CN110305140B - 二氢吡咯并嘧啶类选择性jak2抑制剂 - Google Patents
二氢吡咯并嘧啶类选择性jak2抑制剂 Download PDFInfo
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- CN110305140B CN110305140B CN201910698079.2A CN201910698079A CN110305140B CN 110305140 B CN110305140 B CN 110305140B CN 201910698079 A CN201910698079 A CN 201910698079A CN 110305140 B CN110305140 B CN 110305140B
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Abstract
Description
Claims (8)
Priority Applications (8)
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CN201910698079.2A CN110305140B (zh) | 2019-07-30 | 2019-07-30 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
AU2019459552A AU2019459552A1 (en) | 2019-07-30 | 2019-12-23 | Dihydro-pyrrolo-pyrimidine selective JAK2 inhibitor |
JP2021578190A JP7335644B2 (ja) | 2019-07-30 | 2019-12-23 | ジヒドロピロロピリミジン系選択性jak2阻害剤またはその薬理学的に許容される塩、その製造方法、医薬品、および、組成物 |
EP19939211.9A EP4006031A4 (en) | 2019-07-30 | 2019-12-23 | DIHYDRO-PYRROLO-PYRIMIDINE SELECTIVE JAK2 INHIBITOR |
CA3153437A CA3153437A1 (en) | 2019-07-30 | 2019-12-23 | Selective dihydropyrrolopyrimidine jak2 inhibitors |
PCT/CN2019/127676 WO2021017384A1 (zh) | 2019-07-30 | 2019-12-23 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
GB2204901.9A GB2603386B (en) | 2019-07-30 | 2019-12-23 | Selective dihydropyrrolopyrimidine JAK2 inhibitors |
US17/581,178 US20220144844A1 (en) | 2019-07-30 | 2022-01-21 | Selective dihydropyrrolopyrimidine jak2 inhibitors |
Applications Claiming Priority (1)
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CN201910698079.2A CN110305140B (zh) | 2019-07-30 | 2019-07-30 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
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CN110305140A CN110305140A (zh) | 2019-10-08 |
CN110305140B true CN110305140B (zh) | 2020-08-04 |
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EP (1) | EP4006031A4 (zh) |
JP (1) | JP7335644B2 (zh) |
CN (1) | CN110305140B (zh) |
AU (1) | AU2019459552A1 (zh) |
CA (1) | CA3153437A1 (zh) |
GB (1) | GB2603386B (zh) |
WO (1) | WO2021017384A1 (zh) |
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SG10201706752XA (en) * | 2017-08-17 | 2019-03-28 | Iko Pte Ltd | Systems and methods for analyzing cutaneous conditions |
CN110305140B (zh) * | 2019-07-30 | 2020-08-04 | 上海勋和医药科技有限公司 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
CN113402499B (zh) * | 2021-06-21 | 2022-05-13 | 上海勋和医药科技有限公司 | 一种亚磺酰亚胺取代的吲唑类irak4激酶抑制剂、制备方法及用途 |
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UA109411C2 (uk) * | 2005-11-01 | 2015-08-25 | N-трет-бутил-3-(2-хлор-5-метилпіримідин-4-іламіно)бензолсульфонамід та його застосування в способі одержання сполуки | |
CN103214484B (zh) | 2005-12-13 | 2016-07-06 | 因塞特控股公司 | 作为两面神激酶抑制剂的杂芳基取代的吡咯并[2,3-b]吡啶和吡咯并[2,3-b]嘧啶 |
CN101421250A (zh) | 2006-01-30 | 2009-04-29 | 埃克塞里艾克西斯公司 | 作为jak-2调节剂的4-芳基-2-氨基-嘧啶或4-芳基-2-氨基烷基-嘧啶及包含它们的药物组合物 |
TWI398252B (zh) * | 2006-05-26 | 2013-06-11 | Novartis Ag | 吡咯并嘧啶化合物及其用途 |
WO2009098236A1 (en) * | 2008-02-06 | 2009-08-13 | Novartis Ag | Pyrrolo [2, 3-d] pyridines and use thereof as tyrosine kinase inhibitors |
US8338439B2 (en) * | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
CA2732791A1 (en) * | 2008-08-05 | 2010-02-11 | Targegen, Inc. | Methods of treating thalassemia |
PA8851101A1 (es) | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
CA2869954C (en) * | 2012-04-20 | 2023-01-03 | Advinus Therapeutics Limited | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof in medical conditions related to modulation of bruton's tyrosine kinase activity |
AU2013344049B2 (en) * | 2012-11-06 | 2017-12-21 | Fochon Pharmaceuticals, Ltd. | ALK kinase inhibitors |
EP2947084B8 (en) * | 2013-01-18 | 2021-03-10 | Guangzhou Maxinovel Pharmaceuticals Co. | Five-and-six-membered heterocyclic compound, and preparation method, pharmaceutical composition and use thereof |
WO2015038417A1 (en) * | 2013-09-10 | 2015-03-19 | Asana Biosciences, Llc | Compounds for regulating fak and/or src pathways |
CN104860921A (zh) * | 2014-02-24 | 2015-08-26 | 宁波文达医药科技有限公司 | 作为t790变异抑制剂的嘧啶衍生物 |
CN104860922A (zh) * | 2014-02-24 | 2015-08-26 | 宁波文达医药科技有限公司 | 作为间变性淋巴瘤激酶抑制剂的嘧啶衍生物 |
CN106432246B (zh) * | 2015-08-05 | 2020-07-07 | 广东东阳光药业有限公司 | 杂芳化合物及其在药物中的应用 |
WO2017076990A1 (en) * | 2015-11-05 | 2017-05-11 | Almirall, S.A. | Addition salts of n-[4-(4-{[(1s)-1-(5-methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7h-pyrrolo[2,3-d]pyrimidin-5-yl)-1h-indol-6-yl]sulfamide |
CN106831779B (zh) * | 2015-11-28 | 2019-07-19 | 南昌弘益药业有限公司 | 一类jak激酶抑制剂的新化合物 |
DK3439667T3 (da) * | 2016-04-05 | 2024-04-02 | Immune Sensor Llc | Cgas antagonist forbindelser |
WO2018007331A1 (en) * | 2016-07-08 | 2018-01-11 | F. Hoffmann-La Roche Ag | Fused pyrimidine derivatives |
EP3548496A4 (en) * | 2016-12-01 | 2020-05-13 | Aptose Biosciences Inc. | PYRIMIDINE COMPOUNDS FUSED AS DUAL INHIBITORS OF BRD4 AND JAK2 AND METHODS OF USE THEREOF |
CN110305140B (zh) * | 2019-07-30 | 2020-08-04 | 上海勋和医药科技有限公司 | 二氢吡咯并嘧啶类选择性jak2抑制剂 |
-
2019
- 2019-07-30 CN CN201910698079.2A patent/CN110305140B/zh active Active
- 2019-12-23 WO PCT/CN2019/127676 patent/WO2021017384A1/zh unknown
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2022
- 2022-01-21 US US17/581,178 patent/US20220144844A1/en active Pending
Non-Patent Citations (1)
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Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors;Jason D. Katz et al.;《Bioorganic & Medicinal Chemistry Letters》;20161022;第27卷;第114-120页 * |
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EP4006031A4 (en) | 2023-07-26 |
JP2022540073A (ja) | 2022-09-14 |
GB202204901D0 (en) | 2022-05-18 |
GB2603386B (en) | 2023-07-26 |
CN110305140A (zh) | 2019-10-08 |
AU2019459552A1 (en) | 2022-06-30 |
WO2021017384A1 (zh) | 2021-02-04 |
GB2603386A (en) | 2022-08-03 |
JP7335644B2 (ja) | 2023-08-30 |
US20220144844A1 (en) | 2022-05-12 |
EP4006031A1 (en) | 2022-06-01 |
CA3153437A1 (en) | 2021-02-04 |
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Effective date of registration: 20240321 Address after: No. 2004, 20th Floor, Building 1, No. 333, North Section of Yizhou Avenue, High-tech Zone, Chengdu, Sichuan, 610000 Patentee after: Chengdu Jinrui Jiye Bio-Technology Co.,Ltd. Country or region after: Zhong Guo Address before: 200000 room 216, building 2, No. 1366, Qishen Road, Minhang District, Shanghai Patentee before: Shanghai Xunhe Pharmaceutical Technology Co.,Ltd. Country or region before: Zhong Guo |