ES2089723T3 - 29-demetoxirapamicina para inducir la inmunodepresion. - Google Patents

29-demetoxirapamicina para inducir la inmunodepresion.

Info

Publication number
ES2089723T3
ES2089723T3 ES93302288T ES93302288T ES2089723T3 ES 2089723 T3 ES2089723 T3 ES 2089723T3 ES 93302288 T ES93302288 T ES 93302288T ES 93302288 T ES93302288 T ES 93302288T ES 2089723 T3 ES2089723 T3 ES 2089723T3
Authority
ES
Spain
Prior art keywords
demetoxirapamicina
immunodepression
induce
rejection
demethoxyrapamycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93302288T
Other languages
English (en)
Inventor
Suren Nath Sehgal
Jay Joseph Armstrong
Chee Ping Eng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2089723T3 publication Critical patent/ES2089723T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Abstract

ESTA INVENCION SE REFIERE A UN METODO DE INDUCCION DE INMUNOSUPRESION EN UN MAMIFERO, COMPRENDIENDO ADMINISTRACION EN UNA CANTIDAD EFECTIVA ANTI-RECHAZO DE 29 SOLA O EN COMBINACION CON UNO O MAS AGENTES QUIMIOTERAPEUTICOS ANTI-RECHAZO.
ES93302288T 1992-03-27 1993-03-25 29-demetoxirapamicina para inducir la inmunodepresion. Expired - Lifetime ES2089723T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85892392A 1992-03-27 1992-03-27

Publications (1)

Publication Number Publication Date
ES2089723T3 true ES2089723T3 (es) 1996-10-01

Family

ID=25329511

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93302288T Expired - Lifetime ES2089723T3 (es) 1992-03-27 1993-03-25 29-demetoxirapamicina para inducir la inmunodepresion.

Country Status (9)

Country Link
EP (1) EP0562853B1 (es)
JP (1) JP3179235B2 (es)
AT (1) ATE138807T1 (es)
CA (1) CA2092729A1 (es)
DE (1) DE69302945T2 (es)
DK (1) DK0562853T3 (es)
ES (1) ES2089723T3 (es)
GR (1) GR3020310T3 (es)
MX (1) MX9301707A (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527907A (en) * 1993-11-19 1996-06-18 Abbott Laboratories Macrolide immunomodulators
CA2175215C (en) * 1993-11-19 2008-06-03 Yat Sun Or Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
DK0956034T3 (da) 1996-07-30 2002-12-16 Novartis Ag Farmaceutiske præparater til behandling af transplantatafstødning, autoimmune eller inflammatoriske tilstande omfattende cyclosporin A og 40-O-(2-hydroxyethyl)-rapamycin
JP2002535283A (ja) * 1999-01-22 2002-10-22 藤沢薬品工業株式会社 進行中の急性同種移植片拒絶反応を抑制する方法
EP1879632A2 (en) * 2005-04-29 2008-01-23 Atrium Medical Corporation Drug delivery coating for use with a medical device and methods of treating vascular injury
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
TW201629069A (zh) 2015-01-09 2016-08-16 霍普驅動生物科技股份有限公司 參與協同結合之化合物及其用途
CA3000822A1 (en) 2015-10-01 2017-04-06 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
CA3020594A1 (en) 2016-04-12 2017-10-19 Warp Drive Bio, Inc. Compositions and methods for the production of compounds
CN110506120A (zh) 2016-10-28 2019-11-26 银杏生物制品公司 用于生产化合物的组合物和方法
EP4054720A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
EP4055028A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
TW202132316A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ｒａｓ抑制劑
EP4214209A1 (en) 2020-09-15 2023-07-26 Revolution Medicines, Inc. Indole derivatives as ras inhibitors in the treatment of cancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4375464A (en) 1981-11-19 1983-03-01 Ayerst, Mckenna & Harrison Inc. Antibiotic AY24,668 and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5100899A (en) 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023262A (en) * 1990-08-14 1991-06-11 American Home Products Corporation Hydrogenated rapamycin derivatives
GB9103430D0 (en) * 1991-02-19 1991-04-03 Smithkline Beecham Plc Novel compound
US5080899A (en) 1991-02-22 1992-01-14 American Home Products Corporation Method of treating pulmonary inflammation
US5078999A (en) 1991-02-22 1992-01-07 American Home Products Corporation Method of treating systemic lupus erythematosus
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant

Also Published As

Publication number Publication date
JP3179235B2 (ja) 2001-06-25
JPH0616674A (ja) 1994-01-25
CA2092729A1 (en) 1993-09-28
EP0562853A1 (en) 1993-09-29
DK0562853T3 (da) 1996-07-01
DE69302945D1 (de) 1996-07-11
MX9301707A (es) 1993-09-01
ATE138807T1 (de) 1996-06-15
GR3020310T3 (en) 1996-09-30
EP0562853B1 (en) 1996-06-05
DE69302945T2 (de) 1996-10-10

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