MX2023003060A - Derivados indolicos como inhibidores de ras en el tratamiento del cancer. - Google Patents

Derivados indolicos como inhibidores de ras en el tratamiento del cancer.

Info

Publication number
MX2023003060A
MX2023003060A MX2023003060A MX2023003060A MX2023003060A MX 2023003060 A MX2023003060 A MX 2023003060A MX 2023003060 A MX2023003060 A MX 2023003060A MX 2023003060 A MX2023003060 A MX 2023003060A MX 2023003060 A MX2023003060 A MX 2023003060A
Authority
MX
Mexico
Prior art keywords
treatment
cancer
indole derivatives
ras inhibitors
ras
Prior art date
Application number
MX2023003060A
Other languages
English (en)
Inventor
Naing Aay
Yang Liu
Mallika Singh
Andreas Buckl
James Cregg
Leslie G Burnett
Adrian L Gill
John E Knox
Elena S Koltun
Bianca Jennifer Lee
David E Wildes
Meghan A Rice
Original Assignee
Revolution Medicines Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Revolution Medicines Inc filed Critical Revolution Medicines Inc
Publication of MX2023003060A publication Critical patent/MX2023003060A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La descripción caracteriza compuestos macrocíclicos y composiciones farmacéuticas y sus complejos proteicos, capaces de inhibir proteínas Ras y sus usos en el tratamiento de cánceres.
MX2023003060A 2020-09-15 2021-09-15 Derivados indolicos como inhibidores de ras en el tratamiento del cancer. MX2023003060A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063078802P 2020-09-15 2020-09-15
US202063129231P 2020-12-22 2020-12-22
US202163184412P 2021-05-05 2021-05-05
US202163192775P 2021-05-25 2021-05-25
PCT/US2021/050454 WO2022060836A1 (en) 2020-09-15 2021-09-15 Indole derivatives as ras inhibitors in the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2023003060A true MX2023003060A (es) 2023-04-05

Family

ID=78086091

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023003060A MX2023003060A (es) 2020-09-15 2021-09-15 Derivados indolicos como inhibidores de ras en el tratamiento del cancer.

Country Status (15)

Country Link
US (2) US11690915B2 (es)
EP (1) EP4214209A1 (es)
JP (1) JP2023541916A (es)
KR (1) KR20230067635A (es)
CN (2) CN116457358A (es)
AU (1) AU2021345111A1 (es)
CA (1) CA3194067A1 (es)
CL (1) CL2023000730A1 (es)
CO (1) CO2023004548A2 (es)
CR (1) CR20230165A (es)
IL (1) IL301298A (es)
MX (1) MX2023003060A (es)
PE (1) PE20231207A1 (es)
TW (1) TW202227460A (es)
WO (1) WO2022060836A1 (es)

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TW202400607A (zh) * 2022-04-25 2024-01-01 美商翰森生物有限責任公司 環狀化合物、製備方法及其醫藥用途
WO2023232776A1 (en) * 2022-06-01 2023-12-07 F. Hoffmann-La Roche Ag Haloindole macrocyclic compounds for the treatment of cancer
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024008834A1 (en) 2022-07-08 2024-01-11 F. Hoffmann-La Roche Ag Macrocycle compounds useful as kras inhibitors
WO2024017859A1 (en) * 2022-07-20 2024-01-25 F. Hoffmann-La Roche Ag Macrocycle compounds for the treatment of cancer
WO2024040131A1 (en) * 2022-08-17 2024-02-22 Treeline Biosciences, Inc. Pyridopyrimidine kras inhibitors
WO2024060966A1 (zh) * 2022-09-19 2024-03-28 杭州阿诺生物医药科技有限公司 一种pan-KRAS抑制剂化合物
CN116509868B (zh) * 2023-07-04 2023-10-20 四川大学华西医院 Vs6766联合bay293的应用及药物组合物

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