AR065784A1 - Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. - Google Patents

Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.

Info

Publication number
AR065784A1
AR065784A1 ARP080101118A ARP080101118A AR065784A1 AR 065784 A1 AR065784 A1 AR 065784A1 AR P080101118 A ARP080101118 A AR P080101118A AR P080101118 A ARP080101118 A AR P080101118A AR 065784 A1 AR065784 A1 AR 065784A1
Authority
AR
Argentina
Prior art keywords
unsubstituted
substituted
alkylene
alkyl
oxygen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP080101118A
Other languages
English (en)
Inventor
Tomoaki Nakamura
Yoshiaki Isobe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dainippon Sumitomo Pharma Co Ltd
AstraZeneca AB
DAINIPPON SUMITOMO PHARMA Co
Original Assignee
Dainippon Sumitomo Pharma Co Ltd
AstraZeneca AB
DAINIPPON SUMITOMO PHARMA Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39765921&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR065784(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dainippon Sumitomo Pharma Co Ltd, AstraZeneca AB, DAINIPPON SUMITOMO PHARMA Co filed Critical Dainippon Sumitomo Pharma Co Ltd
Publication of AR065784A1 publication Critical patent/AR065784A1/es
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Abstract

El compuesto y la sal son utiles como medicamentos, antialérgicos, antivirales o antibacterianos. Reivindicacion 1: Un compuesto de adenina caracterizado por la formula {l) donde A es carbociclo aromático sustituido o no sustituido, o heterocicloaromático sustituido o no sustituido, L1 es una unica union, o alquileno de cadena lineal o cadena ramificada; L2 es una unica union, o alquileno da cadena lineal o cadena ramificada opcionalmente sustituido con hidroxi, amino, alquilamino odialquilamino; en el caso de que L2 sea una unica union, -NR2R3 no es un amino no sustituido, alquilamino no sustituido, dialquilamino no sustituido, pirrolidinilo no sustituido, piperidino no sustituido o morfolino no sustituido; cualquiera de unoa tres del/de los grupo(s) metileno en el alquileno en L2 puede reemplazarse por oxigeno, azufre, SO, SO2, carbonilo, NR4CO, CONR4, NR4SO2, SO2NR4, NR4CO2, OCONR4, NR5CONR4, NR6C(=NR4)NR5, C(=NR4)NR5 donde R4, R5 y R6 son independientementehidrogeno o alquilo; y uno a tres del/de los grupo(s) metileno en el alquileno en L1 puede reemplazarse por oxígeno; R1 es halogeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilo sustituido o no sustituido,cicloalquilo sustituido o no sustituido, arilo sustituido o no sustituido, o heteroarilo sustituido o no sustituido; R2 y R3 son independientemente hidrogeno, alquilo sustituido o no sustituido, alquenilo sustituido o no sustituido, alquinilosustituido o no sustituido, cicloalquilo sustituido o no sustituido, heterociclo saturado sustituido o no sustituido, arilo sustituido o no sustituido, o heteroarilo sustituido o no sustituido, o R2 puede combinarse junto con L2 o R3 para formar unheterociclo saturado que contiene nitrogeno de 4 a 8 miembros sustituido o no sustituido; y X es oxígeno, azufre, SO, SO2, NR7, NR7CO donde R7 es hidrogeno o alquilo, o una unica union; siempre que cuando R1 sea halogeno, entonces X sea una unicaunion, o una sal aceptable para uso farmacéutico del mismo.
ARP080101118A 2007-03-20 2008-03-18 Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas. Pending AR065784A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007071713 2007-03-20

Publications (1)

Publication Number Publication Date
AR065784A1 true AR065784A1 (es) 2009-07-01

Family

ID=39765921

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101118A Pending AR065784A1 (es) 2007-03-20 2008-03-18 Derivados de 8-oxo adenina,medicamentos que los contienen y usos como agentes terapeuticos para enfermedades alergicas, antivirales o antibacterianas.

Country Status (21)

Country Link
US (2) US20100093998A1 (es)
EP (1) EP2133353A4 (es)
JP (1) JPWO2008114817A1 (es)
KR (1) KR20090125774A (es)
CN (1) CN101679433A (es)
AR (1) AR065784A1 (es)
AU (1) AU2008227500A1 (es)
BR (1) BRPI0809134A2 (es)
CA (1) CA2680397A1 (es)
CL (1) CL2008000789A1 (es)
CO (1) CO6220972A2 (es)
EC (1) ECSP099638A (es)
IL (1) IL200831A0 (es)
MX (1) MX2009010024A (es)
NZ (1) NZ579744A (es)
PE (1) PE20081887A1 (es)
RU (1) RU2009138471A (es)
TW (1) TW200902018A (es)
UY (1) UY30966A1 (es)
WO (1) WO2008114817A1 (es)
ZA (1) ZA200906253B (es)

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PL2155743T3 (pl) 2007-05-08 2013-01-31 Astrazeneca Ab Imidazochinoliny o właściwościach immunomodulacyjnych
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CA2680397A1 (en) 2008-09-25
UY30966A1 (es) 2008-10-31
PE20081887A1 (es) 2009-01-16
CN101679433A (zh) 2010-03-24
EP2133353A1 (en) 2009-12-16
RU2009138471A (ru) 2011-04-27
NZ579744A (en) 2012-06-29
TW200902018A (en) 2009-01-16
JPWO2008114817A1 (ja) 2010-07-08
EP2133353A4 (en) 2011-08-31
BRPI0809134A2 (pt) 2014-08-26
AU2008227500A1 (en) 2008-09-25
US20100093998A1 (en) 2010-04-15
ECSP099638A (es) 2009-10-30
MX2009010024A (es) 2009-10-12
CO6220972A2 (es) 2010-11-19
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ZA200906253B (en) 2010-01-27
KR20090125774A (ko) 2009-12-07

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