MX2012007507A - Compuestos de heteroarilo y usos de los mismos. - Google Patents

Compuestos de heteroarilo y usos de los mismos.

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Publication number
MX2012007507A
MX2012007507A MX2012007507A MX2012007507A MX2012007507A MX 2012007507 A MX2012007507 A MX 2012007507A MX 2012007507 A MX2012007507 A MX 2012007507A MX 2012007507 A MX2012007507 A MX 2012007507A MX 2012007507 A MX2012007507 A MX 2012007507A
Authority
MX
Mexico
Prior art keywords
heteroaryl compounds
compounds
methods
pharmaceutically acceptable
heteroaryl
Prior art date
Application number
MX2012007507A
Other languages
English (en)
Inventor
Arthur F Kluge
Deqiang Niu
Juswinder Singh
Hormoz Mazdiyasni
Lixin Qiao
Russell Petter
Richland Wayne Tester
William Frederick Westlin Iii
Original Assignee
Avila Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avila Therapeutics Inc filed Critical Avila Therapeutics Inc
Publication of MX2012007507A publication Critical patent/MX2012007507A/es

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

La presente invención se refiere a inhibidores de proteína cinasas de las fórmulas I-a e I-b, composiciones farmacéuticamente aceptables de los mismos, y método para usar los mismos.
MX2012007507A 2009-12-29 2010-12-29 Compuestos de heteroarilo y usos de los mismos. MX2012007507A (es)

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RU2636584C2 (ru) 2017-11-24
BR112012018345A2 (pt) 2018-07-10
RU2012123546A (ru) 2014-02-10
MX341825B (es) 2016-09-05
US8710222B2 (en) 2014-04-29
IL235621A0 (en) 2014-12-31
NZ700236A (en) 2016-06-24
WO2011090760A1 (en) 2011-07-28
US10596172B2 (en) 2020-03-24
KR20120118020A (ko) 2012-10-25
CA2783624A1 (en) 2011-07-28
EP2519235A1 (en) 2012-11-07
US9409921B2 (en) 2016-08-09
CN102740847B (zh) 2016-06-29
NZ600631A (en) 2014-10-31
US10010548B2 (en) 2018-07-03
TW201124399A (en) 2011-07-16
IL220155A0 (en) 2012-07-31
EP2519235B1 (en) 2018-11-21
JP2013515786A (ja) 2013-05-09
US8338439B2 (en) 2012-12-25
US20170100397A1 (en) 2017-04-13
KR101747159B1 (ko) 2017-06-15
AU2010343055A1 (en) 2012-06-21
TWI592405B (zh) 2017-07-21
JP2016117749A (ja) 2016-06-30
US20100249092A1 (en) 2010-09-30
WO2011090760A4 (en) 2011-09-29
CN102740847A (zh) 2012-10-17
CN106146407A (zh) 2016-11-23
EP2519235A4 (en) 2013-07-31
US20130065899A1 (en) 2013-03-14
AU2010343055B2 (en) 2016-11-10
AU2017200697A1 (en) 2017-02-23
US20140213574A1 (en) 2014-07-31
JP5879270B2 (ja) 2016-03-08
CA2783624C (en) 2019-08-20
SG181962A1 (en) 2012-08-30
US20190192512A1 (en) 2019-06-27

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