EA201690618A1 - Ингибиторы тирозинкиназы брутона - Google Patents

Ингибиторы тирозинкиназы брутона

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Publication number
EA201690618A1
EA201690618A1 EA201690618A EA201690618A EA201690618A1 EA 201690618 A1 EA201690618 A1 EA 201690618A1 EA 201690618 A EA201690618 A EA 201690618A EA 201690618 A EA201690618 A EA 201690618A EA 201690618 A1 EA201690618 A1 EA 201690618A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
btk
conditions
compounds
bluton
Prior art date
Application number
EA201690618A
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English (en)
Inventor
Лунчэн Ван
Вэй Чэнь
Чжаочжун Дж. Цзя
Дэвид Дж. Лоури
Original Assignee
Фармасайкликс Элэлси
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Application filed by Фармасайкликс Элэлси filed Critical Фармасайкликс Элэлси
Publication of EA201690618A1 publication Critical patent/EA201690618A1/ru

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Abstract

Описанные в данном документе соединения, представляют собой соединения, которые образуют ковалентные связи с тирозинкиназой Брутона (Btk). Также описанны необратимые ингибиторы Btk. Кроме того, также описаны обратимые ингибиторы Btk. Также описанны фармацевтические композиции, которые включают соединения. Описаны способы использования ингибиторов Btk, отдельно или в комбинации с другими лекарственными средствами, для лечения аутоиммунных заболеваний или состояний, гетероиммунных заболеваний или состояний, рака, включая лимфому, и воспалительных заболеваний или состояний.
EA201690618A 2013-09-30 2014-09-29 Ингибиторы тирозинкиназы брутона EA201690618A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361884888P 2013-09-30 2013-09-30
PCT/US2014/058132 WO2015048689A1 (en) 2013-09-30 2014-09-29 Inhibitors of bruton's tyrosine kinase

Publications (1)

Publication Number Publication Date
EA201690618A1 true EA201690618A1 (ru) 2016-09-30

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EA201690618A EA201690618A1 (ru) 2013-09-30 2014-09-29 Ингибиторы тирозинкиназы брутона

Country Status (20)

Country Link
US (2) US9624224B2 (ru)
EP (1) EP3052486A1 (ru)
JP (1) JP2016531941A (ru)
KR (1) KR20160062103A (ru)
CN (1) CN105764896A (ru)
AR (1) AR097862A1 (ru)
AU (1) AU2014324532A1 (ru)
BR (1) BR112016006978A2 (ru)
CA (1) CA2925124A1 (ru)
CR (1) CR20160203A (ru)
DO (1) DOP2016000071A (ru)
EA (1) EA201690618A1 (ru)
IL (1) IL244492A0 (ru)
MA (1) MA38961A1 (ru)
PE (1) PE20160560A1 (ru)
PH (1) PH12016500575A1 (ru)
SG (1) SG11201602421VA (ru)
TN (1) TN2016000094A1 (ru)
TW (1) TW201546061A (ru)
WO (1) WO2015048689A1 (ru)

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