MX2017002134A - Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes. - Google Patents
Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes.Info
- Publication number
- MX2017002134A MX2017002134A MX2017002134A MX2017002134A MX2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A MX 2017002134 A MX2017002134 A MX 2017002134A
- Authority
- MX
- Mexico
- Prior art keywords
- multifunctionality
- immune cells
- immune cell
- biguanide
- buformin
- Prior art date
Links
- 210000002865 immune cell Anatomy 0.000 title abstract 10
- 230000003915 cell function Effects 0.000 title abstract 2
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 abstract 5
- 239000003814 drug Substances 0.000 abstract 5
- 229940123208 Biguanide Drugs 0.000 abstract 4
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 abstract 4
- 230000003178 anti-diabetic effect Effects 0.000 abstract 4
- 239000003472 antidiabetic agent Substances 0.000 abstract 4
- 229960004111 buformin Drugs 0.000 abstract 3
- XSEUMFJMFFMCIU-UHFFFAOYSA-N buformin Chemical compound CCCC\N=C(/N)N=C(N)N XSEUMFJMFFMCIU-UHFFFAOYSA-N 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 229960003105 metformin Drugs 0.000 abstract 3
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 3
- 229960003243 phenformin Drugs 0.000 abstract 3
- ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 abstract 3
- 230000036039 immunity Effects 0.000 abstract 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 abstract 1
- 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 108700012920 TNF Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000006870 function Effects 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
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- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
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- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
Abstract
La presente invención proporciona un método para mejorar la función de células inmunes al reactivar varias células ex vivo y proporciona células inmunes con función mejorada; la invención adicionalmente proporciona un método de evaluación de multifuncionalidad relacionado a células inmunes; un fármaco antidiabético de biguanida seleccionado de metformina, fenformína, y buformina es capaz de mejorar la multifuncionalidad de células inmunes al incrementar células TCD8+ que tienen una alta habilidad para producir IL-2, TNF-a, e IFN?; la multifuncionalidad de células inmunes puede ser evaluada al comparar células inmunes tratadas con un fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina, contra células inmunes control que no fueron tratadas con el fármaco antidiabético de biguanida; cuando la multifuncionalidad de células inmunes tratadas con el fármaco antidiabético de biguanida seleccionado de metformina, fenformina, y buformina se determina que es incrementada significativamente en comparación con el control, se puede evaluar que la sensibilidad de las células inmunes al agente terapéutico es mejorada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014166593 | 2014-08-19 | ||
JP2015085556 | 2015-04-20 | ||
PCT/JP2015/073011 WO2016027764A1 (ja) | 2014-08-19 | 2015-08-17 | 免疫細胞の機能増強方法及び免疫細胞の多機能性評価方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017002134A true MX2017002134A (es) | 2017-09-13 |
Family
ID=55350709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002134A MX2017002134A (es) | 2014-08-19 | 2015-08-17 | Agente para el tratamiento y/o prevencion de enfermedades asociadas con anormalidades inmunes. |
Country Status (15)
Country | Link |
---|---|
US (2) | US20170231929A1 (es) |
EP (2) | EP3192517A4 (es) |
JP (3) | JP6629211B2 (es) |
KR (1) | KR20170042778A (es) |
CN (1) | CN107148274A (es) |
AU (1) | AU2015304448B2 (es) |
BR (1) | BR112017002807A2 (es) |
CA (1) | CA2958573A1 (es) |
ES (1) | ES2915849T3 (es) |
IL (1) | IL250639B (es) |
MX (1) | MX2017002134A (es) |
PH (1) | PH12017500224A1 (es) |
RU (2) | RU2020127099A (es) |
SG (2) | SG10202005315SA (es) |
WO (1) | WO2016027764A1 (es) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2970873C (en) * | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
CR20160319A (es) | 2013-12-12 | 2016-11-08 | Jiangsu Hengrui Medicine Co | Anticuerpo pd-1, fragmento de union al antigeno de este y uso médico de este |
CN117586403A (zh) | 2016-10-11 | 2024-02-23 | 艾吉纳斯公司 | 抗lag-3抗体及其使用方法 |
CN107082812B (zh) | 2017-03-29 | 2018-11-13 | 上海科医联创生物科技有限公司 | 一种恢复衰竭性免疫细胞功能的融合蛋白及其应用 |
BR112019025478A8 (pt) * | 2017-06-02 | 2022-12-06 | Bayer Ag | Combinação de regorafenib e inibidores de pd-1/pd-l1(2) para tratamento de câncer |
JPWO2019069449A1 (ja) * | 2017-10-06 | 2019-11-14 | 純児 赤木 | 測定方法 |
JPWO2019124423A1 (ja) * | 2017-12-19 | 2020-10-22 | 国立大学法人 岡山大学 | がんの進行抑制、治療、予防及び/又は再発予防剤 |
JP2019112353A (ja) * | 2017-12-25 | 2019-07-11 | 合同会社チューモス | 自家腫瘍ワクチン及び免疫誘導方法 |
US11959916B2 (en) * | 2017-12-26 | 2024-04-16 | Tamio Yamauchi | Method, system, and program for supplying immunodynamics-related information |
IL264068B2 (en) * | 2018-01-05 | 2023-07-01 | Great Novel Therapeutics Biotech & Medicals Corp | Aggregate and pharmaceutical preparation containing an hdac inhibitor and an nsaid aggregate together with an immune checkpoint inhibitor for use in a method for removing immunosuppression in the microenvironment of a tumor or stimulating an immune system against cancer cells |
WO2019202473A1 (en) * | 2018-04-16 | 2019-10-24 | Université de Lausanne | Ucp2 inducing agents for the treatment of cancer resistant to immune checkpoint blockade |
US20220017969A1 (en) * | 2018-12-07 | 2022-01-20 | Arizona Board Of Regents On Behalf Of The University Of Arizona | A method of determining risk for skin cancer development and skin cancer therapeutic prevention by measuring pd-1/pd-l1 signaling pathway members |
KR102510381B1 (ko) * | 2019-10-16 | 2023-03-15 | 한국과학기술원 | 메트포민을 유효성분으로 포함하는 뇌암의 예방 또는 치료용 면역치료제 조성물 |
WO2022072745A1 (en) * | 2020-10-01 | 2022-04-07 | The Regents Of The University Of California | Methods and compositions to treat and prevent viral infections and acute respiratory distress syndrome |
CN112791182A (zh) * | 2020-12-31 | 2021-05-14 | 中山大学 | 二甲双胍和抗pd-1抗体药物组合物在制备肝癌药物中的应用 |
CN113421627B (zh) * | 2021-05-11 | 2023-04-07 | 深圳市罗湖区人民医院 | 体外评估药物对nk细胞抗衰作用的*** |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0624207B2 (ja) * | 1986-06-25 | 1994-03-30 | 新電元工業株式会社 | 高耐圧半導体装置の製造方法 |
US4938949A (en) * | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
US5260275A (en) * | 1990-08-14 | 1993-11-09 | Amylin Pharmaceuticals, Inc. | Hypoglycemics |
CA2174132A1 (en) * | 1993-10-14 | 1995-04-20 | Immunex Corporation | Fas antagonists and uses thereof |
JP2004505913A (ja) * | 2000-08-07 | 2004-02-26 | ランバクシー シグネチャー,エルエルシー | メトフォルミンの液体処方 |
EP3287144A1 (en) * | 2002-07-03 | 2018-02-28 | ONO Pharmaceutical Co., Ltd. | Immunopotentiating compositions |
CA2970873C (en) | 2005-05-09 | 2022-05-17 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
US8563500B2 (en) * | 2007-09-05 | 2013-10-22 | Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts | Methods and compounds for treating diseases caused by reactive oxygen species |
CA2772120A1 (en) | 2009-08-25 | 2011-03-17 | President And Fellows Of Harvard College | Use of metformin in cancer treatment and prevention |
US20130059916A1 (en) * | 2010-05-26 | 2013-03-07 | Stephane Rocchi | Biguanide compounds and its use for treating cancer |
BR112013017499A2 (pt) * | 2011-01-11 | 2016-09-27 | Univ Basel | combinação de sirosingopina e inibidores mitocondriais para o tratamento de câncer e imunossupressão |
WO2013009535A1 (en) * | 2011-07-08 | 2013-01-17 | Merck Sharp & Dohme Corp. | Il-23 antagonists for treatment or prevention of skin rash associated with treatment with p13k/akt pathway inhibitors |
CN103371991A (zh) * | 2012-04-18 | 2013-10-30 | 中国人民解放军第二军医大学 | 二甲双胍在制备预防或治疗肝细胞癌药物中的应用 |
PL2872646T3 (pl) * | 2012-07-12 | 2018-03-30 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Sposoby przewidywania czasu przeżycia i responsywności na leczenie pacjenta cierpiącego na nowotwór lity z sygnaturą przynajmniej 7 genów |
EP3470531A1 (en) * | 2012-08-06 | 2019-04-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and kits for screening patients with a cancer |
RS56624B1 (sr) * | 2012-10-02 | 2018-03-30 | Bristol Myers Squibb Co | Kombinacija anti-kir antitela i anti-pd-1 antitela u lečenju kancera |
WO2014083095A1 (en) * | 2012-11-29 | 2014-06-05 | Universitaet Basel | Combinations of metformin with other compounds for the treatment of cancer and for immunosuppression |
JP6125041B2 (ja) * | 2013-01-02 | 2017-05-10 | デコイ バイオシステムズ インコーポレイテッドDecoy Biosystems, Inc. | 細菌を用いた癌治療用組成物およびその製造のための菌の使用 |
JP6242071B2 (ja) * | 2013-04-23 | 2017-12-06 | 国立大学法人 岡山大学 | 免疫疲弊cd8+t細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬 |
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AU2015304448A1 (en) | 2017-03-09 |
JPWO2016027764A1 (ja) | 2017-06-01 |
WO2016027764A1 (ja) | 2016-02-25 |
RU2017108754A (ru) | 2018-09-20 |
ES2915849T3 (es) | 2022-06-27 |
RU2017108754A3 (es) | 2019-03-29 |
RU2020127099A (ru) | 2020-09-02 |
EP3232199B1 (en) | 2022-05-04 |
JP2020109098A (ja) | 2020-07-16 |
CN107148274A (zh) | 2017-09-08 |
JP6629211B2 (ja) | 2020-01-15 |
JP2017165752A (ja) | 2017-09-21 |
PH12017500224B1 (en) | 2017-07-10 |
JP6672217B2 (ja) | 2020-03-25 |
US20170231929A1 (en) | 2017-08-17 |
SG10202005315SA (en) | 2020-07-29 |
PH12017500224A1 (en) | 2017-07-10 |
RU2731098C2 (ru) | 2020-08-28 |
EP3232199A8 (en) | 2017-12-13 |
IL250639B (en) | 2020-02-27 |
AU2015304448B2 (en) | 2020-04-30 |
US20170281569A1 (en) | 2017-10-05 |
KR20170042778A (ko) | 2017-04-19 |
EP3192517A1 (en) | 2017-07-19 |
EP3232199A3 (en) | 2018-02-14 |
BR112017002807A2 (pt) | 2017-12-19 |
EP3192517A4 (en) | 2018-04-25 |
CA2958573A1 (en) | 2016-02-25 |
EP3232199A2 (en) | 2017-10-18 |
IL250639A0 (en) | 2017-04-30 |
SG11201700978SA (en) | 2017-03-30 |
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