AP1445A
(en)
|
1997-10-27 |
2005-07-10 |
Agouron Pharma |
Substituted 4-amino-thiazol-2-yl compounds as CDKs inhibitors.
|
FR2781154B1
(en)
*
|
1998-07-15 |
2001-09-07 |
Lafon Labor |
THERAPEUTIC COMPOSITION BASED ON ISOFLAVONOIDS FOR USE IN THE TREATMENT OF TUMORS WITH CYTOTOXIC AGENTS
|
FR2797444B1
(en)
*
|
1999-08-13 |
2003-02-07 |
Lafon Labor |
PHARMACEUTICAL COMPOSITIONS COMPRISING 4-QUINOLONES
|
YU54202A
(en)
|
2000-01-18 |
2006-01-16 |
Agouron Pharmaceuticals Inc. |
Indazole compounds,pharmaceutical compositions,and methods for mediating or inhibiting cell proliferation
|
HN2001000008A
(en)
|
2000-01-21 |
2003-12-11 |
Inc Agouron Pharmaceuticals |
AMIDA COMPOSITE AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT PROTEINKINASES, AND THE INSTRUCTIONS FOR USE
|
JP2004501083A
(en)
|
2000-04-18 |
2004-01-15 |
アゴーロン・ファーマシューティカルズ・インコーポレイテッド |
Pyrazole for inhibiting protein kinases
|
KR100399364B1
(en)
*
|
2000-09-18 |
2003-09-26 |
주식회사 엘지생명과학 |
3-Hydroxy-6-aminochromene-4-on derivatives useful as cyclin dependendent kinase inhibitors
|
EP1280789A1
(en)
|
2000-05-03 |
2003-02-05 |
LG Life Sciences Ltd. |
Cdk inhibitors having 3-hydroxychromen-4-one structure
|
CA2411928A1
(en)
|
2000-08-09 |
2002-02-14 |
Agouron Pharmaceuticals, Inc. |
Pyrazole-thiazole compounds, pharmaceutical compositions containing them, and methods of their use for inhibiting cyclindependent kinases
|
JP2004506720A
(en)
|
2000-08-18 |
2004-03-04 |
アグーロン ファーマシューティカルズ,インコーポレイテッド |
Heterocyclic hydroxyiminofluorenes and their use for protein kinase inhibition
|
FR2813791B1
(en)
*
|
2000-09-14 |
2004-03-12 |
Lafon Labor |
USE OF 2- AND 4-QUINOLONES TO INHIBIT INTIMAL NEO-PROLIFERATION
|
GB0030729D0
(en)
*
|
2000-12-16 |
2001-01-31 |
Univ Nottingham |
Substituted-4-Quinolones
|
AUPR846401A0
(en)
*
|
2001-10-25 |
2001-11-15 |
Novogen Research Pty Ltd |
6-Hydroxy isoflavones, derivatives and medicaments involving same
|
AU2002951833A0
(en)
*
|
2002-10-02 |
2002-10-24 |
Novogen Research Pty Ltd |
Compositions and therapeutic methods invloving platinum complexes
|
AU2003265737B2
(en)
*
|
2002-10-02 |
2008-10-16 |
Novogen Research Pty Ltd |
Combination chemotherapy compositions and methods
|
CN100378105C
(en)
*
|
2003-01-31 |
2008-04-02 |
中国人民解放军***联勤部军事医学研究所 |
Pyran isoflavone molluscacide synthesizing method and formulation
|
AU2004230841A1
(en)
*
|
2003-04-03 |
2004-10-28 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of protein kinases
|
US7601855B2
(en)
|
2004-09-21 |
2009-10-13 |
Novogen Research Pty Ltd |
Substituted chroman derivatives, medicaments and use in therapy
|
US8080675B2
(en)
|
2004-09-21 |
2011-12-20 |
Marshall Edwards, Inc. |
Chroman derivatives, medicaments and use in therapy
|
EP1856083A4
(en)
*
|
2005-03-11 |
2009-05-27 |
Univ Michigan |
Chromen-4-one inhibitors of anti-apoptotic bcl-2 family members and the uses thereof
|
EP1886996A1
(en)
*
|
2006-08-10 |
2008-02-13 |
Ferrer Internacional, S.A. |
1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions
|
KR20090035744A
(en)
*
|
2006-08-10 |
2009-04-10 |
페레르 인터내쇼날 에스.에이. |
1h-quinolin-4-one compounds, with affinity for the gaba receptor, processes, uses and compositions
|
TWI366565B
(en)
|
2007-06-06 |
2012-06-21 |
Otsuka Pharma Co Ltd |
Quinolone compound and pharmaceutical composition
|
WO2009026657A1
(en)
*
|
2007-08-29 |
2009-03-05 |
The University Of Sydney |
Flavonoid ppar agonists
|
WO2010054264A1
(en)
|
2008-11-07 |
2010-05-14 |
Triact Therapeutics, Inc. |
Use of catecholic butane derivatives in cancer therapy
|
CN102238951A
(en)
*
|
2008-12-05 |
2011-11-09 |
大塚制药株式会社 |
Pharmaceutical agent comprising quinolone compound
|
TWI472525B
(en)
|
2008-12-05 |
2015-02-11 |
Otsuka Pharma Co Ltd |
Quinolone compound and pharmaceutical composition
|
US20120189641A1
(en)
|
2009-02-25 |
2012-07-26 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
JP2012519170A
(en)
|
2009-02-26 |
2012-08-23 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
INSITU method for monitoring EMT status of tumor cells in vivo
|
US8465912B2
(en)
|
2009-02-27 |
2013-06-18 |
OSI Pharmaceuticals, LLC |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
WO2010099138A2
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
WO2010099363A1
(en)
|
2009-02-27 |
2010-09-02 |
Osi Pharmaceuticals, Inc. |
Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
|
JP2012520893A
(en)
|
2009-03-18 |
2012-09-10 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
Combination cancer treatment comprising administration of an EGFR inhibitor and an IGF-1R inhibitor
|
JP2013510564A
(en)
|
2009-11-13 |
2013-03-28 |
パンガエア ビオテック、ソシエダッド、リミターダ |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
CA2816322A1
(en)
|
2010-11-01 |
2012-05-10 |
Marshall Edwards, Inc. |
Isoflavonoid compositions and methods for the treatment of cancer
|
EP2468883A1
(en)
|
2010-12-22 |
2012-06-27 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
US9134297B2
(en)
|
2011-01-11 |
2015-09-15 |
Icahn School Of Medicine At Mount Sinai |
Method and compositions for treating cancer and related methods
|
EP2492688A1
(en)
|
2011-02-23 |
2012-08-29 |
Pangaea Biotech, S.A. |
Molecular biomarkers for predicting response to antitumor treatment in lung cancer
|
WO2012129145A1
(en)
|
2011-03-18 |
2012-09-27 |
OSI Pharmaceuticals, LLC |
Nscle combination therapy
|
WO2012149014A1
(en)
|
2011-04-25 |
2012-11-01 |
OSI Pharmaceuticals, LLC |
Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
|
US20130084286A1
(en)
|
2011-08-31 |
2013-04-04 |
Thomas E. Januario |
Diagnostic markers
|
EP2761025A1
(en)
|
2011-09-30 |
2014-08-06 |
Genentech, Inc. |
Diagnostic methylation markers of epithelial or mesenchymal phenotype and response to egfr kinase inhibitor in tumours or tumour cells
|
WO2013152252A1
(en)
|
2012-04-06 |
2013-10-10 |
OSI Pharmaceuticals, LLC |
Combination anti-cancer therapy
|
WO2013190089A1
(en)
|
2012-06-21 |
2013-12-27 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting outcome in lung cancer
|
CN105017145B
(en)
*
|
2012-12-12 |
2017-12-05 |
王子厚 |
7-chloro-4-oxo-quinoline derivative with antitumor activity
|
CA2941010A1
(en)
|
2013-02-26 |
2014-09-04 |
Triact Therapeutics, Inc. |
Cancer therapy
|
EP2976085A1
(en)
|
2013-03-21 |
2016-01-27 |
INSERM - Institut National de la Santé et de la Recherche Médicale |
Method and pharmaceutical composition for use in the treatment of chronic liver diseases associated with a low hepcidin expression
|
CA2923667A1
(en)
|
2013-09-09 |
2015-03-12 |
Triact Therapeutics, Inc. |
Cancer therapy
|
WO2015156674A2
(en)
|
2014-04-10 |
2015-10-15 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
KR20170095893A
(en)
|
2014-12-24 |
2017-08-23 |
제넨테크, 인크. |
Therapeutic, diagnostic, and prognostic methods for cancer of the bladder
|
MX2017010002A
(en)
|
2015-02-02 |
2018-02-09 |
Mei Pharma Inc |
Combination therapies.
|
SG11201906223TA
(en)
|
2016-12-22 |
2019-08-27 |
Amgen Inc |
Benzisothiazole, isothiazolo[3,4-b]pyridine, quinazoline, phthalazine, pyrido[2,3-d]pyridazine and pyrido[2,3-d]pyrimidine derivatives as kras g12c inhibitors for treating lung, pancreatic or colorectal cancer
|
JOP20190272A1
(en)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
Kras g12c inhibitors and methods of using the same
|
EP3679040B1
(en)
|
2017-09-08 |
2022-08-03 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
JP7361722B2
(en)
|
2018-05-04 |
2023-10-16 |
アムジエン・インコーポレーテツド |
KRAS G12C inhibitors and methods of using the same
|
MA52501A
(en)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
KRAS G12C INHIBITORS AND THEIR PROCEDURES FOR USE
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
AU2019278998B2
(en)
|
2018-06-01 |
2023-11-09 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
US20190375749A1
(en)
|
2018-06-11 |
2019-12-12 |
Amgen Inc. |
Kras g12c inhibitors and methods of using the same
|
MX2020012261A
(en)
|
2018-06-12 |
2021-03-31 |
Amgen Inc |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer.
|
US20210393632A1
(en)
|
2018-10-04 |
2021-12-23 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Egfr inhibitors for treating keratodermas
|
JP2020090482A
(en)
|
2018-11-16 |
2020-06-11 |
アムジエン・インコーポレーテツド |
Improved synthesis of key intermediate of kras g12c inhibitor compound
|
JP7377679B2
(en)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
Combination therapy comprising a KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancer
|
US11053226B2
(en)
|
2018-11-19 |
2021-07-06 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
MX2021007104A
(en)
|
2018-12-20 |
2021-08-11 |
Amgen Inc |
Kif18a inhibitors.
|
MA54546A
(en)
|
2018-12-20 |
2022-03-30 |
Amgen Inc |
HETEROARYL AMIDES USEFUL AS KIF18A INHIBITORS
|
EP3898592A1
(en)
|
2018-12-20 |
2021-10-27 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
CA3123871A1
(en)
|
2018-12-20 |
2020-06-25 |
Amgen Inc. |
Kif18a inhibitors
|
US20230148450A9
(en)
|
2019-03-01 |
2023-05-11 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
CN113727758A
(en)
|
2019-03-01 |
2021-11-30 |
锐新医药公司 |
Bicyclic heterocyclic compounds and use thereof
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
US11236091B2
(en)
|
2019-05-21 |
2022-02-01 |
Amgen Inc. |
Solid state forms
|
JP2022542967A
(en)
|
2019-08-02 |
2022-10-07 |
アムジエン・インコーポレーテツド |
KIF18A inhibitor
|
MX2022001296A
(en)
|
2019-08-02 |
2022-02-22 |
Amgen Inc |
Kif18a inhibitors.
|
JP2022542394A
(en)
|
2019-08-02 |
2022-10-03 |
アムジエン・インコーポレーテツド |
Heteroarylamides useful as KIF18A inhibitors
|
CN114391012A
(en)
|
2019-08-02 |
2022-04-22 |
美国安进公司 |
Pyridine derivatives as KIF18A inhibitors
|
WO2021081212A1
(en)
|
2019-10-24 |
2021-04-29 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
KR20220109407A
(en)
|
2019-11-04 |
2022-08-04 |
레볼루션 메디슨즈, 인크. |
RAS inhibitors
|
PE20221278A1
(en)
|
2019-11-04 |
2022-09-05 |
Revolution Medicines Inc |
RAS INHIBITORS
|
BR112022008534A2
(en)
|
2019-11-04 |
2022-08-09 |
Revolution Medicines Inc |
COMPOUNDS, PHARMACEUTICAL COMPOSITION, CONJUGATE AND METHODS TO TREAT CANCER AND TO TREAT A RAS PROTEIN-RELATED DISORDER
|
CR20220200A
(en)
|
2019-11-08 |
2022-07-28 |
Revolution Medicines Inc |
Bicyclic heteroaryl compounds and uses thereof
|
BR112022009390A2
(en)
|
2019-11-14 |
2022-08-09 |
Amgen Inc |
IMPROVED SYNTHESIS OF KRAS INHIBITOR COMPOUND G12C
|
WO2021097207A1
(en)
|
2019-11-14 |
2021-05-20 |
Amgen Inc. |
Improved synthesis of kras g12c inhibitor compound
|
CN114980976A
(en)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
Covalent RAS inhibitors and uses thereof
|
CA3163703A1
(en)
|
2020-01-07 |
2021-07-15 |
Steve Kelsey |
Shp2 inhibitor dosing and methods of treating cancer
|
EP4168002A1
(en)
|
2020-06-18 |
2023-04-26 |
Revolution Medicines, Inc. |
Methods for delaying, preventing, and treating acquired resistance to ras inhibitors
|
EP4208261A1
(en)
|
2020-09-03 |
2023-07-12 |
Revolution Medicines, Inc. |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
US11690915B2
(en)
|
2020-09-15 |
2023-07-04 |
Revolution Medicines, Inc. |
Ras inhibitors
|
WO2022140427A1
(en)
|
2020-12-22 |
2022-06-30 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
AU2022270116A1
(en)
|
2021-05-05 |
2023-12-21 |
Revolution Medicines, Inc. |
Ras inhibitors
|
EP4334324A1
(en)
|
2021-05-05 |
2024-03-13 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
CN117616031A
(en)
|
2021-05-05 |
2024-02-27 |
锐新医药公司 |
RAS inhibitors for the treatment of cancer
|
AR127308A1
(en)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
RAS INHIBITORS
|
WO2023114954A1
(en)
|
2021-12-17 |
2023-06-22 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
WO2023172940A1
(en)
|
2022-03-08 |
2023-09-14 |
Revolution Medicines, Inc. |
Methods for treating immune refractory lung cancer
|
WO2023240263A1
(en)
|
2022-06-10 |
2023-12-14 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|