETEROARYL PYRIDONE OR PYRIMIDINE DERIVATIVE, PREPARATION METHOD AND USE THEREOF
|
JP7392164B2
(ja)
|
2020-01-16 |
2023-12-05 |
浙江海正薬業股▲ふん▼有限公司 |
ヘテロアリール誘導体、その製造方法およびその使用
|
CN114761394B
(zh)
|
2020-01-16 |
2024-03-29 |
浙江海正药业股份有限公司 |
吡啶或嘧啶类衍生物及其制备方法和用途
|
CN113135910A
(zh)
|
2020-01-19 |
2021-07-20 |
北京诺诚健华医药科技有限公司 |
嘧啶-4(3h)-酮类杂环化合物、其制备方法及其在医药学上的应用
|
WO2021150613A1
(en)
|
2020-01-20 |
2021-07-29 |
Incyte Corporation |
Spiro compounds as inhibitors of kras
|
WO2021147965A1
(zh)
|
2020-01-21 |
2021-07-29 |
南京明德新药研发有限公司 |
作为kras抑制剂的大环类化合物
|
WO2021147879A1
(zh)
|
2020-01-21 |
2021-07-29 |
贝达药业股份有限公司 |
Shp2抑制剂及其应用
|
WO2021148010A1
(zh)
|
2020-01-22 |
2021-07-29 |
南京明德新药研发有限公司 |
吡唑并杂芳环类化合物及其应用
|
WO2021149817A1
(en)
|
2020-01-24 |
2021-07-29 |
Taiho Pharmaceutical Co., Ltd. |
Enhancement of anti-tumor activity of SHP2 inhibitor pyrimidinone in combination with novel cancer medicines in cancers
|
GB202001344D0
(en)
|
2020-01-31 |
2020-03-18 |
Redx Pharma Plc |
Ras Inhibitors
|
CN112159405B
(zh)
|
2020-02-04 |
2021-09-14 |
广州必贝特医药技术有限公司 |
吡啶并嘧啶酮类化合物及其应用
|
KR20210100557A
(ko)
|
2020-02-06 |
2021-08-17 |
웰마커바이오 주식회사 |
Kras 돌연변이와 관련된 암의 예방 또는 치료용 약학 조성물
|
EP4077328A4
(en)
|
2020-02-20 |
2023-11-29 |
Beta Pharma, Inc. |
PYRIDOPYRIMIDE DERIVATIVES AS KRAS INHIBITORS
|
TW202140450A
(zh)
|
2020-02-24 |
2021-11-01 |
大陸商泰勵生物科技(上海)有限公司 |
用於癌症治療的kras抑制劑
|
WO2021173524A1
(en)
|
2020-02-24 |
2021-09-02 |
Mirati Therapeutics, Inc. |
Sos1 inhibitors
|
JP7462985B2
(ja)
|
2020-02-24 |
2024-04-08 |
上海▲テツ▼▲ギョウ▼生物科技有限公司 |
芳香族化合物および抗腫瘍薬物の調製におけるその使用
|
US20210292330A1
(en)
|
2020-02-28 |
2021-09-23 |
Erasca, Inc. |
Pyrrolidine-fused heterocycles
|
EP4208261A1
(en)
|
2020-09-03 |
2023-07-12 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
US11690915B2
(en)
|
2020-09-15 |
2023-07-04 |
Revolution Medicines, Inc. |
Ras inhibitors
|