WO2009025358A1 - 複素環化合物およびその用途 - Google Patents
複素環化合物およびその用途 Download PDFInfo
- Publication number
- WO2009025358A1 WO2009025358A1 PCT/JP2008/065011 JP2008065011W WO2009025358A1 WO 2009025358 A1 WO2009025358 A1 WO 2009025358A1 JP 2008065011 W JP2008065011 W JP 2008065011W WO 2009025358 A1 WO2009025358 A1 WO 2009025358A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- heterocyclic compound
- disclosed
- formulae
- iii
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/674,801 US8324395B2 (en) | 2007-08-23 | 2008-08-22 | Heterocyclic compound and use thereof |
JP2009529075A JP5270553B2 (ja) | 2007-08-23 | 2008-08-22 | 複素環化合物およびその用途 |
EP08827923.7A EP2181987B9 (en) | 2007-08-23 | 2008-08-22 | 2-Carbonylaminobenzothiazoles and their use for the prophylaxis and treatment of cancer |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-217633 | 2007-08-23 | ||
JP2007217633 | 2007-08-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009025358A1 true WO2009025358A1 (ja) | 2009-02-26 |
Family
ID=40378258
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/065011 WO2009025358A1 (ja) | 2007-08-23 | 2008-08-22 | 複素環化合物およびその用途 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8324395B2 (ja) |
EP (1) | EP2181987B9 (ja) |
JP (1) | JP5270553B2 (ja) |
WO (1) | WO2009025358A1 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8143258B2 (en) | 2008-12-02 | 2012-03-27 | Takeda Pharmaceutical Company Limited | Benzothiazole compounds useful for Raf inhibition |
US8304557B2 (en) | 2007-06-05 | 2012-11-06 | Takeda Pharmaceutical Company Limited | Fused heterocycle derivatives and use thereof |
US8324395B2 (en) | 2007-08-23 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8344135B2 (en) | 2007-08-29 | 2013-01-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8445509B2 (en) | 2008-05-08 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
US8697874B2 (en) | 2008-12-01 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ, インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009111280A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
CA2716952A1 (en) * | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Pyrazole [3,4-b] pyridine raf inhibitors |
TW200940540A (en) * | 2008-02-29 | 2009-10-01 | Array Biopharma Inc | RAF inhibitor compounds and methods of use thereof |
ES2392482T3 (es) * | 2008-02-29 | 2012-12-11 | Array Biopharma, Inc. | Derivados de imidazo[4,5-b] piridina usados como inhibidores de RAF |
WO2013032951A1 (en) | 2011-08-26 | 2013-03-07 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
WO2013043935A1 (en) | 2011-09-21 | 2013-03-28 | Neupharma, Inc. | Certain chemical entites, compositions, and methods |
WO2013049701A1 (en) * | 2011-09-30 | 2013-04-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN109053630B (zh) * | 2018-08-22 | 2022-04-01 | 中国人民解放军第二军医大学 | 一种苯并噻唑类衍生物及其用途 |
CN114805120A (zh) * | 2022-05-23 | 2022-07-29 | 江苏瑞达环保科技有限公司 | 一种间氰甲基苯甲酸甲酯的合成工艺 |
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WO2007121484A2 (en) * | 2006-04-19 | 2007-10-25 | Novartis Ag | 6-o-substituted benzoxazole and benzothiazole compounds and methods of inhibiting csf-1r signaling |
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2008
- 2008-08-22 US US12/674,801 patent/US8324395B2/en active Active
- 2008-08-22 EP EP08827923.7A patent/EP2181987B9/en active Active
- 2008-08-22 WO PCT/JP2008/065011 patent/WO2009025358A1/ja active Application Filing
- 2008-08-22 JP JP2009529075A patent/JP5270553B2/ja not_active Expired - Fee Related
Patent Citations (22)
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US2399026A (en) | 1941-02-06 | 1946-04-23 | Chem Ind Basel | Amides of 2-aminoarylenethiazoles |
WO1999010325A1 (en) | 1997-08-06 | 1999-03-04 | Glaxo Group Limited | Benzylidene-1,3-dihydro-indol-2-one derivatives as receptor tyrosine kinase inhibitors, particularly of raf kinases |
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---|---|---|---|---|
US8304557B2 (en) | 2007-06-05 | 2012-11-06 | Takeda Pharmaceutical Company Limited | Fused heterocycle derivatives and use thereof |
US8324395B2 (en) | 2007-08-23 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8344135B2 (en) | 2007-08-29 | 2013-01-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8445509B2 (en) | 2008-05-08 | 2013-05-21 | Takeda Pharmaceutical Company Limited | Fused heterocyclic derivatives and use thereof |
US8697874B2 (en) | 2008-12-01 | 2014-04-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8497274B2 (en) | 2008-12-02 | 2013-07-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
US8143258B2 (en) | 2008-12-02 | 2012-03-27 | Takeda Pharmaceutical Company Limited | Benzothiazole compounds useful for Raf inhibition |
JP2014530194A (ja) * | 2011-09-14 | 2014-11-17 | ニューファーマ, インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
JP2017082011A (ja) * | 2011-09-14 | 2017-05-18 | ニューファーマ, インコーポレイテッド | 特定の化学的実体、組成物、および方法 |
US10065932B2 (en) | 2011-09-14 | 2018-09-04 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10759766B2 (en) | 2011-09-14 | 2020-09-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10590106B2 (en) | 2012-01-25 | 2020-03-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10457641B2 (en) | 2012-09-24 | 2019-10-29 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
US10047059B2 (en) | 2012-11-12 | 2018-08-14 | Neupharma, Inc. | Substituted quinoxalines for inhibiting kinase activity |
Also Published As
Publication number | Publication date |
---|---|
EP2181987B9 (en) | 2014-09-03 |
EP2181987A1 (en) | 2010-05-05 |
EP2181987A4 (en) | 2012-03-07 |
US20110172245A1 (en) | 2011-07-14 |
JPWO2009025358A1 (ja) | 2010-11-25 |
US8324395B2 (en) | 2012-12-04 |
EP2181987B1 (en) | 2014-03-05 |
JP5270553B2 (ja) | 2013-08-21 |
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