SG10201804945WA - Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof - Google Patents

Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof

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Publication number
SG10201804945WA
SG10201804945WA SG10201804945WA SG10201804945WA SG10201804945WA SG 10201804945W A SG10201804945W A SG 10201804945WA SG 10201804945W A SG10201804945W A SG 10201804945WA SG 10201804945W A SG10201804945W A SG 10201804945WA SG 10201804945W A SG10201804945W A SG 10201804945WA
Authority
SG
Singapore
Prior art keywords
antibody
antigen
binding fragment
medical application
human
Prior art date
Application number
SG10201804945WA
Inventor
Jijun Yuan
Xiangdong Qu
Jufang Lin
Xin Ye
Guoqing Cao
Weikang Tao
Lianshan Zhang
Lei Zhang
Li Yang
Original Assignee
Shanghai hengrui pharmaceutical co ltd
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53370605&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201804945W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Shanghai hengrui pharmaceutical co ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai hengrui pharmaceutical co ltd
Publication of SG10201804945WA publication Critical patent/SG10201804945WA/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

PD-1 ANTIBODY, ANTIGEN-BINDING FRAGMENT THEREOF, AND MEDICAL APPLICATION THEREOF The present invention provides a human PD-1 antibody, an antigen-binding fragment 5 thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders. 10 Figure 1 accompanies the abstract. 15
SG10201804945WA 2013-12-12 2014-11-14 Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof SG10201804945WA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201310681942 2013-12-12

Publications (1)

Publication Number Publication Date
SG10201804945WA true SG10201804945WA (en) 2018-07-30

Family

ID=53370605

Family Applications (2)

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SG11201604738TA SG11201604738TA (en) 2013-12-12 2014-11-14 Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
SG10201804945WA SG10201804945WA (en) 2013-12-12 2014-11-14 Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof

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US (2) US10344090B2 (en)
EP (1) EP3081576B1 (en)
JP (1) JP6502959B2 (en)
KR (1) KR102256152B1 (en)
CN (1) CN105026428B (en)
AU (1) AU2014361473B2 (en)
BR (1) BR112016013338B1 (en)
CA (1) CA2932966C (en)
CL (1) CL2016001460A1 (en)
CR (1) CR20160319A (en)
CY (1) CY1122245T1 (en)
DK (1) DK3081576T3 (en)
DO (1) DOP2016000133A (en)
EA (1) EA035037B1 (en)
EC (1) ECSP16060104A (en)
ES (1) ES2746805T3 (en)
HK (1) HK1213910A1 (en)
HR (1) HRP20191678T1 (en)
HU (1) HUE046249T2 (en)
IL (1) IL246137B (en)
LT (1) LT3081576T (en)
ME (1) ME03527B (en)
MX (1) MX370449B (en)
MY (1) MY184154A (en)
PE (1) PE20160953A1 (en)
PH (1) PH12016501120B1 (en)
PL (1) PL3081576T3 (en)
PT (1) PT3081576T (en)
RS (1) RS59480B1 (en)
SG (2) SG11201604738TA (en)
SI (1) SI3081576T1 (en)
TW (1) TWI654201B (en)
UA (1) UA119659C2 (en)
WO (1) WO2015085847A1 (en)
ZA (1) ZA201604660B (en)

Families Citing this family (359)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101506235B (en) 2006-09-01 2012-07-25 人类多细胞株治疗学公司 Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals
PL2376535T3 (en) 2008-12-09 2017-09-29 F.Hoffmann-La Roche Ag Anti-pd-l1 antibodies and their use to enhance t-cell function
EP3812387A1 (en) 2011-07-21 2021-04-28 Sumitomo Dainippon Pharma Oncology, Inc. Heterocyclic protein kinase inhibitors
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
SI3081576T1 (en) 2013-12-12 2019-12-31 Shanghai Hengrui Pharmaceutical Co., Ltd., Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
JOP20200096A1 (en) 2014-01-31 2017-06-16 Children’S Medical Center Corp Antibody molecules to tim-3 and uses thereof
US10618963B2 (en) 2014-03-12 2020-04-14 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
US9394365B1 (en) 2014-03-12 2016-07-19 Yeda Research And Development Co., Ltd Reducing systemic regulatory T cell levels or activity for treatment of alzheimer's disease
NZ725006A (en) 2014-03-12 2019-11-29 Yeda Res & Dev Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
US10519237B2 (en) 2014-03-12 2019-12-31 Yeda Research And Development Co. Ltd Reducing systemic regulatory T cell levels or activity for treatment of disease and injury of the CNS
WO2016040892A1 (en) 2014-09-13 2016-03-17 Novartis Ag Combination therapies
WO2016041945A1 (en) 2014-09-16 2016-03-24 Innate Pharma Neutralization of inhibitory pathways in lymphocytes
JP7037359B2 (en) 2014-10-10 2022-03-16 イナート・ファルマ・ソシエテ・アノニム CD73 block
US11933786B2 (en) 2015-03-30 2024-03-19 Stcube, Inc. Antibodies specific to glycosylated PD-L1 and methods of use thereof
CN107849144B (en) 2015-05-29 2021-09-17 艾吉纳斯公司 anti-CTLA-4 antibodies and methods of use thereof
JP7014706B2 (en) 2015-07-13 2022-02-01 サイトメックス セラピューティクス インコーポレイテッド Anti-PD-1 antibody, activating anti-PD-1 antibody, and how to use it
PL3328419T3 (en) 2015-07-30 2021-12-27 Macrogenics, Inc. Pd-1-binding molecules and methods of use thereof
WO2017020291A1 (en) * 2015-08-06 2017-02-09 Wuxi Biologics (Shanghai) Co. Ltd. Novel anti-pd-l1 antibodies
WO2017024465A1 (en) * 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
JP6868862B2 (en) * 2015-08-31 2021-05-12 国立研究開発法人産業技術総合研究所 Mesoporous silica particles
US10323091B2 (en) 2015-09-01 2019-06-18 Agenus Inc. Anti-PD-1 antibodies and methods of use thereof
CN106999591B (en) * 2015-09-28 2021-02-23 苏州盛迪亚生物医药有限公司 anti-PD-1 antibody preparation and application thereof in medicine
KR20180083318A (en) 2015-09-29 2018-07-20 아시아 바이오테크 피티이. 엘티디. PD-1 antibodies and uses thereof
KR20180054824A (en) * 2015-09-29 2018-05-24 셀진 코포레이션 PD-1 binding protein and method of use thereof
SG10201912943RA (en) 2015-10-02 2020-02-27 Symphogen As Anti-pd-1 antibodies and compositions
CN108137699B (en) 2015-10-02 2022-05-27 豪夫迈·罗氏有限公司 Bispecific antibodies specific for PD1 and TIM3
EP3362475B1 (en) 2015-10-12 2023-08-30 Innate Pharma Cd73 blocking agents
CN113862300A (en) * 2015-10-29 2021-12-31 豪夫迈·罗氏有限公司 Transgenic rabbits with common light chain
EP3370768B9 (en) 2015-11-03 2022-03-16 Janssen Biotech, Inc. Antibodies specifically binding pd-1 and their uses
WO2017084495A1 (en) * 2015-11-17 2017-05-26 江苏恒瑞医药股份有限公司 Pd-l1 antibody, antigen fragment binding thereof and pharmaceutical use thereof
KR102220275B1 (en) 2015-11-18 2021-02-26 머크 샤프 앤드 돔 코포레이션 Pd1 and/or lag3 binders
KR20180085793A (en) * 2015-12-02 2018-07-27 주식회사 에스티큐브 Antibodies specific for glycosylated PD-1 and methods for their use
AR107781A1 (en) 2015-12-14 2018-06-06 Macrogenics Inc BISPECIFIC MOLECULES THAT HAVE IMMUNORREACTIVITY WITH PD-1 AND CTLA-4, AND METHODS OF USE OF THE SAME
US10392442B2 (en) 2015-12-17 2019-08-27 Bristol-Myers Squibb Company Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment
CN116327916A (en) 2016-01-21 2023-06-27 依奈特制药公司 Neutralization of inhibitory pathways in lymphocytes
AU2017219254B2 (en) 2016-02-17 2019-12-12 Novartis Ag TGFbeta 2 antibodies
KR102398425B1 (en) 2016-03-08 2022-05-16 이나뜨 파르마 에스.에이. SIGLEC neutralizing antibody
US20200232974A1 (en) 2016-03-30 2020-07-23 Centre Léon-Bérard Lymphocytes expressing cd73 in cancerous patient dictates therapy
AU2017266298B2 (en) 2016-05-18 2024-01-04 Boehringer Ingelheim International Gmbh Anti PD-1 and anti-LAG3 antibodies for cancer treatment
CN105968200B (en) 2016-05-20 2019-03-15 瑞阳(苏州)生物科技有限公司 Anti human PD-L 1 Humanized monoclonal antibodies and its application
CN106008714B (en) 2016-05-24 2019-03-15 瑞阳(苏州)生物科技有限公司 Anti-human PD-1 Humanized monoclonal antibodies and its application
KR20230091191A (en) 2016-05-27 2023-06-22 아게누스 인코포레이티드 Anti-tim-3 antibodies and methods of use thereof
KR20190008962A (en) 2016-06-02 2019-01-25 브리스톨-마이어스 스큅 컴퍼니 Use of anti-PD-1 antibodies in combination with anti-CD30 antibodies in the treatment of lymphoma
ES2954139T3 (en) 2016-06-02 2023-11-20 Bristol Myers Squibb Co PD-1 Blockade With Nivolumab in Refractory Hodgkin Lymphoma
CN109476754A (en) 2016-06-03 2019-03-15 百时美施贵宝公司 Purposes of the anti-PD-1 antibody in treatment colorectal cancer patients
EP3464369A1 (en) 2016-06-03 2019-04-10 Bristol-Myers Squibb Company Anti-pd-1 antibody for use in a method of treating a tumor
KR20190015407A (en) 2016-06-03 2019-02-13 브리스톨-마이어스 스큅 컴퍼니 Anti-PD-1 antibody for use in the treatment of recurrent small cell lung cancer
WO2017218533A1 (en) 2016-06-13 2017-12-21 Torque Therapeutics, Inc. Methods and compositions for promoting immune cell function
SG11201810509PA (en) 2016-06-20 2018-12-28 Kymab Ltd Anti-pd-l1 antibodies
JP2019528251A (en) 2016-07-20 2019-10-10 エスティーキューブ，インコーポレイテッド Methods of treating and treating cancer using a combination of antibodies that bind to glycosylated PD-L1
CN106967172B (en) 2016-08-23 2019-01-08 康方药业有限公司 The anti-PD-1 bifunctional antibody of anti-CTLA 4-, its medical composition and its use
CN106977602B (en) * 2016-08-23 2018-09-25 中山康方生物医药有限公司 A kind of anti-PD1 monoclonal antibodies, its medical composition and its use
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
KR102266788B1 (en) 2016-09-14 2021-06-22 베이징 한미 파마슈티컬 컴퍼니 리미티드 Antibodies specifically binding to PD-1 and functional fragments thereof
JP2019531284A (en) 2016-09-19 2019-10-31 セルジーン コーポレイション Methods of treating immune disorders using PD-1 binding proteins
JP2019534859A (en) 2016-09-19 2019-12-05 セルジーン コーポレイション Method for treating vitiligo using PD-1 binding protein
TWI764943B (en) * 2016-10-10 2022-05-21 大陸商蘇州盛迪亞生物醫藥有限公司 Combination use of anti-pd-1 antibody and vegfr inhibitor in the preparation of a medicament for the treatment of cancer
MA46529A (en) 2016-10-11 2019-08-21 Agenus Inc ANTI-LAG-3 ANTIBODIES AND PROCESSES FOR USE
CN108778332B (en) * 2016-10-21 2019-10-18 苏州盛迪亚生物医药有限公司 PD-1 antibody is combined with IDO inhibitor is preparing the purposes in anti-tumor drug
CN110099925A (en) 2016-10-28 2019-08-06 百时美施贵宝公司 Use the method for anti-PD-1 Antybody therapy urothelial cancer
MA49863A (en) * 2016-11-01 2020-06-17 Anaptysbio Inc ANTIBODIES DIRECTED AGAINST PROGRAMMED DEATH 1 (PD -1)
PL3535298T3 (en) 2016-11-02 2021-12-27 Jounce Therapeutics, Inc. Antibodies to pd-1 and uses thereof
EP3535300A1 (en) 2016-11-03 2019-09-11 Bristol-Myers Squibb Company Activatable anti-ctla-4 antibodies and uses thereof
AU2017356860A1 (en) * 2016-11-08 2019-05-16 Qilu Puget Sound Biotherapeutics Corporation Anti-PD1 and anti-CTLA4 antibodies
WO2018094275A1 (en) 2016-11-18 2018-05-24 Tolero Pharmaceuticals, Inc. Alvocidib prodrugs and their use as protein kinase inhibitors
CN108079292A (en) * 2016-11-23 2018-05-29 苏州盛迪亚生物医药有限公司 A kind of purposes of anti-PD-1 antibody in the drug for preparing treatment liver cancer
MA50948A (en) 2016-12-07 2020-10-14 Agenus Inc ANTIBODIES AND METHODS OF USING THE SAME
IL266918B2 (en) 2016-12-07 2024-03-01 Agenus Inc Anti-ctla-4 antibodies and methods of use thereof
EA039433B1 (en) 2017-01-05 2022-01-27 Нетрис Фарма Combined treatment with netrin-1 interfering drugs and immune checkpoint inhibitors drugs
MX2019008207A (en) 2017-01-09 2019-12-11 Tesaro Inc Methods of treating cancer with anti-pd-1 antibodies.
EA201991696A1 (en) 2017-01-13 2020-02-05 Эйдженус Инк. T-CELL RECEPTORS RELATING TO NY-ESO-1 AND METHODS OF APPLICATION
ES2902670T3 (en) * 2017-01-13 2022-03-29 Taizhou Hanzhong Biopharmaceutics Inc Monoclonal antibody against PD-1 and applications thereof
EP3570870A1 (en) 2017-01-20 2019-11-27 Novartis AG Combination therapy for the treatment of cancer
WO2018133842A1 (en) * 2017-01-20 2018-07-26 大有华夏生物医药集团有限公司 Monoclonal antibody of human programmed death receptor pd-1 and fragment thereof
CN108341871A (en) * 2017-01-24 2018-07-31 三生国健药业（上海）股份有限公司 Anti- PD-1 monoclonal antibodies and its preparation method and application
CN108387731A (en) * 2017-02-03 2018-08-10 武汉三鹰生物技术有限公司 A kind of enzyme linked immunosorbent detection and preparation method for people's PD1 albumen
WO2018141959A1 (en) 2017-02-06 2018-08-09 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
SI3579874T1 (en) 2017-02-10 2021-11-30 Novartis Ag 1-(4-amino-5-bromo-6-(1 h-pyrazol-1-yl)pyrimidin-2-yl)-1 h-pyrazol-4-ol and use thereof in the treatment of cancer
TWI674261B (en) 2017-02-17 2019-10-11 美商英能腫瘤免疫股份有限公司 Nlrp3 modulators
EP3589308A1 (en) 2017-02-28 2020-01-08 Sanofi Therapeutic rna
EP3596124A1 (en) 2017-03-16 2020-01-22 Innate Pharma Compositions and methods for treating cancer
WO2018183928A1 (en) 2017-03-31 2018-10-04 Bristol-Myers Squibb Company Methods of treating tumor
DK3606946T3 (en) 2017-04-03 2022-10-24 Hoffmann La Roche Immunoconjugates of an anti-PD-1 antibody with a mutated IL-2 or with IL-15
TWI747215B (en) 2017-04-05 2021-11-21 瑞士商赫孚孟拉羅股份公司 Bispecific antibodies specifically binding to pd1 and lag3
EP4116328A1 (en) 2017-04-05 2023-01-11 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Combination therapies targeting pd-1, tim-3, and lag-3
TWI788340B (en) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 Anti-icos agonist antibodies and uses thereof
MX2019012223A (en) 2017-04-13 2019-12-09 Agenus Inc Anti-cd137 antibodies and methods of use thereof.
CN106939049B (en) 2017-04-20 2019-10-01 苏州思坦维生物技术股份有限公司 The monoclonal antibody and the preparation method and application thereof of antagonism inhibition people PD-1 antigen and its ligand binding
AR111651A1 (en) 2017-04-28 2019-08-07 Novartis Ag CONJUGATES OF ANTIBODIES THAT INCLUDE TOLL TYPE RECEIVER AGONISTS AND COMBINATION THERAPIES
PL3618863T3 (en) 2017-05-01 2023-11-06 Agenus Inc. Anti-tigit antibodies and methods of use thereof
AR111760A1 (en) 2017-05-19 2019-08-14 Novartis Ag COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF SOLID TUMORS THROUGH INTRATUMORAL ADMINISTRATION
JP7301002B2 (en) 2017-05-30 2023-06-30 ブリストル－マイヤーズ スクイブ カンパニー Compositions comprising anti-LAG-3 antibodies or anti-LAG-3 antibodies and anti-PD-1 or anti-PD-L1 antibodies
DK3631454T3 (en) 2017-05-30 2023-12-04 Bristol Myers Squibb Co TREATMENT OF LAYER-3 POSITIVE TUMORS
AU2018277559A1 (en) 2017-05-30 2019-10-17 Bristol-Myers Squibb Company Compositions comprising a combination of an anti-LAG-3 antibody, a PD-1 pathway inhibitor, and an immunotherapeutic agent
JOP20190279A1 (en) 2017-05-31 2019-11-28 Novartis Ag Crystalline forms of 5-bromo-2,6-di(1 h-pyrazol-1-yl)pyrimidin-4-amine and new salts
WO2018223040A1 (en) 2017-06-01 2018-12-06 Bristol-Myers Squibb Company Methods of treating a tumor using an anti-pd-1 antibody
UA128035C2 (en) 2017-06-05 2024-03-20 Янссен Байотек, Інк. Antibodies that specifically bind pd-1 and methods of use
WO2018223923A1 (en) * 2017-06-05 2018-12-13 江苏恒瑞医药股份有限公司 Use of pd-1 antibody combined with vegf ligand or vegf receptor inhibitor in preparing drug for treating tumor
WO2018229715A1 (en) 2017-06-16 2018-12-20 Novartis Ag Compositions comprising anti-cd32b antibodies and methods of use thereof
WO2018237173A1 (en) 2017-06-22 2018-12-27 Novartis Ag Antibody molecules to cd73 and uses thereof
WO2018235056A1 (en) 2017-06-22 2018-12-27 Novartis Ag Il-1beta binding antibodies for use in treating cancer
AU2018287519B2 (en) 2017-06-22 2021-07-22 Novartis Ag IL-1beta binding antibodies for use in treating cancer
CN110785187B (en) 2017-06-22 2024-04-05 诺华股份有限公司 Antibody molecules against CD73 and uses thereof
CA3066747A1 (en) 2017-06-27 2019-01-03 Novartis Ag Dosage regimens for anti-tim-3 antibodies and uses thereof
US11623954B2 (en) 2017-07-10 2023-04-11 Innate Pharma Siglec-9-neutralizing antibodies
EP3652166A1 (en) 2017-07-14 2020-05-20 Innate Tumor Immunity, Inc. Nlrp3 modulators
WO2019018730A1 (en) 2017-07-20 2019-01-24 Novartis Ag Dosage regimens of anti-lag-3 antibodies and uses thereof
EP3658565B1 (en) 2017-07-28 2022-11-09 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
PT3661954T (en) 2017-08-03 2022-04-14 Amgen Inc Interleukin-21 muteins and methods of treatment
JP7209697B2 (en) 2017-08-31 2023-01-20 ブリストル－マイヤーズ スクイブ カンパニー Cyclic dinucleotides as anticancer agents
JP7316263B2 (en) 2017-08-31 2023-07-27 ブリストル－マイヤーズ スクイブ カンパニー Cyclic dinucleotides as anticancer agents
EP3676279B1 (en) 2017-08-31 2021-12-01 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7387585B2 (en) 2017-09-04 2023-11-28 アジェナス インコーポレイテッド T-cell receptor that binds mixed lineage leukemia (MLL)-specific phosphopeptide and methods of use thereof
US11497756B2 (en) 2017-09-12 2022-11-15 Sumitomo Pharma Oncology, Inc. Treatment regimen for cancers that are insensitive to BCL-2 inhibitors using the MCL-1 inhibitor alvocidib
AU2018346447A1 (en) 2017-10-06 2020-03-19 Innate Pharma Restoration of T cell activity via the CD39/CD73 axis
CN111344297B (en) 2017-10-10 2023-10-20 百时美施贵宝公司 Cyclic dinucleotides as anticancer agents
WO2019072220A1 (en) * 2017-10-13 2019-04-18 江苏恒瑞医药股份有限公司 Use of pd-1 antibody combined with epigenetic regulator in preparation of drug for treating tumors
KR20200064132A (en) 2017-10-15 2020-06-05 브리스톨-마이어스 스큅 컴퍼니 How to treat a tumor
US11427610B2 (en) 2017-10-16 2022-08-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019076277A1 (en) * 2017-10-17 2019-04-25 江苏恒瑞医药股份有限公司 Uses of anti-pd-1 antibody and anti-lag-3 antibody jointly in preparing medicament for treating tumor
US20210040205A1 (en) 2017-10-25 2021-02-11 Novartis Ag Antibodies targeting cd32b and methods of use thereof
KR20200075860A (en) 2017-11-06 2020-06-26 제넨테크, 인크. How to diagnose and treat cancer
CN111315397A (en) 2017-11-06 2020-06-19 百时美施贵宝公司 Method for treating tumors
TW201922793A (en) * 2017-11-16 2019-06-16 大陸商江蘇恆瑞醫藥股份有限公司 Uses of PD-1 antibody combined with VEGFR inhibitor for treating small cell lung cancer
CN109793892B (en) * 2017-11-16 2022-07-26 江苏恒瑞医药股份有限公司 Application of anti-PD-1 antibody in preparation of medicine for treating esophageal cancer
TW201922291A (en) 2017-11-16 2019-06-16 瑞士商諾華公司 Combination therapies
CN109806393B (en) * 2017-11-17 2022-07-26 江苏恒瑞医药股份有限公司 Application of anti-PD-1 antibody, pemetrexed and platinum drugs in combined treatment of non-small cell lung cancer
WO2019096233A1 (en) * 2017-11-17 2019-05-23 江苏恒瑞医药股份有限公司 Use of combination of immunotherapeutic agent, nucleoside antimetabolite, and platinum in preparing drug for treating tumor
MX2020005651A (en) 2017-11-30 2020-10-28 Novartis Ag Bcma-targeting chimeric antigen receptor, and uses thereof.
CN111246881B (en) * 2017-12-14 2023-03-10 江苏恒瑞医药股份有限公司 Use of PD-1 antibodies for treating tumors
BR112020011796A2 (en) * 2017-12-29 2020-11-17 Jiangsu Hengrui Medicine Co., Ltd. use of combined treatment of pd-1 antibody and apati-nib for the treatment of triple negative breast cancer
CN110013552B (en) * 2018-01-08 2023-03-10 江苏恒瑞医药股份有限公司 Application of anti-PD-1 antibody, gemcitabine and platinum drug combination in treating malignant biliary tract tumor
EP3737408A1 (en) 2018-01-08 2020-11-18 Novartis AG Immune-enhancing rnas for combination with chimeric antigen receptor therapy
SG11202005605SA (en) 2018-01-12 2020-07-29 Amgen Inc Anti-pd-1 antibodies and methods of treatment
US20210363242A1 (en) 2018-01-16 2021-11-25 Bristol-Myers Squibb Company Methods of treating cancer with antibodies against tim3
KR20200112904A (en) 2018-01-22 2020-10-05 브리스톨-마이어스 스큅 컴퍼니 Compositions and methods for treating cancer
EP3743061A1 (en) 2018-01-22 2020-12-02 Pascal Biosciences Inc. Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells
WO2019152660A1 (en) 2018-01-31 2019-08-08 Novartis Ag Combination therapy using a chimeric antigen receptor
WO2019151771A1 (en) * 2018-02-02 2019-08-08 주식회사 뉴라클제네틱스 Pd-1 variant having improved binding to pd-l1
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
EP3752203A1 (en) 2018-02-13 2020-12-23 Novartis AG Chimeric antigen receptor therapy in combination with il-15r and il15
EP3762397A1 (en) 2018-03-08 2021-01-13 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
GB201803746D0 (en) * 2018-03-08 2018-04-25 Ultrahuman Eight Ltd PD1 binding agents
GB201803745D0 (en) 2018-03-08 2018-04-25 Ultrahuman Eight Ltd PD1 binding agents
CN110272491B (en) * 2018-03-13 2023-01-24 江苏恒瑞医药股份有限公司 Purification process of anti-PD-1 antibody
CA3093407A1 (en) 2018-03-23 2019-09-26 Bristol-Myers Squibb Company Antibodies against mica and/or micb and uses thereof
WO2019191676A1 (en) 2018-03-30 2019-10-03 Bristol-Myers Squibb Company Methods of treating tumor
EP3774903A1 (en) 2018-04-04 2021-02-17 Bristol-Myers Squibb Company Anti-cd27 antibodies and uses thereof
US20210147547A1 (en) 2018-04-13 2021-05-20 Novartis Ag Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
US20210267964A1 (en) 2018-04-25 2021-09-02 Innate Tumor Immunity, Inc. Nlrp3 modulators
JP2021522239A (en) 2018-04-26 2021-08-30 アジェナス インコーポレイテッド Heat shock protein-binding peptide composition and how to use it
JP2021522308A (en) 2018-05-04 2021-08-30 トゥリーズ TLR3 ligand that activates both epithelial and bone marrow cells
IL278400B2 (en) 2018-05-07 2024-03-01 Genmab As Combination of an anti pd-1 antibody and anti tissue factor (tf) antibody drug conjugate for use in the treatment of cancer
JP2021523949A (en) 2018-05-17 2021-09-09 ナンジン リーズ バイオラブズ カンパニー リミテッド Antibodies that bind to PD-1 and their use
CN110507820A (en) * 2018-05-21 2019-11-29 江苏恒瑞医药股份有限公司 A kind of purposes of the antibody combined radiotherapy of anti-PD-1 in the drug of preparation treatment tumor patient
TWI806870B (en) * 2018-05-23 2023-07-01 中國大陸商大有華夏生物醫藥集團有限公司 Anti-pd-1 antibodies and uses thereof
AR126019A1 (en) 2018-05-30 2023-09-06 Novartis Ag ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES
TW202017569A (en) 2018-05-31 2020-05-16 美商佩樂敦治療公司 Compositions and methods for inhibiting cd73
US20210214459A1 (en) 2018-05-31 2021-07-15 Novartis Ag Antibody molecules to cd73 and uses thereof
JP7398396B2 (en) 2018-06-01 2023-12-14 ノバルティス アーゲー Binding molecules for BCMA and their uses
CN108636356A (en) * 2018-06-05 2018-10-12 吉林农业大学 A kind of cornstalk biological charcoal and restorative procedure that can repair nitrogen phosphorus pollution of area source
CA3099893A1 (en) 2018-06-18 2019-12-26 Innate Pharma Compositions and methods for treating cancer
MX2020014091A (en) 2018-06-23 2021-05-27 Genentech Inc Methods of treating lung cancer with a pd-1 axis binding antagonist, a platinum agent, and a topoisomerase ii inhibitor.
CA3103385A1 (en) 2018-07-10 2020-01-16 Novartis Ag 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
AR116109A1 (en) 2018-07-10 2021-03-31 Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
US20200171146A1 (en) 2018-07-18 2020-06-04 Genentech, Inc. Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent
EP3842070A4 (en) 2018-07-18 2022-04-20 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Drug combination of quinoline derivative and antibody
US20210261665A1 (en) * 2018-07-19 2021-08-26 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-pd-1 antibodies, dosages and uses thereof
WO2020021465A1 (en) 2018-07-25 2020-01-30 Advanced Accelerator Applications (Italy) S.R.L. Method of treatment of neuroendocrine tumors
KR20210040080A (en) 2018-07-26 2021-04-12 브리스톨-마이어스 스큅 컴퍼니 LAG-3 combination therapy for cancer treatment
CN110790839B (en) * 2018-08-03 2023-05-12 江苏恒瑞医药股份有限公司 anti-PD-1 antibody, antigen binding fragment thereof and medical application thereof
JP7433291B2 (en) 2018-08-16 2024-02-19 イネイト・テューマー・イミュニティ・インコーポレイテッド NLRP3 modulators of imidazo[4,5-c]quinoline derivatives
JP7364663B2 (en) 2018-08-16 2023-10-18 イネイト・テューマー・イミュニティ・インコーポレイテッド NLRP3 modulators of imidazo[4,5-c]quinoline derivatives
JP2021534180A (en) 2018-08-16 2021-12-09 イネイト・テューマー・イミュニティ・インコーポレイテッドInnate Tumor Immunity, Inc. Substituted 4-amino-1H-imidazole [4,5-c] quinoline compound and improved method for its production
US20220017618A1 (en) * 2018-08-20 2022-01-20 Jiangsu Hengrui Medicine Co., Ltd. Use of tim-3 antibody in preparation of medicines for treating tumors
WO2020044252A1 (en) 2018-08-31 2020-03-05 Novartis Ag Dosage regimes for anti-m-csf antibodies and uses thereof
JP2021535169A (en) 2018-09-03 2021-12-16 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Carboxamide and sulfonamide derivatives useful as TEAD modulators
WO2020049534A1 (en) 2018-09-07 2020-03-12 Novartis Ag Sting agonist and combination therapy thereof for the treatment of cancer
WO2020076799A1 (en) 2018-10-09 2020-04-16 Bristol-Myers Squibb Company Anti-mertk antibodies for treating cancer
CN112867803A (en) 2018-10-16 2021-05-28 诺华股份有限公司 Tumor mutational burden alone or in combination with immune markers as biomarkers for predicting response to targeted therapy
WO2020081928A1 (en) 2018-10-19 2020-04-23 Bristol-Myers Squibb Company Combination therapy for melanoma
KR20210081384A (en) 2018-10-23 2021-07-01 브리스톨-마이어스 스큅 컴퍼니 how to treat a tumor
EP3873532A1 (en) 2018-10-31 2021-09-08 Novartis AG Dc-sign antibody drug conjugates
CA3117819A1 (en) 2018-11-06 2020-05-14 Jiangsu Hengrui Medicine Co., Ltd. Use of anti-pd-1 antibody in combination with famitinib in preparation of drug for treating tumors
WO2020102501A1 (en) 2018-11-16 2020-05-22 Bristol-Myers Squibb Company Anti-nkg2a antibodies and uses thereof
EP3891508A1 (en) 2018-12-04 2021-10-13 Bristol-Myers Squibb Company Methods of analysis using in-sample calibration curve by multiple isotopologue reaction monitoring
AU2019391097A1 (en) 2018-12-04 2021-05-20 Sumitomo Pharma Oncology, Inc. CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer
EP3666905A1 (en) 2018-12-11 2020-06-17 Sanofi E. coli positive for pks island as marker of positive response to anti-pd1 therapy in colorectal cancer
TW202039459A (en) 2018-12-11 2020-11-01 美商施萬生物製藥研發 Ip有限責任公司 Alk5 inhibitors
CN113271945A (en) 2018-12-20 2021-08-17 诺华股份有限公司 Dosing regimens and pharmaceutical combinations comprising 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives
WO2020128637A1 (en) 2018-12-21 2020-06-25 Novartis Ag Use of il-1 binding antibodies in the treatment of a msi-h cancer
WO2020128613A1 (en) 2018-12-21 2020-06-25 Novartis Ag Use of il-1beta binding antibodies
CN113227137A (en) 2018-12-21 2021-08-06 诺华股份有限公司 Use of IL-1 beta antibodies in the treatment or prevention of myelodysplastic syndrome
CN111349162A (en) * 2018-12-21 2020-06-30 神州细胞工程有限公司 Humanized anti-PD-1 antibodies and uses thereof
CN113227138A (en) 2018-12-21 2021-08-06 诺华股份有限公司 Use of IL-1 beta binding antibodies
WO2020127965A1 (en) 2018-12-21 2020-06-25 Onxeo New conjugated nucleic acid molecules and their uses
EP3899951A1 (en) 2018-12-23 2021-10-27 F. Hoffmann-La Roche AG Tumor classification based on predicted tumor mutational burden
CN111423510B (en) 2019-01-10 2024-02-06 迈威(上海)生物科技股份有限公司 Recombinant anti-human PD-1 antibody and application thereof
WO2020150115A1 (en) 2019-01-14 2020-07-23 Innate Tumor Immunity, Inc. Nlrp3 modulators
WO2020150114A1 (en) 2019-01-14 2020-07-23 Innate Tumor Immunity, Inc. Heterocyclic nlrp3 modulators, for use in the treatment of cancer
KR20210114983A (en) 2019-01-14 2021-09-24 인네이트 튜머 이뮤니티, 인코포레이티드 NLRP3 modulators
AU2020208193A1 (en) 2019-01-14 2021-07-29 BioNTech SE Methods of treating cancer with a PD-1 axis binding antagonist and an RNA vaccine
WO2020150113A1 (en) 2019-01-14 2020-07-23 Innate Tumor Immunity, Inc. Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer
CA3126110A1 (en) 2019-01-21 2020-07-30 Sanofi Therapeutic rna and anti-pd1 antibodies for advanced stage solid tumor cancers
CN112969716B (en) * 2019-02-03 2022-11-22 江苏恒瑞医药股份有限公司 anti-PD-1 antibody, antigen binding fragment thereof and medical application
KR20210146290A (en) 2019-02-12 2021-12-03 스미토모 다이니폰 파마 온콜로지, 인크. Formulations comprising heterocyclic protein kinase inhibitors
CN113395967A (en) 2019-02-12 2021-09-14 诺华股份有限公司 Pharmaceutical combination comprising TNO155 and PD-1 inhibitor
MX2021009763A (en) 2019-02-15 2021-09-08 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof.
AU2020222346B2 (en) 2019-02-15 2021-12-09 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
JP2022525149A (en) 2019-03-20 2022-05-11 スミトモ ダイニッポン ファーマ オンコロジー， インコーポレイテッド Treatment of Acute Myeloid Leukemia (AML) with Venetoclax Failure
US11712433B2 (en) 2019-03-22 2023-08-01 Sumitomo Pharma Oncology, Inc. Compositions comprising PKM2 modulators and methods of treatment using the same
EP3946625A1 (en) 2019-03-28 2022-02-09 Bristol-Myers Squibb Company Methods of treating tumor
WO2020198676A1 (en) 2019-03-28 2020-10-01 Bristol-Myers Squibb Company Methods of treating tumor
EP3725370A1 (en) 2019-04-19 2020-10-21 ImmunoBrain Checkpoint, Inc. Modified anti-pd-l1 antibodies and methods and uses for treating a neurodegenerative disease
CN114364703A (en) 2019-04-19 2022-04-15 豪夫迈·罗氏有限公司 Anti-merk antibodies and methods of use thereof
CA3136698A1 (en) 2019-04-23 2020-10-29 Innate Pharma Cd73 blocking antibodies
WO2020228657A1 (en) 2019-05-10 2020-11-19 正大天晴药业集团股份有限公司 Quinoline derivative and antibody soft tissue sarcoma combination therapy
US20230295087A1 (en) 2019-05-13 2023-09-21 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
WO2020231713A1 (en) 2019-05-13 2020-11-19 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
WO2020233602A1 (en) 2019-05-20 2020-11-26 正大天晴药业集团股份有限公司 Quinoline derivative used for combination treatment of small cell lung cancer
EP3973963A4 (en) 2019-05-23 2023-06-14 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Quinoline derivatives for treatment of head and neck cancer
US20220241412A1 (en) 2019-05-24 2022-08-04 Pfizer Inc. Combination therapies using cdk inhibitors
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
JP2022534967A (en) 2019-05-30 2022-08-04 ブリストル－マイヤーズ スクイブ カンパニー Multiple tumor gene signatures and their uses
EP3976832A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
CN114302878A (en) 2019-07-03 2022-04-08 大日本住友制药肿瘤公司 Tyrosine kinase non-receptor 1(TNK1) inhibitors and uses thereof
EP3998081A4 (en) 2019-07-05 2023-07-12 Ono Pharmaceutical Co., Ltd. Treatment of hematologic cancer with pd-1/cd3 dual specificity protein
WO2021026179A1 (en) 2019-08-06 2021-02-11 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
JPWO2021025140A1 (en) 2019-08-08 2021-02-11
KR20220053007A (en) 2019-08-30 2022-04-28 아게누스 인코포레이티드 Anti-CD96 antibodies and methods of use thereof
WO2021053559A1 (en) 2019-09-18 2021-03-25 Novartis Ag Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies
TW202124446A (en) 2019-09-18 2021-07-01 瑞士商諾華公司 Combination therapies with entpd2 antibodies
US20220348653A1 (en) 2019-09-22 2022-11-03 Bristol-Myers Squibb Company Quantitative Spatial Profiling for LAG-3 Antagonist Therapy
JP2022549495A (en) 2019-09-25 2022-11-25 シージェン インコーポレイテッド Combination of anti-CD30 ADC, anti-PD-1, and chemotherapeutic agents for treatment of hematopoietic cancer
US20220339249A1 (en) 2019-09-25 2022-10-27 Bristol-Myers Squibb Company Composite biomarker for cancer therapy
GB201914747D0 (en) * 2019-10-11 2019-11-27 Ultrahuman Eight Ltd PD1 and vegfr2 dual-binding agents
MX2022004769A (en) 2019-10-21 2022-05-16 Novartis Ag Tim-3 inhibitors and uses thereof.
CN114786679A (en) 2019-10-21 2022-07-22 诺华股份有限公司 Combination therapy with Vernetork and TIM-3 inhibitors
JP2022553821A (en) 2019-11-05 2022-12-26 ブリストル－マイヤーズ スクイブ カンパニー M-protein assay and its use
WO2021092221A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
WO2021092220A1 (en) 2019-11-06 2021-05-14 Bristol-Myers Squibb Company Methods of identifying a subject with a tumor suitable for a checkpoint inhibitor therapy
CA3160479A1 (en) 2019-11-08 2021-05-14 Bristol-Myers Squibb Company Lag-3 antagonist therapy for melanoma
JP2023501989A (en) 2019-11-13 2023-01-20 ジェネンテック， インコーポレイテッド Therapeutic compounds and methods of use
US20220395553A1 (en) 2019-11-14 2022-12-15 Cohbar, Inc. Cxcr4 antagonist peptides
WO2021102343A1 (en) 2019-11-22 2021-05-27 Sumitomo Dainippon Pharma Oncology, Inc. Solid dose pharmaceutical composition
AU2020385400A1 (en) 2019-11-22 2022-06-09 Theravance Biopharma R&D Ip, Llc Substituted 1,5-naphthyridines or quinolines as ALK5 inhibitors
AU2020399976A1 (en) 2019-12-09 2022-06-30 Merck Sharp & Dohme B.V. Combination therapy with LIV1-ADC and PD-1 antagonist
KR20220118481A (en) 2019-12-19 2022-08-25 브리스톨-마이어스 스큅 컴퍼니 Combinations of DGK inhibitors and checkpoint antagonists
CN113004408B (en) * 2019-12-20 2022-07-01 广东菲鹏制药股份有限公司 Anti-human apoptosis factor-1 monoclonal antibody
KR20220116257A (en) 2019-12-20 2022-08-22 노파르티스 아게 Combination of anti-TIM-3 antibody MBG453 and anti-TGF-beta antibody NIS793 with or without decitabine or anti-PD-1 antibody spartalizumab for treating myelofibrosis and myelodysplastic syndrome
KR20220127848A (en) 2020-01-10 2022-09-20 인네이트 튜머 이뮤니티, 인코포레이티드 NLRP3 modulators
IL293752A (en) 2020-01-17 2022-08-01 Novartis Ag Combination comprising a tim-3 inhibitor and a hypomethylating agent for use in treating myelodysplastic syndrome or chronic myelomonocytic leukemia
IL295093A (en) 2020-01-30 2022-09-01 Ona Therapeutics S L Combination therapy for treatment of cancer and cancer metastasis
IL294859A (en) 2020-01-31 2022-09-01 Genentech Inc Methods of inducing neoepitope-specific t cells with a pd-1 axis binding antagonist and an rna vaccine
KR20220139915A (en) 2020-02-06 2022-10-17 브리스톨-마이어스 스큅 컴퍼니 IL-10 and its uses
KR20220148846A (en) 2020-02-28 2022-11-07 노파르티스 아게 Triple Pharmaceutical Combination Comprising Dabrafenib, ERK Inhibitor, and RAF Inhibitor
JP2023516745A (en) 2020-03-06 2023-04-20 セルジーン・クオンティセル・リサーチ・インコーポレイテッド Methods of treating small cell lung cancer and/or squamous non-small cell lung cancer
AU2021232158A1 (en) 2020-03-06 2022-09-29 Ona Therapeutics, S.L. Anti-CD36 antibodies and their use to treat cancer
AU2021244200A1 (en) 2020-03-23 2022-11-24 Bristol-Myers Squibb Company Anti-CCR8 antibodies for treating cancer
EP4126824A1 (en) 2020-03-31 2023-02-08 Theravance Biopharma R&D IP, LLC Substituted pyrimidines and methods of use
TW202144007A (en) * 2020-04-10 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 Use of an anti-pd-1 antibody in the preparation of a medicament for the treatment of acral melanoma
JP2023523193A (en) 2020-04-21 2023-06-02 ノバルティス アーゲー Dosing Regimens for Treating Diseases Modulated by CSF-1R
TW202214623A (en) 2020-06-10 2022-04-16 美商施萬生物製藥研發 Ip有限責任公司 Crystalline alk5 inhibitors and uses thereof
AR122644A1 (en) 2020-06-19 2022-09-28 Onxeo NEW CONJUGATED NUCLEIC ACID MOLECULES AND THEIR USES
KR20230027056A (en) 2020-06-23 2023-02-27 노파르티스 아게 Dosage regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
US20220023405A1 (en) 2020-06-30 2022-01-27 Dcprime B.V. Use of leukemia-derived cells in ovarian cancer vaccines
MX2023000197A (en) 2020-07-07 2023-02-22 BioNTech SE Therapeutic rna for hpv-positive cancer.
WO2022009157A1 (en) 2020-07-10 2022-01-13 Novartis Ag Lhc165 and spartalizumab combinations for treating solid tumors
US11787775B2 (en) 2020-07-24 2023-10-17 Genentech, Inc. Therapeutic compounds and methods of use
AU2021317805A1 (en) * 2020-07-31 2023-03-16 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Anti-PD-1 antibody pharmaceutical composition and use thereof
EP4188549A1 (en) 2020-08-03 2023-06-07 Novartis AG Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN111705038B (en) * 2020-08-24 2020-11-03 江苏集萃药康生物科技有限公司 Construction method and application of cell strain capable of stably expressing human PDL1/CD73 protein
BR112023003427A2 (en) 2020-08-28 2023-03-21 Bristol Myers Squibb Co LAG-3 ANTAGONIST THERAPY FOR HEPATOCELLULAR CARCINOMA
EP4204020A1 (en) 2020-08-31 2023-07-05 Advanced Accelerator Applications International S.A. Method of treating psma-expressing cancers
WO2022043557A1 (en) 2020-08-31 2022-03-03 Advanced Accelerator Applications International Sa Method of treating psma-expressing cancers
JP2023538955A (en) 2020-08-31 2023-09-12 ブリストル－マイヤーズ スクイブ カンパニー Cellular localization signatures and immunotherapy
CA3189987A1 (en) 2020-09-02 2022-03-10 Pharmabcine Inc. Combination therapy of a pd-1 antagonist and an antagonist for vegfr-2 for treating patients with cancer
BR112023005377A2 (en) 2020-09-24 2023-04-25 Merck Sharp & Dohme Llc STABLE FORMULATIONS OF PROGRAMMED DEATH 1 (PD-1) RECEPTOR ANTIBODIES AND HYALURONIDASE VARIANTS AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOF
CN112285352A (en) * 2020-10-02 2021-01-29 朱吉安 Method for measuring biological activity of anti-PD-1 monoclonal antibody
JP2023544410A (en) 2020-10-05 2023-10-23 ブリストル－マイヤーズ スクイブ カンパニー Methods for concentrating proteins
US20230364127A1 (en) 2020-10-06 2023-11-16 Codiak Biosciences, Inc. Extracellular vesicle-aso constructs targeting stat6
TW202233671A (en) 2020-10-20 2022-09-01 美商建南德克公司 Peg-conjugated anti-mertk antibodies and methods of use
CA3196496A1 (en) 2020-10-23 2022-04-28 Laurence David TOMS Lag-3 antagonist therapy for lung cancer
JP2023549678A (en) 2020-10-28 2023-11-29 イケナ オンコロジー， インコーポレイテッド Combination of AHR inhibitors with PDx inhibitors or doxorubicin
WO2022093981A1 (en) 2020-10-28 2022-05-05 Genentech, Inc. Combination therapy comprising ptpn22 inhibitors and pd-l1 binding antagonists
CA3196191A1 (en) 2020-11-04 2022-05-12 Chi-Chung Li Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates
US20220162329A1 (en) 2020-11-04 2022-05-26 Genentech, Inc. Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
AU2021374590A1 (en) 2020-11-04 2023-06-01 Genentech, Inc. Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies
CA3199095A1 (en) 2020-11-06 2022-05-12 Novartis Ag Cd19 binding molecules and uses thereof
US20240024320A1 (en) 2020-11-17 2024-01-25 Seagen Inc. Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody
WO2022118197A1 (en) 2020-12-02 2022-06-09 Pfizer Inc. Time to resolution of axitinib-related adverse events
WO2022119830A1 (en) 2020-12-02 2022-06-09 Genentech, Inc. Methods and compositions for neoadjuvant and adjuvant urothelial carcinoma therapy
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
TW202237119A (en) 2020-12-10 2022-10-01 美商住友製藥腫瘤公司 Alk-5 inhibitors and uses thereof
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
TW202245808A (en) 2020-12-21 2022-12-01 德商拜恩迪克公司 Therapeutic rna for treating cancer
WO2022146947A1 (en) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
WO2022146948A1 (en) 2020-12-28 2022-07-07 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
EP4281102A1 (en) 2021-01-22 2023-11-29 Mendus B.V. Methods of tumor vaccination
WO2022162569A1 (en) 2021-01-29 2022-08-04 Novartis Ag Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof
AU2022218137A1 (en) 2021-02-03 2023-08-24 Mozart Therapeutics, Inc. Binding agents and methods of using the same
US20240109899A1 (en) 2021-02-04 2024-04-04 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
WO2022195551A1 (en) 2021-03-18 2022-09-22 Novartis Ag Biomarkers for cancer and methods of use thereof
TW202304506A (en) 2021-03-25 2023-02-01 日商安斯泰來製藥公司 Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
KR20240005700A (en) 2021-03-29 2024-01-12 주노 쎄러퓨티크스 인코퍼레이티드 Dosing and Treatment Methods Using Combination of Checkpoint Inhibitor Therapy and CAR T Cell Therapy
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
TW202304979A (en) 2021-04-07 2023-02-01 瑞士商諾華公司 USES OF ANTI-TGFβ ANTIBODIES AND OTHER THERAPEUTIC AGENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
TW202309022A (en) 2021-04-13 2023-03-01 美商努法倫特公司 Amino-substituted heterocycles for treating cancers with egfr mutations
EP4330436A1 (en) 2021-04-30 2024-03-06 Genentech, Inc. Therapeutic and diagnostic methods and compositions for cancer
AU2021443318A1 (en) 2021-04-30 2023-09-07 F. Hoffmann-La Roche Ag Dosing for combination treatment with anti-cd20/anti-cd3 bispecific antibody and anti-cd79b antibody drug conjugate
AR125874A1 (en) 2021-05-18 2023-08-23 Novartis Ag COMBINATION THERAPIES
CN117412767A (en) 2021-05-25 2024-01-16 雪绒花免疫公司 C-X-C motif chemokine receptor 6 (CXCR 6) binding molecules and methods of use thereof
WO2022251359A1 (en) 2021-05-26 2022-12-01 Theravance Biopharma R&D Ip, Llc Bicyclic inhibitors of alk5 and methods of use
TW202313117A (en) 2021-06-03 2023-04-01 美商欣爍克斯公司 Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
GB202107994D0 (en) 2021-06-04 2021-07-21 Kymab Ltd Treatment of cancer
BR112023026966A2 (en) 2021-07-02 2024-03-12 Hoffmann La Roche METHODS FOR TREATING AN INDIVIDUAL WITH MELANOMA, FOR ACHIEVING A CLINICAL RESPONSE, FOR TREATING AN INDIVIDUAL WITH NON-HODGKIN LYMPHOMA, FOR TREATING A POPULATION OF INDIVIDUALS WITH NON-HODGKIN LYMPHOMA, AND FOR TREATING AN INDIVIDUAL WITH METASTATIC COLORECTAL CANCER
CA3225254A1 (en) 2021-07-13 2023-01-19 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
TW202320848A (en) 2021-07-28 2023-06-01 美商建南德克公司 Methods and compositions for treating cancer
CN117715936A (en) 2021-07-28 2024-03-15 豪夫迈·罗氏有限公司 Methods and compositions for treating cancer
AU2022320051A1 (en) 2021-07-30 2024-01-25 ONA Therapeutics S.L. Anti-cd36 antibodies and their use to treat cancer
WO2023056403A1 (en) 2021-09-30 2023-04-06 Genentech, Inc. Methods for treatment of hematologic cancers using anti-tigit antibodies, anti-cd38 antibodies, and pd-1 axis binding antagonists
WO2023051926A1 (en) 2021-09-30 2023-04-06 BioNTech SE Treatment involving non-immunogenic rna for antigen vaccination and pd-1 axis binding antagonists
TW202327595A (en) 2021-10-05 2023-07-16 美商輝瑞大藥廠 Combinations of azalactam compounds for the treatment of cancer
WO2023057534A1 (en) 2021-10-06 2023-04-13 Genmab A/S Multispecific binding agents against pd-l1 and cd137 in combination
TW202333802A (en) 2021-10-11 2023-09-01 德商拜恩迪克公司 Therapeutic rna for lung cancer
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
IL309227A (en) 2021-10-29 2024-02-01 Bristol Myers Squibb Co Lag-3 antagonist therapy for hematological cancer
WO2023079428A1 (en) 2021-11-03 2023-05-11 Pfizer Inc. Combination therapies using tlr7/8 agonist
WO2023080900A1 (en) 2021-11-05 2023-05-11 Genentech, Inc. Methods and compositions for classifying and treating kidney cancer
WO2023083439A1 (en) 2021-11-09 2023-05-19 BioNTech SE Tlr7 agonist and combinations for cancer treatment
TW202319073A (en) 2021-11-12 2023-05-16 瑞士商諾華公司 Combination therapy for treating lung cancer
WO2023097195A1 (en) 2021-11-24 2023-06-01 Genentech, Inc. Therapeutic indazole compounds and methods of use in the treatment of cancer
TW202340212A (en) 2021-11-24 2023-10-16 美商建南德克公司 Therapeutic compounds and methods of use
WO2023111203A1 (en) 2021-12-16 2023-06-22 Onxeo New conjugated nucleic acid molecules and their uses
WO2023122573A1 (en) 2021-12-20 2023-06-29 Synthorx, Inc. Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
WO2023147371A1 (en) 2022-01-26 2023-08-03 Bristol-Myers Squibb Company Combination therapy for hepatocellular carcinoma
WO2023164638A1 (en) 2022-02-25 2023-08-31 Bristol-Myers Squibb Company Combination therapy for colorectal carcinoma
WO2023168404A1 (en) 2022-03-04 2023-09-07 Bristol-Myers Squibb Company Methods of treating a tumor
WO2023170606A1 (en) 2022-03-08 2023-09-14 Alentis Therapeutics Ag Use of anti-claudin-1 antibodies to increase t cell availability
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
WO2023191816A1 (en) 2022-04-01 2023-10-05 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2023196987A1 (en) 2022-04-07 2023-10-12 Bristol-Myers Squibb Company Methods of treating tumor
US20230326022A1 (en) 2022-04-08 2023-10-12 Bristol-Myers Squibb Company Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures
WO2023214325A1 (en) 2022-05-05 2023-11-09 Novartis Ag Pyrazolopyrimidine derivatives and uses thereof as tet2 inhibitors
WO2023219613A1 (en) 2022-05-11 2023-11-16 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2023218046A1 (en) 2022-05-12 2023-11-16 Genmab A/S Binding agents capable of binding to cd27 in combination therapy
WO2023230554A1 (en) 2022-05-25 2023-11-30 Pfizer Inc. Combination of a braf inhibitor, an egfr inhibitor, and a pd-1 antagonist for the treatment of braf v600e-mutant, msi-h/dmmr colorectal cancer
WO2023235847A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
WO2023240058A2 (en) 2022-06-07 2023-12-14 Genentech, Inc. Prognostic and therapeutic methods for cancer
WO2024015897A1 (en) 2022-07-13 2024-01-18 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
WO2024020432A1 (en) 2022-07-19 2024-01-25 Genentech, Inc. Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies
EP4310197A1 (en) 2022-07-21 2024-01-24 Fundación para la Investigación Biomédica del Hospital Universitario Puerta de Hierro Majadahonda Method for identifying lung cancer patients for a combination treatment of immuno- and chemotherapy
WO2024023740A1 (en) 2022-07-27 2024-02-01 Astrazeneca Ab Combinations of recombinant virus expressing interleukin-12 with pd-1/pd-l1 inhibitors
WO2024049949A1 (en) 2022-09-01 2024-03-07 Genentech, Inc. Therapeutic and diagnostic methods for bladder cancer
WO2024069009A1 (en) 2022-09-30 2024-04-04 Alentis Therapeutics Ag Treatment of drug-resistant hepatocellular carcinoma

Family Cites Families (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5159730A (en) 1974-10-24 1976-05-25 Furukawa Electric Co Ltd Sutenresu no nitsukerumetsukiho
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
CN1080311A (en) 1992-06-14 1994-01-05 江苏省盐城市师范专科学校科技部 A kind of smoke-stopping fireproofing material
JPH07291996A (en) 1994-03-01 1995-11-07 Yuu Honshiyo Polypeptide related to programmed cell death in human, dna coding the same, vector consisting of the same dna, host cell transformed with the same vector, antibody of the same polypeptide and pharmaceutical composition containing the same polypeptide or the same antibody
CN104231078A (en) 1997-04-07 2014-12-24 基因技术股份有限公司 Anti-vegf antibodies
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
WO2001014557A1 (en) 1999-08-23 2001-03-01 Dana-Farber Cancer Institute, Inc. Pd-1, a receptor for b7-4, and uses therefor
GB0029360D0 (en) * 2000-12-01 2001-01-17 Univ Nottingham Humanised antibodies and uses thereof
AR036993A1 (en) 2001-04-02 2004-10-20 Wyeth Corp USE OF AGENTS THAT MODULATE THE INTERACTION BETWEEN PD-1 AND ITS LINKS IN THE SUBMODULATION OF IMMUNOLOGICAL ANSWERS
ATE481985T1 (en) 2002-07-03 2010-10-15 Ono Pharmaceutical Co IMMUNOPOTENTATING COMPOSITIONS
US7488802B2 (en) 2002-12-23 2009-02-10 Wyeth Antibodies against PD-1
EP1591527B1 (en) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specific to human pd-1
GB0400440D0 (en) 2004-01-09 2004-02-11 Isis Innovation Receptor modulators
GB0521621D0 (en) 2005-10-24 2005-11-30 Domantis Ltd Tumor necrosis factor receptor 1 antagonists for treating respiratory diseases
DK2161336T4 (en) * 2005-05-09 2017-04-24 Ono Pharmaceutical Co Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies
MX349137B (en) 2005-06-08 2017-07-13 Dana-Farber Cancer Inst Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (pd-1) pathway.
CN105056226A (en) 2006-12-27 2015-11-18 埃默里大学 Compositions and methods for the treatment of infections and tumors
EP4119579A1 (en) 2007-05-31 2023-01-18 Genmab A/S Stable igg4 antibodies
PL2170959T3 (en) * 2007-06-18 2014-03-31 Merck Sharp & Dohme Antibodies to human programmed death receptor pd-1
US20090028857A1 (en) 2007-07-23 2009-01-29 Cell Genesys, Inc. Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
US9243052B2 (en) 2007-08-17 2016-01-26 Daniel Olive Method for treating and diagnosing hematologic malignancies
WO2009026472A1 (en) 2007-08-21 2009-02-26 The General Hospital Corporation Methods for inducing tolerance
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
EP2307050A4 (en) 2008-07-04 2012-07-25 Ono Pharmaceutical Co Use of an efficacy marker for optimizing therapeutic efficacy of an anti-human pd-1 antibody on cancers
AU2009288730B2 (en) 2008-08-25 2013-06-20 Amplimmune, Inc. Compositions of PD-1 antagonists and methods of use
US20110223188A1 (en) 2008-08-25 2011-09-15 Solomon Langermann Targeted costimulatory polypeptides and methods of use to treat cancer
EP2342228B1 (en) 2008-09-12 2017-09-06 Oxford University Innovation Limited Pd-1 specific antibodies and uses thereof
US8927697B2 (en) 2008-09-12 2015-01-06 Isis Innovation Limited PD-1 specific antibodies and uses thereof
KR101814408B1 (en) 2008-09-26 2018-01-04 다나-파버 캔서 인스티튜트 인크. Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
JP5840494B2 (en) 2008-10-02 2016-01-06 エマージェント プロダクト デベロップメント シアトル， エルエルシー Multi-target binding protein of CD86 antagonist
KR101050829B1 (en) 2008-10-02 2011-07-20 서울대학교산학협력단 Anticancer agents comprising an anti-PD-1 antibody or an anti-PD-L1 antibody
CN102282265B (en) 2008-11-28 2020-07-24 埃默里大学 Methods for treating infectious diseases and tumors
EP3153524A1 (en) 2008-12-03 2017-04-12 Genmab A/S Antibody variants having modifications in the constant region
PL2379600T5 (en) * 2008-12-22 2021-03-08 Novo Nordisk A/S Antibodies against tissue factor pathway inhibitor
ES2629337T3 (en) 2009-02-09 2017-08-08 Inserm - Institut National De La Santé Et De La Recherche Médicale Antibodies against PD-1 and antibodies against PD-L1 and uses thereof
WO2010102278A1 (en) 2009-03-06 2010-09-10 President And Fellows Of Harvard College Methods and compositions for the generation and maintenance of regulatory t cells
EP2408818A1 (en) 2009-03-17 2012-01-25 Université de la Méditerranée Btla antibodies and uses thereof
WO2011041613A2 (en) 2009-09-30 2011-04-07 Memorial Sloan-Kettering Cancer Center Combination immunotherapy for the treatment of cancer
JP2013512251A (en) 2009-11-24 2013-04-11 アンプリミューン、インコーポレーテッド Simultaneous inhibition of PD-L1 / PD-L2
WO2011100841A1 (en) 2010-02-16 2011-08-25 Valorisation-Recherche, Limited Partnership Pd-1 modulation and uses thereof for modulating hiv replication
US8993731B2 (en) 2010-03-11 2015-03-31 Ucb Biopharma Sprl PD-1 antibody
TW201134488A (en) * 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
JP2013532153A (en) 2010-06-18 2013-08-15 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Bispecific antibodies against TIM-3 and PD-1 for immunotherapy against chronic immune disease
KR101834026B1 (en) * 2010-06-19 2018-03-02 메모리얼 슬로안-케터링 캔서 센터 Anti-gd2 antibodies
US20120014947A1 (en) 2010-07-16 2012-01-19 The University Of Chicago Methods and compositions to reduce liver damage associated with conditions or therapies that affect the immune system
WO2012086346A1 (en) 2010-12-22 2012-06-28 国立大学法人 岡山大学 Diagnostic method for chronic inflammatory diseases using antibody against inhibitory co-stimulatory molecules as marker
WO2012113064A1 (en) 2011-02-25 2012-08-30 Bc Cancer Agency Branch Method of diagnosing primary mediastinal b-cell lymphoma or classical hodgkin lymphoma by detecting functional mutation at ciita locus.
HUE039209T2 (en) 2011-03-31 2018-12-28 Merck Sharp & Dohme Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments
KR101970025B1 (en) 2011-04-20 2019-04-17 메디뮨 엘엘씨 Antibodies and other molecules that bind b7-h1 and pd-1
US9580496B2 (en) * 2011-05-06 2017-02-28 Nexvet Australia Pty Ltd Therapeutic canine immunoglobulins and methods of using same
WO2012177624A2 (en) 2011-06-21 2012-12-27 The Johns Hopkins University Focused radiation for augmenting immune-based therapies against neoplasms
BR112014002353B1 (en) 2011-08-01 2022-09-27 Genentech, Inc USES OF PD-1 AXIS BINDING ANTAGONISTS AND MEK INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND KIT
ES2893855T3 (en) 2011-08-11 2022-02-10 Ono Pharmaceutical Co Therapeutic agent for autoimmune diseases comprising PD-1 agonist
WO2013043647A1 (en) 2011-09-19 2013-03-28 The Johns Hopkins University Cancer immunotherapy
US8956619B2 (en) 2011-10-25 2015-02-17 University Of Maryland, Baltimore County Soluble CD80 as a therapeutic to reverse immune supression in cancer patients
GB201120527D0 (en) 2011-11-29 2012-01-11 Ucl Business Plc Method
WO2013090552A1 (en) 2011-12-13 2013-06-20 Yale University Compositions and methods for reducing ctl exhaustion
US9863935B2 (en) 2012-05-08 2018-01-09 H. Lee Moffitt Cancer And Research Institute, Inc. Predictive biomarkers for CTLA-4 blockade therapy and for PD-1 blockade therapy
WO2013169693A1 (en) 2012-05-09 2013-11-14 Bristol-Myers Squibb Company Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
US9856320B2 (en) 2012-05-15 2018-01-02 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting PD-1/PD-L1 signaling
AU2013267267B2 (en) 2012-05-31 2017-10-26 Genentech, Inc. Methods of treating cancer using PD-L1 axis binding antagonists and VEGF antagonists
UY34887A (en) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES
AU2013315019B2 (en) 2012-09-17 2017-06-01 Galectin Therapeutics, Inc. Method for enhancing specific immunotherapies in cancer treatment
MX2015003643A (en) 2012-09-21 2016-04-06 Intensity Therapeutics Inc Method of treating cancer.
PL2904011T3 (en) 2012-10-02 2018-01-31 Bristol Myers Squibb Co Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
US20150273056A1 (en) 2012-10-12 2015-10-01 The Brigham And Women's Hospital, Inc. Enhancement of the immune response
CN104936621A (en) * 2012-11-07 2015-09-23 辉瑞公司 Anti-iL-13 receptor alpha 2 antibodies and antibody-drug conjugates
WO2014074852A1 (en) 2012-11-09 2014-05-15 President And Fellows Of Harvard College Compositions and methods for modulating an immune response
US20140147411A1 (en) 2012-11-14 2014-05-29 U.S. GOVERNMENT represented by the UNITED STATES DEPARTMENT OF VETERANS AFFAIRS Methods of treating cancer and testing mutation zygosity related thereto
US9550986B2 (en) * 2012-12-21 2017-01-24 Abbvie Inc. High-throughput antibody humanization
US20150344577A1 (en) 2013-01-11 2015-12-03 Dingfu Biotarget Co., Ltd Agents for treating tumors, use and method thereof
SG11201506052PA (en) 2013-02-22 2015-09-29 Curevac Gmbh Combination of vaccination and inhibition of the pd-1 pathway
MY180687A (en) 2013-03-14 2020-12-07 Icahn School Med Mount Sinai Newcastle disease viruses and uses thereof
SI2970473T1 (en) 2013-03-14 2017-10-30 Bristol-Myers Squibb Company Combination of dr5 agonist and anti-pd-1 antagonist and methods of use
DK2970486T3 (en) 2013-03-15 2018-08-06 Xencor Inc MODULATION OF T-CELLS WITH BISPECIFIC ANTIBODIES AND FC-FUSIONS
WO2014140240A1 (en) * 2013-03-15 2014-09-18 Novo Nordisk A/S Antibodies capable of specifically binding two epitopes on tissue factor pathway inhibitor
WO2014161509A1 (en) 2013-04-05 2014-10-09 The University Of Hong Kong Novel pd1 isoforms, and uses thereof for potentiating immune responses
CN111423511B (en) 2013-05-31 2024-02-23 索伦托药业有限公司 Antigen binding proteins that bind to PD-1
EP3003316B1 (en) 2013-05-31 2020-07-22 Merck Sharp & Dohme Corp. Combination therapies for cancer
RU2015154275A (en) 2013-06-03 2017-07-17 Новартис Аг COMBINATIONS OF ANTIBODY AGAINST PD-L1 AND MEK INHIBITOR AND / OR BRAF INHIBITOR
WO2014209804A1 (en) 2013-06-24 2014-12-31 Biomed Valley Discoveries, Inc. Bispecific antibodies
CN104250302B (en) 2013-06-26 2017-11-14 上海君实生物医药科技股份有限公司 The anti-antibody of PD 1 and its application
RU2016107426A (en) 2013-08-02 2017-09-07 Адуро Байотек Холдингс, Юроуп Б.В. COMBINING CD27 AGONISTS AND INHIBITING IMMUNE CONTROL POINTS TO STIMULATE IMMUNITY
US20160194369A1 (en) 2013-08-12 2016-07-07 Merck Sharp & Dohme Corp. Methods and compositions for co-expression of polypeptides of inerest and il6
AR097306A1 (en) 2013-08-20 2016-03-02 Merck Sharp & Dohme MODULATION OF TUMOR IMMUNITY
US20160200814A1 (en) 2013-08-22 2016-07-14 The Council Of The Queensland Institute Of Medical Research Immunoreceptor modulation for treating cancer and viral infections
US10966998B2 (en) 2013-09-05 2021-04-06 The Johns Hopkins University Cancer therapy via a combination of epigenetic modulation and immune modulation
US10077305B2 (en) 2013-09-10 2018-09-18 Medimmune Limited Antibodies against PD-1 and uses thereof
WO2015038538A1 (en) 2013-09-10 2015-03-19 Medimmune, Llc Compositions and methods for treating sepsis
MX2016003292A (en) 2013-09-13 2016-06-24 Beigene Ltd Anti-pd1 antibodies and their use as therapeutics and diagnostics.
ES2728578T3 (en) 2013-09-20 2019-10-25 Bristol Myers Squibb Co Combination of anti-LAG-3 antibodies and anti-PD-1 antibodies to treat tumors
US10350275B2 (en) 2013-09-21 2019-07-16 Advantagene, Inc. Methods of cytotoxic gene therapy to treat tumors
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
US10259875B2 (en) 2013-10-01 2019-04-16 Mayo Foundation For Medical Education And Research Methods for treating cancer in patients with elevated levels of BIM
CN104558177B (en) 2013-10-25 2020-02-18 苏州思坦维生物技术股份有限公司 Monoclonal antibody for antagonizing and inhibiting programmed death receptor PD-1and ligand combination thereof, and coding sequence and application thereof
WO2015069697A2 (en) 2013-11-05 2015-05-14 Nkt Therapeutics Inc. Combination therapy
KR20160070095A (en) 2013-11-05 2016-06-17 버베리안 노딕 에이/에스 Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist and/or agonist of an immune checkpoint inhibitor
EP3065772A4 (en) 2013-11-05 2017-09-13 Cognate Bioservices, Inc. Combinations of checkpoint inhibitors and therapeutics to treat cancer
US10081679B2 (en) 2013-11-25 2018-09-25 Ccam Biotherapeutics Ltd. Compositions comprising anti-CEACAM1 and anti-PD antibodies for cancer therapy
WO2015081158A1 (en) 2013-11-26 2015-06-04 Bristol-Myers Squibb Company Method of treating hiv by disrupting pd-1/pd-l1 signaling
US20160303231A1 (en) 2013-12-11 2016-10-20 Robert Iannone Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor
SI3081576T1 (en) 2013-12-12 2019-12-31 Shanghai Hengrui Pharmaceutical Co., Ltd., Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
EP3084001A4 (en) 2013-12-17 2017-07-12 Merck Sharp & Dohme Corp. Gene signature biomarkers of tumor response to pd-1 antagonists
EP3680254A1 (en) 2013-12-17 2020-07-15 F. Hoffmann-La Roche AG Methods of treating her2-positive cancers using pd-1 axis binding antagonists and anti-her2 antibodies
EP3084003A4 (en) 2013-12-17 2017-07-19 Merck Sharp & Dohme Corp. Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists
WO2015094996A2 (en) 2013-12-17 2015-06-25 Merck Sharp & Dohme Corp. Pd-l1 gene signature biomarkers of tumor response to pd-1 antagonists
WO2015095868A1 (en) 2013-12-20 2015-06-25 Wake Forest University Health Sciences Methods and compositions for increasing protective antibody levels induced by pneumococcal polysaccharide vaccines
CA2934073A1 (en) 2013-12-20 2015-06-25 The Broad Institute, Inc. Combination therapy with neoantigen vaccine
AU2014374055B2 (en) 2013-12-30 2018-11-08 Epimab Biotherapeutics Inc. Fabs-in-tandem immunoglobulin and uses thereof
CA2935804A1 (en) 2014-01-14 2015-07-23 Dana-Farber Cancer Institute, Inc. Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
TWI681969B (en) 2014-01-23 2020-01-11 美商再生元醫藥公司 Human antibodies to pd-1
JOP20200094A1 (en) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc Antibody molecules to pd-1 and uses thereof
US20170037125A1 (en) 2014-02-04 2017-02-09 Incyte Corporation Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer
EP3102605B1 (en) 2014-02-04 2018-11-14 Pfizer Inc Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer
ES2783026T3 (en) 2014-02-04 2020-09-16 Pfizer Combination of a PD-1 antagonist and a 4-1BB agonist for the treatment of cancer
US20170058045A1 (en) 2014-02-21 2017-03-02 Regeneron Pharmaceuticals, Inc. Methods, compositions and kits for cell specific modulation of target antigens
HUE053982T2 (en) 2014-02-21 2021-08-30 Nektar Therapeutics India Pvt Ltd Il-2rbeta-selective agonists in combination with an anti-ctla-4 antibody or an an anti-pd-1 antibody
AU2015222685A1 (en) 2014-02-27 2016-09-08 Viralytics Limited Combination method for treatment of cancer
EP3114144A1 (en) 2014-03-05 2017-01-11 Bristol-Myers Squibb Company Treatment of renal cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
NZ725006A (en) 2014-03-12 2019-11-29 Yeda Res & Dev Reducing systemic regulatory t cell levels or activity for treatment of disease and injury of the cns
CN113583129A (en) 2014-03-14 2021-11-02 诺华股份有限公司 Antibody molecules against LAG-3 and uses thereof
AU2015240884B2 (en) 2014-03-31 2020-06-18 Biomed Valley Discoveries, Inc. Use of bacteria, bacterial products, and other immunoregulatory entities in combination with anti-CTLA-4 and/or anti-PD-1 antibodies to treat solid tumor malignancies
CN104974253A (en) 2014-04-01 2015-10-14 上海中信国健药业股份有限公司 Anti-CTLA-4/PD-1 bispecific antibody as well as preparation method and application thereof
MX2016014753A (en) 2014-05-15 2017-03-06 Bristol Myers Squibb Co Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent.
CN105085680A (en) 2014-05-23 2015-11-25 复旦大学 Humanized anti-PD-1 and c-MET bispecific antibody, and preparation method and application thereof
US20160031990A1 (en) 2014-05-29 2016-02-04 Medlmmune, Llc Antagonists of pdl-1 and pd-1 for the treatment of hpv-negative cancers
WO2015190538A1 (en) 2014-06-11 2015-12-17 Ｉｄａｃセラノスティクス株式会社 Method for reducing side effects of immune checkpoint control agent
US20170106067A1 (en) 2014-06-12 2017-04-20 The Johns Hopkins University Combinatorial immunotherapy for pancreatic cancer treatment
US10092645B2 (en) 2014-06-17 2018-10-09 Medimmune Limited Methods of treatment with antagonists against PD-1 and PD-L1 in combination with radiation therapy
TWI693232B (en) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof
CA2958643A1 (en) 2014-07-07 2016-01-14 Dana Farber Cancer Institute, Inc. Methods of treating cancer
CA2955177A1 (en) 2014-07-15 2016-01-21 The Johns Hopkins University Suppression of myeloid derived suppressor cells and immune checkpoint blockade
PL3169341T3 (en) 2014-07-16 2019-12-31 Transgene Sa Oncolytic virus for expression of immune checkpoint modulators
SG10201913696YA (en) 2014-07-18 2020-03-30 Advaxis Inc Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer
KR102524920B1 (en) 2014-07-22 2023-04-25 아폴로믹스 인코포레이티드 Anti-pd-1 antibodies
EP3171896A4 (en) 2014-07-23 2018-03-21 Mayo Foundation for Medical Education and Research Targeting dna-pkcs and b7-h1 to treat cancer
WO2016014799A1 (en) 2014-07-23 2016-01-28 University Of Iowa Research Foundation Epidermal growth factor and blockade of immune checkpoints in cancer immunotherapy
CN105330740B (en) 2014-07-30 2018-08-17 珠海市丽珠单抗生物技术有限公司 Anti- PD-1 antibody and its application
US9539245B2 (en) 2014-08-07 2017-01-10 Aerpio Therapeutics, Inc. Combination of immunotherapies with activators of Tie-2
HRP20220738T1 (en) 2014-08-11 2022-08-19 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor
EP3180087B1 (en) 2014-08-12 2019-03-13 Alligator Bioscience AB Combination therapies with anti cd40 antibodies
US20170216403A1 (en) 2014-08-12 2017-08-03 Massachusetts Institute Of Technology Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
TN2017000024A1 (en) 2014-08-19 2018-07-04 Merck Sharp & Dohme Anti-tigit antibodies.
JP6629211B2 (en) 2014-08-19 2020-01-15 国立大学法人 岡山大学 Method for enhancing function of immune cell and method for evaluating multifunctionality of immune cell
JO3663B1 (en) 2014-08-19 2020-08-27 Merck Sharp & Dohme Anti-lag3 antibodies and antigen-binding fragments
EP3183269A2 (en) 2014-08-22 2017-06-28 Bristol-Myers Squibb Company Treatment of cancer using a combination of an anti-pd-1 antibody and an anti-cd137 antibody
CA2955676A1 (en) 2014-08-25 2016-03-03 Pfizer Inc. Combination of a pd-1 antagonist and an alk inhibitor for treating cancer
TR201907471T4 (en) 2014-08-28 2019-06-21 Halozyme Inc Combination therapy with a hyaluronan degrading enzyme and an immune checkpoint inhibitor.
JP2017526700A (en) 2014-09-08 2017-09-14 セルジーン コーポレイション Method for treating diseases or disorders using oral preparations of cytidine analogues in combination with anti-PD1 or anti-PDL1 monoclonal antibodies
WO2016040892A1 (en) 2014-09-13 2016-03-17 Novartis Ag Combination therapies
US20170275705A1 (en) 2014-09-15 2017-09-28 The Johns Hopkins University Biomarkers useful for determining response to pd-1 blockade therapy
WO2016041945A1 (en) 2014-09-16 2016-03-24 Innate Pharma Neutralization of inhibitory pathways in lymphocytes
EP3197495A4 (en) 2014-09-28 2018-08-29 The Regents of The University of California Modulation of stimulatory and non-stimulatory myeloid cells
AU2015327868A1 (en) 2014-10-03 2017-04-20 Novartis Ag Combination therapies
MA41044A (en) 2014-10-08 2017-08-15 Novartis Ag COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
AU2015332533B2 (en) 2014-10-14 2018-08-30 Halozyme, Inc. Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
GB201419084D0 (en) 2014-10-27 2014-12-10 Agency Science Tech & Res Anti-PD-1 antibodies
SG11201702723VA (en) 2014-10-29 2017-05-30 Five Prime Therapeutics Inc Combination therapy for cancer
WO2016070001A1 (en) 2014-10-31 2016-05-06 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
DK3212233T3 (en) 2014-10-31 2020-07-27 Oncomed Pharm Inc COMBINATION THERAPY FOR TREATMENT OF DISEASE
EP3215539A4 (en) 2014-11-06 2018-05-23 Children's Research Institute, Children's National Immunotherapeutics for cancer and autoimmune diseases
JP6755866B2 (en) 2014-11-10 2020-09-16 メディミューン リミテッド CD73-specific binding molecule and its use
US10822414B2 (en) 2014-11-11 2020-11-03 Sutro Biopharma, Inc. Anti-PD-1 antibodies, compositions comprising anti-PD-1 antibodies and methods of using anti-PD-1 antibodies
RU2017120063A (en) 2014-11-11 2018-12-13 Медиммьюн Лимитед THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF NEOPLASIA
KR20170080697A (en) 2014-11-13 2017-07-10 더 존스 홉킨스 유니버시티 Checkpoint blockade and microsatellite instability
AU2015350242A1 (en) 2014-11-17 2017-06-29 Genentech, Inc. Combination therapy comprising OX40 binding agonists and PD-1 axis binding antagonists
ES2835823T3 (en) 2014-11-20 2021-06-23 Hoffmann La Roche Combination of T-cell activating bispecific antigen-binding molecules for CD3 and folate receptor 1 (FolR1) and PD-1 axis-binding antagonists
MA40737A (en) 2014-11-21 2017-07-04 Memorial Sloan Kettering Cancer Center DETERMINANTS OF CANCER RESPONSE TO PD-1 BLOCKED IMMUNOTHERAPY
BR112017011536A2 (en) 2014-12-02 2018-02-27 Celgene Corp combination therapies
JP2017537927A (en) 2014-12-04 2017-12-21 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Combination of anti-CS1 and anti-PD1 antibodies to treat cancer (myeloma)
JP2017537929A (en) 2014-12-05 2017-12-21 ジェネンテック， インコーポレイテッド Methods and compositions for cancer treatment using PD-1 axis antagonists and HPK1 antagonists
WO2016094273A1 (en) 2014-12-08 2016-06-16 Dana-Farber Cancer Institute, Inc. Methods for upregulating immune responses using combinations of anti-rgmb and anti-pd-1 agents
SG11201704124YA (en) 2014-12-08 2017-06-29 1Globe Biomedical Co Ltd Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof
TWI595006B (en) 2014-12-09 2017-08-11 禮納特神經系統科學公司 Anti-pd-1 antibodies and methods of use thereof
KR20170086661A (en) 2014-12-09 2017-07-26 머크 샤프 앤드 돔 코포레이션 System and methods for deriving gene signature biomarkers of response to pd-1 antagonists
CA2969338A1 (en) 2014-12-16 2016-06-23 Bristol-Myers Squibb Company Use of immune checkpoint inhibitors in central nervous systems neoplasms
WO2016100882A1 (en) 2014-12-19 2016-06-23 Novartis Ag Combination therapies
EP3237446B1 (en) 2014-12-22 2021-05-05 PD-1 Acquisition Group, LLC Anti-pd-1 antibodies
TN2017000267A1 (en) 2014-12-23 2018-10-19 Bristol Myers Squibb Co Antibodies to tigit
PT3240801T (en) 2014-12-31 2021-02-18 Checkmate Pharmaceuticals Inc Combination tumor immunotherapy
GB201500319D0 (en) 2015-01-09 2015-02-25 Agency Science Tech & Res Anti-PD-L1 antibodies
GB201500374D0 (en) 2015-01-09 2015-02-25 Immutep S A Combined preparations for the treatment of cancer
CN107530423B (en) 2015-01-14 2022-04-05 布里格姆及妇女医院股份有限公司 Treatment of cancer with anti-LAP monoclonal antibodies
EP3244927A1 (en) 2015-01-16 2017-11-22 Vedantra Pharmaceuticals Inc. Multilamellar lipid vesicle compositions including a conjugated anaplastic lymphoma kinase (alk) variant and uses thereof
MA41414A (en) 2015-01-28 2017-12-05 Centre Nat Rech Scient ICOS AGONIST BINDING PROTEINS
CN105983097B (en) 2015-01-28 2021-06-08 华中科技大学同济医学院附属协和医院 Anti-tumor preparation and preparation method thereof
EP3253413A2 (en) 2015-02-06 2017-12-13 Kadmon Corporation, LLC Immunomodulatory agents
CN104987421A (en) 2015-05-13 2015-10-21 北京比洋生物技术有限公司 Anti-CTLA-4 and PD-1 dual variable domain immunoglobulin
CN106999591B (en) * 2015-09-28 2021-02-23 苏州盛迪亚生物医药有限公司 anti-PD-1 antibody preparation and application thereof in medicine
CN105175545B (en) 2015-10-20 2019-01-25 安徽瀚海博兴生物技术有限公司 A kind of anti-PD-1 bifunctional antibody of anti-vegf-and its application
CN105754990A (en) 2016-01-29 2016-07-13 深圳精准医疗科技有限公司 Preparation method and application of PD-1/CTLA-4 (programmed death-1/cytotoxic T lymphocyte antigen-4) bispecific antibody
TWI764943B (en) * 2016-10-10 2022-05-21 大陸商蘇州盛迪亞生物醫藥有限公司 Combination use of anti-pd-1 antibody and vegfr inhibitor in the preparation of a medicament for the treatment of cancer
CN109806393B (en) * 2017-11-17 2022-07-26 江苏恒瑞医药股份有限公司 Application of anti-PD-1 antibody, pemetrexed and platinum drugs in combined treatment of non-small cell lung cancer
EP3568415A4 (en) * 2018-02-06 2021-01-06 I-Mab Biopharma US Limited Antibodies to t cell immunoreceptor with ig and itim domains (tigit) and uses thereof

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