CY1106166T1 - Παραγωγα κουιναζολινης ως αναστολεις vegf. - Google Patents

Παραγωγα κουιναζολινης ως αναστολεις vegf.

Info

Publication number
CY1106166T1
CY1106166T1 CY20061101355T CY061101355T CY1106166T1 CY 1106166 T1 CY1106166 T1 CY 1106166T1 CY 20061101355 T CY20061101355 T CY 20061101355T CY 061101355 T CY061101355 T CY 061101355T CY 1106166 T1 CY1106166 T1 CY 1106166T1
Authority
CY
Cyprus
Prior art keywords
formula
halogen
quinazoline derivatives
bear
alkenyl
Prior art date
Application number
CY20061101355T
Other languages
English (en)
Inventor
Laurent Francois Andre Hennequin
Elaine Sophie Elizabeth Stokes
Andrew Peter Thomas
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26153696&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106166(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1106166T1 publication Critical patent/CY1106166T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Abstract

Η εφεύρεση αναφέρεται σε παράγωγα κουιναζολίνης του τύπου (I) όπου το m είναι ένας ακέραιος από 1 έως 3˙ το R1 αντιπροσωπεύει αλογόνο ή C1-3αλκυλ˙ το Χ1 αντιπροσωπεύει -Ο-˙ το R2 επιλέγεται από μία από τις ακόλουθες τρεις ομάδες: 1) C1-5αλκυλR3 (όπου το R3 είναι πιπεριδιν-4-υλ το οποίο μπορεί να φέρει έναν ή δύο υποκαταστάτες που επιλέγονται από υδροξυ, αλογόνο, C1-4αλκυλ, C1-4υδροξυαλκυλ και C1-4αλκοξυ˙ 2) C2-5αλκενυλR3 (όπου το R3 είναι όπως ορίστηκε παραπάνω) ˙ 3) C2-5αλκυνυλR3 (όπου το R3 είναι όπως ορίστηκε παραπάνω) ˙ και όπου οποιαδήποτε αλκυλ, αλκενυλ ή αλκυνυλ ομάδα μπορεί να φέρει έναν ή περισσότερους υποκαταστάτες που επιλέγονται από υδροξυ, αλογόνο και αμινο˙ και άλατα αυτών˙ διαδικασίες για την παρασκευή τους, φαρμακευτικές συνθέσεις που περιέχουν μία ένωση του τύπου (I) ή ένα φαρμακευτικώς ανεκτό άλας αυτής ως δραστικό συστατικό. Οι ενώσεις του τύπου (I) και τα φαρμακευτικώς ανεκτά άλατα αυτών αναστέλλουν τις επιδράσεις του VEGF, μία σημαντική ιδιότητα για τη θεραπευτική αντιμετώπιση πολλών ασθενειών στις οποίες περιλαμβάνονται ο καρκίνος και η ρευματοειδής αρθρίτιδα.
CY20061101355T 1999-11-05 2006-09-21 Παραγωγα κουιναζολινης ως αναστολεις vegf. CY1106166T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP99402759 1999-11-05
EP99402877 1999-11-19
EP00974667A EP1244647B1 (en) 1999-11-05 2000-11-01 Quinazoline derivatives as vegf inhibitors
PCT/GB2000/004181 WO2001032651A1 (en) 1999-11-05 2000-11-01 Quinazoline derivatives as vegf inhibitors

Publications (1)

Publication Number Publication Date
CY1106166T1 true CY1106166T1 (el) 2011-06-08

Family

ID=26153696

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20061101355T CY1106166T1 (el) 1999-11-05 2006-09-21 Παραγωγα κουιναζολινης ως αναστολεις vegf.
CY20081100853T CY1108256T1 (el) 1999-11-05 2008-08-12 Νεα παραγωγα κουιναζολινης
CY2012026C CY2012026I2 (el) 1999-11-05 2012-08-14 Παραγωγα κουιναζολινης ως αναστολεις vegf

Family Applications After (2)

Application Number Title Priority Date Filing Date
CY20081100853T CY1108256T1 (el) 1999-11-05 2008-08-12 Νεα παραγωγα κουιναζολινης
CY2012026C CY2012026I2 (el) 1999-11-05 2012-08-14 Παραγωγα κουιναζολινης ως αναστολεις vegf

Country Status (36)

Country Link
US (9) US7173038B1 (el)
EP (2) EP1676845B1 (el)
JP (1) JP3522727B2 (el)
KR (3) KR100849151B1 (el)
CN (2) CN101219145A (el)
AR (1) AR033499A1 (el)
AT (2) ATE398120T1 (el)
AU (1) AU769222B2 (el)
BE (1) BE2012C036I2 (el)
BG (1) BG65861B1 (el)
BR (2) BR0015203A (el)
CA (1) CA2389767C (el)
CY (3) CY1106166T1 (el)
CZ (1) CZ301689B6 (el)
DE (2) DE60029007T2 (el)
DK (2) DK1244647T3 (el)
EE (1) EE05330B1 (el)
ES (2) ES2265998T3 (el)
FR (1) FR12C0048I2 (el)
HK (2) HK1049664B (el)
HU (1) HU229414B1 (el)
IL (2) IL149034A0 (el)
IS (2) IS2284B (el)
LU (1) LU92057I2 (el)
MX (1) MXPA02004366A (el)
NO (2) NO322298B1 (el)
NZ (1) NZ518028A (el)
PL (1) PL203782B1 (el)
PT (2) PT1676845E (el)
RU (1) RU2291868C2 (el)
SI (2) SI1676845T1 (el)
SK (1) SK287401B6 (el)
TW (1) TWI287540B (el)
UA (1) UA72946C2 (el)
WO (1) WO2001032651A1 (el)
ZA (1) ZA200202775B (el)

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