ES2159760T3 - Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina. - Google Patents

Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina.

Info

Publication number
ES2159760T3
ES2159760T3 ES96934673T ES96934673T ES2159760T3 ES 2159760 T3 ES2159760 T3 ES 2159760T3 ES 96934673 T ES96934673 T ES 96934673T ES 96934673 T ES96934673 T ES 96934673T ES 2159760 T3 ES2159760 T3 ES 2159760T3
Authority
ES
Spain
Prior art keywords
sub
rent
piridopirimidina
purina
ring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934673T
Other languages
English (en)
Inventor
Franco Buzzetti
Maria Gabriella Brasca
Antonio Longo
Dario Ballinari
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9523242.7A external-priority patent/GB9523242D0/en
Priority claimed from GBGB9524131.1A external-priority patent/GB9524131D0/en
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of ES2159760T3 publication Critical patent/ES2159760T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/28—Oxygen atom
    • C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE PIRIMIDINA CONDENSADA BICICLICA, QUE POSEEN LA FORMULA GENERAL (I), EN LA QUE X ES UB,2}){SUB,N} CERO O 1; A ES UN ANILLO DE IMIDAZOL CONDENSADO EN 4,5, N SUSTITUIDO CON R{SUB,3}, QUE ES HIDROGENO, ALQUILO C{SUB,1} C{SUB,4} O BENCILO, O A ES UN ANILLO DE PIRIDINA CONDENSADO EN LA POSICION 2,3, C UILO C{SUB,1} O NR{SUB,5}R{SUB,6}, EN EL QUE CADA UNO DE LOS R{SUB,5} Y R{SUB,6} SON INDEPENDIENTEMENTE H O ALQUILO C{SUB,1} ES UN ANILLO BICICLICO QUE SE SELECCIONA ENTRE TETRALINA, INDANO Y 2 PENDIENTEMENTE HIDROGENO, ALQUILO C{SUB,1} O, HIDROXI, ALCOXI C{SUB,1} 4} CARBONILO, NITRO, CIANO O CF{SUB,3}; Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS; Y EN LOS QUE CUANDO AL MISMO TIEMPO A ES PIRIDINA Y B ES UN ANILLO DE TETRALINA, R{SUB,4} ES ALQUILO C{SUB,1} ENO, Y X ES COMO SE HA DEFINIDO ANTERIORMENTE, ENTONCES CADA UNO DE R{SUB,1} Y R{SUB,2} ES DISTINTO DE H; Y EN LOS QUE CUANDO AL MISMO TIEMPO A ES IMIDAZOL, X ES - NH (CH{SUB,2}){SUB,N} COMOSE HA DEFINIDO ANTERIORMENTE, Y B ES UN ANILLO DE INDANO SIN SUSTITUIR O SUSTITUIDO CON UNO O MAS DE HALOGENO, HIDROXI, ALCOXI C{SUB,1} NTO DE ALQUILO C{SUB,1}
ES96934673T 1995-11-14 1996-10-14 Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina. Expired - Lifetime ES2159760T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9523242.7A GB9523242D0 (en) 1995-11-14 1995-11-14 Aryl and heteroaryl purine compounds
GBGB9524131.1A GB9524131D0 (en) 1995-11-24 1995-11-24 Pyrido-pyrimidine compounds as tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
ES2159760T3 true ES2159760T3 (es) 2001-10-16

Family

ID=26308112

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96934673T Expired - Lifetime ES2159760T3 (es) 1995-11-14 1996-10-14 Derivados de aril purina y piridopirimidina y de heteroaril purina y piridopirimidina.

Country Status (17)

Country Link
US (1) US5965563A (es)
EP (1) EP0802914B1 (es)
JP (1) JPH10512896A (es)
CN (1) CN1168138A (es)
AR (1) AR004320A1 (es)
AT (1) ATE201873T1 (es)
AU (1) AU7292096A (es)
BR (1) BR9607089A (es)
CA (1) CA2209598C (es)
DE (1) DE69613211T2 (es)
EA (1) EA000072B1 (es)
ES (1) ES2159760T3 (es)
HU (1) HUP9801177A3 (es)
IL (1) IL121090A0 (es)
NO (1) NO973198L (es)
PL (1) PL321296A1 (es)
WO (1) WO1997018212A1 (es)

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TW321649B (es) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
US5932574A (en) * 1995-04-27 1999-08-03 Zeneca Limited Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
JP4471404B2 (ja) 1996-02-13 2010-06-02 アストラゼネカ ユーケイ リミテッド Ｖｅｇｆインヒビターとしてのキナゾリン誘導体
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
SI0892789T2 (sl) 1996-04-12 2010-03-31 Warner Lambert Co Ireverzibilni inhibitorji tirozin kinaz
HRP970371A2 (en) * 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
JP2001509483A (ja) 1997-07-12 2001-07-24 カンサー リサーチ キャンペーン テクノロジー リミテッド サイクリン依存性キナーゼ阻害性プリン誘導体
RS49779B (sr) 1998-01-12 2008-06-05 Glaxo Group Limited, Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
ATE265458T1 (de) 1998-06-19 2004-05-15 Pfizer Prod Inc Pyrrolo(2,3-d)pyrimidin-verbindungen
US6933299B1 (en) 1999-07-09 2005-08-23 Smithkline Beecham Corporation Anilinoquinazolines as protein tyrosine kinase inhibitors
ES2295035T3 (es) 1999-07-09 2008-04-16 Glaxo Group Limited Anilinoquinazolinas como inhibidores de proteina tirosina quinasa.
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
DE60007552T2 (de) 1999-12-10 2004-09-23 Pfizer Products Inc., Groton PYRROLO[2,3-d]PYRIMIDIN-VERBINDUNGEN ALS PROTEIN KINASEN HEMMER
MXPA03000068A (es) 2000-06-26 2003-09-25 Pfizer Prod Inc Compuestos de pirrolo (2,3-d)pirimidina como agentes inmunosupresores.
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
US6936620B2 (en) * 2001-12-20 2005-08-30 Bristol Myers Squibb Company Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases
EP1352910A1 (en) * 2002-04-10 2003-10-15 Grünenthal GmbH New analogs of nitrobenzylthioinosine
JP2006509000A (ja) 2002-11-26 2006-03-16 ファイザー・プロダクツ・インク 移植片拒絶反応の処置の方法
SG145748A1 (en) * 2003-08-15 2008-09-29 Irm Llc 6-substituted anilino purines as rtk inhibitors
EP1711495A2 (en) 2004-01-23 2006-10-18 Amgen Inc. Quinoline, quinazoline, pyridine and pyrimidine counds and their use in the treatment of inflammation, angiogenesis and cancer
UA86614C2 (ru) * 2004-01-23 2009-05-12 Амген Инк Соединение, которое имеет активность ингибитора киназ, фармацевтическая композиция, которая включает указанное соединение, и их применение для приготовления лекарственного препарата
ATE374202T1 (de) * 2004-06-29 2007-10-15 Gruenenthal Gmbh Neue analoga von nitrobenzylthioinosin
EP1827434B1 (en) * 2004-11-30 2014-01-15 Amgen Inc. Quinolines and quinazoline analogs and their use as medicaments for treating cancer
JO2787B1 (en) * 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
WO2007076034A2 (en) * 2005-12-21 2007-07-05 Abbott Laboratories Anti-viral compounds
EP1971611B1 (en) 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
TWI399380B (zh) * 2006-12-20 2013-06-21 Abbott Lab 抗病毒化合物
EP2220078B1 (en) * 2007-10-29 2013-05-22 Amgen, Inc Benzomorpholine derivatives and methods of use
SI2384326T1 (sl) 2008-08-20 2014-06-30 Zoetis Llc Pirolo(2,3-d)pirimidinske spojine
DE102011111400A1 (de) * 2011-08-23 2013-02-28 Merck Patent Gmbh Bicyclische heteroaromatische Verbindungen
ES2592404T3 (es) 2012-05-21 2016-11-30 Bayer Pharma Aktiengesellschaft Benzotienopirimidinas sustituidas
TW201412740A (zh) 2012-09-20 2014-04-01 Bayer Pharma AG 經取代之吡咯并嘧啶胺基苯并噻唑酮
ES2686909B1 (es) 2017-03-22 2019-08-16 Consejo Superior Investigacion Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas
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US3112192A (en) * 1960-09-19 1963-11-26 Shell Oil Co Preservation of cut flowers
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Also Published As

Publication number Publication date
BR9607089A (pt) 1997-11-11
NO973198D0 (no) 1997-07-09
IL121090A0 (en) 1997-11-20
CN1168138A (zh) 1997-12-17
WO1997018212A1 (en) 1997-05-22
CA2209598A1 (en) 1997-05-22
HUP9801177A2 (hu) 1998-09-28
DE69613211T2 (de) 2001-11-15
CA2209598C (en) 2005-06-07
HUP9801177A3 (en) 1998-11-30
EP0802914B1 (en) 2001-06-06
MX9705010A (es) 1997-10-31
NO973198L (no) 1997-07-09
DE69613211D1 (de) 2001-07-12
AU7292096A (en) 1997-06-05
ATE201873T1 (de) 2001-06-15
AR004320A1 (es) 1998-11-04
JPH10512896A (ja) 1998-12-08
PL321296A1 (en) 1997-12-08
EP0802914A1 (en) 1997-10-29
EA199700107A1 (ru) 1997-12-30
US5965563A (en) 1999-10-12
EA000072B1 (ru) 1998-06-25

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