MX2009010045A - Compuestos quimicos. - Google Patents
Compuestos quimicos.Info
- Publication number
- MX2009010045A MX2009010045A MX2009010045A MX2009010045A MX2009010045A MX 2009010045 A MX2009010045 A MX 2009010045A MX 2009010045 A MX2009010045 A MX 2009010045A MX 2009010045 A MX2009010045 A MX 2009010045A MX 2009010045 A MX2009010045 A MX 2009010045A
- Authority
- MX
- Mexico
- Prior art keywords
- chemical compounds
- compositions
- medicaments
- compounds
- dianilinopyrimidine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
La presente invención se refiere a derivados de dianilinopirimidina, a composiciones y medicamentos que los contienen, así como también a procesos para la preparación y uso de estos compuestos, composiciones y medicamentos. Estos derivados de dianilinopirimidina son útiles en el tratamiento de enfermedades asociadas con la actividad inapropiada de quinasa Wee1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89589307P | 2007-03-20 | 2007-03-20 | |
PCT/US2008/056591 WO2008115738A1 (en) | 2007-03-20 | 2008-03-12 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009010045A true MX2009010045A (es) | 2009-12-04 |
Family
ID=39766347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009010045A MX2009010045A (es) | 2007-03-20 | 2008-03-12 | Compuestos quimicos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20100105674A1 (es) |
EP (1) | EP2136635A4 (es) |
JP (1) | JP2010522186A (es) |
KR (1) | KR20090122300A (es) |
CN (1) | CN101677554A (es) |
AU (1) | AU2008229147A1 (es) |
BR (1) | BRPI0809188A2 (es) |
CA (1) | CA2681248A1 (es) |
EA (1) | EA200901138A1 (es) |
MX (1) | MX2009010045A (es) |
WO (1) | WO2008115738A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR065015A1 (es) * | 2007-01-26 | 2009-05-13 | Smithkline Beecham Corp | Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer |
KR101956261B1 (ko) | 2008-05-21 | 2019-03-08 | 어리어드 파마슈티칼스, 인코포레이티드 | 키나아제 억제제로서 포스포러스 유도체 |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
KR101892989B1 (ko) | 2008-06-27 | 2018-08-30 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
JP2012501980A (ja) * | 2008-09-03 | 2012-01-26 | バイエル・クロップサイエンス・アーゲー | アルコキシ置換およびアルキルチオ置換アニリノピリミジン |
US9908884B2 (en) | 2009-05-05 | 2018-03-06 | Dana-Farber Cancer Institute, Inc. | EGFR inhibitors and methods of treating disorders |
JP6068340B2 (ja) | 2010-08-10 | 2017-01-25 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | Btk阻害剤のベシル酸塩 |
JP5956999B2 (ja) | 2010-11-01 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | ヘテロアリール化合物およびその使用 |
EP2635284B1 (en) | 2010-11-01 | 2019-12-18 | Celgene CAR LLC | Heterocyclic compounds and uses thereof |
JP5957003B2 (ja) | 2010-11-10 | 2016-07-27 | セルジーン アヴィロミクス リサーチ, インコーポレイテッド | 変異体選択的egfr阻害剤およびその使用 |
BR112013011918A2 (pt) | 2010-11-16 | 2020-08-25 | Array Biopharma, Inc | inibidor de chk1, composição farmacêutica e kit compreendendo o referido inibidor |
JP5999177B2 (ja) | 2011-05-04 | 2016-09-28 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Egfr発動性がんの細胞増殖阻害用化合物 |
TW201325593A (zh) | 2011-10-28 | 2013-07-01 | Celgene Avilomics Res Inc | 治療布魯頓(bruton’s)酪胺酸激酶疾病或病症之方法 |
CA2866857C (en) | 2012-03-15 | 2021-03-09 | Celgene Avilomics Research, Inc. | Salts of an epidermal growth factor receptor kinase inhibitor |
KR102081042B1 (ko) | 2012-03-15 | 2020-02-26 | 셀젠 카르 엘엘씨 | 상피 성장 인자 수용체 키나제 억제제의 고체 형태 |
WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
EP2935226A4 (en) | 2012-12-21 | 2016-11-02 | Celgene Avilomics Res Inc | HETEROARYL COMPOUNDS AND USES THEREOF |
TW201446745A (zh) | 2013-02-08 | 2014-12-16 | Celgene Avilomics Res Inc | Erk抑制劑及其用途 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
WO2016025561A1 (en) | 2014-08-13 | 2016-02-18 | Celgene Avilomics Research, Inc. | Forms and compositions of an erk inhibitor |
CN108047204A (zh) * | 2018-01-08 | 2018-05-18 | 沈阳药科大学 | 2,4-二芳氨基嘧啶衍生物及其制备方法和应用 |
MX2021015572A (es) | 2019-06-28 | 2022-04-06 | Shanghai Pharmaceuticals Holding Co Ltd | Compuesto de pirazolopirimidina, método de preparación para el mismo y sus aplicaciones. |
CN112142748B (zh) | 2019-06-28 | 2023-07-04 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9325217D0 (en) * | 1993-12-09 | 1994-02-09 | Zeneca Ltd | Pyrimidine derivatives |
GB0004887D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
US7176312B2 (en) * | 2001-10-12 | 2007-02-13 | The Scripps Research Institute | Kinase inhibitor scaffolds and methods for their preparation |
NZ539823A (en) * | 2002-11-28 | 2008-04-30 | Schering Aktiengessellschaft | Chk-, Pdk- and Akt-inhibitory pyrimidines, their production and use as pharmaceutical agents |
-
2008
- 2008-03-12 CA CA002681248A patent/CA2681248A1/en not_active Abandoned
- 2008-03-12 EA EA200901138A patent/EA200901138A1/ru unknown
- 2008-03-12 JP JP2009554639A patent/JP2010522186A/ja active Pending
- 2008-03-12 EP EP08743783A patent/EP2136635A4/en not_active Withdrawn
- 2008-03-12 WO PCT/US2008/056591 patent/WO2008115738A1/en active Application Filing
- 2008-03-12 KR KR1020097021776A patent/KR20090122300A/ko not_active Application Discontinuation
- 2008-03-12 BR BRPI0809188-9A patent/BRPI0809188A2/pt not_active Application Discontinuation
- 2008-03-12 AU AU2008229147A patent/AU2008229147A1/en not_active Abandoned
- 2008-03-12 CN CN200880014765A patent/CN101677554A/zh active Pending
- 2008-03-12 US US12/531,763 patent/US20100105674A1/en not_active Abandoned
- 2008-03-12 MX MX2009010045A patent/MX2009010045A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP2136635A4 (en) | 2011-07-27 |
JP2010522186A (ja) | 2010-07-01 |
EA200901138A1 (ru) | 2010-04-30 |
EP2136635A1 (en) | 2009-12-30 |
BRPI0809188A2 (pt) | 2014-09-16 |
CA2681248A1 (en) | 2008-09-25 |
WO2008115738A1 (en) | 2008-09-25 |
US20100105674A1 (en) | 2010-04-29 |
AU2008229147A1 (en) | 2008-09-25 |
KR20090122300A (ko) | 2009-11-26 |
CN101677554A (zh) | 2010-03-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |