HUE046249T2 - PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása - Google Patents

PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása

Info

Publication number
HUE046249T2
HUE046249T2 HUE14868918A HUE14868918A HUE046249T2 HU E046249 T2 HUE046249 T2 HU E046249T2 HU E14868918 A HUE14868918 A HU E14868918A HU E14868918 A HUE14868918 A HU E14868918A HU E046249 T2 HUE046249 T2 HU E046249T2
Authority
HU
Hungary
Prior art keywords
antigen
antibody
binding fragment
medical application
medical
Prior art date
Application number
HUE14868918A
Other languages
English (en)
Inventor
Jijun Yuan
Xiangdong Qu
Jufang Lin
Xin Ye
Guoqing Cao
Weikang Tao
Lianshan Zhang
Lei Zhang
Li Yang
Original Assignee
Shanghai hengrui pharmaceutical co ltd
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53370605&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE046249(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shanghai hengrui pharmaceutical co ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai hengrui pharmaceutical co ltd
Publication of HUE046249T2 publication Critical patent/HUE046249T2/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
HUE14868918A 2013-12-12 2014-11-14 PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása HUE046249T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310681942 2013-12-12

Publications (1)

Publication Number Publication Date
HUE046249T2 true HUE046249T2 (hu) 2020-02-28

Family

ID=53370605

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE14868918A HUE046249T2 (hu) 2013-12-12 2014-11-14 PD-1 antitest, antigén-kötõ fragmense, és gyógyászati alkalmazása

Country Status (35)

Country Link
US (2) US10344090B2 (hu)
EP (1) EP3081576B1 (hu)
JP (1) JP6502959B2 (hu)
KR (1) KR102256152B1 (hu)
CN (1) CN105026428B (hu)
AU (1) AU2014361473B2 (hu)
BR (1) BR112016013338B1 (hu)
CA (1) CA2932966C (hu)
CL (1) CL2016001460A1 (hu)
CR (1) CR20160319A (hu)
CY (1) CY1122245T1 (hu)
DK (1) DK3081576T3 (hu)
DO (1) DOP2016000133A (hu)
EA (1) EA035037B1 (hu)
EC (1) ECSP16060104A (hu)
ES (1) ES2746805T3 (hu)
HK (1) HK1213910A1 (hu)
HR (1) HRP20191678T1 (hu)
HU (1) HUE046249T2 (hu)
IL (1) IL246137B (hu)
LT (1) LT3081576T (hu)
ME (1) ME03527B (hu)
MX (1) MX370449B (hu)
MY (1) MY184154A (hu)
PE (1) PE20160953A1 (hu)
PH (1) PH12016501120A1 (hu)
PL (1) PL3081576T3 (hu)
PT (1) PT3081576T (hu)
RS (1) RS59480B1 (hu)
SG (2) SG11201604738TA (hu)
SI (1) SI3081576T1 (hu)
TW (1) TWI654201B (hu)
UA (1) UA119659C2 (hu)
WO (1) WO2015085847A1 (hu)
ZA (1) ZA201604660B (hu)

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