KR20080023270A - Vegf 억제제로서의 퀴나졸린 유도체 - Google Patents
Vegf 억제제로서의 퀴나졸린 유도체 Download PDFInfo
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- KR20080023270A KR20080023270A KR1020087004070A KR20087004070A KR20080023270A KR 20080023270 A KR20080023270 A KR 20080023270A KR 1020087004070 A KR1020087004070 A KR 1020087004070A KR 20087004070 A KR20087004070 A KR 20087004070A KR 20080023270 A KR20080023270 A KR 20080023270A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Abstract
Description
Claims (1)
- (a) 하기 화학식 III의 화합물과 하기 화학식 IV의 화합물과의 반응화학식 III[상기 식 중, R2 및 X1은 하기 화학식 I에서 정의한 바와 같고, L1은 치환 가능한 부위임]화학식 IV[상기 식 중, R1과 m은 하기 화학식 I에서 정의한 바와 같음]; 또는(b) 하기 화학식 V의 화합물과 하기 화학식 VI의 화합물과의 반응화학식 V[상기 식 중, m, X1 및 R1은 하기 화학식 I에서 정의한 바와 같음]화학식 VIR2-L1[상기 식 중, R2는 하기 화학식 I에서 정의한 바와 같고, L1은 상기 정의한 바와 같음]; 또는(c) 하기 화학식 VII의 화합물과 하기 화학식 VIII의 화합물과의 반응화학식 VII화학식 VIIIR2-X1-H[상기 식 중, R1, R2, m 및 X1은 하기 화학식 I에서 정의한 바와 같고, L1은 상기 정의한 바와 같음]; 또는(d) 하기 화학식 IX의 화합물의 탈보호 반응화학식 IX[상기 식 중, R1, m 및 X1은 하기 화학식 I에서 정의한 바와 같고, R4는 보호된 R2기를 나타내며, 여기서 R2는 하기 화학식 I에서 정의한 바와 같지만, 추가로 하나의 보호기 P2를 함유함]; 및화학식 I의 퀴나졸린 유도체의 약학적으로 허용 가능한 염이 필요한 경우, 얻어진 화합물을 반응시켜서 필요한 약학적으로 허용 가능한 염을 얻는 반응을 포함하여, 하기 화학식 I의 퀴나졸린 유도체 또는 이것의 염을 제조하는 방법.화학식 I상기 식 중,m은 1 내지 3의 정수이고,R1은 할로게노 또는 (C1-C3)알킬을 나타내며,X1은 -O-를 나타내고,R2는 하기 열거한 3가지 기, 즉(1) (C1-C5)알킬R3(여기서, R3은 히드록시, 할로게노, (C1-C4)알킬, (C1-C4)히드록시알킬 및 (C1-C4)알콕시 중에서 선택된 1개 또는 2개의 치환체를 함유할 수 있는 피페리딘-4-일임),(2) (C2-C5)알케닐R3(여기서, R3은 상기 정의한 바와 같음), 및(3) (C2-C5)알키닐R3(여기서, R3은 상기 정의한 바와 같음)중 하나로부터 선택되며,여기서 알킬기, 알케닐기 또는 알키닐기는 히드록시, 할로게노 및 아미노 중에서 선택된 하나의 치환체를 함유할 수 있다.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99402759.7 | 1999-11-05 | ||
EP99402759 | 1999-11-05 | ||
EP99402877.7 | 1999-11-19 | ||
EP99402877 | 1999-11-19 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027005814A Division KR100849151B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20080023270A true KR20080023270A (ko) | 2008-03-12 |
KR100881105B1 KR100881105B1 (ko) | 2009-02-02 |
Family
ID=26153696
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027005814A KR100849151B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
KR1020077022543A KR100881104B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
KR1020087004070A KR100881105B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020027005814A KR100849151B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
KR1020077022543A KR100881104B1 (ko) | 1999-11-05 | 2000-11-01 | Vegf 억제제로서의 퀴나졸린 유도체 |
Country Status (36)
Country | Link |
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US (9) | US7173038B1 (ko) |
EP (2) | EP1244647B1 (ko) |
JP (1) | JP3522727B2 (ko) |
KR (3) | KR100849151B1 (ko) |
CN (2) | CN100376567C (ko) |
AR (1) | AR033499A1 (ko) |
AT (2) | ATE398120T1 (ko) |
AU (1) | AU769222B2 (ko) |
BE (1) | BE2012C036I2 (ko) |
BG (1) | BG65861B1 (ko) |
BR (2) | BR0015203A (ko) |
CA (1) | CA2389767C (ko) |
CY (3) | CY1106166T1 (ko) |
CZ (1) | CZ301689B6 (ko) |
DE (2) | DE60039206D1 (ko) |
DK (2) | DK1676845T3 (ko) |
EE (1) | EE05330B1 (ko) |
ES (2) | ES2265998T3 (ko) |
FR (1) | FR12C0048I2 (ko) |
HK (2) | HK1049664B (ko) |
HU (1) | HU229414B1 (ko) |
IL (2) | IL149034A0 (ko) |
IS (2) | IS2284B (ko) |
LU (1) | LU92057I2 (ko) |
MX (1) | MXPA02004366A (ko) |
NO (2) | NO322298B1 (ko) |
NZ (1) | NZ518028A (ko) |
PL (1) | PL203782B1 (ko) |
PT (2) | PT1676845E (ko) |
RU (1) | RU2291868C2 (ko) |
SI (2) | SI1676845T1 (ko) |
SK (1) | SK287401B6 (ko) |
TW (1) | TWI287540B (ko) |
UA (1) | UA72946C2 (ko) |
WO (1) | WO2001032651A1 (ko) |
ZA (1) | ZA200202775B (ko) |
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2007
- 2007-09-04 IS IS8673A patent/IS2556B/is unknown
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2008
- 2008-08-12 CY CY20081100853T patent/CY1108256T1/el unknown
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2010
- 2010-04-15 US US12/761,105 patent/US8642608B2/en not_active Expired - Lifetime
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2012
- 2012-08-07 NO NO2012014C patent/NO2012014I1/no unknown
- 2012-08-07 LU LU92057C patent/LU92057I2/fr unknown
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2014
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2015
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2017
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2019
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