AR082418A1 - Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico - Google Patents
Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilicoInfo
- Publication number
- AR082418A1 AR082418A1 ARP110102747A ARP110102747A AR082418A1 AR 082418 A1 AR082418 A1 AR 082418A1 AR P110102747 A ARP110102747 A AR P110102747A AR P110102747 A ARP110102747 A AR P110102747A AR 082418 A1 AR082418 A1 AR 082418A1
- Authority
- AR
- Argentina
- Prior art keywords
- trifluoro
- amide
- dimethyl
- ethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
La presente se refiere a formas sólidas específicas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il-amida de 2-amida del ácido (S)-pirrolidin-1,2-dicarboxílico, y sus hidratos y solvatos. La presente se refiere además a procesos para la preparación de estas formas sólidas, a composiciones farmacéuticas que comprenden tales formas sólidas, y a métodos para utilizar las formas sólidas mencionadas y composiciones farmacéuticas para tratar enfermedades.Reivindicación 1: Una forma cristalina del compuesto de la fórmula (1) o un hidrato o solvato de la forma cristalina del compuesto de la fórmula (1).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36983710P | 2010-08-02 | 2010-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR082418A1 true AR082418A1 (es) | 2012-12-05 |
Family
ID=44503814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110102747A AR082418A1 (es) | 2010-08-02 | 2011-07-29 | Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico |
Country Status (3)
Country | Link |
---|---|
AR (1) | AR082418A1 (es) |
TW (1) | TW201206922A (es) |
WO (1) | WO2012016970A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2839621A1 (en) * | 2011-06-21 | 2012-12-27 | Novartis Ag | Polymorphs of (s)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide |
BR112014023530A2 (pt) | 2012-03-29 | 2017-07-18 | Novartis Ag | diagnóstico farmacêutico |
US8980259B2 (en) | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
WO2014191938A1 (en) * | 2013-05-31 | 2014-12-04 | Novartis Ag | Combination therapy containing a pi3k-alpha inhibitor and fgfr kinase inhibitor for treating cancer |
PL3200772T3 (pl) * | 2014-10-03 | 2022-12-19 | Novartis Ag | Kompozycje farmaceutyczne zawierające alpelisyb |
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2011
- 2011-07-29 AR ARP110102747A patent/AR082418A1/es unknown
- 2011-08-01 TW TW100127240A patent/TW201206922A/zh unknown
- 2011-08-01 WO PCT/EP2011/063256 patent/WO2012016970A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012016970A1 (en) | 2012-02-09 |
TW201206922A (en) | 2012-02-16 |
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